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21. 发明申请

WO2011053787A2 SYSTEMS AND METHODS FOR APPLICATION TO SKIN AND CONTROL OF ACTUATION, DELIVERY AND/OR PERCEPTION THEREOF 审中-公开
标题翻译：用于皮肤应用的系统和方法及其致动，传递和/或认知的控制
公开(公告)号：WO2011053787A2
公开(公告)日：2011-05-05
申请号：PCT/US2010/054723
申请日：2010-10-29
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , CHICKERING, Donald, E. , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHOOIE, Ramin , BERNSTEIN, Howard , WALT, David, R.
发明人： CHICKERING, Donald, E. , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHOOIE, Ramin , BERNSTEIN, Howard , WALT, David, R.
IPC分类号： A61M5/32 , A61B5/155 , A61B5/151
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150106 , A61B5/150122 , A61B5/150129 , A61B5/150137 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150809 , A61B5/150824 , A61B5/150893 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15109 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685 , A61B2560/0412 , A61B2560/0443 , A61M5/425 , A61M35/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588
摘要： The present invention generally relates, in certain aspects, to systems and methods for application to the skin, and control of actuation, delivery, and/or perception thereof. For example, certain aspects of the invention are generally directed to devices for delivering to and/or withdrawing fluid or from subjects, e.g., to or from the skin and/or beneath the skin. In one aspect, the delivery and/or withdrawal of fluid is at least partially obscured. For example, the obscuration may be by time, and/or by sensory obscuration (e.g., by providing tactile, olfactory, auditory, and/or visual sensations). Certain aspects of the invention are generally directed to devices able to automatically deliver to and/or withdraw fluid from the skin and/or beneath the skin after activation, e.g., where the fluid is delivered and/or withdrawn without the need for any additional intervention. The devices may be activated by any suitable technique. In other aspects, a device may be contained in a package, and when removed from the package, the device may be constructed and arranged to be able to deliver and/or withdraw fluid when the device is applied to the skin, and in some cases, automatically and/or without any further intervention by the subject or another person.
摘要翻译：本发明在某些方面一般涉及用于皮肤的系统和方法，以及对其致动，传递和/或感知的控制。例如，本发明的某些方面通常涉及用于递送到和/或从流体或从受试者递送到皮肤和/或从皮肤下方的装置。在一个方面，流体的递送和/或排出至少部分地模糊。例如，遮蔽可以是时间，和/或通过感觉遮蔽（例如，通过提供触觉，嗅觉，听觉和/或视觉感觉）。本发明的某些方面通常涉及能够在活化后自动递送至皮肤和/或皮下的流体的装置，例如在流体被输送和/或取出而不需要任何额外干预的情况下。可以通过任何合适的技术来激活装置。在其他方面，装置可以包含在包装中，并且当从包装中取出时，可以构造和布置该装置，以便当该装置应用于皮肤时能够输送和/或抽出流体，并且在某些情况下，自动地和/或没有受试者或另一个人的进一步干预。

22. 发明申请

WO2010101626A8 TECHNIQUES AND DEVICES ASSOCIATED WITH BLOOD SAMPLING 审中-公开
标题翻译：与血液采样相关的技术和设备
公开(公告)号：WO2010101626A8
公开(公告)日：2010-10-28
申请号：PCT/US2010000631
申请日：2010-03-02
申请人： SEVENTH SENSE BIOSYSTEMS INC , LEVINSON DOUGLAS A , BERNSTEIN HOWARD , CHICKERING DOANLD E , DAVIS SHAWN , HAGHGOOIE RAMIN , MICHELMAN MARK
发明人： LEVINSON DOUGLAS A , BERNSTEIN HOWARD , CHICKERING DOANLD E , DAVIS SHAWN , HAGHGOOIE RAMIN , MICHELMAN MARK
IPC分类号： A61B5/151
CPC分类号： A61B5/150099 , A61B5/0013 , A61B5/0022 , A61B5/0077 , A61B5/1438 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15125 , A61B5/157 , A61B5/411 , A61B5/4839 , A61B5/4845 , A61B5/486 , A61B5/685 , A61B5/6898 , A61B5/743
摘要： The present invention generally relates to a device for withdrawing blood from the skin and/or from beneath the skin of a subject, the device comprising: a fluid transporter, a vacuum chamber having an internal pressure less than atmospheric pressure before blood is withdrawn into the device and a storage chamber for receiving blood withdrawn from the subject through the fluid transporter when a negative pressure is applied to the skin of the subject. The device may further comprise one or more microneedles.
摘要翻译：本发明总体上涉及一种用于从皮肤和/或从受试者皮肤下面抽出血液的装置，该装置包括：流体输送器，具有内压低于大气压的真空室，然后血液被抽出到装置和存储室，用于当对受试者的皮肤施加负压时，通过流体输送器接收从受试者抽出的血液。该装置还可以包括一个或多个微针。

23. 发明申请

WO2010101626A1 TECHNIQUES AND DEVICES ASSOCIATED WITH BLOOD SAMPLING 审中-公开
标题翻译：与血液采样相关的技术和设备
公开(公告)号：WO2010101626A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/000631
申请日：2010-03-02
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , LEVINSON, Douglas, A. , BERNSTEIN, Howard , CHICKERING, Doanld, E. , DAVIS, Shawn , HAGHGOOIE, Ramin , MICHELMAN, Mark
发明人： LEVINSON, Douglas, A. , BERNSTEIN, Howard , CHICKERING, Doanld, E. , DAVIS, Shawn , HAGHGOOIE, Ramin , MICHELMAN, Mark
IPC分类号： A61B5/151
CPC分类号： A61B5/150099 , A61B5/0013 , A61B5/0022 , A61B5/0077 , A61B5/1438 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15125 , A61B5/157 , A61B5/411 , A61B5/4839 , A61B5/4845 , A61B5/486 , A61B5/685 , A61B5/6898 , A61B5/743
摘要： The present invention generally relates to a device for withdrawing blood from the skin and/or from beneath the skin of a subject, the device comprising: a fluid transporter, a vacuum chamber having an internal pressure less than atmospheric pressure before blood is withdrawn into the device and a storage chamber for receiving blood withdrawn from the subject through the fluid transporter when a negative presure is applied to the skin of the subject. The device may further comprises one or more microwelles.
摘要翻译：本发明总体上涉及一种用于从皮肤和/或从受试者皮肤下面抽出血液的装置，该装置包括：流体输送器，具有内压低于大气压的真空室，然后血液被抽出到装置和存储室，用于当对受试者的皮肤施加负面压力时，通过流体转运器接收从对象抽出的血液。该装置还可以包括一个或多个微孔。

24. 发明申请

WO2007070852A3 PROCESSES FOR MAKING PARTICLE-BASED PHARMACEUTICAL FORMULATIONS FOR PARENTERAL ADMINISTRATION 审中-公开
标题翻译：用于制备基于颗粒的药物制剂用于肠胃外给药的过程
公开(公告)号：WO2007070852A3
公开(公告)日：2007-11-01
申请号：PCT/US2006062094
申请日：2006-12-14
申请人： ACUSPHERE INC , ALTREUTER DAVID , BERNSTEIN HOWARD , BRITO LUIS , BRITO SHAINA , CARNEIRO OLINDA C , CHICKERING DONALD E , HUANG ERIC K , JAIN RAJEEV , NARASIMHAN SRIDHAR , PANDIT NAMRATA , STRAUB JULIE A
发明人： ALTREUTER DAVID , BERNSTEIN HOWARD , BRITO LUIS , BRITO SHAINA , CARNEIRO OLINDA C , CHICKERING DONALD E , HUANG ERIC K , JAIN RAJEEV , NARASIMHAN SRIDHAR , PANDIT NAMRATA , STRAUB JULIE A
IPC分类号： A61K9/14
CPC分类号： A61K9/0019 , A61K9/145 , A61K9/146 , A61K9/19
摘要： A method is provided for making a parenteral dosage form of a pharmaceutical agent which Includes (a) providing particles of a pharmaceutical agent; (b) blending the particles with particles of at least one bulking agent to form a first powder blend, which does not include a surfactant; (c) milling the first powder blend to form a milled blend which comprises microparticles or nanopartides of the pharmaceutical agent; and (d) reconstituting the milled blend with a liquid vehicle, which includes at least one surfactant, for parenteral administration. A method also is provided which includes (a) providing particles of a pharmaceutical agent; (b) blending these particles with particles of an excipient to form a first blend; and (c) milling the first blend to form a milled blend that includes microparticles or tianopartÊcles, which exhibits a greater dispersibility, wettability, and suspcndability as compared to the particles of step (a) or the first blend.
摘要翻译：提供了用于制备药剂的肠胃外剂型的方法，其包括（a）提供药剂颗粒; （b）将所述颗粒与至少一种填充剂的颗粒共混以形成不包含表面活性剂的第一粉末混合物; （c）研磨第一粉末混合物以形成包含药剂的微粒或纳米粒子的研磨混合物; 和（d）用含有至少一种表面活性剂的液体载体重新配制经碾磨的混合物用于肠胃外给药。还提供了一种方法，其包括（a）提供药剂颗粒; （b）将这些颗粒与赋形剂颗粒混合以形成第一混合物; 和（c）研磨第一种共混物以形成包含微粒或天鹅绒的研磨混合物，与步骤（a）或第一种混合物的颗粒相比，该混合物显示出更大的分散性，润湿性和可悬浮性。

25. 发明申请

WO2007070851A2 PROCESSES FOR MAKING PARTICLE-BASED PHARMACEUTICAL FORMULATIONS FOR PULMONARY OR NASAL ADMINISTRATION 审中-公开
标题翻译：制备基于粒子的药物制剂用于肺癌或鼻咽管理的方法
公开(公告)号：WO2007070851A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/062093
申请日：2006-12-14
申请人： ACUSPHERE, INC. , BERNSTEIN, Howard , BRITO, Shaina , CHICKERING, Donald, E. , HUANG, Eric, K. , JAIN, Rajeev , STRAUB, Julie, A.
发明人： BERNSTEIN, Howard , BRITO, Shaina , CHICKERING, Donald, E. , HUANG, Eric, K. , JAIN, Rajeev , STRAUB, Julie, A.
IPC分类号： A61K9/00 , A61K9/14
CPC分类号： A61K9/0075 , A61K9/0043 , A61K9/0073 , A61K9/143 , A61K9/145
摘要： Dry powder pharmaceutical formulations for pulmonary or nasal administration are made to provide an improved respired dose. These formulations may be blends of milled blends and may include a phospholipid, alone or Ên combination with other excipient materials. In one case, the process includes the steps of (a) providing particles which comprise a pharmaceutical agent; (b) blending the particles with particles of at least one first excipient to form a first powder blend; (c) railling the first powder blend to form a milled blend which comprises microparticies or nanoparticles of the pharmaceutical agent; and (d) blending the milled blend with particles of a second excipient to form a blended dry powder blend pharmaceutical formulation suitable for pulmonary or nasal administration.
摘要翻译：制备用于肺或鼻给药的干粉药物制剂以提供改善的呼吸剂量。这些制剂可以是研磨的共混物的混合物，并且可以包括单独的磷脂或与其它赋形剂材料组合的磷脂。在一种情况下，该方法包括以下步骤：（a）提供包含药剂的颗粒; （b）将颗粒与至少一种第一赋形剂的颗粒混合以形成第一粉末混合物; （c）冲击第一粉末混合物以形成包含药剂的微粒或纳米颗粒的研磨混合物; 和（d）将研磨的共混物与第二赋形剂的颗粒混合以形成适于肺或鼻施用的混合的干粉混合药物制剂。

26. 发明申请

WO1996040074A2 DEVICE FOR RELEASING AGGREGATION-STABILIZED, BIOLOGICALLY ACTIVE AGENT 审中-公开
标题翻译：用于释放聚集稳定的生物活性剂的装置
公开(公告)号：WO1996040074A2
公开(公告)日：1996-12-19
申请号：PCT/US1996008526
申请日：1996-06-04
申请人： ALKERMES CONTROLLED THERAPEUTICS, INC. , BURKE, Paul, A. , ZALE, Stephen, E. , TRACY, Mark, A. , JOHNSON, OluFunmi, Lily , BERNSTEIN, Howard , KHAN, M., Amin , BRICKNER, Avram , AUER, Henry
发明人： ALKERMES CONTROLLED THERAPEUTICS, INC.
IPC分类号： A61K09/16
CPC分类号： B82Y5/00 , A61K9/0019 , A61K9/1611 , A61K9/1647 , A61K38/1816 , A61K38/27 , A61K47/02 , A61K47/26
摘要： A device for the sustained release in vivo of a water soluble, biologically active agent wherein the agent is susceptible to aggregation comprising a drug delivery device and aggregation-stabilized, biologically active agent wherein the aggregation-stabilized agent is disposed within the drug delivery device.
摘要翻译：用于在体内持续释放水溶性生物活性剂的装置，其中所述试剂易于凝集，其包含药物递送装置和聚集稳定的生物活性剂，其中所述聚集稳定的试剂置于所述药物递送装置内。

27. 发明申请

WO1995018602A1 ORAL DOSAGE FORM OF DESMOPRESSIN (dDAVP) 审中-公开
标题翻译： DESMOPRESSIN的口服剂型（dDAVP）
公开(公告)号：WO1995018602A1
公开(公告)日：1995-07-13
申请号：PCT/US1995000275
申请日：1995-01-09
申请人： ALKERMES CONTROLLED THERAPEUTICS, INC. , DIBIASE, Mary , BERNSTEIN, Howard
发明人： ALKERMES CONTROLLED THERAPEUTICS, INC.
IPC分类号： A61K09/51
CPC分类号： A61K9/5169 , A61K9/1658
摘要： dDAVP oral delivery systems are described wherein dDAVP retains good biological activity. In the preferred embodiment, dDAVP protein microspheres are made by emulsifying a solution of a protein such as zein and dDAVP with an immiscible solvent. Pellets containing the microspheres are prepared by an extrusion and spheronisation process, and are placed in a hard gelatin capsule. Release of biologically active dDAVP is achieved when the capsules are administered in vivo to cynomolgus monkeys.
摘要翻译：描述了dDAVP口服递送系统，其中dDAVP保持良好的生物活性。在优选的实施方案中，dDAVP蛋白质微球体是通过将蛋白质如玉米醇溶蛋白和dDAVP的溶液与不混溶的溶剂乳化而制成的。通过挤出和滚圆法制备含有微球的颗粒，并置于硬明胶胶囊中。当将胶囊在体内施用于食蟹猴时，实现生物活性dDAVP的释放。

28. 发明申请

WO2011088214A2 RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS 审中-公开
标题翻译：快速交付和/或取消流体
公开(公告)号：WO2011088214A2
公开(公告)日：2011-07-21
申请号：PCT/US2011/021134
申请日：2011-01-13
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , CHICKERING, Donald, E. ,III , DAVIS, Shawn , HAGHGOOIE, Ramin , BERNSTEIN, Howard , LEVINSON, Douglas, A. , MICHELMAN, Mark
发明人： CHICKERING, Donald, E. ,III , DAVIS, Shawn , HAGHGOOIE, Ramin , BERNSTEIN, Howard , LEVINSON, Douglas, A. , MICHELMAN, Mark
IPC分类号： A61M5/178 , A61B5/151 , A61B5/145
CPC分类号： A61B5/6849 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685
摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明总体上涉及用于递送和/或从皮肤和/或皮肤下面的受试者递送和/或取出物质或诸如血液或间质液的物质的方法。在一个方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从皮肤和/或从皮肤下方抽取或提取血液的装置和方法）和在接收血液之前具有小于大气压的内部压力的储存室。在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者中抽出血液。然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液中的分析物。例如，血液可以从装置中取出，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。本发明的其它方面涉及用于抽出血液（或其它体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

29. 发明申请

WO2011088211A2 SAMPLING DEVICE INTERFACES 审中-公开
标题翻译：采样设备接口
公开(公告)号：WO2011088211A2
公开(公告)日：2011-07-21
申请号：PCT/US2011/021131
申请日：2011-01-13
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , CHICKERING, Donald, E. , DAVIS, Shawn , HAGHGOOIE, Ramin , BERNSTEIN, Howard , LEVINSON, Douglas, A.
发明人： CHICKERING, Donald, E. , DAVIS, Shawn , HAGHGOOIE, Ramin , BERNSTEIN, Howard , LEVINSON, Douglas, A.
IPC分类号： A61B5/151
CPC分类号： A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150297 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685
摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self- contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
摘要翻译：本发明总体上涉及用于从受试者（例如从皮肤和/或从皮肤下方）输送和/或排出一种或多种物质（例如血液或间质液）的系统和方法。在一个方面，本发明总体上涉及用于使用含有液体转运体的装置（例如，一个或多个微针）从受试者（例如从皮肤和/或皮肤下面）抽取或抽取血液的装置和方法）以及在接收血液之前具有小于大气压的内部压力的储存室。在某些情况下，该装置可以是自包含的，并且在某些情况下，该装置可以被施加到皮肤上，并且被激活以从受试者中抽取血液。该装置在某些情况下可以与外部设备连接以确定装置内包含的或被装置收集的流体内包含的分析物。例如，该装置可以被安装或接合在外部保持器上，该装置可以包括用于将流体输送出装置的端口，该装置可以包括用于询问容纳在装置内的流体的窗口等。然后可以处理装置或其一部分，以单独地或利用外部装置来确定血液和/或血液内的分析物。例如，血液可以从装置中取出，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。本发明的其它方面涉及用于抽取血液（或其他体液，例如间质液）的其它装置，涉及这种装置的套件，制造这种装置的方法，使用这种装置的方法等。

30. 发明申请

WO2011053796A2 SYSTEMS AND METHODS FOR TREATING, SANITIZING, AND/OR SHIELDING THE SKIN OR DEVICES APPLIED TO THE SKIN 审中-公开
标题翻译：用于治疗，消毒和/或屏蔽皮肤或适用于皮肤的装置的系统和方法
公开(公告)号：WO2011053796A2
公开(公告)日：2011-05-05
申请号：PCT/US2010/054741
申请日：2010-10-29
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , BERNSTEIN, Howard , CHICKERING, Donald, E., III , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHGOOIE, Ramin
发明人： BERNSTEIN, Howard , CHICKERING, Donald, E., III , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHGOOIE, Ramin
IPC分类号： A61M5/32
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685 , A61B2560/0412 , A61B2560/0443 , A61M5/425 , A61M35/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588
摘要： The present invention generally relates, in certain aspects, to systems and methods for treating, sanitizing, and/or shielding blood on the surface of the skin or devices applied to the skin. In one set of embodiments, while blood is withdrawn from the skin of the subject, the blood is covered and/or shielded such that the blood is not seen by the subject. In another set of embodiments, any blood present on the skin may be altered or treated such that it no longer appears as blood, e.g., by exposing the blood to a chemical such as a peroxide that alters the color of the blood. In yet another set of embodiments, blood present on the skin is withdrawn or taken up by the device such that visible residual blood is not present in an amount visible to the unaided eye once the device is removed. In some cases, the same device may be used to sanitize the skin and deliver to and/or withdraw fluid from the skin and/or beneath the skin. The sanitization may be performed before, during, or after delivering to and/or withdrawing fluid from the skin and/or beneath the skin. Sanitization may be performed, for example, using a sanitizer such as hydrogen peroxide, ethyl alcohol, isopropyl alcohol, or the like.
摘要翻译：本发明在某些方面通常涉及用于治疗，消毒和/或屏蔽皮肤表面上的血液或施用于皮肤的装置的系统和方法。在一组实施方案中，当血液从受试者的皮肤中抽出时，血液被覆盖和/或被屏蔽，使得受试者看不到血液。在另一组实施方案中，存在于皮肤上的任何血液可以被改变或治疗，使得其不再像血液一样出现，例如通过将血液暴露于改变血液颜色的化学物质例如过氧化物。在另一组实施方案中，存在于皮肤上的血液被装置取出或吸收，使得一旦该装置被移除，可见的残留血液就不能以肉眼可见的量存在。在一些情况下，可以使用相同的装置来消毒皮肤并递送至/或从皮肤和/或皮肤下方排出流体。消毒可以在从皮肤和/或皮肤之下输送和/或从中释放流体之前，期间或之后进行。可以例如使用消毒剂如过氧化氢，乙醇，异丙醇等进行消毒。

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