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11. 发明申请

WO2012135786A2 CRYOELECTRIC SYSTEMS AND METHODS FOR TREATMENT OF BIOLOGICAL MATTER 审中-公开
标题翻译：用于处理生物物质的热电系统和方法
公开(公告)号：WO2012135786A2
公开(公告)日：2012-10-04
申请号：PCT/US2012/031728
申请日：2012-03-30
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , RUBINSKY, Boris , DANIELS, Charlotte , GRANOT, Yair
发明人： RUBINSKY, Boris , DANIELS, Charlotte , GRANOT, Yair
IPC分类号： A61B18/02 , A61N1/18 , A61N1/28 , A61N1/04
CPC分类号： A61B18/02 , A61B18/1477 , A61B2018/00577 , A61B2018/00994 , A61B2018/0293
摘要： Systems and methods are disclosed for treating a target volume of biological matter, by cooling a volume of tissue to a temperature below freezing, and directing an electric field through the cooled volume of tissue or tissue adjacent to the cooled volume of tissue to generate at least a temporary physiological affect on one or more of the cooled volume of tissue and adjacent volume of tissue. The generated physiological affect may include shielding a region of tissue from treatment, focusing treatment on a particular region of tissue, and sterilization of tissue.
摘要翻译：公开了用于通过将一定体积的组织冷却至低于冰点的温度来处理目标体积的生物物质的系统和方法，并且引导电场穿过冷却体积的组织或组织邻近冷却体积的组织，以对冷却体积的组织和相邻体积的组织中的一个或多个产生至少暂时的生理影响。所产生的生理影响可以包括屏蔽组织的一个区域，治疗集中于组织的特定区域，以及组织的消毒。

12. 发明申请

WO2014105964A1 SYSTEMS AND METHODS FOR DELIVERING PULSED ELECTRIC FIELDS TO SKIN TISSUE 审中-公开
标题翻译：用于将脉冲电场传送到皮肤组织的系统和方法
公开(公告)号：WO2014105964A1
公开(公告)日：2014-07-03
申请号：PCT/US2013/077829
申请日：2013-12-26
申请人： THE GENERAL HOSPITAL CORPORATION , GOLBERG, Alexander , YARMUSH, Martin L. , SHERIDAN, Robert L. , AUSTEN, William Gerald Jr. , BROELSCH, G. Felix , RUBINSKY, Boris , BELKIN, Michael
发明人： GOLBERG, Alexander , YARMUSH, Martin L. , SHERIDAN, Robert L. , AUSTEN, William Gerald Jr. , BROELSCH, G. Felix , RUBINSKY, Boris , BELKIN, Michael
IPC分类号： A61N1/36
CPC分类号： A61N1/36014 , A61B2018/00613 , A61N1/0464 , A61N1/0468 , A61N1/0476 , A61N1/0492 , A61N1/325 , A61N1/326 , A61N1/327 , A61N1/328
摘要： Systems and methods for controlling a tissue of a subject using applied pulsed electric fields. The system for controlling a therapy provided to a tissue of a subject using applied pulsed electric fields. The system includes an electrode assembly configured to engage a skin tissue of a subject to deliver a series of electric field pulses to the skin tissue and a user input configured to receive an operational instruction for the series of electric field pulses. The operational instruction defines at least one of a pulse duration, a pulse frequency, a pulse number, and a pulse amplitude. The system also includes at least one processor configured to access the operational instruction received by the user input and, using the operational instruction, create an electric field profile to be generated by the electrode assembly about the skin tissue of the subject to control a fibroblast characteristic while preserving a vascular perfusion in at least a portion of the skin tissue. The processor is also caused to control the electrode assembly using the electric field profile to deliver the series of electric field pulses to control the fibroblast characteristic.
摘要翻译：使用施加的脉冲电场来控制受试者的组织的系统和方法。用于使用施加的脉冲电场来控制提供给对象的组织的治疗的系统。该系统包括电极组件，其被配置为接合对象的皮肤组织以向皮肤组织递送一系列电场脉冲，以及用户输入，其被配置为接收用于该一系列电场脉冲的操作指令。操作指令定义脉冲持续时间，脉冲频率，脉冲数和脉冲幅度中的至少一个。该系统还包括至少一个处理器，其被配置为访问由用户输入接收的操作指令，并且使用操作指令创建由电极组件围绕对象的皮肤组织产生的电场分布，以控制成纤维细胞特征同时在至少一部分皮肤组织中保持血管灌注。还使处理器使用电场分布来控制电极组件以递送一系列电场脉冲以控制成纤维细胞特征。

13. 发明申请

WO2011028937A1 EXTRACELLULAR MATRIX MATERIAL CREATED USING NON-THERMAL IRREVERSIBLE ELECTROPORATION 审中-公开
标题翻译：使用非热不可逆电极制造的细小基体材料
公开(公告)号：WO2011028937A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/047725
申请日：2010-09-02
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , PHILLIPS, Mary , MAOR, Elad , RUBINSKY, Boris , LAVEE, Jacob
发明人： PHILLIPS, Mary , MAOR, Elad , RUBINSKY, Boris , LAVEE, Jacob
IPC分类号： A61K35/12
CPC分类号： A61K35/34 , A61K35/22 , A61K35/38 , A61K35/42 , A61K35/44 , A61L27/3604 , A61L27/3683 , A61L27/3834 , A61L2430/40
摘要： Extracellular matrix material is disclosed which is created by subjecting a target area to non-thermal irreversible electroporation (NTIRE) with a pulsed electrical field to kill cells in the absence of thermal damage. The dead cellular material may be removed and the remaining non-cellular matrix material may be implanted into a repair site to be treated medically or cosmetically.
摘要翻译：公开了细胞外基质材料，其通过用脉冲电场对目标区域进行非热不可逆电穿孔（NTIRE）而产生，以在不存在热损伤的情况下杀死细胞。可以去除死细胞材料，并将剩余的非细胞基质材料植入修复部位以进行医疗或化妆品处理。

14. 发明申请

WO2009121009A2 IRREVERSIBLE ELECTROPORATION DEVICE FOR USE IN ATTENUATING NEOINTIMAL 审中-公开
标题翻译：不可逆电气设备用于衰减极端
公开(公告)号：WO2009121009A2
公开(公告)日：2009-10-01
申请号：PCT/US2009/038647
申请日：2009-03-27
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , RUBINSKY, Boris , MAOR, Elad , IVORRA, Antoni
发明人： RUBINSKY, Boris , MAOR, Elad , IVORRA, Antoni
IPC分类号： A61B18/18
CPC分类号： A61M5/14 , A61B18/14 , A61B18/1492 , A61B2017/22038 , A61B2018/00166 , A61B2018/00214 , A61B2018/0022 , A61B2018/0041 , A61B2018/00613 , A61B2018/1435 , A61N1/327
摘要： Restenosis or neointimal formation may occur following angioplasty or other trauma to an artery such as by-pass surgery. This presents a major clinical problem which narrows the artery. The invention provides a device and a method whereby vascular cells in the area of the artery subjected to the trauma are subjected to irreversible electroporation which is a non-thermal, non-pharmaceutical method of applying electrical pulses to the cells so that substantially all of the cells in the area are ablated while leaving the structure of the vessel in place and substantially unharmed due to the non-thermal nature of the procedure.
摘要翻译：血管成形术或其他对动脉的创伤如旁路手术可能发生再狭窄或新内膜形成。这是导致动脉狭窄的主要临床问题。本发明提供了一种装置和方法，其中经受创伤的动脉区域中的血管细胞经受不可逆电穿孔，其是对细胞施加电脉冲的非热非药物方法，使得基本上全部该区域中的细胞被消融，同时使血管的结构保持在适当位置，并且由于该程序的非热性质而基本上没有受到伤害。

15. 发明申请

WO2009067142A1 CONTROLLED MULTI-HOLES ELECTROPORATION 审中-公开
标题翻译：控制多孔电气
公开(公告)号：WO2009067142A1
公开(公告)日：2009-05-28
申请号：PCT/US2008/012277
申请日：2008-10-28
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , RUBINSKY, Boris , DIAZ, Ruben
发明人： RUBINSKY, Boris , DIAZ, Ruben
IPC分类号： C12N13/00
CPC分类号： C12N13/00 , C12M35/02 , C12N15/87
摘要： A method of controlled electroporation of a plurality of cells is provided. When electroporating a plurality of cells using a microelectroporation set-up at a given temperature, the critical voltage required for achieving electroporation is independent of the cell radius and is only dependent on the radii of the openings holding the cells. Thus if the radii of the openings is kept constant, the same voltage will induce electroporation of all the cells irrespective of their radii.
摘要翻译：提供了多个电池受控电穿孔的方法。当在给定温度下使用微电镀装置电穿孔多个细胞时，实现电穿孔所需的临界电压与电池半径无关，并且仅取决于保持电池的开口的半径。因此，如果开口的半径保持恒定，相同的电压将引起所有电池的电穿孔，而不管其半径如何。

16. 发明申请

WO2008051463A2 NEUROLOGICAL STIMULATION AND ANALYSIS 审中-公开
标题翻译：神经刺激与分析
公开(公告)号：WO2008051463A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/022304
申请日：2007-10-19
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , IVORRA, Antoni , RUBINSKY, Boris
发明人： IVORRA, Antoni , RUBINSKY, Boris
IPC分类号： A61N1/36
CPC分类号： A61N1/0456 , A61N1/0472 , A61N1/0551 , A61N1/36025
摘要： In one embodiment, a method for neurological interrogation and response analysis is provided. The method includes inducing, at the device, a non-optical excitation for a user. The device comprises a wearable device being worn by the user such that the non-optical excitation can be sensed. A response of a voluntary conscious movement is detected from the user. An outcome is analyzed based on the response and the non-optical excitation. An action can be performed in response to the analysis.
摘要翻译：在一个实施例中，提供了用于神经询问和响应分析的方法。该方法包括在设备处引起用户的非光学激励。该装置包括由用户佩戴的可佩戴装置，使得可以感测非光学激励。从用户检测到自愿意识运动的响应。根据响应和非光学激励分析结果。可以根据分析结果执行操作。

17. 发明申请

WO2013119511A1 COMPOSITION, METHOD, AND DEVICES FOR REDUCTION OF CELLS IN A VOLUME OF MATTER 审中-公开
标题翻译：用于减少细胞数量的组合物，方法和装置
公开(公告)号：WO2013119511A1
公开(公告)日：2013-08-15
申请号：PCT/US2013/024661
申请日：2013-02-04
申请人： ELMEDTECH, LLC , RUBINSKY, Boris , RUBINSKY, Liel
发明人： RUBINSKY, Boris , RUBINSKY, Liel
IPC分类号： C12N13/00
CPC分类号： A61L2/03 , A23L3/32
摘要： The present disclosure provides devices, systems, and methods for affecting cells using low voltage high electric fields (LVHEF). In one embodiment, the present disclosure provides for reduction of microbial contamination using low voltage high electric fields. The devices of the disclosure are generally capable of affecting cells in a portion of a volume of matter of interest using one or more arrangements of electrodes configured to generate high electric fields powered by low voltages (L VHEF). In one embodiment, the present disclosure provides for exposure of cells to a low voltage high electric field such that at least a portion of the cells in a portion of the volume of interest are killed.
摘要翻译：本公开提供了使用低电压高电场（LVHEF）来影响细胞的装置，系统和方法。在一个实施方案中，本公开提供了使用低电压高电场来减少微生物污染。本公开的装置通常能够使用被配置为产生由低电压（L VHEF）供电的高电场的电极的一个或多个布置来影响感兴趣的体积体积的一部分中的细胞。在一个实施例中，本公开提供了将细胞暴露于低电压高电场，使得感兴趣体积的一部分中的至少一部分细胞被杀死。

18. 发明申请

WO2009050712A3 METHOD, SYSTEM AND COMPUTER PROGRAM PRODUCT FOR TISSUE CHARACTERIZATION 审中-公开
公开(公告)号：WO2009050712A3
公开(公告)日：2009-04-23
申请号：PCT/IL2008/001374
申请日：2008-10-22
申请人： RUBINSKY, Boris , SHINI, Mohanad , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERCITY OF JERUSALEM , LAUFER, Shlomi
发明人： RUBINSKY, Boris , SHINI, Mohanad , LAUFER, Shlomi
IPC分类号： A61B5/05
摘要： A method for characterizing a tissue, the method includes: inserting, in a sequential manner, a biopsy probe to the tissue at multiple locations of a tissue region of interest, while monitoring the insertion to provide location information; wherein the locations are determined in view of tissue information indicative of a tissue region of interest; performing electrical measurements at each of the multiple locations utilizing at least one biopsy probe electrode to provide electrical measurement information; taking a tissue biopsy at one or more locations of the multiple locations; and generating impedance information reflecting a spatial distribution of electrical impedance of the tissue in response to electrical measurement information and location information obtained from the multiple locations.

19. 发明申请

WO2007018947A2 ISOCHORIC METHOD AND DEVICE FOR REDUCING THE PROBABILITY OF ICE NUCLEATION DURING PRESERVATION OF BIOLOGICAL MATTER AT SUBZERO CENTIGRADE TEMPERATURES 审中-公开
标题翻译：用于降低生物物质在亚洲中心温度下保留冰核的可行性的多功能方法和装置
公开(公告)号：WO2007018947A2
公开(公告)日：2007-02-15
申请号：PCT/US2006/027179
申请日：2006-07-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , RUBINSKY, Boris , SZOBOTA, Stephanie
发明人： RUBINSKY, Boris , SZOBOTA, Stephanie
IPC分类号： A61L2/02 , A01N1/02
CPC分类号： A61L2/0011 , A01N1/02 , A01N1/0221
摘要： Because ice-I is less dense than water, the formation of an ice nucleus in an isochoric (constant volume) system containing water at pressures lower than about 200 MPa will cause an increase in pressure. This increase in pressure increases the energy required for reducing the probability for ice nucleation in an isochoric system containing water. In the present invention, a system for decreasing the probability of ice nucleation in a system containing water based on isochoric cooling and warming is provided. Reduction in the probability of ice nucleation has use in biological material preservation at low temperatures in: a supercooled state, by rapid freezing and through vitrification.
摘要翻译：因为冰I比水密度低，所以在低于约200MPa的压力下含有水的等离子体（恒定体积）体系中形成冰核将导致压力增加。这种压力增加增加了降低含有水的等离子体系中冰晶化的可能性所需的能量。在本发明中，提供了一种用于降低基于等离子体冷却和加热的含水体系中的冰成核概率的系统。冰成核概率的降低可用于低温生物材料的保存：过冷状态，通过快速冷冻和通过玻璃化。

20. 发明申请

WO2006135520A1 VOLUMETRIC INDUCTION PHASE SHIFT DETECTION SYSTEM FOR DETERMINING TISSUE WATER CONTENT PROPERTIES 审中-公开
标题翻译：用于确定组织水含量特性的体积感应相位移动检测系统
公开(公告)号：WO2006135520A1
公开(公告)日：2006-12-21
申请号：PCT/US2006/018384
申请日：2006-05-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , RUBINSKY, Boris , GONZALEZ, Cesar A.
发明人： RUBINSKY, Boris , GONZALEZ, Cesar A.
IPC分类号： G01N33/48 , G01N27/00
CPC分类号： A61B5/0537 , A61B5/02042 , A61B5/0205 , A61B5/05 , A61B5/053 , A61B5/4064 , A61B5/413 , A61B5/4244 , A61B5/443 , A61B5/4519 , A61B5/4869 , A61B5/4878 , A61B5/7225 , A61B5/7228 , A61B5/725 , A61B2562/143 , G01N27/026 , G01R33/34 , G01R33/36 , G01R33/4828 , G01R33/483
摘要： A method of determining the condition of a bulk tissue sample (S) by positioning a bulk tissue sample (S) between a pair of induction coils (or antennae) ( 12, 14), passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae) (12), measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae) (14), and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae) (12, 14), thereby determining the condition of the bulk tissue sample (S). An apparatus for determining the condition of a bulk tissue sample (S) having a first induction coil (or antenna) (12), a second induction coil (or antenna) (14), an alternating current power supply configured to generate a spectrum of currents (or voltage) in the first induction coil (or antenna) (12), and a measurement system connected to the second induction coil (or antenna) (14), wherein the measurement system is configured to measure a phase shift difference in the spectrum of currents (or voltages) between the first and second induction coils (or antennae) (12, 14) when the first and second induction coils (or antennae) (12, 14) are positioned on opposite sides of a tissue sample (S).
摘要翻译：一种通过将体组织样本（S）定位在一对感应线圈（或天线）（12,14）之间，通过交流电流（或电压）通过的频率的方式来确定体组织样本（S）的状态的方法感应线圈（或天线）（12）中的第一个测量在第二感应线圈（或天线）（14）中产生的交流（或电压）的频谱，并且比较交流电流的频谱（或天线）（12,14）中的（或电压），从而确定体组织样本（S）的状况。一种用于确定具有第一感应线圈（或天线）（12），第二感应线圈（或天线）（14））的体组织样本（S）的状况的装置，被配置为产生第一感应线圈（或天线）（12）中的电流（或电压）以及连接到第二感应线圈（或天线））的测量系统，其中测量系统被配置为测量第当第一和第二感应线圈（或天线）（12,14）位于组织样本的相对侧上时，第一和第二感应线圈（或天线）（12,14）之间的电流（或电压）频谱（S ）。

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