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11. 发明申请

WO2007016121A2 HYDROFLUOROCARBON REFRIGERANT COMPOSITIONS 审中-公开
标题翻译：氢氟烃制冷剂组合物
公开(公告)号：WO2007016121A2
公开(公告)日：2007-02-08
申请号：PCT/US2006/028906
申请日：2006-07-26
申请人： HONEYWELL INTERNATIONAL INC. , PAONESSA, Martin , SINGH, Rajiv , WILSON, David , SPATZ, Mark , MOTTA, Samuel, Yana
发明人： PAONESSA, Martin , SINGH, Rajiv , WILSON, David , SPATZ, Mark , MOTTA, Samuel, Yana
CPC分类号： C09K5/045
摘要： A composition comprising from about 80 weight percent to about 99.9 weight percent of at least one C 1 - C 5 hydrofluorocarbon and from about 0.1 weight percent to about 20 weight percent of at least one C 3 - C 7 alcohol, and the use of these composition for in methods of the recharging of refrigeration systems.
摘要翻译：包含约80重量％至约99.9重量％的至少一种C 1 -C 5氢氟烃和约0.1重量％百分比至约20重量百分比的至少一种C 3 -C 7醇，以及将这些组合物用于制冷系统再充装的方法。

12. 发明申请

WO2012083370A1 MODIFIED ANTIBODY WITH IMPROVED HALF-LIFE 审中-公开
标题翻译：改良抗体与改善的半衰期
公开(公告)号：WO2012083370A1
公开(公告)日：2012-06-28
申请号：PCT/AU2011/001662
申请日：2011-12-22
申请人： CEPHALON AUSTRALIA PTY LTD , WILSON, David , TAURA, Tetsuya
发明人： WILSON, David , TAURA, Tetsuya
IPC分类号： A61K39/395 , C07K16/18 , C12N15/13
CPC分类号： C07K16/00 , C07K16/2803 , C07K2317/52 , C07K2317/90
摘要： The present invention relates to antibodies, immunoglobulin constructs or immunoglobulin IgG4 fusion proteins whose in vivo half-lives are increased by the combination of (i) a modified IgG4 Fc region or FcRn binding domain thereof and (ii) a modified IgG4 hinge region sequence.
摘要翻译：本发明涉及抗体，免疫球蛋白构建体或免疫球蛋白IgG4融合蛋白，其体内半衰期通过（i）修饰的IgG4 Fc区或FcRn结合结构域和（ii）修饰的IgG4铰链区序列的组合而增加。

13. 发明申请

WO2010036613A8 NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS 审中-公开
公开(公告)号：WO2010036613A8
公开(公告)日：2010-04-01
申请号：PCT/US2009/057686
申请日：2009-09-21
申请人： MERCK SHARP & DOHME CORP. , METABASIS THERAPEUTICS, INC. , BOOKSER, Brett, C. , DANG, Qun , GIBSON, Tony, S. , JIANG, Hongjian , CHUNG, De Michael , BAO, Jianming , JIANG, Jinlong , KASSICK, Andy , KEKEC, Ahmet , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F. Anthony , SEBHAT, Iyassu , WILSON, David , WODKA, Dariusz
发明人： BOOKSER, Brett, C. , DANG, Qun , GIBSON, Tony, S. , JIANG, Hongjian , CHUNG, De Michael , BAO, Jianming , JIANG, Jinlong , KASSICK, Andy , KEKEC, Ahmet , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F. Anthony , SEBHAT, Iyassu , WILSON, David , WODKA, Dariusz
IPC分类号： C07D235/26 , C07D235/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , A61K31/4184 , A61K31/4439 , A61P3/10
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK- activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.

14. 发明申请

WO2009127848A2 CLOCK DISTRIBUTION BUFFER 审中-公开
标题翻译：时钟分配缓冲器
公开(公告)号：WO2009127848A2
公开(公告)日：2009-10-22
申请号：PCT/GB2009/050279
申请日：2009-03-25
申请人： ELONICS LIMITED , WILSON, David
发明人： WILSON, David
IPC分类号： H03K19/0175 , H03K6/02 , H03K3/0233 , H03K3/356
CPC分类号： H03K3/356139 , H03K19/0005 , H03K19/0016 , H03K19/00361 , H03K19/018564 , H03K19/018585
摘要： A clock distribution buffer, and a local oscillator circuit comprising a clock pulse generator and one or more such buffers, that provides efficient power consumption across a wide range of operational frequencies of a local oscillator. The buffer comprises a resistive load and a bias current source, one or both being controllable to vary the slew rate of the buffer. The controllable nature of the resistive load and bias current source enables the slew rate of the buffer to be tailored to the operational frequency desired so as to reduce unnecessary power consumption.
摘要翻译：包括时钟脉冲发生器和一个或多个这样的缓冲器的时钟分配缓冲器和本地振荡器电路，其在本地振荡器的宽范围的工作频率上提供有效的功率消耗。缓冲器包括电阻负载和偏置电流源，其中一个或两个可控制以改变缓冲器的转换速率。电阻负载和偏置电流源的可控特性使得缓冲器的转换速率可以适应所需的工作频率，从而减少不必要的功耗。

15. 发明申请

WO2009042590A1 TITANIUM COMPOUNDS AND COMPLEXES AS ADDITIVES IN LUBRICANTS 审中-公开
标题翻译：钛化合物和复合物作为润滑剂中的添加剂
公开(公告)号：WO2009042590A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/077371
申请日：2008-09-23
申请人： THE LUBRIZOL CORPORATION , DEREVJANIK, Thomas, S. , SCINTO, Philip, T. , GALIC-RAGUZ, Mary , WILSON, David
发明人： DEREVJANIK, Thomas, S. , SCINTO, Philip, T. , GALIC-RAGUZ, Mary , WILSON, David
IPC分类号： C10M163/00
CPC分类号： C10M163/00 , C10M2203/1006 , C10M2207/028 , C10M2207/262 , C10M2215/064 , C10M2215/086 , C10M2219/046 , C10M2219/089 , C10M2223/045 , C10M2227/061 , C10M2227/065 , C10N2210/02 , C10N2210/03 , C10N2210/04 , C10N2230/10 , C10N2230/40 , C10N2230/42 , C10N2230/52 , C10N2240/10
摘要： A lubricating composition comprising an oil of lubricating viscosity, at least 25 parts per million by weight of titanium in the form of an oil-soluble titanium-containing material, and at least 70 parts per million boron in the form of a soluble boron compound such as a borate ester provides beneficial effects on properties such as deposit control, oxidation, and filterability in engine oils and lubrication of engines.
摘要翻译：一种润滑组合物，其包含润滑粘度的油，至少25重量份的以油溶性含钛材料形式的钛，以及可溶性硼化合物形式的至少70ppm的硼，作为硼酸酯对发动机油中的沉积物控制，氧化和过滤性以及发动机的润滑等性质提供有益的影响。

16. 发明申请

WO2008069879A1 POWERED DRIVER WITH LOCATION SPECIFIC SWITCHING 审中-公开
标题翻译：带有位置特定开关的动力驱动器
公开(公告)号：WO2008069879A1
公开(公告)日：2008-06-12
申请号：PCT/US2007/023034
申请日：2007-11-02
申请人： AMERICAN POWER TOOL COMPANY , WILSON, David
发明人： WILSON, David
IPC分类号： B25B23/145
CPC分类号： B25B13/481 , B25B21/00 , B25B21/002 , B25B23/145 , B25B23/147
摘要： Powered drivers and methods are disclosed, the drivers including a head housing a motor driven drive transfer assembly for operating a rotatable socket engageable at a threaded connector. A reaction unit having a fitting engagement attached to rail guides is movably maintained through the head. A biasing unit is maintained at the head and is operatively associated with the rail guides of the reaction unit to bias the fitting engagement of the reaction unit toward the rotatable socket during tightening rotation of the engaged threaded connector. A probe and switch are associated with different ones of the reaction unit and the head, and are brought into operative association at selected relative locations of the reaction unit and the head during connector rotation to cause motor cessation.
摘要翻译：公开了驱动驱动器和方法，驱动器包括头部，其容纳用于操作可接合于螺纹连接器的可旋转插座的马达驱动驱动传递组件。具有附接到轨道导轨的配合接合的反作用单元通过头部被可移动地保持。偏压单元保持在头部并且与反应单元的轨道导轨可操作地相关联，以在拧紧接合的螺纹连接器的旋转期间将反应单元的配合接合偏压到可旋转的插座。探头和开关与反应单元和头部中的不同部件相关联，并且在连接器旋转期间在反应单元和头部的选定相对位置处进行操作关联以引起电动机停止。

17. 发明申请

WO2020072006A1 APPARATUS FOR CONNECTING AND SUBSEQUENT DISCONNECTION OF PIPES 审中-公开
公开(公告)号：WO2020072006A1
公开(公告)日：2020-04-09
申请号：PCT/TH2019/000044
申请日：2019-10-04
申请人： WILSON, David
发明人： WILSON, David
IPC分类号： F16L1/12 , F16L1/26 , F16L1/16 , E21B43/01 , E21B41/00 , F16L1/235
摘要： An apparatus for connecting pipes (2), the apparatus comprising a base member (10) for receiving sections of pipes to be connected, wherein the base member is configured to permit movement of the pipes between a first pipe section receiving position, and a second pipe section connecting position, and wherein the base member comprises a pipe section connection device (14), a device (20) for moving the sections of pipes relative to the base member, and a co- dependent protection apparatus (40).

18. 发明申请

WO2015013012A1 COMPOSITE MATERIAL INCORPORATING WATER INGRESS BARRIER 审中-公开
标题翻译：复合材料混合水入侵障碍物
公开(公告)号：WO2015013012A1
公开(公告)日：2015-01-29
申请号：PCT/US2014/045055
申请日：2014-07-01
申请人： LEARJET INC. , MOURTAZOV, Khassan , DROLET, Pierre , HARTER, Pierre , WILSON, David
发明人： MOURTAZOV, Khassan , DROLET, Pierre , HARTER, Pierre , WILSON, David
IPC分类号： B29D24/00 , B29C70/08 , B32B37/14 , B32B3/12
CPC分类号： B32B3/12 , B29D99/0021 , B32B5/022 , B32B5/024 , B32B5/26 , B32B7/10 , B32B7/12 , B32B37/12 , B32B37/146 , B32B2038/0076 , B32B2262/0269 , B32B2262/106 , B32B2307/54 , B32B2307/542 , B32B2307/714 , B32B2605/00 , B32B2605/08 , B32B2605/12 , B32B2605/18
摘要： A composite material includes a honeycomb layer with top and bottom sides. The honeycomb layer includes a plurality of walls defining a plurality of cells therein. A first adhesive layer is disposed adjacent to the top side of the honeycomb layer. A second adhesive layer is disposed adjacent to the bottom side of the honeycomb layer. A third adhesive layer is disposed adjacent to the first adhesive layer on the top side of the honeycomb layer. A first composite layer is disposed adjacent to the third adhesive layer on the top side of the honeycomb layer. A second composite layer is disposed adjacent to the second adhesive layer on the bottom side of the honey comb layer. At least the third adhesive layer comprises viscous properties that discourage the creation of channels within the first composite layer when co-cured.
摘要翻译：复合材料包括具有顶侧和底侧的蜂窝层。蜂窝层包括在其中限定多个电池的多个壁。第一粘合剂层邻近蜂窝层的顶侧设置。第二粘合剂层邻近蜂窝层的底侧设置。第三粘合剂层邻近第一粘合剂层布置在蜂窝层的顶侧上。第一复合层与蜂窝层的顶侧上的第三粘合剂层相邻设置。第二复合层邻近蜂窝梳层的底侧上的第二粘合剂层设置。至少第三粘合剂层包含粘性特性，其在共固化时阻止第一复合层内的通道的产生。

19. 发明申请

WO2013130510A1 IMPROVED PHOSPHORESCENT MOLECULES FOR MEASURING OXYGEN AND IMAGING METHODS 审中-公开
标题翻译：用于测量氧气和成像方法的改进的磷酸盐分子
公开(公告)号：WO2013130510A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/027888
申请日：2013-02-27
申请人： VINOGRADOV, Sergei , WILSON, David
发明人： VINOGRADOV, Sergei , WILSON, David
IPC分类号： G01N21/64 , G01N31/22
CPC分类号： C07F15/0066 , C07D257/02 , C07D275/00 , C07D487/22 , G01N21/643 , Y10T436/207497
摘要： Oxygen levels in biological tissue or systems can be measured by the phosphorescence quenching method using phosphorescent porphyrin probes, also referred to as a dendritic oxygen probes, with controllable quenching parameters and defined biodistributions. Provided are a "next generation" of oxygen sensors with substantially improved phosphorescence emission for better imaging capabilities, ease of use, increasing the quantum efficiency (phosphorescence intensity) and extending their range of applicability including constructing a class of oxygen sensors for making measurements in organic media. In addition, provided are methods for synthesizing new porphyrin constructs in which the porphyrin is made less flexible and more planar, changing with decrease internal quenching, and thereby increasing the phosphorescence emission used for oxygen sensing. Additional methods are provided for structurally modifying the dendrimer used to encapsulate the porphyrin phosphor to provide internal quenching of singlet oxygen molecules formed during oxygen measurements.
摘要翻译：生物组织或系统中的氧水平可以通过使用磷光卟啉探针（也称为树枝状氧探针）的磷光猝灭法测量，具有可控的淬灭参数和定义的生物分布。提供了一种“下一代”氧传感器，具有显着改善的磷光发射，以获得更好的成像能力，易于使用，增加量子效率（磷光强度）并扩展其适用范围，包括构建一类氧传感器，用于在有机媒体。此外，提供了合成新的卟啉构建体的方法，其中卟啉被制成较少的柔性和更平面，随着内部淬灭的减少而改变，从而增加用于氧气感测的磷光发射。提供了另外的方法用于结构修饰用于包封卟啉磷光体的树状聚合物，以提供在氧测量期间形成的单线态氧分子的内部猝灭。

20. 发明申请

WO2010000025A1 ANTI-PAMP THERAPEUTIC ANTIBODIES 审中-公开
标题翻译：抗抑郁治疗抗体
公开(公告)号：WO2010000025A1
公开(公告)日：2010-01-07
申请号：PCT/AU2009/000850
申请日：2009-07-01
申请人： ARANA THERAPEUTICS (VIC) PTY LTD , WILSON, David , TAURA, Tetsuya
发明人： WILSON, David , TAURA, Tetsuya
IPC分类号： C07K16/18 , A61P5/40 , A61P35/00 , A61K39/395 , A61P9/00 , C12P21/08
CPC分类号： C07K16/26 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： The invention relates to antibodies and antigen-binding fragments thereof which bind to proadrenomedullin N-terminal peptide ("PAMP"). Furthermore, the invention comprises monoclonal antibody EGX-P-E9 as well as engineered variants thereof, including chimeric, humanized or de-immunized versions thereof. The antibodies of the invention are useful for inhibiting the physiological activities of PAMP as well as in diagnosis of PAMP-responsive conditions.
摘要翻译：本发明涉及与前肾上腺髓质素N-末端肽（“PAMP”）结合的抗体及其抗原结合片段。此外，本发明包括单克隆抗体EGX-P-E9及其工程变体，包括其嵌合，人源化或去免疫的形式。本发明的抗体可用于抑制PAMP的生理活性以及PAMP反应性病症的诊断。

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