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11. 发明申请

WO2011163394A2 COMPSTATIN ANALOGS FOR TREATMENT OF NEUROPATHIC PAIN 审中-公开
标题翻译：用于治疗神经性疼痛的COMPSTATIN模拟物
公开(公告)号：WO2011163394A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041492
申请日：2011-06-22
申请人： APELLIS PHARMACEUTICALS, INC. , FRANCOIS, Cedric , DESCHATELETS, Pascal
发明人： FRANCOIS, Cedric , DESCHATELETS, Pascal
IPC分类号： A61K38/08 , A61K38/10 , A61K38/16 , A61P25/00
CPC分类号： C07K7/52 , A61F13/532 , A61F13/535 , A61F2013/530554 , A61K9/0019 , A61K38/10 , A61K38/12 , A61K38/16 , A61K45/06
摘要： In some aspects, the present invention provides methods of treating a subject in need of treatment for neuropathic pain, the method comprising administering a compstatin analog to the subject. In some embodiments, the compstatin analog is administered parenterally, e.g., intravenously.
摘要翻译：在一些方面，本发明提供治疗需要治疗神经性疼痛的受试者的方法，所述方法包括向受试者施用化合物抑制素类似物。在一些实施方案中，所述化合物抑制素类似物肠胃外给药，例如静脉内给药。

12. 发明申请

WO2012178083A1 METHODS OF TREATING CHRONIC DISORDERS WITH COMPLEMENT INHIBITORS 审中-公开
标题翻译：用补充抑制剂治疗慢性疾病的方法
公开(公告)号：WO2012178083A1
公开(公告)日：2012-12-27
申请号：PCT/US2012/043845
申请日：2012-06-22
申请人： APELLIS PHARMACEUTICALS, INC. , FRANCOIS, Cedric , DESCHATELETS, Pascal
发明人： FRANCOIS, Cedric , DESCHATELETS, Pascal
IPC分类号： A61K38/10 , A61K38/12 , A61P27/00 , A61P11/06 , A61K39/395 , G01N33/53
CPC分类号： A61K38/12 , A61B5/14546 , A61B5/414 , A61K38/10 , A61K39/3955 , G01N33/6869 , G01N33/6884 , G01N2800/12 , G01N2800/122 , G01N2800/14 , G01N2800/24
摘要： In some aspects, the invention provides methods of treating a subject in need of treatment for a chronic complement-mediated disorder. In some aspects, the invention provides methods of treating a subject in need of treatment for a Thl7-associated disorder. In some aspects, the invention provides methods of treating a subject in need of treatment for a chronic respiratory system disorder. In some aspects, the invention provides methods of administering a complement inhibitor to a subject. In some embodiments, a method of treating a subject comprises administering multiple doses of a complement inhibitor to the subject according to a dosing schedule that leverages the prolonged effect of complement inhibition in chronic respiratory disorders. In some embodiments, a subject has chronic obstructive pulmonary disease. In some embodiments, a subject has asthma.
摘要翻译：在一些方面，本发明提供治疗需要治疗慢性补体介导的病症的受试者的方法。在一些方面，本发明提供治疗需要治疗Th17相关病症的受试者的方法。在一些方面，本发明提供治疗需要治疗慢性呼吸系统疾病的受试者的方法。在一些方面，本发明提供了向受试者施用补体抑制剂的方法。在一些实施方案中，治疗受试者的方法包括根据给药方案对受试者施用多个剂量的补体抑制剂，所述给药方案利用长期呼吸障碍中补体抑制的延长作用。在一些实施方案中，受试者具有慢性阻塞性肺疾病。在一些实施方案中，受试者具有哮喘。

13. 发明申请

WO2012006599A2 COMPSTATIN ANALOGS FOR TREATMENT OF RHINOSINUSITIS AND NASAL POLYPOSIS 审中-公开
标题翻译： COMPSTATIN类似物治疗鼻窦炎和鼻息肉的疗效观察
公开(公告)号：WO2012006599A2
公开(公告)日：2012-01-12
申请号：PCT/US2011/043466
申请日：2011-07-08
申请人： APELLIS PHARMACEUTICALS, INC. , FRANCOIS, Cedric , DESCHATELETS, Pascal
发明人： FRANCOIS, Cedric , DESCHATELETS, Pascal
IPC分类号： A61K38/10 , A61K38/08 , A61P11/02 , A61P11/00
CPC分类号： C07K7/54 , A61K9/0043 , A61K38/08 , A61K38/10 , A61K38/12 , A61K45/06
摘要： In some aspects, the present invention provides methods treating a subject in need of treatment for chronic rhinosinusitis or nasal polyposis, the methods comprising administrering a complement inhibitor such as a compstatin analog to the subject. In some embodiments, the complement inhibitor is administered intranasally, e.g., in a nasal spray.
摘要翻译：在一些方面，本发明提供治疗需要治疗慢性鼻鼻窦炎或鼻息肉病的受试者的方法，所述方法包括向受试者施用补体抑制剂例如坎普他汀类似物。在一些实施方案中，补体抑制剂例如在鼻腔喷雾剂中鼻内施用。

14. 发明申请

WO2012155107A1 CELL-REACTIVE, LONG-ACTING, OR TARGETED COMPSTATIN ANALOGS AND USES THEREOF 审中-公开
标题翻译：细胞反应性，长期作用或靶向的同型异基体类似物及其用途
公开(公告)号：WO2012155107A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/037648
申请日：2012-05-11
申请人： APELLIS PHARMACEUTICALS, INC. , FRANCOIS, Cedric , DESCHATELETS, Pascal
发明人： FRANCOIS, Cedric , DESCHATELETS, Pascal
IPC分类号： C07K7/00 , A61K38/04 , C12N5/00 , A61P37/00
CPC分类号： C07K7/64 , A61K38/00 , A61K47/60 , A61K47/643 , C07K7/08 , C07K14/472
摘要： In some aspects, thepresent invention provides cell-reactive compstatin analogs and compositions comprising cell-reactive compstatin analogs. In some aspects, theinvention further provides methods of using cell-reactive compstatin analogs, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ. In some aspects, the invention provides long-acting compstatin analogs and compositions comprising long-acting compstatin analogs. In some aspects, the invention further provides methods of using long- acting compstatin analogs, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ. In some aspects, the invention provides targeted compstatin analogs and compositions comprising targeted compstatin analogs. In some aspects, the invention further provides methods of using targeted compstatin analogs, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ.
摘要翻译：在一些方面，本发明提供了细胞反应性的compstatin类似物和包含细胞反应性的compstatin类似物的组合物。在一些方面，本发明还提供使用细胞反应性化合物抑制素类似物的方法，例如抑制补体介导的对细胞，组织或器官的损伤。在一些方面，本发明提供了长效化合物抑制素类似物和包含长效化合物抑制素类似物的组合物。在一些方面，本发明还提供了使用长效化合物抑制素类似物的方法，例如抑制补体介导的对细胞，组织或器官的损伤。在一些方面，本发明提供靶向化合物抑制素类似物和包含目标化合物抑制物类似物的组合物。在一些方面，本发明还提供了使用靶标化合物抑制素类似物的方法，例如抑制补体介导的对细胞，组织或器官的损伤。

15. 发明申请

WO2005098967A1 PHOTOVOLTAIC DEVICE WITH TRIMETASPHERES 审中-公开
标题翻译：具有三甲基吡咯烷酮的光电器件
公开(公告)号：WO2005098967A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/010214
申请日：2005-03-25
申请人： LUNA INNOVATIONS INCORPORATED , PHILLIPS, J., Paige , TOPASNA, Daniela, M. , STEVENSON, Steven, A. , DESCHATELETS, Pascal , KOENE, Bryan
发明人： PHILLIPS, J., Paige , TOPASNA, Daniela, M. , STEVENSON, Steven, A. , DESCHATELETS, Pascal , KOENE, Bryan
IPC分类号： H01L31/0256
CPC分类号： H01L51/4253 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C01B32/15 , C01B32/152 , H01L51/0036 , H01L51/0037 , H01L51/0046 , H01L51/0077 , H01L51/0089 , H01L51/424 , Y02E10/549
摘要： An exemplary photovoltaic device for conversion of an incident wavelength of electromagnetic radiation to electricity has an absorber of incident wavelength of electromagnetic radiation, a trimetasphere in electron transferring contact with the absorber, an anode in electrical contact with the trimetasphere, and a cathode in electrical contact with the absorber. The absorber and trimetasphere can be arranged as a heterojunction or a blended junction. An exemplary electrical circuit has an absorber of incident electromagnetic radiation, a trimetasphere-containing material in electron transferring contact with the absorber, an anode, a cathode and a current path from the anode to the cathode. An exemplary method of converting incident electromagnetic radiation to an electrical signal using a trimetasphere-containing material is also disclosed.
摘要翻译：用于将电磁辐射的入射波长转换为电的示例性光伏器件具有电磁辐射的入射波长的吸收体，与吸收体的电子转移接触的三角肌，与三角肌电接触的阳极和电接触的阴极与吸收器。吸收体和三角突耳可以排列成异质结或混合结。示例性电路具有入射电磁辐射的吸收体，与吸收体电子转移接触的含三聚甲醛的材料，阳极，阴极和从阳极到阴极的电流路径。还公开了一种用入射电磁辐射将电子信号转换为电信号的示例性方法。

16. 发明申请

WO2004099293A2 FLAME RETARDANT THERMOSET RESINS AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：阻燃热固性树脂及其制备方法
公开(公告)号：WO2004099293A2
公开(公告)日：2004-11-18
申请号：PCT/US2004/012657
申请日：2004-04-22
申请人： LUNA INNOVATIONS INCORPORATED , ROGERS, Martin, E. , DESCHATELETS, Pascal , STEVENSON, Janice, P.
发明人： ROGERS, Martin, E. , DESCHATELETS, Pascal , STEVENSON, Janice, P.
IPC分类号： C08J
CPC分类号： C08J3/203 , C08K3/016 , C08K3/32 , Y10T428/31504
摘要： Articles and processes are provided whereby flame-retardant SAP particles are incorporated into synthetic resins, especially curable thermosettable resins. The SAP particles are most preferably hydrated with an aqueous flame-retardant solution. In this regard, the flame-retardant solution may consist essentially of water alone or a water solution containing one or more water soluble inorganic flame retardants. When SAP particles are hydrated with an aqueous inorganic flame retardant solution, the SAP particles may thereafter be dried to remove substantially the water component. In such a manner, the inorganic flame retardant will remain as a dried residue physically entrained within the SAP particles. As such, the SAP particles serve as a physical matrix in which the inorganic flame retardant is homogenously dispersed. The SAP particles may then be blended with a synthetic resin as is or alternatively may be ground into more finely divided particles which contain the dried residue of the aqueous inorganic flame retardant solution and then blended with a suitable synthetic resin.
摘要翻译：提供了制品和方法，其中阻燃SAP颗粒被并入合成树脂，特别是可固化的可热固树脂中。 SAP颗粒最优选用含水阻燃溶液水合。在这方面，阻燃溶液可以基本上由单独的水或含有一种或多种水溶性无机阻燃剂的水溶液组成。当SAP颗粒与含水无机阻燃剂溶液水合时，此后可将SAP颗粒干燥以除去基本上水分。以这种方式，无机阻燃剂将保留为物理夹带在SAP颗粒内的干燥残余物。因此，SAP颗粒用作其中无机阻燃剂均匀分散的物理基体。然后可以将SAP颗粒与合成树脂共混，或者可以研磨成更细的颗粒，其含有无机阻燃剂水溶液的干燥残余物，然后与合适的合成树脂混合。

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