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11. 发明申请

WO1996018645A1 PEPTIDES AND SYNTHETIC CELL MEMBRANES 审中-公开
标题翻译：肽和合成细胞膜
公开(公告)号：WO1996018645A1
公开(公告)日：1996-06-20
申请号：PCT/EP1995004681
申请日：1995-11-29
申请人： MERCK PATENT GMBH , NAUMANN, Renate , JONCZYK, Alfred
发明人： MERCK PATENT GMBH
IPC分类号： C07K07/06
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , C07K7/06
摘要： Die Erfindung betrifft lineare Peptide der Formel (I) R-A-B-C-D-E-OH, worin R, A, B, C, D und E die angegebenen Bedeutungen besitzen, sowie daraus aufgebaute Peptidschichten und Zellmembranen, deren Herstellung und die Verwendung als Biosensoren, Solarzellen und als Membranmodell zur Untersuchung biochemischer Reaktionsabläufe.
摘要翻译：本发明涉及式的线性肽（I）R-A-B-C-D-E-OH，worin R，A，B，C，D和E具有所示的含义; 产生所述线性肽; 及其作为生物传感器，太阳能电池和薄膜模型的生化过程的调查使用使用。

12. 发明申请

WO1996014333A1 PEPTIDES FOR ANTI-ALLERGY TREATMENT 审中-公开
标题翻译：用于抗过敏治疗的肽
公开(公告)号：WO1996014333A1
公开(公告)日：1996-05-17
申请号：PCT/GB1995002580
申请日：1995-11-03
申请人： PEPTIDE THERAPEUTICS LIMITED , STANWORTH, Denis, Raymond , LEWIN, Ian, Victor
发明人： PEPTIDE THERAPEUTICS LIMITED
IPC分类号： C07K07/06
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , C07K7/08
摘要： Peptides of the above-mentioned sequence wherein Xaa is any amino acid residue, but most preferably Val or Ile, and their simple derivatives, including those chain-extended at the N-terminus or C-terminus, are useful in anti-allergy treatment.
摘要翻译：上述序列的肽，其中Xaa是任何氨基酸残基，但最优选Val或Ile，及其简单衍生物，包括在N末端或C末端扩链的那些，可用于抗过敏治疗。

13. 发明申请

WO1996012731A1 PEPTIDE SPECIFICITY OF ANTI-MYELIN BASIC PROTEIN AND THE ADMINISTRATION OF MYELIN BASIC PROTEIN PEPTIDES TO MULTIPLE SCLEROSIS PATIENTS 审中-公开
标题翻译：抗谷氨酸蛋白酶基因蛋白的肽特异性和髓鞘基础蛋白质肽对多发性硬化症患者的治疗
公开(公告)号：WO1996012731A1
公开(公告)日：1996-05-02
申请号：PCT/CA1995000583
申请日：1995-10-20
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
发明人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , WARREN, Kenneth, G. , CATZ, Ingrid
IPC分类号： C07K07/06
CPC分类号： C07K14/4713 , A61K38/00
摘要： Human myelin basic protein (h-MBP) has a molecular weight of 18.5 KD and contains 170 amino acid residues. Synthetic peptides ranging in length from about 8 to 25 residues and covering the entire length of the protein have been produced. Antibodies to h-MBP (anti-MBP) were found to be neutralized by the synthetic peptides, in vitro, which span the h-MBP from about amino acid residue 61 to about amino acid residue 106. The peptides, which cover both the amino (about residues 1 to 63) and carboxy (about residues 117 to 162) terminals of h-MBP did not neutralize purified anti-MBP. Intrathecal administration of peptide MBP75-95, either as a single dose, or as repeated injections for periods up to 10 weeks, produced complete binding-neutralization of free (F) anti-MBP with no change in bound (B) levels. A control peptide MBP35-58 had no effect on F or B anti-MBP levels. Intravenous administration of MBP75-95 resulted in significant decline of F and B CSF anti-MBP levels over a period of one month. Administration of MBP synthetic peptides to MS patients either intrathecally or intravenously did not have any adverse neurological effects and systemic complications did not occur. The MBP epitope for MS anti-MBP has been localized to an area between Pro85 and Pro96.
摘要翻译：人髓磷脂碱性蛋白（h-MBP）的分子量为18.5KD，含有170个氨基酸残基。已经生产了长度为约8至25个残基并覆盖蛋白质整个长度的合成肽。发现h-MBP（抗MBP）的抗体在体外被合成肽中和，其跨越从约氨基酸残基61至约氨基酸残基106的h-MBP。涵盖氨基酸（约1至63个残基）和羧基（约117至162个）末端未中和纯化的抗MBP。鞘内给药MBP75-95作为单一剂量，或重复注射至多达10周，产生游离（F）抗MBP的完全结合中和，结合（B）水平无变化。对照肽MBP35-58对F或B抗MBP水平没有影响。 MBP75-95的静脉内给药导致F和B CSF抗MBP水平在一个月内显着下降。对鞘内或静脉内的MS患者施用MBP合成肽没有任何不良的神经系统影响，并没有发生全身并发症。用于MS抗MBP的MBP表位已被定位到Pro85和Pro96之间的区域。

14. 发明申请

WO1996004299A1 STREPTOGRAMINE DERIVATIVES, PREPARATION OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME 审中-公开
标题翻译：环糊精衍生物，其制备和含有其的药物组合物
公开(公告)号：WO1996004299A1
公开(公告)日：1996-02-15
申请号：PCT/FR1995001025
申请日：1995-07-31
申请人： RHONE-POULENC RORER S.A. , BARRIERE, Jean-Claude , PARIS, Jean-Marc , PUCHAULT, Gérard
发明人： RHONE-POULENC RORER S.A.
IPC分类号： C07K07/06
CPC分类号： C07K7/06 , A61K38/00
摘要： Streptogramine derivatives of general formula (I), wherein the radical R1 is a methyl or ethyl radical, the radical R2 is a bromine or chlorine atom, or is an alkenyl radical with 3 to 5 carbon atoms when R3 and R4 are methyl, and one of R3 and R4 is a hydrogen atom or a methyl radical and the other is a methyl radical. The streptogramine derivatives of general formula (I) have particularly useful antibacterial properties, and may be used in combination with a pristinamycin II derivative.
摘要翻译：通式（I）的链霉素衍生物，其中基团R1是甲基或乙基，基团R2是溴或氯原子，或当R3和R4是甲基时，是具有3至5个碳原子的烯基，一个的R3和R4是氢原子或甲基，另一个是甲基。通式（I）的链霉素衍生物具有特别有用的抗菌性质，并且可以与普瑞霉素II衍生物组合使用。

15. 发明申请

WO1996000238A1 T CELL EPITOPES OF RYE GRASS POLLEN ALLERGEN 审中-公开
标题翻译： RYE GRASS POLLEN ALLERGEN的T细胞抗原
公开(公告)号：WO1996000238A1
公开(公告)日：1996-01-04
申请号：PCT/GB1995001493
申请日：1995-06-26
申请人： PEPTIDE THERAPEUTICS LIMITED , LEWIN, Ian, Victor , BUNGY, Ali, Gholam
发明人： PEPTIDE THERAPEUTICS LIMITED
IPC分类号： C07K07/06
CPC分类号： C07K14/415 , A61K38/00 , C07K2319/00
摘要： The present invention relates to the immunodominant T cell epitope of rye grass, its minimal sequence, its role in hayfever and its use in the manufacture of a medicament for the treatment or prophylaxis of hayfever. According to the present invention there is provided a polypeptide of nine amino acid residues including the six amino acid residues VXRIDT, and analogues and mimetics thereof. The polypeptide can be administered to provide a method for treatment or prophylaxis of allergies particularly of rye grass allergy or hayfever.
摘要翻译：本发明涉及黑麦草的免疫显性T细胞表位，其最小序列，其在干草中的作用及其在制备用于治疗或预防干草的药物中的用途。根据本发明，提供了包含六个氨基酸残基VXRIDT的九个氨基酸残基的多肽及其类似物和模拟物。可以施用多肽以提供治疗或预防特别是黑麦草过敏或过敏的过敏的方法。

16. 发明申请

WO1995017423A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES 审中-公开
标题翻译：具有生长激素释放特性的化合物
公开(公告)号：WO1995017423A1
公开(公告)日：1995-06-29
申请号：PCT/DK1994000485
申请日：1994-12-22
申请人： NOVO NORDISK A/S , JOHANSEN, Nils, Langeland , LAU, Jesper , MADSEN, Kjeld , LUNDT, Behrend, Friedrich , THOGERSEN, Henning , HANSEN, Birgit, Sehested , PESCHKE, Bernd
发明人： NOVO NORDISK A/S
IPC分类号： C07K07/06
CPC分类号： C07K5/1024 , A61K38/00 , C07K5/0812 , C07K14/60
摘要： Synthetic peptides of the general formula A-B-C-D-(E)p, wherein p is 0 or 1, with an improved resistance to proteolytic degradation by enzymes due to the presence of adjacent amino acids, optionally combined with the substitution of an amide bond (-CONH-) by (Y-N-R18), e.g. aminomethylene (-CH2NH-) and/or modification at the N- or C- terminal end of the peptide. The peptide derivatives stimulate the release of growth hormone from the pituitary.
摘要翻译：通式ABCD-（E）p的合成肽，其中p为0或1，由于相邻氨基酸的存在而具有改进的对蛋白水解降解的抗性，任选地与酰胺键（-CONH - ）由（YN-R18），例如氨基亚甲基（-CH2NH-）和/或在肽的N-或C-末端修饰。肽衍生物刺激垂体中生长激素的释放。

17. 发明申请

WO1995008564A1 PEPTIDE DERIVATIVES OF 'alpha'-MSH AND THEIR APPLICATION 审中-公开
标题翻译： α-MSH的肽衍生物及其应用
公开(公告)号：WO1995008564A1
公开(公告)日：1995-03-30
申请号：PCT/FR1994001108
申请日：1994-09-22
申请人： INSTITUT EUROPEEN DE BIOLOGIE CELLULAIRE , DUSSOURD d'HINTERLAND, Lucien , PINEL, Anne-Marie
发明人： INSTITUT EUROPEEN DE BIOLOGIE CELLULAIRE
IPC分类号： C07K07/06
CPC分类号： C07K14/685 , A61K8/64 , A61K38/00 , A61Q19/04
摘要： Compound comprising a peptide sequence having at least one sequence of 4 amino acids from alpha -MSH, the amino acids being in natural or non-natural form, said sequence being conjugated with thioctic acid or a derivative thereof in the form of corresponding salts, esters or amides.
摘要翻译：化合物包含具有至少一个来自α-MSH的4个氨基酸序列的肽序列，氨基酸为天然或非天然形式，所述序列与硫辛酸或其衍生物以相应的盐，酯的形式缀合或酰胺。

18. 发明申请

WO1995001990A1 HEMOREGULATORY PENTA- OR HEXAPEPTIDES 审中-公开
标题翻译： HEMOREGULATORY PENTA-或HEXAPEPTIDES
公开(公告)号：WO1995001990A1
公开(公告)日：1995-01-19
申请号：PCT/GB1994001501
申请日：1994-07-11
申请人： HOLMES, Michael, John , NYCOMED PHARMA A.S , SMITHKLIME BEECHAM CORPORATION , AGNER, Erik , CUTHBERTSON, Alan , FISCHER, Peter , BHATNAGAR, Pradip , HUSBYN, Mette , UNDHEIM, Kjell
发明人： HOLMES, Michael, John , NYCOMED PHARMA A.S , SMITHKLIME BEECHAM CORPORATION
IPC分类号： C07K07/06
CPC分类号： C07K7/067 , A61K38/00
摘要： The invention relates to peptide compounds comprising two monomeric peptides having cell proliferation regulatory activity joined together by two or more divalent bridging units. Such compounds have a stimulating activity on cell division, especially for myelopoietic and bone marrow cells.
摘要翻译：本发明涉及包含两个单体肽的肽化合物，其具有通过两个或更多个二价桥接单元连接在一起的细胞增殖调节活性。这些化合物对细胞分裂具有刺激活性，特别是对于骨髓细胞和骨髓细胞。

19. 发明申请

WO1995001372A1 PEPTIDASE RESISTANT THROMBIN RECEPTOR PEPTIDE LIGAND 审中-公开
标题翻译：耐药THROMBIN受体肽配体
公开(公告)号：WO1995001372A1
公开(公告)日：1995-01-12
申请号：PCT/US1994007420
申请日：1994-06-30
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , COLLER, Barry, S. , PRESTWICH, Glenn, D.
IPC分类号： C07K07/06
CPC分类号： C07K14/705 , A61K38/00
摘要： A peptide ligand analogue of peptide ligands derived from thrombin-cleaved thrombin receptor site on platelets resists inactivation by aminopeptidase M by substituting the B-amino acid isoserine for the N-terminal serine of the peptide ligand.
摘要翻译：衍生自血小板上的凝血酶切割的凝血酶受体位点的肽配体的肽配体类似物通过用B-氨基酸异丝氨酸取代肽配体的N-末端丝氨酸抵抗氨基肽酶M的灭活。

20. 发明申请

WO1994028013A1 PEPTIDES FOR SUPPRESSION OF MYELOID PROGENITOR CELL PROLIFERATION AND TREATMENT OF SEPTIC SHOCK 审中-公开
标题翻译：抑制髓磷脂细胞增殖和分解治疗的抑制剂
公开(公告)号：WO1994028013A1
公开(公告)日：1994-12-08
申请号：PCT/US1994005773
申请日：1994-05-18
申请人： RESEARCH CORPORATION TECHNOLOGIES, INC. , BROXMEYER, Hal, E. , COOPER, Scott , LU, Li
发明人： RESEARCH CORPORATION TECHNOLOGIES, INC. , MOORE, Robert, N. , KREISBERG, Robert , KREISBERG, Melinda, Detrick
IPC分类号： C07K07/06
CPC分类号： C07K7/08 , A61K38/00 , C07K14/4703
摘要： Peptides containing the sequence Ala-Lys-Pro-Arg have suppressive effects on the proliferation of a broad range of myelopoietic progenitor cells. In a preferred embodiment, the peptide has the sequence Glu-Thr-Val-Ile-Met-Lys-Ala-Lys-Pro-Arg-Ala-Asn-Phe-Pro. The peptides of the present invention are useful in the treatment of myelopoietic hyperproliferative disorders, and in protecting myeloid cells from damage induced by chemotherapy and radiation. Peptides containing the sequence Ala-Lys-Pro-Arg are also useful in the treatment of endotoxin-induced septic shock.
摘要翻译：含有序列Ala-Lys-Pro-Arg的肽对广泛的骨髓祖细胞的增殖具有抑制作用。在优选的实施方案中，肽具有序列Glu-Thr-Val-Ile-Met-Lys-Ala-Lys-Pro-Arg-Ala-Asn-Phe-Pro。本发明的肽可用于治疗骨髓增生性过度增生性疾病，并且可用于保护骨髓细胞免受化疗和放射诱导的损伤。含有序列Ala-Lys-Pro-Arg的肽也可用于治疗内毒素诱导的败血性休克。

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