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11. 发明申请

WO2008153962A2 METHOD OF REDUCING TISSUE LOSS IN PANCREATIC ISLET CELL TRANSPLANTATION 审中-公开
标题翻译：减少胰岛细胞移植组织损失的方法
公开(公告)号：WO2008153962A2
公开(公告)日：2008-12-18
申请号：PCT/US2008/007151
申请日：2008-06-06
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNYLVANIA , UPPSALA UNIVERSITY , LAMBRIS, John, D. , KORSGREN, Olie , NILSSON, Bo
发明人： LAMBRIS, John, D. , KORSGREN, Olie , NILSSON, Bo
IPC分类号： A61K39/395
CPC分类号： A61K35/39 , A61K38/10 , A61K2300/00
摘要： Methods for reducing rejection of pancreatic islet cells transplanted into a subject are disclosed. The methods involve transplanting pancreatic islet cells into a subject in the presence of a complement inhibitor, alone or combined with dextran sulfate.
摘要翻译：公开了减少移植到受试者中的胰岛细胞排斥反应的方法。所述方法包括在补体抑制剂存在下单独或与硫酸葡聚糖组合将胰岛细胞移植到受试者中。

12. 发明申请

WO2014058359A1 METHOD OF COATING AND ENCAPSULATION OF CELLS AND CELL AGGREGATES WITH THICK AND STABLE POLYMER MEMBRANE 审中-公开
标题翻译：使用厚度稳定的聚合物膜对细胞和细胞聚集体进行涂覆和包封的方法
公开(公告)号：WO2014058359A1
公开(公告)日：2014-04-17
申请号：PCT/SE2012/051079
申请日：2012-10-09
申请人： TERAMURA, Yuji , NILSSON, Bo
发明人： TERAMURA, Yuji , NILSSON, Bo
IPC分类号： C12N5/00 , A61K9/50 , B01J13/14 , C08G81/00
CPC分类号： B01J13/14 , A61K9/1075 , A61K35/39 , A61K47/34 , A61K47/36 , A61K47/6901 , A61K2035/128 , C12N5/0012 , C12N5/0677 , C12N2533/30
摘要： The present invention relates to a cross-linked polymer for surface modification of a cell or cell aggregate, said cross-linked polymer comprising micelles of a maleimide-conjugated amphiphilic first polymer, and a second polymer having multiple thiol groups. It further relates to cell and cell aggregates encapsulated by such polymers, and theire use in therapy, as well as kits and methods for preparing such polymers.
摘要翻译：本发明涉及用于细胞或细胞骨架表面改性的交联聚合物，所述交联聚合物包含马来酰亚胺缀合的两亲性第一聚合物的胶束和具有多个硫醇基团的第二聚合物。它还涉及由这样的聚合物包封的细胞和细胞聚集体，并且在治疗中使用，以及制备这种聚合物的试剂盒和方法。

13. 发明申请

WO2007057752A1 CHIPBOARD COMPRISING DECORATIVE RECESS AND MANUFACTURING METHOD 审中-公开
标题翻译：包装装饰和制造方法的芯片
公开(公告)号：WO2007057752A1
公开(公告)日：2007-05-24
申请号：PCT/IB2006/003232
申请日：2006-11-16
申请人： INTER IKEA SYSTEMS B.V. , NILSSON, Bo
发明人： NILSSON, Bo
IPC分类号： B27N3/08 , B27N3/18 , B27N3/20
CPC分类号： B27N3/08 , B27N3/18 , B27N3/203
摘要： The present invention relates to a board constructed from essentially wood material (10), the board (8) comprising at least one decorative recess (2). The wood material (10) consists of wood chips (4) pressed together with one another and has greater density within the area of the decorative recess (2). The board is produced by application of the wood material (10) to a first pressure pad (6), movement of the first pressure pad (6) and a second pressure pad (11) towards one another by the drive means (15), the second pressure pad (11) comprising a projecting means (17) corresponding to the shape of the decorative recess (2), until the pressure pads (6, 11) are in the position of completed compression, separation of the pressure pads (6, 11) from one another and removal of the board (8), as a finished product, from the pressing arrangement (13).
摘要翻译：本发明涉及由基本上木材（10）构成的板，所述板（8）包括至少一个装饰凹部（2）。木材（10）由彼此压在一起并且在装饰凹部（2）的区域内具有更大密度的木屑（4）组成。通过将木材（10）施加到第一压力垫（6），通过驱动装置（15）使第一压力垫（6）和第二压力垫（11）彼此相对移动而产生板，所述第二压力垫（11）包括与所述装饰凹部（2）的形状相对应的突出装置（17），直到所述压力垫（6,11）处于完全压缩的位置，所述压力垫，11）并且从压制装置（13）移除作为成品的板（8）。

14. 发明申请

WO2005042025A1 ELUTABLE SURFACE COATING 审中-公开
标题翻译：可表面涂层
公开(公告)号：WO2005042025A1
公开(公告)日：2005-05-12
申请号：PCT/US2004/034866
申请日：2004-10-21
申请人： ALLVIVO, INC. , NEFF, Jennifer, A. , CALDWELL, Karin, D. , ANDERSSON, Jonas , NILSSON, Bo , NILSSON-EKDAHL, Kristina
发明人： NEFF, Jennifer, A. , CALDWELL, Karin, D. , ANDERSSON, Jonas , NILSSON, Bo , NILSSON-EKDAHL, Kristina
IPC分类号： A61K47/30
CPC分类号： A61L27/54 , A61K47/56 , A61K47/60 , A61L27/34 , A61L2300/25 , A61L2300/252 , A61L2300/258 , A61L2300/604 , C08L71/02
摘要： Elutable coatings comprising protein resistant components and bioactive agent on medical devices are disclosed. The elutable coatings comprise labile linkers that can be cleaved under controlled conditions.
摘要翻译：公开了包含蛋白质抗性组分和生物活性剂在医疗装置上的可洗涤涂层。可洗涤涂层包括可在受控条件下裂解的不稳定接头。

15. 发明申请

WO2005030283A1 BIOARTIFICIAL IMPLANT AND ITS USE AND METHOD OF REDUCING THE RISK FOR FORMATION OF CONNECTIVE TISSUE AFTER IMPLANTATION 审中-公开
标题翻译：生物植入物及其使用和减少在植入后形成连接组织的风险的方法
公开(公告)号：WO2005030283A1
公开(公告)日：2005-04-07
申请号：PCT/SE2004/001418
申请日：2004-10-04
申请人： TIKOMED AB , BRUCE, Adam , BRUCE, Lars , NILSSON, Bo , KORSGREN, Olle
发明人： BRUCE, Adam , BRUCE, Lars , NILSSON, Bo , KORSGREN, Olle
IPC分类号： A61L27/50
CPC分类号： A61L27/306 , A61L27/50
摘要： A bioartificial implant comprises a semipermeable barrier designed from one side to allow diffusion or prevent diffusion of predetermined substances/materials/molecules/cells/cell lines produced in the human body to the other opposite side of the barrier, and from said other opposite side to allow diffusion or prevent diffusion of predetermined substances which are the same as or different from the first mentioned substances/materials/molecules/cells/cell lines. The semipermeable barrier has a surface coating at least on said one side a bioactive metal, such as titanium, which surface coating is permeable to allow said diffusions. In a method for reducing the risk of formation/growth of connective tissue in connection with an implant which comprises a semipermeable barrier, the barrier is provided at least on one side with a permeable coating of bioactive metal. An example of the use of the implant is bioartificial pancreas.
摘要翻译：生物人造植入物包括从一侧设计的半透膜，以允许扩散或防止在人体中产生的预定物质/材料/分子/细胞/细胞系扩散到屏障的另一相对侧，并且从所述另一相对侧扩散允许扩散或防止与前述物质/材料/分子/细胞/细胞系相同或不同的预定物质的扩散。所述半渗透屏障至少在所述一侧上具有生物活性金属（例如钛）的表面涂层，所述表面涂层是可渗透的，以允许所述扩散。在减少与包括半透性屏障的植入物相关的结缔组织形成/生长的风险的方法中，至少在一侧上设置有可渗透的生物活性金属涂层的屏障。使用植入物的实例是生物人造胰腺。

16. 发明申请

WO2003070275A1 USE OF AN INHIBITOR OR ANTAGONIST AGAINST TISSUE FACTOR 审中-公开
标题翻译：使用抗组织蛋白酶抑制剂或拮抗剂
公开(公告)号：WO2003070275A1
公开(公告)日：2003-08-28
申请号：PCT/SE2003/000289
申请日：2003-02-21
申请人： FORSKARPATENT I UPPSALA AB , KORSGREN, Olle , NILSSON, Bo
发明人： KORSGREN, Olle , NILSSON, Bo
IPC分类号： A61K39/395
CPC分类号： C07K16/36 , A61K38/1709 , A61K2039/505
摘要： The present invention relates to use of an inhibitor or antagonist against tissue factor, TF, in the production of a drug for treatment or prevention of diabetes or diabetes related diseases. The inhibitor or antagonist is mainly intended for treatment of diabetic patients suffering from type I or type II diabetes, respectively, as well as the metabolic syndrome preceding type II diabetes. The inhibitor or antagonist is an agent which completely or partially inhibits TF productions, such as an anti-TF antibody or an antisense construct acting on the TF gene.
摘要翻译：本发明涉及抗组织因子TF的抑制剂或拮抗剂在制备用于治疗或预防糖尿病或糖尿病相关疾病的药物中的用途。抑制剂或拮抗剂主要用于治疗分别患有I型或II型糖尿病的糖尿病患者以及II型糖尿病前的代谢综合征。抑制剂或拮抗剂是完全或部分抑制TF产生的试剂，例如抗TF抗体或作用于TF基因的反义构建体。

17. 发明申请

WO2012008908A1 CELL THERAPY 审中-公开
标题翻译：细胞治疗
公开(公告)号：WO2012008908A1
公开(公告)日：2012-01-19
申请号：PCT/SE2011/050928
申请日：2011-07-08
申请人： TX MEDIC AB , KORSGREN, Olle , NILSSON, Bo
发明人： KORSGREN, Olle , NILSSON, Bo
IPC分类号： A61K31/737 , A61K35/12 , A61P35/04
CPC分类号： A61K31/737 , A61K35/26
摘要： Dextran sulfate is used in order to reduce pulmonary uptake of intravenously injected Dextran sulfate is capable of reducing the pulmonary uptake of the intravenously injected cells to the levels obtained for intraarterial injection of the cells but without the accompanying risks and side effects of using intraarterial cell injection. The dextran sulfate can therefore be used in a composition together with tumor infiltrating T-lymphocytes to treat metastatic cancer in a subject.
摘要翻译：使用硫酸葡聚糖以减少静脉内注射的硫酸葡聚糖的肺吸收能够将静脉内注射的细胞的肺吸收降低至动脉内注射细胞获得的水平，但不伴随使用动脉内细胞注射的风险和副作用。因此，硫酸葡聚糖因此可以与肿瘤浸润性T淋巴细胞一起用于组合物中以治疗受试者的转移性癌症。

18. 发明申请

WO2011159223A1 DEVICE FOR OPENABLE LATCHING OF AN OPENABLE ELEMENT, OPENABLE ELEMENT COMPRISING THE DEVICE AND USE THEREOF 审中-公开
标题翻译：可拆卸元件可拆卸装置的设备，包含设备的可执行元件及其使用
公开(公告)号：WO2011159223A1
公开(公告)日：2011-12-22
申请号：PCT/SE2011/050555
申请日：2011-05-03
申请人： MARKSTREET INVEST AB , NILSSON, Bo
发明人： NILSSON, Bo
IPC分类号： E05B65/10
CPC分类号： E05C9/002 , E05B15/102 , E05B17/2034 , E05B57/00 , E05B65/1006 , E05C9/08 , E05C9/1875
摘要： A device (11) for openable locking of an openable element (10), comprising a latch housing (16) having a latch (17) being adjustable between a protruding position and a retracted position, and a movably arranged arm (18) cooperating with the latch (17), wherein the arm (18) is arranged for connection with a control device (12) for controlling the latch (17) through the arm (18). The arm (18) is arranged with a blocking surface (37) for engaging a portion (42) of the latch (17) in the protruding position of the latch and thereby forming a blocking function for preventing the latch (17) from being displaced into the latch housing (16) due to a force applied on an outer side (31) of the latch (17) outside the latch housing (16). The device (11) comprises a movably arranged unblocking element (19) having a strike surface (41) for cooperation with an element (13) outside the latch housing (16), and a portion (40) for cooperation with the arm (18), wherein the unblocking element (19) is arranged for unblocking the blocking function when a force is applied on the strike surface (41) of the unblocking element (19).
摘要翻译：一种用于可打开元件（10）的可开启锁定的装置（11），包括可在突出位置和缩回位置之间调节的闩锁（17）的闩锁壳体（16）以及可移动布置的臂（18）所述闩锁（17），其中所述臂（18）布置成与用于通过所述臂（18）控制所述闩锁（17）的控制装置（12）连接。臂（18）布置有阻挡表面（37），用于在闩锁的突出位置中接合闩锁（17）的部分（42），从而形成阻止闩锁（17）移位的阻挡功能由于施加在闩锁壳体（16）外部的闩锁（17）的外侧（31）上的力而进入闩锁壳体（16）。所述装置（11）包括可移动布置的阻挡元件（19），其具有用于与所述闩锁壳体（16）外部的元件（13）配合的冲击表面（41）和用于与所述臂（18）配合的部分），其中所述解锁元件（19）布置成当在所述解锁元件（19）的所述撞击表面（41）上施加力时解除所述阻挡功能。

19. 发明申请

WO2005118020A1 SURFACE COATING COMPRISING BIOACTIVE COMPOUND 审中-公开
标题翻译：包裹生物化合物的表面涂层
公开(公告)号：WO2005118020A1
公开(公告)日：2005-12-15
申请号：PCT/US2005/013417
申请日：2005-04-21
申请人： ALLVIVO, INC. , NILSSON, Bo , ANDERSSON, Jonas , CALDWELL, Karin , NEFF, Jennifer, A. , NILSSON-EKDAHL, Kristina , TAKEGUCHI, Wade, Akira
发明人： NILSSON, Bo , ANDERSSON, Jonas , CALDWELL, Karin , NEFF, Jennifer, A. , NILSSON-EKDAHL, Kristina , TAKEGUCHI, Wade, Akira
IPC分类号： A61L33/00
CPC分类号： A61L33/0017 , A61L27/34 , A61L29/085 , A61L31/10 , C08L71/02
摘要： Coatings comprising protein resistant components and therapeutic components on medical devices are disclosed. The coatings act to down-regulate complement activation. Medical devices can be coated with these coatings to prevent side effects and improve patency.
摘要翻译：公开了在医疗装置上包含蛋白质抗性组分和治疗成分的涂层。涂层用于下调补体活化。医疗器械可以涂上这些涂层，以防止副作用并改善通畅。

20. 发明申请

WO2004047848A1 NEW USE OF DEXTRAN SULFATE 审中-公开
标题翻译：新西兰硫酸锌的使用
公开(公告)号：WO2004047848A1
公开(公告)日：2004-06-10
申请号：PCT/SE2003/001830
申请日：2003-11-26
申请人： PROPHYMED AB , NILSSON, Bo , KORSGREN, Olle
发明人： NILSSON, Bo , KORSGREN, Olle
IPC分类号： A61K31/721
CPC分类号： A61K31/737 , A61K31/721 , A61K35/39 , A61L27/3804 , A61L27/3839 , A61L27/54 , A61L2300/232 , A61L2300/41 , A61L2300/45 , A61L2300/64
摘要： The present invention refers to use of dextran sulfate, or a pharmaceutically acceptable derivate thereof, for manufacturing of a medicament for treatment of Instant Blood-Mediated Inflammatory Reaction (IBMIR). In addition, the invention refers to the use of dextran sulfate, or a pharmaceutically acceptable derivate thereof, for manufacturing of a medicament for treatment of morphological disruption of cell transplants and graft-rejection of cell transplants caused by IBMIR. The invention may be applied to patients suffering from type I diabetes, in which porcine islets of Langerhans are transplanted in their portal vein. Administration of dextran sulfate according to the invention inhibits and prevents rejection and destruction of the transplanted islets and makes normoglycemia in the patients possible.
摘要翻译：本发明涉及硫酸葡聚糖或其药学上可接受的衍生物在制备用于治疗即时血液介导的炎性反应（IBMIR）的药物中的用途。此外，本发明涉及硫酸葡聚糖或其药学上可接受的衍生物在制备用于治疗由IBMIR引起的细胞移植的形态学破坏和细胞移植的移植排斥的药物中的用途。本发明可以应用于患有I型糖尿病的患者，其中在其门静脉中移植了朗格汉斯猪胰岛。根据本发明的硫酸葡聚糖的施用抑制并防止移植胰岛的排斥和破坏，并使患者的血糖异常成为可能。

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