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11. 发明申请

WO2008150995A3 TRANSDERMAL DRUG DELIVERY SYSTEMS FOR DELIVERING ANTI-INFLAMMATORY DRUGS 审中-公开
标题翻译：用于递送抗炎药物的转运药物递送系统
公开(公告)号：WO2008150995A3
公开(公告)日：2009-03-05
申请号：PCT/US2008065285
申请日：2008-05-30
申请人： ZARS PHARMA INC , ZHANG JIE , WARNER KEVIN S
发明人： ZHANG JIE , WARNER KEVIN S
IPC分类号： A61F13/00 , A61K9/70
CPC分类号： A61F7/034 , A61F7/007 , A61F2007/0078 , A61K9/7061 , A61K31/192 , A61K31/196 , A61M37/00 , A61M37/0092
摘要： Systems for delivering an anti-inflammatory drug, and methods for treating osteoarthritis are provided. Such systems can comprise, in one embodiment, a transdermal patch with a sufficient amount of anti-inflammatory drug in a formulation for sustained transdermal delivery at a human skin site. The system can further include a permeation composition or device, such as a heating device. The heating device can be configured for application over the transdermal patch and the human skin site. Further, the heating device can be configured for heating the human skin site to a specific temperature range from 36 0C to 42 0C, and for maintaining the human skin site within that temperature range for a period of at least 4 or 5 hours.
摘要翻译：提供用于递送抗炎药物的系统和治疗骨关节炎的方法。在一个实施方案中，这样的系统可以包括在人皮肤部位用于持续经皮递送的制剂中具有足够量的抗炎药物的透皮贴剂。该系统还可以包括渗透组合物或装置，例如加热装置。加热装置可以配置用于施用于透皮贴剂和人皮肤部位上。此外，加热装置可以被配置为将人皮肤部位加热到特定温度范围为36℃至42℃，并且用于将人皮肤部位保持在该温度范围内至少4或5小时的时间。

12. 发明申请

WO2007070643A3 COMPOSITIONS AND METHODS FOR TREATING DERMATOLOGICAL CONDITIONS 审中-公开
标题翻译：用于治疗皮肤病症的组合物和方法
公开(公告)号：WO2007070643A3
公开(公告)日：2008-05-08
申请号：PCT/US2006047747
申请日：2006-12-14
申请人： ZARS INC , ZHANG JIE , WARNER KEVIN S , SHARMA SANJAY
发明人： ZHANG JIE , WARNER KEVIN S , SHARMA SANJAY
IPC分类号： A61K9/12 , A61K31/74
CPC分类号： A61K9/0014 , A61K9/7015
摘要： The present invention is drawn to solidifying adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug which can treat various dermatological conditions, such as a bacterial infection, a virus infection, a fungal infection, alopecia, dermatitis, psoriasis, or photo damaged skin. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent. The non-volatile solvent system can facilitate the delivery of the drug at therapeutically effective rates for sustained period of time. The non-volatile solvent system can also act as a plasticizer for the solidifying agent. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及固化粘合剂制剂，药物递送方法和用于皮肤递送药物的固化层，其可以治疗各种皮肤病学条件，例如细菌感染，病毒感染，真菌感染，脱发，皮炎，牛皮癣，或照片损伤的皮肤。制剂可以包括药物，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系。非挥发性溶剂体系可以有助于以治疗有效率持续持续的时间递送药物。非挥发性溶剂体系也可以作为固化剂的增塑剂。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

13. 发明申请

WO2007100376A2 COMPOSITIONS AND METHODS FOR DERMAL DELIVERY OF DRUGS 审中-公开
标题翻译：用于药物递送的组合物和方法
公开(公告)号：WO2007100376A2
公开(公告)日：2007-09-07
申请号：PCT/US2006048059
申请日：2006-12-14
申请人： ZARS INC , ZHANG JIE , WARNER KEVIN S , SHARMA SANJAY
发明人： ZHANG JIE , WARNER KEVIN S , SHARMA SANJAY
CPC分类号： A61K9/0014 , A61K9/7015 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/32 , A61K47/38 , A61K47/44
摘要： The present invention is drawn to adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and at least one solidifying agent. The solvent vehicle can have a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent. The formulation can be formulated to contain at least two volatile solvents, at least two non-volatile solvents, or at least two solidifying agents. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及粘合剂制剂，药物递送方法和用于药物真皮递送的固化层。制剂可以包括药物，溶剂载体和至少一种固化剂。溶剂载体可以具有包括至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系。制剂可配制成含有至少两种挥发性溶剂，至少两种非挥发性溶剂或至少两种固化剂。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

14. 发明申请

WO2005041883A3 REDUCTION OF UNINTENDED USE OF TRANSDERMAL DEVICES 审中-公开
标题翻译：减少意外使用变形设备
公开(公告)号：WO2005041883A3
公开(公告)日：2005-11-17
申请号：PCT/US2004036131
申请日：2004-10-28
申请人： ZARS INC , WARNER KEVIN S , ASHBURN MICHAEL A , NIU SUYI
发明人： WARNER KEVIN S , ASHBURN MICHAEL A , NIU SUYI
IPC分类号： A61F13/00 , A61K20060101 , A61K9/70 , A61K49/00
CPC分类号： A61K9/7023 , B09B3/0075 , B09B2220/14
摘要： The present invention is drawn to systems and methods for reducing unintended use of an active ingredient, such as residual active ingredients present in spent dermal patches and peels. The system can include a dermal patch including an active ingredient and a destructive agent configured to chemically react with the active ingredient. The destructive agent can be present in a container or an absorber. In one embodiment, the absorber can be used within the container. The container can be configured to receive the dermal patch such that the active ingredient contacts the destructive agent within the container. The absorber can be configured to contact the dermal patch such that the active ingredient contacts the destructive agent of the absorber. Additionally, systems and methods for impeding the unintended use of an active ingredient, such as those present in dermal patches or peels, are also provided. The system includes a dermal patch having a first side configured to deliver an active ingredient to a skin or mucosal surface, wherein the first side also includes a dermal adhesive. The system also includes an adhesive-coated device. The adhesive-coated surface of the device can be configured to adhere to the first side, wherein upon use of the dermal patch followed by contacting the adhesive-coated surface with the first side, residual active ingredient is rendered substantially inaccessible.
摘要翻译：本发明涉及用于减少活性成分的非预期用途的系统和方法，所述活性成分例如存在于有效皮肤贴剂和皮肤中的残留活性成分。该系统可以包括皮肤贴片，其包括配置成与活性成分发生化学反应的活性成分和破坏剂。破坏剂可存在于容器或吸收器中。在一个实施例中，吸收器可以在容器内使用。容器可以被配置为接收皮肤贴片，使得活性成分与容器内的破坏剂接触。吸收器可以被配置为接触皮肤贴片，使得活性成分与吸收体的破坏剂接触。此外，还提供了用于阻止意图使用活性成分（例如存在于真皮贴剂或皮肤中的那些）的系统和方法。该系统包括皮肤贴片，其具有构造成将活性成分递送至皮肤或粘膜表面的第一侧，其中第一面还包括真皮粘合剂。该系统还包括涂有粘合剂的装置。装置的粘合剂涂覆的表面可以被配置为粘附到第一侧，其中在使用皮肤贴片然后使粘合剂涂覆的表面与第一面接触时，残留的活性成分基本上不可接近。

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