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11. 发明申请

WO2011031432A3 LAYERED SINTERED MICROFLUIDIC DEVICES WITH CONTROLLED COMPRESSION DURING SINTERING AND ASSOCIATED METHODS 审中-公开
标题翻译：在烧结期间控制压缩的分层烧结微流体器件及相关方法
公开(公告)号：WO2011031432A3
公开(公告)日：2011-03-17
申请号：PCT/US2010/046273
申请日：2010-08-23
申请人： CORNING INCORPORATED , BRUNEAUX, Jean-Francois , FRISKE, Mark S , LEREBOULLET, Jean-Pierre H , LOBET, Olivier , NEDELEC, Yann P
发明人： BRUNEAUX, Jean-Francois , FRISKE, Mark S , LEREBOULLET, Jean-Pierre H , LOBET, Olivier , NEDELEC, Yann P
IPC分类号： B81C3/00 , B81C1/00 , B01J19/00 , C03B23/203
摘要： Embodiments are directed a method for reducing and/or controlling compression of stacked layers in a micro fluidic device, wherein the method comprises stacking at least two layers wherein at least one of the stacked layers comprises a microstructure. The microstructure comprises a fluid passage, a plurality of walls configured to define a spacing A1 between layers and a plurality of uniformly spaced pneumatic struts wherein the pneumatic struts define sealed containers comprising entrapped gas. The method further comprises the step of sintering the stacked layers wherein the sintering pressurizes the entrapped gas inside the pneumatic struts to oppose compression of the walls and compression of the spacing A1 between stacked layers.
摘要翻译：实施方式涉及一种用于减小和/或控制微流体装置中的堆叠层的压缩的方法，其中该方法包括堆叠至少两个层，其中至少一个堆叠层包括微结构。微结构包括流体通道，构造成在层之间限定间隔A1的多个壁以及多个均匀隔开的气动支柱，其中气动支柱限定包括截留气体的密封容器。该方法进一步包括烧结堆叠层的步骤，其中烧结加压气动支柱内的截留气体以抵抗壁的压缩和堆叠层之间的间隔A1的压缩。

12. 发明申请

WO2011136915A1 FLUID CONNECTORS FOR MICROREACTOR MODULES 审中-公开
标题翻译：流体连接器用于微型模块
公开(公告)号：WO2011136915A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/032001
申请日：2011-04-12
申请人： CORNING INCORPORATED , BRUNELLO, Pierre , DELAUTRE, Paul , GREMETZ, Sylvain, Maxime, F. , LOBET, Olivier
发明人： BRUNELLO, Pierre , DELAUTRE, Paul , GREMETZ, Sylvain, Maxime, F. , LOBET, Olivier
IPC分类号： B01J19/00 , B01L3/00 , F16L19/02
CPC分类号： B01J19/0093 , B01J2219/0081 , B01L3/502715 , B01L3/563 , B01L3/569 , B01L2200/027
摘要： An end-face sealing fluidic connector [20] for fluidic connection and/or interconnection of glass, glass-ceramic and/or ceramic fluidic modules [12] in a microreactor [10] and includes a connector body [22] having a circular first end face [26]with a recess [28] for retaining one or more O-rings [30]. The connector body [22] has a first end section [32] having a circular cylindrical outer surface [34] having a diameter [36] in the range of from 3 to 25 mm extending along the connector body [22] from the first end face [26]. The outer surface [34] of the first end section [32] is having a circumferential recess [38] dividing the first end section [32] into a proximal portion [40] adjacent the first end face [26] and a distal portion [42] separated from the proximal portion [40] by the circumferential recess [38]. A retaining ring [48] is seated in the circumferential recess and a circular cylindrical circumferential reinforcing and/or protecting ring [50] surrounds the proximal portion [40] of the first end section [32], the ring [50] being comprised of a high-compression-strength polymer. A circular cylindrical sleeve [58] surrounds the first end section [32] and the reinforcing and/or protecting ring [50], the sleeve [58] including a circumferentially extending inside bearing surface for engaging the retaining ring [48] on the distal side thereof. The circular cylindrical sleeve [58] further comprises an external thread [66] on a proximal outer surface [68] thereof and a gripping surface [70] on a distal outer surface [72] thereof.
摘要翻译：用于在微反应器[10]中的玻璃，玻璃 - 陶瓷和/或陶瓷流体模块[12]的流体连接和/或互连的端面密封流体连接器[20]，并且包括连接器本体[22] 端面[26]具有用于保持一个或多个O形环[30]的凹部[28]。连接器主体[22]具有第一端部部分32，其具有从第一端部沿着连接器主体[22]延伸的直径[36]在3至25mm范围内的圆柱形外表面[34] 脸[26]。第一端部部分[32]的外表面[34]具有将第一端部部分[32]分成邻近第一端面[26]的近端部分[40]的周向凹部[38] 42]通过周向凹部[38]与近侧部分[40]分离。保持环[48]位于周向凹槽中，并且环形圆周周向增强和/或保护环围绕第一端部[32]的近端部分[40]，环[50]包括高压缩强度聚合物。环形圆柱形套筒围绕第一端部部分[32]和加强和/或保护环[50]，套筒（58）包括周向延伸的内部支承表面，用于将保持环[48]接合在远端侧。圆柱形套筒[58]还包括在其近端外表面[68]上的外螺纹[66]和位于其远侧外表面[72]上的抓握表面[70]。

13. 发明申请

WO2007131925A1 MODULAR MOUNTING AND CONNECTION OR INTERCONNECTION SYSTEM FOR MICROFLUIDIC DEVICES 审中-公开
标题翻译：用于微流量器件的模块化安装和连接或互连系统
公开(公告)号：WO2007131925A1
公开(公告)日：2007-11-22
申请号：PCT/EP2007/054498
申请日：2007-05-09
申请人： CORNING INCORPORATED , DELAUTRE, Paul , LOBET, Olivier
发明人： DELAUTRE, Paul , LOBET, Olivier
IPC分类号： B01L9/00
CPC分类号： B01L9/527 , B01J2219/0081 , B01J2219/0813 , B01L3/565 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2300/0816 , F16B2/06 , Y10T137/7504 , Y10T137/87153 , Y10T137/87249 , Y10T403/18
摘要： A modular mounting and connection or interconnection system for microfluidic devices (20) includes a plurality of end-butting compression-sealing fluid connectors or adapters (32), and one or more clamping structures (54, 56) each structured to hold one of the fluid connectors (32) in compression against a planar surface of a microfluidic device (20), and to press against the device, on another directly opposing planar surface thereof, either a contact pad (48) or another of the fluid connectors (32), with each clamping structure (54,56) including an individually moveable compression-providing element such as a compression screw (36) structured to provide a controlled amount of compression. The system desirably further includes one or more device frames (58) each structured so as to receive and hold a microfluidic device (20) with one or more of the clamping structures (54, 56) attached, the device frame (58) being structured to retain the device (20) and attached clamping structures (54, 56) by constraining only one or two of the clamping structures (54,56) in a manner such that no torsion or bending is applied to the device (20), and one or more system frames (70) structured so as to receive and hold a plurality of device frames (58) in proximity to each other in a three-dimensional array, such that volumes of desired fluid interconnections between devices (20) can be minimized.
摘要翻译：用于微流体装置（20）的模块化安装和连接或互连系统包括多个端对接压缩密封流体连接器或适配器（32），以及一个或多个夹紧结构（54,56），每个夹紧结构被构造成保持流体连接器（32），其抵抗微流体装置（20）的平坦表面压缩，并且在另一个直接相对的平面表面上压靠在所述装置上的接触垫（48）或另一个流体连接器（32），，每个夹紧结构（54,56）包括单独可移动的压缩提供元件，例如被构造成提供受控量的压缩的压缩螺钉（36）。系统期望地还包括一个或多个装置框架（58），每个装置框架（58）被构造成接收和保持具有附接的一个或多个夹紧结构（54,56）的微流体装置（20），所述装置框架（58）被构造通过以不使扭转或弯曲施加到装置（20）的方式仅约束一个或两个夹紧结构（54,56）来保持装置（20）和附接的夹紧结构（54,56），以及一个或多个系统框架（70）被构造成以三维阵列接收和保持彼此靠近的多个设备框架（58），使得可以最小化设备（20）之间的所需流体互连体积。

14. 发明申请

WO2018165006A1 FLOW REACTOR FOR PHOTOCHEMICAL REACTIONS 审中-公开
公开(公告)号：WO2018165006A1
公开(公告)日：2018-09-13
申请号：PCT/US2018/020882
申请日：2018-03-05
申请人： CORNING INCORPORATED , LOBET, Olivier , HORN, Clemens Rudolf
发明人： LOBET, Olivier , HORN, Clemens Rudolf
IPC分类号： B01J19/00 , B01J19/12
CPC分类号： B01J19/0093 , B01J19/123 , B01J19/127 , B01J2219/00783 , B01J2219/00936 , B01J2219/00943 , B01J2219/1203 , B01J2219/2458
摘要： A flow reactor has a fluidic module with a first major outer surface. The module contains a fluid passage and has a transmittance through the first major outer surface to the fluid passage of at least 20% over a range of wavelengths. The reactor has an illumination module comprising one or more radiation sources, which can emit within the range, positioned within an enclosure. The enclosure has a back wall and a side wall and an opening opposite the back wall. An edge of the side wall surrounds the opening. The illumination module is positioned such that the opening of the illumination module faces the first major outer surface of the fluidic module. The side wall comprises a telescoping portion such that a distance from the back wall of the enclosure to the edge of the side wall is adjustable.

15. 发明申请

WO2013082347A1 FLUIDIC MODULE PERMANENT STACK ASSEMBLIES AND METHODS 审中-公开
标题翻译：流体模块永久堆叠组装和方法
公开(公告)号：WO2013082347A1
公开(公告)日：2013-06-06
申请号：PCT/US2012/067177
申请日：2012-11-30
申请人： CORNING INCORPORATED , DANNOUX, Thierry Luc Alain , GREMETZ, Sylvain Maxime F , LOBET, Olivier , TANGUY, Ronan
发明人： DANNOUX, Thierry Luc Alain , GREMETZ, Sylvain Maxime F , LOBET, Olivier , TANGUY, Ronan
IPC分类号： B01J19/00 , C03B23/24
CPC分类号： B01J19/32 , B01J19/0093 , B01J2219/00786 , B01J2219/00806 , B01J2219/00808 , B01J2219/00824 , B01J2219/00831 , B01J2219/32213 , B01J2219/32275 , B01J2219/32425 , B01J2219/32441 , B01J2219/328 , B23P19/10 , B81B2201/058 , B81C3/001 , B81C2201/019 , C03B23/245 , C03C3/091 , C03C27/00 , Y10T29/49904
摘要： The present disclosure provides an assembled stack of fluidic modules comprising at least first and second fluidic modules assembled in a stacked configuration. The first fluidic module has first and second major planar surfaces and encloses a first fluidic passage extending therethrough from a first passage entrance to a first passage exit with the first passage exit located on the second major planar surface of the first fluidic module. The second fluidic module also has first and second major planar surfaces and encloses a second fluidic passage extending therethrough from a second passage entrance to a second passage exit, with the second passage entrance located on the first major planar surface of the second fluidic module. The second major planar surface of the first fluidic module and the first major planar surface of the second fluidic module are spaced apart and physically joined together by at least three separate glass or glass-ceramic pads fused therebetween, and the at least three pads include at least one pad having no through-hole and at least one pad having a through-hole, with the through-hole forming a sealed fluidic interconnection between the first fluidic passage and the second fluidic passage. A method of forming the assembled stack is also disclosed.
摘要翻译：本公开提供了一组流体模块，其包括以堆叠结构组装的至少第一和第二流体模块。第一流体模块具有第一和第二主平面表面，并且包围第一流体通道，其从第一通道入口延伸到第一通道出口，第一通道出口位于第一流体模块的第二主平面上。第二流体模块还具有第一和第二主平面表面，并且包围从第二通道入口延伸穿过第二通道出口的第二流体通道，第二通道入口位于第二流体模块的第一主平面上。第一流体模块的第二主平面表面和第二流体模块的第一主平面表面间隔开并通过至少三个分开的玻璃或玻璃 - 陶瓷垫在其间融合并物理地连接在一起，并且至少三个垫包括在至少一个不具有通孔的垫和至少一个具有通孔的垫，所述通孔在所述第一流体通道和所述第二流体通道之间形成密封的流体互连。还公开了形成组装的堆叠的方法。

16. 发明申请

WO2009070288A1 FLUID PORTING ASSEMBLY AND MICROREACTOR INCORPORATING THE SAME 审中-公开
标题翻译：流体成型装置和与其同时进行的微型反应器
公开(公告)号：WO2009070288A1
公开(公告)日：2009-06-04
申请号：PCT/US2008/013119
申请日：2008-11-25
申请人： CORNING INCORPORATED , LOBET, Olivier
发明人： LOBET, Olivier
IPC分类号： B01J19/00
CPC分类号： B01L3/565 , B01J19/0093 , B01J2219/0081 , B01J2219/00891 , B01L3/502707 , B01L2300/1894
摘要： A fluid porting assembly for a microreactor comprising a process fluid passageway, a pliable seal, and a cooling fluid passageway is provided. The pliable seal is positioned in the vicinity of the process fluid outlet and is configured to define a sealing interface between the process fluid outlet and a fluid port of a microreactor. The cooling fluid passageway terminates at a cooling fluid interface and defines a dispensing gap between the cooling fluid interface and the sealing interface. The cooling fluid outlet is configured to distribute cooling fluid about a periphery of the pliable seal and to direct cooling fluid away from the periphery of the pliable seal through the dispensing gap when the pliable seal of the fluid porting assembly engages a fluid port of a microreactor. The cooling fluid removes heat from areas of the microreactor in the vicinity of the fluid port and pliable seal.
摘要翻译：提供了一种用于微反应器的流体移植组件，其包括过程流体通道，柔性密封件和冷却流体通道。柔性密封件位于过程流体出口附近，并且构造成限定过程流体出口和微反应器的流体端口之间的密封界面。冷却流体通道终止于冷却流体界面并且限定冷却流体界面和密封界面之间的分配间隙。冷却流体出口构造成在柔性密封件的周边分布冷却流体，并且当流体移动组件的柔性密封件接合微反应器的流体端口时，将冷却流体引导通过分配间隙远离柔性密封件的周边。冷却流体从流体端口附近的微反应器区域和柔性密封件移除热量。

17. 发明申请

WO2008085429A2 MICROFLUIDIC STRUCTURES WITH INTEGRATED DEVICES 审中-公开
标题翻译：具有集成设备的微流体结构
公开(公告)号：WO2008085429A2
公开(公告)日：2008-07-17
申请号：PCT/US2007/026227
申请日：2007-12-21
申请人： CORNING INCORPORATED , LOBET, Olivier , MARQUES, Gaspar P. , TANGUY, Ronan
发明人： LOBET, Olivier , MARQUES, Gaspar P. , TANGUY, Ronan
IPC分类号： B81C1/00
CPC分类号： B81B1/00 , B01F5/14 , B01F13/0059 , B01F13/0818 , B01F13/0827 , B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00831 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01L3/5027 , B01L7/00 , B81B2201/058 , F04C2/18 , Y10T29/49826 , Y10T137/6606 , Y10T137/8593
摘要： A microfluidic device having a glass, glass-ceramic, or ceramic structure, said structure including one or more passages defined therein with at least one first passage accessible through at least one first port wherein the first passage contains at least one solid object disposed therein said solid object including a material having a coefficient of thermal expansion differeing from the glass, glass-ceramic, or ceramic of said structure, said solid object resting in said first passage substantially without compressive stress from an inside surface of said passage at room temperature.
摘要翻译：一种具有玻璃，玻璃陶瓷或陶瓷结构的微流体装置，所述结构包括限定在其中的一个或多个通道，其中至少一个第一通道可通过至少一个第一端口接近，其中第一通道包含设置在其中的至少一个固体物体，包括具有与所述结构的玻璃，玻璃陶瓷或陶瓷不同的热膨胀系数的材料的固体物体，所述固体物体在室温下基本上没有来自所述通道的内表面的压缩应力而停留在所述第一通道中。

18. 发明申请

WO2011044350A2 INTERCONNECTION OF MICROFLUIDIC DEVICES 审中-公开
标题翻译：微流体装置互连
公开(公告)号：WO2011044350A2
公开(公告)日：2011-04-14
申请号：PCT/US2010/051806
申请日：2010-10-07
申请人： CORNING INCORPORATED , BRUNELLO, Pierre , CUTLER, Willard A , DELAUTRE, Paul , GREMETZ, Sylvan M , LAZER, Ionel , LOBET, Olivier
发明人： BRUNELLO, Pierre , CUTLER, Willard A , DELAUTRE, Paul , GREMETZ, Sylvan M , LAZER, Ionel , LOBET, Olivier
IPC分类号： B01J19/00 , B81B1/00 , B01F5/06
CPC分类号： B01J19/0093 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F15/065 , B01J2219/00783 , B01J2219/00804 , B01J2219/0081 , B01J2219/00822 , B01J2219/00831 , B01J2219/00873 , B01J2219/00889 , B01L3/502715 , B01L3/563 , B01L3/569 , B01L2200/027 , B01L2200/028 , B01L2300/185 , F28D9/0043 , F28F3/083 , F28F9/26 , F28F2260/02 , Y10T137/8593
摘要： A microfluidic device (10) includes at least two glass, ceramic or glass ceramic microfluidic modules (20) fluidicaly interconnected and of substantially plate shape defining generally four relatively thin edges (20a, 20b, 20c, 20d) and two opposite relatively large faces (22, 24), each microfluidic module (20) including at least one microfluidic channel (30) defining at least in part a microchamber (32); at least one fluidic inlet (50) and at least one fluidic outlet (60); and said microfluidic modules being tightly interconnected with a fluid duct (120) through at least one tightly holding connector (90) comprising at least one clamping structure or means (95, 97), and is characterized in that the at least one clamping means (95, 97) comprises a joint (150) comprising a spherical shaped member (160) and a cup shaped member (170).
摘要翻译：微流体装置（10）包括至少两个流体相互连接并且基本上为板状的玻璃，陶瓷或玻璃陶瓷微流体模块（20），其大体上限定了四个相对较薄的边缘（20a，20b，20c，20d）和两个相对较大的面每个微流体模块（20）包括至少部分地限定微室（32）的至少一个微流体通道（30）; 至少一个流体入口（50）和至少一个流体出口（60）; 并且所述微流体模块通过包括至少一个夹持结构或装置（95,97）的至少一个紧密保持连接器（90）与流体管道（120）紧密互连，并且其特征在于，所述至少一个夹紧装置 95，97）包括包括球形构件（160）和杯形构件（170）的接头（150）。

19. 发明申请

WO2009099536A2 MICROREACTOR ASSEMBLY INCORPORATING INTERCONNECT BACKBONE AND DIVERSE FLUIDIC MICROSTRUCTURES 审中-公开
标题翻译：连接互连逆流和微流体微结构的微电脑组件
公开(公告)号：WO2009099536A2
公开(公告)日：2009-08-13
申请号：PCT/US2009/000534
申请日：2009-01-27
申请人： CORNING INCORPORATED , LEREBOULLET, Jean-Pierre H , LOBET, Olivier , NEDELEC, Yann P , TANGUY, Ronan
发明人： LEREBOULLET, Jean-Pierre H , LOBET, Olivier , NEDELEC, Yann P , TANGUY, Ronan
IPC分类号： B01J19/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01J2219/00824 , B01J2219/00831 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01L3/502715 , B01L3/565
摘要： A microreactor assembly [100] is provided comprising a fluidic interconnect backbone [10] and plurality of fluidic microstructures. Interconnect input/output ports [12] of the fluidic interconnect backbone [10] are interfaced with microchannel input/output ports [14] of the fluidic microstructures at a plurality of non-polymeric interconnect seals [50]. Interconnect microchannels [15] are defined entirely by the fluidic interconnect backbone [10] and extend between the non-polymeric interconnect seals [50] without interruption by additional sealed interfaces. At least one of the fluidic microstructures [20, 30, 40] may comprise a mixing microstructure formed by a molding process. Another of the fluidic microstructures [20, 30, 40] may comprise an extruded reactor body. Still another fluidic microstructure [20, 30, 40] may comprise a quench-flow or hydrolysis microreactor formed by a hot-pressing method.
摘要翻译：提供了微反应器组件[100]，其包括流体互连骨架[10]和多个流体微结构。流体互连骨架[10]的互连输入/输出端口[12]在多个非聚合物互连密封件[50]处与流体显微组织的微通道输入/输出端口[14]接口连接。互连微通道[15]完全由流体互连骨架[10]限定，并在非聚合物互连密封件[50]之间延伸，而不会被额外的密封接口中断。至少一个流体微结构[20,30,40]可以包括通过模塑工艺形成的混合微结构。另一种流体微结构[20,30,40]可以包括挤出的反应器主体。另一种流体微结构[20,30,40]可以包括通过热压法形成的骤冷或水解微反应器。

20. 发明申请

WO2016154384A1 METHODS FOR PERFORMING FLOW REACTIONS UTILIZING HIGH TEMPERATURE HYDROFLUORIC ACID 审中-公开
标题翻译：利用高温氢氟酸进行流动反应的方法
公开(公告)号：WO2016154384A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/023911
申请日：2016-03-24
申请人： CORNING INCORPORATED
发明人： LAYOUNI, Khaled , LOBET, Olivier
IPC分类号： B01J19/00
CPC分类号： B01J19/0093 , B01J19/0013 , B01J19/0073 , B01J19/02 , B01J2219/00051 , B01J2219/00761 , B01J2219/00783 , B01J2219/00813 , B01J2219/00824 , B01J2219/00833 , B01J2219/0086 , B01J2219/00867 , C07C13/00
摘要： A method of performing a reaction is disclosed comprising flowing a reaction mixture (50) comprising HF past a compression seal (40) within a flow reactor (20), wherein the compression seal (40) includes an O-ring or gasket (30, 32) and where the O-ring or gasket (30, 32) comprises fluoroelastomer (to include fluoroelastomers and perfluoroelastomers), while maintaining the reaction mixture comprising HF at a temperature of 50° C or greater [generally at a temperature in the range of from 50° C and greater (60, 70, 80, 90, 100, 120, 150, and 180° C) up to 220° C], using O-rings or gaskets (30, 32) that comprise a fluoroelastomer having a pre-use tensile strength in the range of from 0.1 to 14 MPa measured according to IS037, and desirably further having a compressive set in the range of from 0 to 12% measured according to IS0815.
摘要翻译：公开了一种进行反应的方法，包括将流过反应器（20）内的经过压缩密封件（40）的HF的反应混合物（50）流动，其中压缩密封件（40）包括O形环或垫圈（30， 32），并且其中O形环或垫圈（30,32）包含含氟弹性体（包括含氟弹性体和全氟弹性体），同时保持包含HF的反应混合物在50℃或更高的温度下[通常在使用O形环或垫圈（30,32）从50℃和更高（60,70,80,90,100,120,150和180℃）至高达220℃]，其包含含氟弹性体，其具有根据IS037测量的预先使用拉伸强度在0.1至14MPa的范围内，并且期望地进一步具有根据IS0815测量的0至12％范围内的压缩永久变形。

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