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2. 发明申请

WO2013130510A1 IMPROVED PHOSPHORESCENT MOLECULES FOR MEASURING OXYGEN AND IMAGING METHODS 审中-公开
标题翻译：用于测量氧气和成像方法的改进的磷酸盐分子
公开(公告)号：WO2013130510A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/027888
申请日：2013-02-27
申请人： VINOGRADOV, Sergei , WILSON, David
发明人： VINOGRADOV, Sergei , WILSON, David
IPC分类号： G01N21/64 , G01N31/22
CPC分类号： C07F15/0066 , C07D257/02 , C07D275/00 , C07D487/22 , G01N21/643 , Y10T436/207497
摘要： Oxygen levels in biological tissue or systems can be measured by the phosphorescence quenching method using phosphorescent porphyrin probes, also referred to as a dendritic oxygen probes, with controllable quenching parameters and defined biodistributions. Provided are a "next generation" of oxygen sensors with substantially improved phosphorescence emission for better imaging capabilities, ease of use, increasing the quantum efficiency (phosphorescence intensity) and extending their range of applicability including constructing a class of oxygen sensors for making measurements in organic media. In addition, provided are methods for synthesizing new porphyrin constructs in which the porphyrin is made less flexible and more planar, changing with decrease internal quenching, and thereby increasing the phosphorescence emission used for oxygen sensing. Additional methods are provided for structurally modifying the dendrimer used to encapsulate the porphyrin phosphor to provide internal quenching of singlet oxygen molecules formed during oxygen measurements.
摘要翻译：生物组织或系统中的氧水平可以通过使用磷光卟啉探针（也称为树枝状氧探针）的磷光猝灭法测量，具有可控的淬灭参数和定义的生物分布。提供了一种“下一代”氧传感器，具有显着改善的磷光发射，以获得更好的成像能力，易于使用，增加量子效率（磷光强度）并扩展其适用范围，包括构建一类氧传感器，用于在有机媒体。此外，提供了合成新的卟啉构建体的方法，其中卟啉被制成较少的柔性和更平面，随着内部淬灭的减少而改变，从而增加用于氧气感测的磷光发射。提供了另外的方法用于结构修饰用于包封卟啉磷光体的树状聚合物，以提供在氧测量期间形成的单线态氧分子的内部猝灭。

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