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1. 发明申请

WO2008033069A1 SELECTIVE CHEMOKINE MODULATION 审中-公开
标题翻译：选择性CHEMOKINE调节
公开(公告)号：WO2008033069A1
公开(公告)日：2008-03-20
申请号：PCT/SE2007/000785
申请日：2007-09-11
申请人： TIKOMED AB , BRUCE, Lars , LYNGSTADAAS, Staale, Petter
发明人： BRUCE, Lars , LYNGSTADAAS, Staale, Petter
IPC分类号： A61K33/24 , A61P29/00 , A61P37/02 , A61P37/04 , A61P37/06
CPC分类号： A61M1/38 , A61K9/14 , A61K33/24 , A61M1/3679 , B01J20/02 , B01J20/06 , Y02A50/387
摘要： The present invention teaches the use of a metal or an oxide of a metal having a capability of reducing the amount of the chemokine IP-IO in a sample and/or reducing the production of IP-IO in cells. The metal is a metal of group 4 or 5 in the period table of the elements and preferably titanium. These metals and metal oxides can selectively bind IP-IO to its surface to thereby scavenge IP-IO from the surrounding medium. In addition, a metal-cell contact induces a reduction in the production of IP-IO from IP-IO producing cells. The metals and metal oxides of the present invention can therefore be used for treating and/ or preventing medical conditions characterized by adverse IP-IO expression, such as inflammatory reactions.
摘要翻译：本发明教导了具有降低样品中趋化因子IP-IO量的金属或金属的氧化物和/或减少细胞中IP-IO的产生的用途。金属是元素周期表中第4或5族的金属，优选为钛。这些金属和金属氧化物可以选择性地将IP-IO结合到其表面上，从而从周围介质中清除IP-IO。此外，金属电池接触引起IP-IO生产电池的IP-IO生产的降低。因此，本发明的金属和金属氧化物可用于治疗和/或预防以不利的IP-IO表达为特征的医学病症，例如炎性反应。

2. 发明申请

WO2015094111A1 SURFACE-BINDING PEPTIDE 审中-公开
标题翻译：表面结合肽
公开(公告)号：WO2015094111A1
公开(公告)日：2015-06-25
申请号：PCT/SE2014/051543
申请日：2014-12-19
申请人： TIKOMED AB
发明人： BRUCE, Lars , LYNGSTADAAS, Staale
IPC分类号： C07K14/52 , A61L27/34 , C07K5/10
CPC分类号： C07K14/57 , A61L27/04 , A61L27/047 , A61L27/06 , A61L27/28 , A61L27/50 , A61L27/54 , A61L2300/25 , A61L2400/18 , C07K5/1013 , C07K5/1019 , C07K14/522 , C07K2319/00
摘要： The embodiments relate to surface-binding peptides having the capability of binding to surfaces of biocompatible materials and can thereby be used to immobilize various heterologous molecules of interest onto the surface. This means that surfaces of, for instance, implants and implantable medical devices can be tailored to present various characteristics by immobilizing selected heterologous molecules of interest on the surfaces of the implants and implantable medical devices. The surface-binding peptides consist of 4-17 consecutive amino acids of an extended beta-hairpin motif EIIATMKKKGEKRCLNP in Interferon gamma-induced protein 10 (IP-10).
摘要翻译：实施方案涉及具有结合生物相容性材料表面的能力的表面结合肽，因此可用于将各种感兴趣的异源分子固定在表面上。这意味着例如植入物和可植入医疗装置的表面可以通过将所选择的感兴趣的异源分子固定在植入物和可植入医疗装置的表面上来定制以呈现各种特征。表面结合肽由干扰素γ诱导蛋白10（IP-10）中延伸的β-发夹基序EIIATMKKKGEKRCLNP的4-17个连续氨基酸组成。

3. 发明申请

WO2005030283A1 BIOARTIFICIAL IMPLANT AND ITS USE AND METHOD OF REDUCING THE RISK FOR FORMATION OF CONNECTIVE TISSUE AFTER IMPLANTATION 审中-公开
标题翻译：生物植入物及其使用和减少在植入后形成连接组织的风险的方法
公开(公告)号：WO2005030283A1
公开(公告)日：2005-04-07
申请号：PCT/SE2004/001418
申请日：2004-10-04
申请人： TIKOMED AB , BRUCE, Adam , BRUCE, Lars , NILSSON, Bo , KORSGREN, Olle
发明人： BRUCE, Adam , BRUCE, Lars , NILSSON, Bo , KORSGREN, Olle
IPC分类号： A61L27/50
CPC分类号： A61L27/306 , A61L27/50
摘要： A bioartificial implant comprises a semipermeable barrier designed from one side to allow diffusion or prevent diffusion of predetermined substances/materials/molecules/cells/cell lines produced in the human body to the other opposite side of the barrier, and from said other opposite side to allow diffusion or prevent diffusion of predetermined substances which are the same as or different from the first mentioned substances/materials/molecules/cells/cell lines. The semipermeable barrier has a surface coating at least on said one side a bioactive metal, such as titanium, which surface coating is permeable to allow said diffusions. In a method for reducing the risk of formation/growth of connective tissue in connection with an implant which comprises a semipermeable barrier, the barrier is provided at least on one side with a permeable coating of bioactive metal. An example of the use of the implant is bioartificial pancreas.
摘要翻译：生物人造植入物包括从一侧设计的半透膜，以允许扩散或防止在人体中产生的预定物质/材料/分子/细胞/细胞系扩散到屏障的另一相对侧，并且从所述另一相对侧扩散允许扩散或防止与前述物质/材料/分子/细胞/细胞系相同或不同的预定物质的扩散。所述半渗透屏障至少在所述一侧上具有生物活性金属（例如钛）的表面涂层，所述表面涂层是可渗透的，以允许所述扩散。在减少与包括半透性屏障的植入物相关的结缔组织形成/生长的风险的方法中，至少在一侧上设置有可渗透的生物活性金属涂层的屏障。使用植入物的实例是生物人造胰腺。

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