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21. 发明申请

WO2010071970A1 A SYSTEM, NETWORK AND METHOD FOR MULTI-PLATFORM PUBLISHING AND SYNCHRONIZED CONTENT 审中-公开
标题翻译：一种用于多平台发布和同步内容的系统，网络和方法
公开(公告)号：WO2010071970A1
公开(公告)日：2010-07-01
申请号：PCT/CA2009/000615
申请日：2009-05-04
申请人： CHALK MEDIA SERVICE CORP. , LEBLANC, Michael , GLIDDEN, Jody, D. , HUDSON, David, James , O'REILLY, Jacob, Samuel , WAUGH, Michael, Derek , VERZILLI, Silvio , POWELL, Howard, Frith
发明人： LEBLANC, Michael , GLIDDEN, Jody, D. , HUDSON, David, James , O'REILLY, Jacob, Samuel , WAUGH, Michael, Derek , VERZILLI, Silvio , POWELL, Howard, Frith
IPC分类号： H04W4/18 , H04L12/16
CPC分类号： H04L67/2823 , H04L67/303 , H04L69/28
摘要： A method for synchronizing content delivery to a plurality of delivery devices of a user. A communications network and a system are also provided. The delivery devices include at least one computer connected to internet and at least one mobile device. The method comprises retrieving profile data concerning the plurality of delivery devices of the user; sending an invitation to deliver content to the plurality of delivery devices of the user; receiving at least two responses to the invitation, for each response received : identifying a responding delivery device of the plurality of delivery devices from which the response is received using the profile data; retrieving a platform type of the responding delivery device accepting the invitation; and retrieving and providing a delivery version of the content in a delivery format acceptable for the platform of the responding delivery device.
摘要翻译：一种用于将内容传送同步到用户的多个递送设备的方法。还提供通信网络和系统。传送设备包括连接到因特网和至少一个移动设备的至少一台计算机。该方法包括检索关于用户的多个传送设备的简档数据; 向所述用户的所述多个传送设备发送内容传送邀请; 对于所接收的每个响应，接收对所述邀请的至少两个响应：识别使用所述简档数据从其接收所述响应的所述多个递送设备中的响应递送设备; 检索接受邀请的响应传送设备的平台类型; 以及以所述响应传递设备的平台可接受的传送格式检索和提供所述内容的传送版本。

22. 发明申请

WO2010066026A1 INCREASING ALKALINE PULPING YIELD FOR SOFTWOOD WITH METAL IONS 审中-公开
标题翻译：用金属离子增加软木浆的碱性腐蚀
公开(公告)号：WO2010066026A1
公开(公告)日：2010-06-17
申请号：PCT/CA2009/001755
申请日：2009-12-03
申请人： FPINNOVATIONS , SUN, Yujun , BERRY, Richard McKinnon , RADIOTIS, Theodore
发明人： SUN, Yujun , BERRY, Richard McKinnon , RADIOTIS, Theodore
IPC分类号： D21C1/06 , D21C3/02
CPC分类号： D21C1/06 , D21C3/02
摘要： Impregnating or spraying softwood chips in a solution containing an appropriate concentration of alkaline earth metal ions selected from the group consisting of calcium ions, barium ions and strontium, preferably calcium ions, at room temperature before a reductive alkaline pulping process, for example kraft pulping, significantly increases pulp yield. Using an agent that complexes with the metal ions, such as hydroxyethylidene diphosphonic acid (HEDP) allows this benefit of metal ions to be achieved during the pulping process rather than in a separate impregnation step.
摘要翻译：在还原性碱性制浆过程（例如硫酸盐法制浆）之前，室温下，将含有适当浓度的选自钙离子，钡离子和锶（优选钙离子）的碱土金属离子的溶液浸渍或喷洒软木屑，显着提高纸浆产量。使用与金属离子（如羟基亚乙基二膦酸（HEDP））复合的试剂允许在制浆过程中实现金属离子的这种益处，而不是在单独的浸渍步骤中实现。

23. 发明申请

WO2010063121A1 METHODS FOR BIOMARKER IDENTIFICATION AND BIOMARKER FOR NON-SMALL CELL LUNG CANCER 审中-公开
标题翻译：生物标记识别方法和非小细胞肺癌生物标志物
公开(公告)号：WO2010063121A1
公开(公告)日：2010-06-10
申请号：PCT/CA2009/001775
申请日：2009-12-02
申请人： UNIVERSITY HEALTH NETWORK , TSAO, Ming-Sound , BOUTROS, Paul, C. , LAU, Suzanne, K. , SHEPHERD, Frances, A. , PENN, Linda, Z. , JURISICA, Igor , DER, Sandy, D.
发明人： TSAO, Ming-Sound , BOUTROS, Paul, C. , LAU, Suzanne, K. , SHEPHERD, Frances, A. , PENN, Linda, Z. , JURISICA, Igor , DER, Sandy, D.
IPC分类号： C40B40/06 , C12Q1/68 , C40B30/02 , C40B30/04 , G01N33/574 , G06F19/00
CPC分类号： G06F19/24 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , G01N33/57423 , G01N2800/50 , G06F19/20 , G06F19/28
摘要： There is provided a method for identifying a biomarker, such as a gene signature, associated with a biological parameter A 6-gene signature for non-small cell lung cancer (NSCLC) is also provided, as well as a method of prognosmg or classifying a subject with non-small cell lung cancer into a poor survival group or a good survival group, using said gene signature
摘要翻译：提供了用于鉴定与生物学参数相关的生物标志物（例如基因特征）的方法，还提供了用于非小细胞肺癌（NSCLC）的6种基因特征，以及一种预测或分类患有非小细胞肺癌的患者生存期较差或生存期较差，采用该基因标记

24. 发明申请

WO2010043055A1 ENDOGENOUS AUTO-FLUORESCENT BIOLOGICAL MARKERS FOR ASSESSING A BIOLOGICAL PARAMETER OF A CELL 审中-公开
标题翻译：用于评估细胞生物学参数的内源自发荧光生物标志物
公开(公告)号：WO2010043055A1
公开(公告)日：2010-04-22
申请号：PCT/CA2009/001492
申请日：2009-10-16
申请人： SOCPRA SCIENCES ET GÉNIE S.E.C. , SIROIS, Joël , BIZIER, Emmanuel , CARDIN-BERNIER, Guillaume
发明人： SIROIS, Joël , BIZIER, Emmanuel , CARDIN-BERNIER, Guillaume
IPC分类号： C12Q1/02 , C12N1/00 , C12N5/00 , C12Q1/00
CPC分类号： G01N21/6428 , C12Q1/02 , C12Q1/06 , G01N21/6408 , G01N21/6458 , G01N21/6486 , G01N33/487 , G01N33/582 , G01N2021/6491
摘要： The present application relates to the use of endogenous fluorescent biological markers to determine a biological parameter of a cell in a liquid. The methods provided herein provide accurate results in a relatively short amount of time and can be used to monitor and optimize cell culture online as well as determining the presence of a cellular contamination in a cell suspension.
摘要翻译：本申请涉及使用内源荧光生物标记物来确定液体中细胞的生物学参数。本文提供的方法在相对较短的时间内提供准确的结果，并且可用于在线监测和优化细胞培养以及确定细胞悬浮液中细胞污染的存在。

25. 发明申请

WO2010043052A1 AZETIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开
标题翻译：作为硬脂酸苄酯A DELTA-9去饱和酶抑制剂的AZETIDINE DERIVATIVES
公开(公告)号：WO2010043052A1
公开(公告)日：2010-04-22
申请号：PCT/CA2009/001489
申请日：2009-10-15
申请人： MERCK FROSST CANADA LTD. , POWELL, David , TRANMER, Geoffrey, K.
发明人： POWELL, David , TRANMER, Geoffrey, K.
IPC分类号： C07D403/04 , A61K31/497 , A61P3/00 , C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14
CPC分类号： C07D403/04 , A61K31/497 , C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14
摘要： Azetidine derivatives of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis.
摘要翻译：结构式I的氮杂环丁烷衍生物是硬脂酰辅酶A delta-9去饱和酶（SCD）的抑制剂。本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病; 动脉粥样硬化; 肥胖; 糖尿病; 神经系统疾病; 代谢综合征; 胰岛素抵抗; 癌症; 肝脂肪变性和非酒精性脂肪性肝炎。

26. 发明申请

WO2010034110A1 BETA-CARBOLINE SULPHONYLUREA DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为EP4受体拮抗剂的β-碳酰胺磺酰胺衍生物
公开(公告)号：WO2010034110A1
公开(公告)日：2010-04-01
申请号：PCT/CA2009/001330
申请日：2009-09-22
申请人： MERCK FROSST CANADA LTD. , BERTHELETTE, Carl , BOYD, Michael , BURCH, Jason , DUFRESNE, Claude , FARAND, Julie , HAN, Yongxin , STURINO, Claudio, F.
发明人： BERTHELETTE, Carl , BOYD, Michael , BURCH, Jason , DUFRESNE, Claude , FARAND, Julie , HAN, Yongxin , STURINO, Claudio, F.
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00
CPC分类号： C07D471/04
摘要： The invention is directed to ß-carboline sulphonylurea derivatives as EP4 receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, inflammation, osteoarthritis, and rheumatoid arthritis. Pharmaceutical compositions and methods of use are also included.
摘要翻译：本发明涉及作为EP4受体拮抗剂的β-咔啉磺酰脲衍生物，其可用于治疗EP4介导的疾病或病症，例如急性和慢性疼痛，炎症，骨关节炎和类风湿性关节炎。还包括药物组合物和使用方法。

27. 发明申请

WO2010031190A1 CULTURE MEDIUM FOR MYOBLASTS, PRECURSORS THEREOF AND DERIVATIVES THEREOF 审中-公开
标题翻译：文化传播媒介，其前身及其衍生物
公开(公告)号：WO2010031190A1
公开(公告)日：2010-03-25
申请号：PCT/CA2009/001342
申请日：2009-09-22
申请人： UNIVERSITÉ LAVAL , PARENT, Victor-Alain , GARNIER, Alain , TREMBLAY, Jacques P.
发明人： PARENT, Victor-Alain , GARNIER, Alain , TREMBLAY, Jacques P.
IPC分类号： C12N5/071 , A61K35/34 , A61P21/00 , C12N5/02 , C12N5/07
CPC分类号： C12N5/0658 , A61K35/12 , C12N2500/25 , C12N2500/84 , C12N2500/90 , C12N2500/99 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/135
摘要： This application relates to a serum-free culture medium that enables the proliferation of cell of the myogenic lineage while maintaining their ability to differentiate into functional muscle cells. Also contemplated herewith are method of culturing cells of the myogenic lineages and uses of the cultured cells for the treatment or the alleviation of symptoms of a muscular deficiencies.
摘要翻译：本申请涉及一种无血清培养基，其能够在保持其分化为功能性肌肉细胞的能力的同时使肌源性谱系的细胞增殖。本发明还考虑培养肌源性细胞的细胞和培养细胞的用途来治疗或减轻肌肉缺陷症状的方法。

28. 发明申请

WO2010031184A8 AZAINDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2010031184A8
公开(公告)日：2010-03-25
申请号：PCT/CA2009/001322
申请日：2009-09-17
申请人： MERCK FROSST CANADA LTD. , LEBLANC, Yves , BERTHELETTE, Carl , SIMARD, Daniel , ZAGHDANE, Mohamed, Helmi
发明人： LEBLANC, Yves , BERTHELETTE, Carl , SIMARD, Daniel , ZAGHDANE, Mohamed, Helmi
IPC分类号： C07D471/14 , A61K31/4375
摘要： Compounds of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2 -mediated diseases such as asthma.

29. 发明申请

WO2010031183A1 INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为CRTH2受体拮抗剂的吲哚衍生物
公开(公告)号：WO2010031183A1
公开(公告)日：2010-03-25
申请号：PCT/CA2009/001321
申请日：2009-09-17
申请人： MERCK FROSST CANADA LTD. , COLUCCI, John , BOYD, Michael , ZAGHDANE, Mohamed, Helmi
发明人： COLUCCI, John , BOYD, Michael , ZAGHDANE, Mohamed, Helmi
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： Compound of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma.
摘要翻译：式I化合物是PGD2受体CRTH2的拮抗剂，因此可用于治疗和/或预防CRTH2介导的疾病如哮喘。

30. 发明申请

WO2010031179A1 HARD-LANDING OCCURRENCE DETERMINATION SYSTEM AND METHOD FOR AIRCRAFT 审中-公开
标题翻译：用于飞机的硬接地确定系统和方法
公开(公告)号：WO2010031179A1
公开(公告)日：2010-03-25
申请号：PCT/CA2009/001315
申请日：2009-09-18
申请人： SOCOVAR, SOCIÉTÉ EN COMMANDITE , STIHARU, Ion , SEDAGHATI, Ramin , FIROOZARAI, Arash
发明人： STIHARU, Ion , SEDAGHATI, Ramin , FIROOZARAI, Arash
IPC分类号： G01M17/00 , B64D43/00
CPC分类号： B64C25/00 , B64D2045/008
摘要： A method for determining a hard-landing occurrence for an aircraft has sensors at selected positions of the aircraft. A model defining critical points throughout the aircraft is obtained. Data is received from the sensors when the aircraft lands. Diagnosis values for all critical points of the aircraft are calculated by applying the model to the data from the sensors. The diagnosis values are compared to threshold values for the critical points of the aircraft. A hard-landing occurrence is determined from the comparison between the diagnosis value and the threshold value. A hard-landing occurrence determination system for an aircraft is also provided. Sensors at selected positions of the aircraft provide data related to accelerations at landing of the aircraft. A diagnosis processor unit determines the hard-landing occurrence, and comprises a model database, a threshold database and a threshold comparator. A hard-landing occurrence interface signals a hard-landing occurrence.
摘要翻译：用于确定飞机的硬着陆发生的方法在飞机的选定位置具有传感器。获得了定义整个飞机上的关键点的模型。当飞机着陆时，从传感器接收数据。通过将模型应用于传感器的数据来计算飞机所有关键点的诊断值。将诊断值与飞机关键点的阈值进行比较。根据诊断值和阈值之间的比较确定硬着陆事件。还提供了用于飞机的硬着陆发生确定系统。飞机选定位置的传感器提供与飞机着陆时的加速度有关的数据。诊断处理器单元确定硬着陆发生，并且包括模型数据库，阈值数据库和阈值比较器。硬着陆发生界面发出硬着陆事件。

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