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    • 13. 发明申请
    • NON-INVASIVE MONITORING OF INTRACRANIAL DYNAMIC EFFECTS AND BRAIN DENSITY FLUCTUATIONS
    • 非侵入性监测动脉内动态和脑密度变化
    • WO2005009244A1
    • 2005-02-03
    • PCT/CA2004/001401
    • 2004-07-26
    • HER MAJESTY THE QUEEN IN RIGHT OF CANADA asrepres ented by THE MINISTER OF NATIONAL DEFENSESTERGIOPOULOS, StergiosWROBEL, Miroslaw
    • STERGIOPOULOS, StergiosWROBEL, Miroslaw
    • A61B8/00
    • A61B5/031A61B5/4064A61B8/0808G01N29/0672G01N29/075G01N29/348G01N2291/02483G01S7/52036G01S15/8909
    • The present invention relates to a method and apparatus for non-invasive monitoring of brain density variations. At least two ultrasonic pulses having different frequencies are provided into the brain for transmission therethrough. The reflected ultrasonic pulses are then sensed and the sensed signal data are then processed for determining at least two phase differences between the phases of the at least two reflected ultrasonic pulses and the phases of the at least two provided ultrasonic pulses. A phase of at least a beat frequency is determined in dependence upon the at least two phase differences. Finally, data indicative of a brain density variation are determined based on the at least two phase differences and the at least a beat frequency. Repeating the process enables continuous monitoring of brain density variations. The method and apparatus for non-invasive monitoring of brain density variations is highly beneficial in clinical settings as well as during emergency and rescue operations by enabling early detection of brain density variations, which are directly related to intracranial pressure (ICP) changes; and provide diagnosis and assessment of head injuries, haemorrhage, stroke and variations of blood flow in the skull due to drug effects, changes in brain temperature and stress.
    • 本发明涉及用于非侵入性监测脑密度变化的方法和装置。 将至少两个具有不同频率的超声波脉冲提供到脑中以通过其传播。 然后感测反射的超声波脉冲,然后处理感测的信号数据,以确定至少两个反射的超声波脉冲的相位和至少两个提供的超声波脉冲的相位之间的至少两个相位差。 根据至少两个相位差确定至少拍频的相位。 最后,基于至少两个相位差和至少一个拍频来确定指示脑密度变化的数据。 重复该过程可以持续监测脑密度变化。 用于非侵入性监测脑密度变化的方法和装置在临床环境以及紧急和救援操作期间是非常有益的,通过能够早期检测与颅内压(ICP)变化直接相关的脑密度变化; 并提供由于药物作用,脑温度和压力变化引起的头部损伤,出血,中风和颅骨血流变化的诊断和评估。