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11. 发明申请

WO2016109700A1 ELECTROLYTIC DIAPHRAGM PUMPS HAVING RIGID RESERVOIRS 审中-公开
标题翻译：具有刚性贮罐的电解膜片泵
公开(公告)号：WO2016109700A1
公开(公告)日：2016-07-07
申请号：PCT/US2015/068112
申请日：2015-12-30
申请人： SHIH, Jason , TAI, Yu-Chong , DUNN, Andrew
发明人： SHIH, Jason , TAI, Yu-Chong , DUNN, Andrew
IPC分类号： A61M5/142 , A61M5/172 , A61M29/02 , A61M31/00 , A61M36/04
CPC分类号： A61M5/14593 , A61M5/14276 , A61M5/16804 , A61M2005/14204
摘要： In various embodiments, an implantable drug-delivery device features one or more rigid drug reservoirs from which therapeutic agents are administered and which are refilled from a flexible reservoir within the device.
摘要翻译：在各种实施方案中，可植入药物递送装置具有一个或多个刚性药物储存器，治疗剂从该药物储存器被施用，并且从装置内的柔性储存器重新填充。

12. 发明申请

WO2011022484A1 ELECTROLYTIC DRUG-DELIVERY PUMP WITH ADAPTIVE CONTROL 审中-公开
标题翻译：具有自适应控制的电解液输送泵
公开(公告)号：WO2011022484A1
公开(公告)日：2011-02-24
申请号：PCT/US2010/045897
申请日：2010-08-18
申请人： REPLENISH PUMPS. LLC , SHIH, Jason , BRENNAN, Jeffrey , JIANG, Fukang , CAFFEY, Sean
发明人： SHIH, Jason , BRENNAN, Jeffrey , JIANG, Fukang , CAFFEY, Sean
IPC分类号： G06F19/00 , A61M5/00
CPC分类号： A61M5/16831 , A61F9/0017 , A61M5/14244 , A61M5/14276 , A61M5/14593 , A61M5/148 , A61M5/16804 , A61M5/16854 , A61M5/172 , A61M31/002 , A61M2005/14204 , A61M2205/3331 , A61M2205/3368 , A61M2210/0612 , A61M2210/0693 , G06F19/00 , G06F19/3468
摘要： Actuation of a drug-delivery pump is controlled based on a change in a condition of the pump.
摘要翻译：基于泵的状况变化来控制药物输送泵的致动。

13. 发明申请

WO2016109539A1 IMPLANTABLE ELECTROLYTIC DIAPHRAGM PUMPS 审中-公开
标题翻译：可植入电解膜片泵
公开(公告)号：WO2016109539A1
公开(公告)日：2016-07-07
申请号：PCT/US2015/067867
申请日：2015-12-29
申请人： MINIPUMPS, LLC
发明人： SHIH, Jason , DUNN, Andrew , PANG, Changlin
IPC分类号： A61M5/172 , A61M5/142
CPC分类号： A61M5/14276 , A61F9/0017 , A61M5/14593 , A61M5/172 , A61M2005/14513
摘要： In various embodiments, an implantable drug-delivery device features drug-delivery and electrolysis chambers incorporated as separate structures within the device. For example, one or both of these chambers may be manufactured in the form of a bladder that "floats" within the main device housing.
摘要翻译：在各种实施方案中，可植入药物递送装置具有作为分离结构并入装置内的药物递送和电解室。例如，这些腔室中的一个或两个可以以“漂浮在主装置壳体内”的膀胱的形式制造。

14. 发明申请

WO2015100248A1 DRUG REFILL APPLICATOR SYSTEM AND METHOD OF USE 审中-公开
标题翻译：药物补充施用者系统及其使用方法
公开(公告)号：WO2015100248A1
公开(公告)日：2015-07-02
申请号：PCT/US2014/071917
申请日：2014-12-22
申请人： MINIPUMPS, LLC , DUNN, Andrew , URAZAKI, Andrew , WANG, Bin , JIANG, Fukang
发明人： DUNN, Andrew , URAZAKI, Andrew , WANG, Bin , JIANG, Fukang , RODRIGUEZ, Andres , MINAIE, Pedrum , SOE, Tun Min , SHIH, Jason
IPC分类号： A61M5/14 , A61M5/142 , A61M5/20
CPC分类号： A61J1/22 , A61J1/201 , A61M5/14276 , A61M2005/14268 , B65B3/003
摘要： Embodiments of the present invention involve a refill apparatus comprising at least one pump, a plurality of reservoirs, a plurality of reservoir fluid channels each associated with one of the reservoirs, a plurality of valves, each having a cracking pressure, for fluidically sealing the reservoir fluid channels and the outlet fluid channel, an outlet fluid channel fluidically connected to the reservoir fluid channels, and a needle having a lumen in fluid communication with the outlet fluid channel. A parameter such as a pressure level is monitored, and one or more pumps and various ones of the valves are actuated in accordance with a protocol comprising a sequence of steps whereby fluidic pathways are opened between different ones of the reservoirs and the needle in a washing and filling sequence, each of the steps being associated with an expected pressure level.
摘要翻译：本发明的实施例涉及一种再填充装置，其包括至少一个泵，多个储存器，多个储存器流体通道，每个储存器流体通道与储存器中的一个相关联，多个阀，每个具有开启压力，用于流体地密封储存器流体通道和出口流体通道，流体连接到储存器流体通道的出口流体通道，以及具有与出口流体通道流体连通的内腔的针。监测诸如压力水平的参数，并且根据包括一系列步骤的方案致动一个或多个泵和各种阀，其中在洗涤中不同储存器和针之间的流体路径打开和填充顺序，每个步骤与预期压力水平相关联。

15. 发明申请

WO2019169299A8 IMPLANTABLE CONTINUOUS-FLOW PUMPS 审中-公开
公开(公告)号：WO2019169299A8
公开(公告)日：2019-09-06
申请号：PCT/US2019/020351
申请日：2019-03-01
申请人： MINIPUMPS LLC
发明人： SHIH, Jason , HARBERS, Gregory , PURVIS, Richard , MATSUOKA, Miho , URAZAKI, Andrew , HUMAYUN, Mark , BRANDT, Andrew, William , LOTFI, Atoosa , SAGAN, Didier , DUNN, Andrew
IPC分类号： A61M5/142 , A61M5/148 , A61M5/155 , A61M5/14 , A61M5/145 , A61M31/00 , A61F9/00 , A61M39/24
摘要： In various embodiments, a drug pump includes a housing and, within the housing, an expandable drug reservoir at least part of which is exposed to a pressurized propellant. The propellant exerts a substantially constant pressure on the drug reservoir. A flow restrictor significantly limits outflow from the pump, and preferably has both a small diameter and a long path length, which acts to control the outflow from the drug reservoir. As a result, the pump produces a substantially constant outflow.

16. 发明申请

WO2016109489A1 PRESSURE SENSING IN IMPLANTABLE DRUG PUMPS 审中-公开
标题翻译：可注射药物泵中的压力感测
公开(公告)号：WO2016109489A1
公开(公告)日：2016-07-07
申请号：PCT/US2015/067798
申请日：2015-12-29
申请人： MINIPUMPS, LLC
发明人： SHIH, Jason , DUNN, Andrew
IPC分类号： A61M5/172 , G01L9/00 , A61M5/165 , A61M5/158
CPC分类号： A61M5/14276 , A61M5/14593 , A61M2005/14204 , A61M2005/14513 , A61M2205/702 , A61M2209/045
摘要： In various embodiments, implantable drug-delivery devices feature drug reservoirs, expandable electrolysis chambers, and integrated strain gauges for monitoring pressure changes within the device.
摘要翻译：在各种实施方案中，可植入药物递送装置具有用于监测装置内的压力变化的药物储存器，可膨胀电解室和集成应变计。

17. 发明申请

WO2004065290A2 INTEGRATED ELECTROSTATIC PERISTALTIC PUMP METHOD AND APPARATUS 审中-公开
标题翻译：综合静电渗透泵方法及装置
公开(公告)号：WO2004065290A2
公开(公告)日：2004-08-05
申请号：PCT/US2004/001052
申请日：2004-01-14
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , XIE, Jun , SHIH, Jason , TAI, Yu-Chong
发明人： XIE, Jun , SHIH, Jason , TAI, Yu-Chong
IPC分类号： B81C
CPC分类号： B81C1/00119 , B81B2201/036 , B81B2203/0127 , B81B2203/0338 , F04B43/043 , F04B43/082 , F04B43/12 , Y10T137/87692
摘要： An electrostatic fluid regulating device and methods. The device has a substrate. The device also has a first electrode coupled to the substrate. The device has a polymer based diaphragm. A second electrode is coupled to the diaphragm. A polymer based fluid chamber is coupled to the diaphragm. The device also has an inlet coupled to the polymer based fluid chamber and an outlet coupled to the polymer based fluid chamber.
摘要翻译：一种静电流体调节装置及方法。该装置具有基板。该器件还具有耦合到衬底的第一电极。该装置具有基于聚合物的隔膜。第二电极耦合到隔膜。基于聚合物的流体室耦合到隔膜。该装置还具有连接到基于聚合物的流体室的入口和连接到基于聚合物的流体室的出口。

18. 发明申请

WO2014182878A1 FLEXIBLE MANUFACTURE OF POLYMERIC TUBING 审中-公开
标题翻译：聚合物管的柔性制造
公开(公告)号：WO2014182878A1
公开(公告)日：2014-11-13
申请号：PCT/US2014/037261
申请日：2014-05-08
申请人： SHIH, Jason , DUNN, Andrew , LIU, Changgeng , CURLEY, Brandon
发明人： SHIH, Jason , DUNN, Andrew , LIU, Changgeng , CURLEY, Brandon
IPC分类号： B29C33/00 , B81C99/00
CPC分类号： B29C41/42 , B29C33/0016 , B29C33/52 , B29C39/10 , B29C64/188 , B33Y40/00
摘要： Tubular polymeric structures are formed by creating a convex mold conforming to a fluid pathway design, depositing a coating of polymer over the mold, and in situ removing the mold without drawing it against the polymer.
摘要翻译：通过产生符合流体路径设计的凸模，通过在模具上沉积聚合物涂层，以及在不将其拉离聚合物的情况下原位移除模具来形成管状聚合物结构。

19. 发明申请

WO2013052795A2 INSTRUMENTS AND METHODS FOR SURGICAL SIZING AND MARKING 审中-公开
标题翻译：仪器和外科尺寸和标记方法
公开(公告)号：WO2013052795A2
公开(公告)日：2013-04-11
申请号：PCT/US2012/058944
申请日：2012-10-05
申请人： JOURNEY, Michelle, L. , SHIH, Jason , CAFFEY, Sean , HARBERS, Gregory
发明人： JOURNEY, Michelle, L. , SHIH, Jason , CAFFEY, Sean , HARBERS, Gregory
IPC分类号： A61B17/02
CPC分类号： A61B90/06 , A61B17/0231 , A61B90/39 , A61B2017/00716 , A61B2090/3908 , A61B2090/3937 , A61F9/0017 , A61F9/0136 , A61F2240/005 , B33Y80/00
摘要： A surgical sizer for creating a tissue pocket for an implantable medical device may include a replica of the device and a (preferably ergonomic) handle portion, optionally with marking features that facilitate marking the tissue for precise implant placement and alignment.
摘要翻译：用于为植入式医疗装置创建组织袋的手术分级器可包括装置的复制品和（优选符合人体工程学的）手柄部分，可选地具有标记特征以便于标记组织以进行精确的植入物放置和对齐。

20. 发明申请

WO2006017217A2 INTEGRATED LC-ESI ON A CHIP 审中-公开
标题翻译：集成LC-ESI芯片
公开(公告)号：WO2006017217A2
公开(公告)日：2006-02-16
申请号：PCT/US2005/024518
申请日：2005-07-11
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , CITY OF HOPE? , TAI, Yu-Chong , XIE, Jun , SHIH, Jason , LEE, Terry , MIAO, Yunan
发明人： TAI, Yu-Chong , XIE, Jun , SHIH, Jason , LEE, Terry , MIAO, Yunan
IPC分类号： C23F1/00
CPC分类号： H01J49/04 , B01L3/5027 , G01N30/6095 , G01N30/7233 , G01N2030/326
摘要： A microfluidic system with on-chip pumping which can be used for liquid chromatography and also electrospray ionization mass spectrometry and which provides improved efficiency, better integration with sensors, improved portability, reduced power consumption, and reduced cost. The system can include (A) a main chip comprising: a substrate having a front face and a back face; a chromatography column on the front face of said substrate, wherein said column has an inlet and an outlet; an electrospray ionization (ESI) nozzle on the front face of said substrate, wherein said nozzle has an inlet and an outlet, and wherein the inlet of the nozzle is microfluidically coupled to the outlet of the column; one or more pump systems on the front face of said substrate comprising a pump chamber, one or more electrodes, and an outlet microfluidically coupled to the inlet of said column; and (B) a reservoir chip comprising a front surface and a back surface, wherein the reservoir chip has one or more cavities in the back surface which when disposed next to the front surface of the main chip extends the volume of the pump chamber of one of the pump system. Microfabrication can be used to prepare the chips, which can be assembled with a cover and inserted into a testing jig for electronic control and mass spectral analysis. Peptide separations are demonstrated which compete with present commercial systems.
摘要翻译：具有片上泵浦的微流体系统，其可用于液相色谱和电喷雾离子化质谱法，其提供更高的效率，更好地与传感器的集成，改进的便携性，降低的功率消耗和降低的成本。该系统可以包括（A）主芯片，其包括：具有正面和背面的基板; 所述基板前表面上的色谱柱，其中所述色谱柱具有入口和出口; 在所述基板的正面上的电喷雾离子化（ESI）喷嘴，其中所述喷嘴具有入口和出口，并且其中所述喷嘴的入口微流体耦合到所述塔的出口; 所述衬底的前表面上的一个或多个泵系统包括泵室，一个或多个电极和微流体耦合到所述塔的入口的出口; 和（B）包括前表面和后表面的储存器芯片，其中所述储存器芯片在所述后表面中具有一个或多个空腔，当所述储存器芯片靠近所述主芯片的前表面设置时，所述泵室的体积将一个的泵系统。可以使用微加工来制备芯片，其可以用盖组装并插入用于电子控制和质谱分析的测试夹具中。展示了与现有商业系统竞争的肽分离。

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