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    • 12. 发明申请
    • BIOMARKERS FOR GOSSYPOL CHEMOTHERAPY AND METHODS OF TREATING DISEASE
    • 生物标记物治疗疾病和治疗疾病的方法
    • WO2011017145A2
    • 2011-02-10
    • PCT/US2010/043477
    • 2010-07-28
    • THE REGENTS OF THE UNIVERSITY OF MICHIGANWANG, ShaomengJIANG, FengLONG, JiantingBAI, Longchuan
    • WANG, ShaomengJIANG, FengLONG, JiantingBAI, Longchuan
    • C12Q1/68G01N33/68G01N33/574G01N33/15
    • G01N33/57434C12Q1/6886C12Q2600/106C12Q2600/158G01N2800/52
    • The present invention provides a biomarker for selecting a patient for treatment with gossypol, wherein the biomarker comprises an elevated expression level of c-Myc, Mcl-1, or combination thereof, relative to the normal expression level of c-Myc, Mcl-1, or combination thereof. The present invention also provides methods for targeting patients for treatment with gossypol, wherein the patient has a disease, condition, or disorder that overexpresses c-Myc, Mcl-1, or combination thereof. The present invention also provides methods for treating or ameliorating a disease, condition, or disorder in a patient comprising determining the expression level of c-Myc, Mcl-1, or combination thereof in the patient and administering gossypol to the patient. In certain embodiments of the invention, the disease is cancer, and the cancer cells show elevated expression levels of c-Myc compared to non-cancerous cells. The invention also provides methods for overcoming Mcl-1-mediated chemoresistance comprising administering gossypol to a patient in need thereof.
    • 本发明提供了一种用于选择用棉酚处理的患者的生物标志物,其中相对于c-Myc,Mcl-1的正常表达水平,生物标志物包括c-Myc,Mcl-1或其组合的升高的表达水平 ,或其组合。 本发明还提供了靶向患者用棉酚治疗的方法,其中患者具有过表达c-Myc,Mcl-1或其组合的疾病,病症或病症。 本发明还提供了用于治疗或改善患者疾病,病症或障碍的方法,包括确定患者中c-Myc,Mcl-1或其组合的表达水平,并向患者施用棉酚。 在本发明的某些实施方案中,该疾病是癌症,与非癌细胞相比,癌细胞表现出c-Myc的升高的表达水平。 本发明还提供克服Mcl-1介导的化学耐药性的方法,包括向有需要的患者施用棉酚。
    • 15. 发明申请
    • ADAPTIVE SCHEDULER FOR COMMUNICATION SYSTEMS APPARATUS, SYSTEM AND METHOD
    • 用于通信系统的自适应调度装置,系统和方法
    • WO2009141008A1
    • 2009-11-26
    • PCT/EP2008/056304
    • 2008-05-22
    • NOKIA SIEMENS NETWORKS OYJIANG, Feng
    • JIANG, Feng
    • H04L12/56
    • H04L47/10H04L45/60H04L47/20H04L47/2408H04L47/2441H04L47/34
    • An apparatus, system, and method may include adaptively scheduling packet processing modules by ordering the packet processing modules based on at least one of traffic composition and computational complexity of the packet processing modules. The apparatus, system and method may analyze at least one of traffic composition information derived from at least one packet data stream and computational complexity information pertaining to packet processing modules, determine an ordering of the packet processing modules based on the analyzing, wherein packets are passed through the packet processing modules until the packet meets criteria associated with a packet processing module or the packet has been passed through all of the packet processing modules, and dynamically rearrange the packet processing modules into the determined ordering.
    • 装置,系统和方法可以包括通过基于分组处理模块的业务组合和计算复杂度中的至少一个来排序分组处理模块来自适应地调度分组处理模块。 装置,系统和方法可以分析从至少一个分组数据流导出的业务组合信息和与分组处理模块有关的计算复杂性信息中的至少一个,基于分析确定分组处理模块的排序,其中分组被传递 通过分组处理模块,直到分组满足与分组处理模块相关联的标准或分组已经通过所有分组处理模块,并且将分组处理模块动态地重新排列成确定的顺序。