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11. 发明申请

WO2020018935A2 DE NOVO DESIGN OF PROTEIN SWITCHES 审中-公开
公开(公告)号：WO2020018935A2
公开(公告)日：2020-01-23
申请号：PCT/US2019/042651
申请日：2019-07-19
申请人： UNIVERSITY OF WASHINGTON , LANGAN, Robert A. , BOYKEN, Scott , BAKER, David , NOVAK, Walter , LAJOIE, Marc Joseph , QUIJANO RUBIO, Alfredo
发明人： LANGAN, Robert A. , BOYKEN, Scott , BAKER, David , NOVAK, Walter , LAJOIE, Marc Joseph , QUIJANO RUBIO, Alfredo
IPC分类号： A61K38/00 , C07K14/00
摘要： Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive ("off"') state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates ("on") the bioactive peptide or binding domain, components of such protein switches, and their use.

12. 发明申请

WO2020018445A1 FRIZZLED SPECIFIC WNT AGONISTS AND ANTAGONISTS 审中-公开
公开(公告)号：WO2020018445A1
公开(公告)日：2020-01-23
申请号：PCT/US2019/041852
申请日：2019-07-15
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , UNIVERSITY OF WASHINGTON , GARCIA, Kenan Christopher , MIAO, Yi , BAKER, David , PARK, Keunwan , DANG, Luke
发明人： GARCIA, Kenan Christopher , MIAO, Yi , BAKER, David , PARK, Keunwan , DANG, Luke
IPC分类号： A61K38/17 , C07K14/435 , C07K14/47 , C07K16/28
摘要： Wnt signaling antagonist and agonist compositions and methods for their use are provided.

13. 发明申请

WO2018145071A1 ABUSE DETERRENT FORMULATIONS OF AMPHETAMINE 审中-公开
公开(公告)号：WO2018145071A1
公开(公告)日：2018-08-09
申请号：PCT/US2018/017019
申请日：2018-02-06
申请人： ARCTURUS THERAPEUTICS LTD , BAKER, David
发明人： BAKER, David , DANIELY, Yaron , RON, Hanna , SINER, David
IPC分类号： A61K9/00 , A61K9/48 , A61K31/137 , A61K47/10 , A61K47/36
摘要： The present invention relates generally to abuse-deterrent formulations containing dextroamphetamine sulfate.

14. 发明申请

WO2013148583A1 BINDING PROTEINS TO THE CONSTANT REGION OF IMMUNOGLOBULIN G 审中-公开
标题翻译：结合蛋白质到免疫球蛋白G的恒定区域
公开(公告)号：WO2013148583A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/033721
申请日：2013-03-25
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION , BAKER, David , STRAUCH, Eva-maria , FLEISHMAN, Sarel, Jacob
发明人： BAKER, David , STRAUCH, Eva-maria , FLEISHMAN, Sarel, Jacob
IPC分类号： C07K1/22 , C07K14/00
CPC分类号： C07K16/00 , A61K38/50 , C07K1/22 , C07K14/001 , C12N9/80 , C12Y305/01019 , G01N33/6854
摘要： The present invention provides polypeptides that bind to immunoglobulin G and methods for their use.
摘要翻译：本发明提供了结合免疫球蛋白G的多肽及其使用方法。

15. 发明申请

WO2013030536A1 CURABLE MONOMERS 审中-公开
标题翻译：可固化单体
公开(公告)号：WO2013030536A1
公开(公告)日：2013-03-07
申请号：PCT/GB2012/052041
申请日：2012-08-21
申请人： BAE SYSTEMS PLC , BAKER, David , REZAI, Amir
发明人： BAKER, David , REZAI, Amir
IPC分类号： C08J3/12 , C08J3/24 , C08J5/04 , B29B15/00 , B29C70/00 , B32B5/24
CPC分类号： C08J3/20 , B29C70/025 , B29C70/465 , B29K2105/124 , B32B5/24 , B32B5/26 , B32B2255/02 , B32B2255/24 , C08J3/12 , C08J3/24 , C08J5/04 , C08J2363/00 , C08J2367/06 , C08J2375/04 , C08J2379/08 , C08K3/04 , C08K3/041 , C08K3/042 , C08K7/24 , C08K2201/011 , C08K2201/016
摘要： The invention relates to methods and novel a powdered curable monomer which may be used to manufacture bulk polymers, adhesives and coatings composite materials with high percentage weight inclusions of particulate filler materials, more specifically to fibre reinforced polymer composite materials with high percentage weight inclusions of particulate filler materials. The preferred particulate filler materials are carbon nanotubes. The method according to the invention allows greater than 0.5wt% of carbon nanotubes, typically greater 10%wt of carbon nanotubes or other high aspect ratio fillers to be readily incorporated in the resin matrix, before being applied to the fibre reinforcing plys.
摘要翻译：本发明涉及可用于制造散装聚合物，粘合剂和涂层复合材料的方法和新型粉末状可固化单体，其具有高百分比重量的颗粒填料材料夹杂物，更具体地说涉及具有高百分比重量的颗粒物夹杂物的纤维增强聚合物复合材料填充材料。优选的颗粒填料是碳纳米管。根据本发明的方法，在施加到纤维增强层之前，允许大于0.5重量％的碳纳米管，通常较大的10重量％的碳纳米管或其它高纵横比的填料容易地结合到树脂基质中。

16. 发明申请

WO2013023151A2 COMPOSITIONS AND METHODS FOR TREATING CELIAC SPRUE DISEASE 审中-公开
标题翻译：用于治疗CELIAC SPRUE疾病的组合物和方法
公开(公告)号：WO2013023151A2
公开(公告)日：2013-02-14
申请号：PCT/US2012/050364
申请日：2012-08-10
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION , SIEGEL, Justin , BAKER, David , GORDON, Sydney, Rin Anna , PULTZ, Ingrid, Swanson , STANLEY, Elizabeth, Joy , WOLF, Sarah, Jane
发明人： SIEGEL, Justin , BAKER, David , GORDON, Sydney, Rin Anna , PULTZ, Ingrid, Swanson , STANLEY, Elizabeth, Joy , WOLF, Sarah, Jane
IPC分类号： C12N15/09
CPC分类号： A61K38/482 , A61K38/48 , C12N9/50 , C12N9/52 , C12Y304/21
摘要： The invention provides compositions and methods for treating celiac sprue.
摘要翻译：本发明提供了治疗乳糜泻的组合物和方法。

17. 发明申请

WO2012167263A1 SOLAR MODULAR FRAME AND WIRING SYSTEM AND METHOD 审中-公开
标题翻译：太阳能模块化框架和接线系统及方法
公开(公告)号：WO2012167263A1
公开(公告)日：2012-12-06
申请号：PCT/US2012/040762
申请日：2012-06-04
申请人： ANDALAY SOLAR, INC. , CINNAMON, Barry , BAKER, David , LEONG, Wilson, W. , AU, Alexander, W.
发明人： CINNAMON, Barry , BAKER, David , LEONG, Wilson, W. , AU, Alexander, W.
IPC分类号： E04D13/00
CPC分类号： H01L31/05 , F24S25/20 , F24S25/65 , H01L31/02013 , H02S30/10 , Y02E10/47 , Y02E10/50
摘要： A solar module frame and wiring system and method are described.
摘要翻译：描述了太阳能模块框架和布线系统和方法。

18. 发明申请

WO2012037413A3 SYSTEMS AND METHODS FOR BIOTRANSFORMATION OF CARBON DIOXIDE INTO HIGHER CARBON COMPOUNDS 审中-公开
公开(公告)号：WO2012037413A3
公开(公告)日：2012-03-22
申请号：PCT/US2011/051847
申请日：2011-09-15
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION , SIEGEL, Justin , BAKER, David , SMITH, Amanda, Lee , LIDSTROM, Mary, E. , LOUW, Catherine
发明人： SIEGEL, Justin , BAKER, David , SMITH, Amanda, Lee , LIDSTROM, Mary, E. , LOUW, Catherine
IPC分类号： C12P7/28 , C12P7/24 , C12N15/60 , C12N15/53
摘要： Systems, compounds and methods for the conversion of C1 carbon compounds to higher carbon compounds useful for the generation of commodity compounds.

19. 发明申请

WO2011061469A1 INDAZOLE DERIVATIVES AND THEIR USE FOR BLOCKADING VOLTAGE DEPENDENT SODIUM CHANNELS 审中-公开
标题翻译：吲哚衍生物及其用于阻断电压依赖性钠通道的用途
公开(公告)号：WO2011061469A1
公开(公告)日：2011-05-26
申请号：PCT/GB2010/001842
申请日：2010-09-30
申请人： UNIVERSITY COLLEGE LONDON , POSADA, Cristina, Garcia , SELWOOD, David , GARTHWAITE, John , BAKER, David , CLUTTERBUCK, Lisa
发明人： POSADA, Cristina, Garcia , SELWOOD, David , GARTHWAITE, John , BAKER, David , CLUTTERBUCK, Lisa
IPC分类号： C07D413/14 , C07D417/14 , A61K31/4245 , A61P25/00 , A61P23/00
CPC分类号： C07D413/14 , C07D417/14
摘要： The invention provides an indazole derivative of formula (1), or a pharmaceutically acceptable salt or N-oxide thereof, wherein R 1 , R 2 , R 3 and R 4 are as defined herein. The indazole derivatives are capable of blockading voltage dependent sodium channels and they are useful in the treatment or prevention of normal tension glaucoma, multiple sclerosis, a motorneurone disease, stroke, spinal cord injury, Alzheimer's disease, Parkinson's disease or pain.
摘要翻译：本发明提供式（1）的吲唑衍生物或其药学上可接受的盐或N-氧化物，其中R 1，R 2，R 3和R 4如本文所定义。吲唑衍生物能够阻断电压依赖性钠通道，并且它们可用于治疗或预防正常张力性青光眼，多发性硬化，运动神经元疾病，中风，脊髓损伤，阿尔茨海默病，帕金森病或疼痛。

20. 发明申请

WO2011044262A2 THERMAL TRANSFORMER 审中-公开
标题翻译：热变压器
公开(公告)号：WO2011044262A2
公开(公告)日：2011-04-14
申请号：PCT/US2010/051667
申请日：2010-10-06
申请人： BAKER, David , LANE, Fred
发明人： BAKER, David , LANE, Fred
IPC分类号： F25B27/00 , F25B27/02 , F25B30/02 , F25B49/02
CPC分类号： F25B29/003 , F25B27/002 , F25B2700/21171 , Y02A30/272 , Y02B10/20 , Y02B10/24
摘要： A system for providing a thermal transformer to provide heating and cooling to enclosed structures, most generally a building using solar power combined with geothermal storage and a heat powered heat pump to raise or lower the temperature of the stored energy to a useful temperature as needed. The system also has an electrical generation embodiment to provide electricity in addition to the heating and cooling. The system will collect and store solar energy and supply heated or cooled water to the building's existing HVAC system while consuming no fossil fuels and emitting no greenhouse gases. The system may also be used in one embodiment to supply power for the pumps/fans used to circulate the heated or cooled air or water throughout the building.
摘要翻译：一种用于提供热变压器以向封闭结构提供加热和冷却的系统，最通常是使用与地热存储结合的太阳能发电的建筑物和热功率热泵，以根据需要将储存的能量的温度升高或降低到有用温度。该系统还具有除了加热和冷却之外还提供电力的发电实施例。该系统将收集和存储太阳能，并向建筑物现有的HVAC系统供应加热或冷却水，同时不消耗化石燃料并且不排放温室气体。该系统也可以用于一个实施例中，为用于在整个建筑物内循环加热或冷却的空气或水的泵/风扇供电。

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