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21. 发明申请

WO2010088144A1 INFUSION PUMP CASSETTE WITH ANT I -FREE -FLOW VALVE MECHANISM 审中-公开
标题翻译：灌注泵与安全流动阀门机构
公开(公告)号：WO2010088144A1
公开(公告)日：2010-08-05
申请号：PCT/US2010/021727
申请日：2010-01-22
申请人： NESTEC S.A. , HARIHARESAN, Seralaathan , HIGHLEY, Brian
发明人： HARIHARESAN, Seralaathan , HIGHLEY, Brian
IPC分类号： A61M5/142 , A61M39/28
CPC分类号： A61M5/14232 , A61M39/281 , A61M2205/128 , A61M2205/14 , A61M2205/6045
摘要： A fluid delivery system that includes an infusion pump and a cassette (1) with tubing (75) that is configured for engaging the pump mechanism of the infusion pump to accurately and repeatably deliver a fluid to a subject. The cassette has a housing with first and second ends for holding flexible tubing through which the fluid is directed, and the tubing engages a pumping mechanism to provide movement of the fluid through the tubing. When engaged with the pumping mechanism, the length of tubing is accurately and repeatably positioned in contact with and between the curved wall and the pumping mechanism.
摘要翻译：一种流体递送系统，其包括输注泵和具有管（75）的盒（1），所述管（75）被配置为接合输注泵的泵机构以精确地并可重复地将流体输送到受试者。盒具有壳体，其具有第一和第二端，用于保持柔性管，流体被引导通过柔性管，并且管接合泵送机构以提供流体通过管的运动。当与泵送机构接合时，管道的长度被精确地且重复地定位成与弯曲壁和泵送机构接触并且在其之间。

22. 发明申请

WO2010080280A1 SEMI-RIGID PARTIALLY COLLAPSIBLE BOTTLES 审中-公开
标题翻译：半刚性部分可收缩的瓶子
公开(公告)号：WO2010080280A1
公开(公告)日：2010-07-15
申请号：PCT/US2009/066978
申请日：2009-12-07
申请人： NESTEC S.A. , GINZBURG, Jean-Daniel , LINDBERG, Bjorn Joakim , TERESI, James Scott , RIGARDO, Andrea
发明人： GINZBURG, Jean-Daniel , LINDBERG, Bjorn Joakim , TERESI, James Scott , RIGARDO, Andrea
IPC分类号： A61J1/14 , A61J9/00 , A61J15/00
CPC分类号： A61J9/005 , A61J1/1418 , A61J1/1468 , A61J1/1487 , A61J15/00
摘要： Partially collapsible bottles (10) for providing nutritional compositions and other fluids and methods of using the partially collapsible bottles are provided. In a general embodiment, the present disclosure provides a bottle (10) having a rigid wall (20), and a semi-rigid wall (30). The semi-rigid wall (30) is constructed and arranged to conform to an inner side of the rigid wall (20) in a collapsed form. The bottle (10) can be sized to hold any suitable volume such as, for example, from about 100 to 5000 mL.
摘要翻译：提供了用于提供营养组合物和其它流体的部分可折叠瓶（10）和使用部分可收缩瓶子的方法。在一般实施例中，本公开提供了一种具有刚性壁（20）和半刚性壁（30）的瓶（10）。半刚性壁（30）被构造和布置成以塌缩的形式与刚性壁（20）的内侧一致。瓶子（10）的大小适于容纳任何合适的体积，例如约100至5000mL。

23. 发明申请

WO2010033426A2 NUTRITIONAL SUPPORT TO PREVENT AND/OR MITIGATE BONE MARROW TOXICITY FROM A CANCEROUS TUMOR 审中-公开
标题翻译：营养支持预防和/或减轻癌肿瘤的骨髓毒性
公开(公告)号：WO2010033426A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/056599
申请日：2009-09-11
申请人： NESTEC S.A. , INSTITUT CURIE , SCHIFFRIN, Eduardo , MILLER, Kevin Burke , BRASSART, Dominique , LANTZ, Olivier Jacques , AMIGORENA, Sebastian Diego
发明人： SCHIFFRIN, Eduardo , MILLER, Kevin Burke , BRASSART, Dominique , LANTZ, Olivier Jacques , AMIGORENA, Sebastian Diego
IPC分类号： A61K35/74 , A61P35/00
CPC分类号： A61K31/195 , A23L33/13 , A23L33/135 , A23L33/175 , A23L33/19 , A23L33/40 , A23V2002/00 , A61K31/20 , A61K31/7088 , A61K33/00 , A61K35/745 , A61K35/747 , A61K38/018 , A61K38/1783 , A61K38/40 , A23V2200/306
摘要： The present invention relates to methods and immunonutritional compositions for preventing or mitigating paralysis of the bone marrow, caused by a tumor or neoplasm, between cycles of and after anti-cancer therapy, thereby attaining a better efficacy of the treatment. More particularly, the present invention relates to methods and immunonutritional compositions that can transiently preventing or moderating, bone marrow paralysis or neutropenia of a subject tumor-induced apoptosis or necrosis or other cell damage such that the innate and adaptive immune functions and normal physiology of the bone marrow are preserved, at least in part, which, in turn, lead to (i) a better tolerance and increased efficacy to treatment; (ii) transient augmentation or enhancement of immunocompetence of the immune cell; and (iii) optimization of the effects of and increase of immunocompetence of the immune cell weakened due to paralysis of the bone marrow, caused by a tumor or neoplasm.
摘要翻译：本发明涉及用于预防或减轻由抗肿瘤治疗周期和之后的肿瘤或肿瘤引起的骨髓瘫痪的方法和免疫营养组合物，从而获得更好的治疗。更具体地说，本发明涉及能瞬时预防或缓和本发明的肿瘤诱导的细胞凋亡或坏死或其他细胞损伤的骨髓麻痹或嗜中性粒细胞减少症的方法和免疫营养组合物，使得天然和适应性免疫功能和至少部分地保留了骨髓，这反过来导致（i）更好的耐受性和增加的治疗效力; （ii）免疫细胞的免疫活性的瞬时增强或增强; 和（iii）优化由于肿瘤或肿瘤引起的骨髓瘫痪而减弱的免疫细胞的免疫活性的影响和增加免疫活性。

24. 发明申请

WO2010033425A2 NUTRITIONAL SUPPORT TO PREVENT OR MODERATE BONE MARROW PARALYSIS OR NEUTROPENIA DURING ANTI-CANCER TREATMENT 审中-公开
标题翻译：在抗癌治疗过程中预防或改变骨质疏松症或中性粒细胞的营养支持
公开(公告)号：WO2010033425A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/056584
申请日：2009-09-11
申请人： NESTEC S.A. , SCHIFFRIN, Eduardo , MILLER, Kevin Burke , BRASSART, Dominique
发明人： SCHIFFRIN, Eduardo , MILLER, Kevin Burke , BRASSART, Dominique
IPC分类号： A61K35/74 , A61P35/00
CPC分类号： A61K38/1783 , A23L33/40 , A23V2002/00 , A61K31/195 , A61K31/20 , A61K31/7088 , A61K33/00 , A61K35/745 , A61K35/747 , A61K38/018 , A61K38/40 , A23V2200/324 , A23V2200/3204 , A23V2250/70 , A23V2250/54 , A23V2250/06 , A23V2200/308
摘要： The present invention relates to methods and immunonutritional compositions for preventing the impairment of the immune function during anti-cancer therapy, thereby attaining a better efficacy of the treatment. More particularly, the present invention relates to methods and immunonutritional compositions that can transiently preventing or moderating, bone marrow paralysis or neutropenia of a subject undergoing anti-cancer therapy-induced apoptosis or necrosis or other cell damage such that the innate and adaptive immune functions and normal physiology of the bone marrow are preserved, at least in part, which, in turn, lead to (i) a better tolerance and increased efficacy to anti-cancer therapy; (ii) transient augmentation or enhancement of immunocompetence of the immune cell; and (iii) optimization of the effects of and increase of immunocompetence of the immune cell weakened by anti-cancer therapy.
摘要翻译：本发明涉及用于预防抗癌治疗期间免疫功能受损的方法和免疫营养组合物，从而获得更好的治疗效果。更具体地说，本发明涉及可以暂时预防或缓和经历抗癌治疗诱导的凋亡或坏死或其他细胞损伤的受试者的骨髓麻痹或中性粒细胞减少的方法和免疫营养组合物，使得先天和适应性免疫功能和至少部分保留骨髓的正常生理学，反过来又导致（i）抗癌治疗更好的耐受性和增强的疗效; （ii）免疫细胞的瞬时增强或增强免疫活性; 和（iii）通过抗癌治疗减弱的免疫细胞的免疫活性的影响和增加的优化。

25. 发明申请

WO2010030528A2 CLOSURE FOR CONTAINERS 审中-公开
标题翻译：集装箱封闭
公开(公告)号：WO2010030528A2
公开(公告)日：2010-03-18
申请号：PCT/US2009/055573
申请日：2009-09-01
申请人： NESTEC S.A. , HATALLA, Chris Daniel
发明人： HATALLA, Chris Daniel
IPC分类号： A61M5/14
CPC分类号： B65D51/002 , A61J1/14 , B65D51/1616 , Y10T29/49833
摘要： Closures for containers and methods for using same are provided. In a general embodiment, the present disclosure provides a closure having a top portion, a bottom portion and a side portion, an aperture extending though the closure, a projection extending from the closure and at least two rib members on an interior of the projection. The projection may also include a cover. In another embodiment, a method for using a closure includes inserting a spike member into a projection, piercing a membrane that hermetically seals a medical container, pushing rib members within the projection to center the spike member inserted into the projection, and tearing the membrane to create a vent hole in the membrane.
摘要翻译：提供容器的封闭件及其使用方法。在一般实施例中，本公开提供了一种具有顶部，底部和侧部的封闭件，延伸穿过封闭件的孔，从封闭件延伸的突起和在突起的内部上的至少两个肋构件。突起还可以包括盖。在另一个实施例中，一种使用闭合件的方法包括将尖钉构件插入到突起中，刺穿密封医疗容器的膜，推动凸起内的肋构件以使插入突出部的钉构件居中，并将膜撕裂到在膜中形成通气孔。

26. 发明申请

WO2007053390A2 METHODS FOR THE USE OF BRANCHED CHAIN AMINO ACIDS 审中-公开
标题翻译：分支链氨基酸的使用方法
公开(公告)号：WO2007053390A2
公开(公告)日：2007-05-10
申请号：PCT/US2006/041615
申请日：2006-10-26
申请人： NOVARTIS AG , NOVARTIS PHARMA GmbH , GREENBERG, Norman Alan
发明人： GREENBERG, Norman Alan
CPC分类号： A23L1/3053 , A23L33/18 , A61K38/05 , A61K45/06 , C07K5/06026
摘要： The invention provides an orally-administrable nutritional product comprising a dipeptide including a branched chain amino acid (BCAA). In one embodiment, the nutritional product comprises a dipeptide selected from at least one of the following: alanyl-leucine, alanyl-isoleucine, alanyl-valine, glycyl-leucine, glycyl-isoleucine, and glycyl-valine.
摘要翻译：本发明提供了包含含有支链氨基酸（BCAA）的二肽的可口服营养产品。在一个实施方案中，营养产品包含选自以下至少一种的二肽：丙氨酰亮氨酸，丙氨酰异亮氨酸，丙氨酰缬氨酸，甘氨酰亮氨酸，甘氨酰异亮氨酸和甘氨酰缬氨酸。

27. 发明申请

WO2012145346A2 NUTRITIONAL COMPOSITIONS FOR ENHANCING PERFORMANCE AND METHODS FOR MAKING AND USING SAME 审中-公开
标题翻译：用于增强性能的营养组合物及其制备和使用方法
公开(公告)号：WO2012145346A2
公开(公告)日：2012-10-26
申请号：PCT/US2012/033991
申请日：2012-04-18
申请人： NESTEC S.A. , ROY, Marie Georgina , GEOFFROY, Gilbert , HAILE, Tesfalidet
发明人： ROY, Marie Georgina , GEOFFROY, Gilbert , HAILE, Tesfalidet
IPC分类号： A23L1/29 , A23L1/09
CPC分类号： A23L1/296 , A23L2/395 , A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23L33/40 , A23V2002/00 , B65D75/5816 , A23V2200/33 , A23V2250/5114 , A23V2250/606 , A23V2250/61
摘要： Nutritional compositions containing carbohydrates for maximizing performance and methods for making and using same are provided. The nutritional compositions provide a refreshing and easy to consume composition that provides adequate amounts and types of nutrition to provide the body with proper fuel for performance. The performance may be, for example, athletic, academic, or other performances requiring physical stamina and/or mental alertness. In an embodiment, the nutritional compositions are powder formulations for reconstitution by the consumer prior to consumption. Methods for making and administering such nutritional compositions to individuals in need of same are also provided.
摘要翻译：提供含有用于最大化性能的碳水化合物和用于制备和使用它们的方法的营养组合物。营养组合物提供清爽和容易消费的组合物，其提供足够的量和类型的营养以为身体提供适当的燃料用于表现。表演可能是例如运动，学术或其他需要体力和/或精神警觉的表演。在一个实施方案中，营养组合物是消费者在消费前重新配制的粉末制剂。还提供了向需要相同的个体制备和施用这种营养组合物的方法。

28. 发明申请

WO2011139621A1 NUTRITIONAL COMPOSITIONS AND METHODS FOR WEANING FROM PARENTERAL NUTRITION TO ENTERAL NUTRITION 审中-公开
标题翻译：从营养营养到营养营养的营养组合物和方法
公开(公告)号：WO2011139621A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/033729
申请日：2011-04-25
申请人： GREENBERG, NORMAN ALAN , ROESSLE, Claudia , NESTEC S.A.
发明人： GREENBERG, NORMAN ALAN , ROESSLE, Claudia
IPC分类号： A23L1/30 , A23L1/305
CPC分类号： A61K9/0029 , A23L33/13 , A23L33/17 , A23L33/175 , A23L33/18 , A23L33/185 , A23L33/19 , A23L33/40
摘要： Nutritional compositions and methods of using the nutritional compositions are provided. In a general embodiment, the present disclosure provides a nutritional composition including one or more proteins, one or more amino acids and one or more exogenous nucleotides. The nutritional compositions can be specifically used to assist a patient in weaning from partial or total parenteral nutrition to enteral nutrition with improved tolerance.
摘要翻译：提供营养组合物和使用营养组合物的方法。在一般实施方案中，本公开提供了包含一种或多种蛋白质，一种或多种氨基酸和一种或多种外源核苷酸的营养组合物。营养组合物可以专门用于帮助患者从部分或全部肠外营养断奶至具有改善耐受性的肠内营养。

29. 发明申请

WO2011087769A2 NUTRITIONAL COMPOSITIONS AND METHODS FOR OPTIMIZING DIETARY ACID-BASE POTENTIAL 审中-公开
标题翻译：营养组合物和优化膳食酸碱性潜力的方法
公开(公告)号：WO2011087769A2
公开(公告)日：2011-07-21
申请号：PCT/US2010/061444
申请日：2010-12-21
申请人： NESTEC S.A. , MILLER, Kevin, Burke , ROUGHEAD, Zamzam Kabiry , MAGER, Jennifer Rae , BOLSTER, Douglad Richard , GREENBERG, Norman, Alan
发明人： MILLER, Kevin, Burke , ROUGHEAD, Zamzam Kabiry , MAGER, Jennifer Rae , BOLSTER, Douglad Richard , GREENBERG, Norman, Alan
IPC分类号： A61P1/00
CPC分类号： A61K33/06 , A23L33/16 , A23L33/17 , A23L33/185 , A23L33/40 , A61K33/08 , A61K33/42 , A61K38/168 , G06F17/10
摘要： Nutritional compositions having the potential to reduce metabolic acid load and methods of making and using the nutritional compositions are provided. In an embodiment, the present disclosure provides methods of selecting and administering nutritional compositions to patients. The methods may include modifications to calculating a metabolic acid potential of a nutritional composition, calculating a base content of a nutritional composition and subtracting the base content from the acid content to determine a potential renal acid load ("PRAL") value. The present disclosure also provides computer implemented processes for predicting PRAL values.
摘要翻译：提供了具有降低代谢酸负荷潜力的营养组合物和制备和使用营养组合物的方法。在一个实施方案中，本公开提供了向患者选择和施用营养组合物的方法。所述方法可以包括计算营养组合物的代谢酸势的修改，计算营养组合物的碱含量并从酸含量中减去碱含量以确定潜在的肾酸负载（“PRAL”）值。本公开还提供了用于预测PRAL值的计算机实现的过程。

30. 发明申请

WO2011071729A1 ENTERAL FEEDING BOTTLES 审中-公开
标题翻译： ENTERAL送料瓶
公开(公告)号：WO2011071729A1
公开(公告)日：2011-06-16
申请号：PCT/US2010/058540
申请日：2010-12-01
申请人： NESTEC S.A. , DOLD, Thomas Anthony , PETERSON, Thomas Lloyd , PILGER, Thomas Guy
发明人： DOLD, Thomas Anthony , PETERSON, Thomas Lloyd , PILGER, Thomas Guy
IPC分类号： A61J9/00 , A61M5/142
CPC分类号： A61J9/001 , A61J15/00 , A61J15/0076
摘要： Enteral feeding bottles for providing nutritional compositions and other fluids and methods of using the enteral feeding bottles are provided. In a general embodiment, the present disclosure provides an enteral feeding bottle including a rigid container, a flexible container located within the rigid container, an adapter cap releasably attached to the rigid container, and an enteral administration set attached to the adaptor cap. The enteral feeding bottle can be located within a portable storage device so that a user may readily carry and use the enteral feeding bottle at any suitable location.
摘要翻译：提供了用于提供营养组合物和其它液体的肠内喂养瓶和使用肠内喂养瓶的方法。在一般实施例中，本公开提供了一种肠内喂养瓶，其包括刚性容器，位于刚性容器内的柔性容器，可释放地附接到刚性容器的适配器盖以及连接到适配器帽的肠内给药组。肠内喂养瓶可以位于便携式存储装置内，使得使用者可以在任何合适的位置容易携带和使用肠内喂养瓶。

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