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11. 发明申请

WO2008019091A1 METAL CARBOXYLATE SALTS 审中-公开
标题翻译：金属羧酸盐
公开(公告)号：WO2008019091A1
公开(公告)日：2008-02-14
申请号：PCT/US2007/017386
申请日：2007-08-03
申请人： KEMIN INDUSTRIES, INC. , GOH, Swee-Keng , ANTONY, Jesuadimai Ignatius Xavier , TAN, Hai Meng , CHOO, Yeun-Mun
发明人： GOH, Swee-Keng , ANTONY, Jesuadimai Ignatius Xavier , TAN, Hai Meng , CHOO, Yeun-Mun
IPC分类号： C07F1/00 , C07F7/00 , C07F11/00 , C07F13/00 , C07F15/00 , A23K1/00 , A23L1/30
CPC分类号： C07F1/005 , C07F3/003 , C07F11/005 , C07F13/005 , C07F15/025 , C07F15/065 , Y10S426/806
摘要： A dietary source of mineral in the form of a metal carboxylate is prepared using the acid-base-like reaction. A salt of a carboxylate anion and a by-product cation is reacted in aqueous solution with a salt of a metal cation and a by-product anion under conditions which form a metal carboxylate and the by-product salt. Solutions formed in the reaction may be applied directly to a dry carrier to produce a dry dietary supplement or, alternatively, the solutions may be filtered to remove precipitated by-product salt and the filtrate used as a liquid dietary supplement. Preferably, a reducing agent, such as ascorbic acid, is added to help prevent the oxidation of divalent to trivalent form of a metal salt, when an easily oxidized divalent metal is used as starting material.
摘要翻译：使用酸碱反应制备金属羧酸盐形式的矿物质的膳食来源。在形成金属羧酸盐和副产物盐的条件下，羧酸根阴离子和副产物阳离子的盐在水溶液中与金属阳离子和副产物阴离子的盐反应。在反应中形成的溶液可以直接施加到干燥的载体上以产生干燥的膳食补充剂，或者可以将溶液过滤以除去沉淀的副产物盐和用作液体膳食补充剂的滤液。优选地，当使用容易氧化的二价金属作为原料时，加入诸如抗坏血酸的还原剂以帮助防止二价至三价形式的金属盐的氧化。

12. 发明申请

WO2007064741A8 THE USE OF BACILLUS PB6 FOR THE PROPHYLAXIS OR TREATMENT OF GASTROINTESTINAL AND IMMUNO-RELATED DISEASES 审中-公开
标题翻译： BACILLUS PB6用于预防或治疗胃肠疾病和免疫相关疾病的使用
公开(公告)号：WO2007064741A8
公开(公告)日：2008-01-31
申请号：PCT/US2006045755
申请日：2006-11-29
申请人： KEMIN IND INC , SAS BENEDIKT , VAN HEMEL JOHAN , VANDENKERCKHOVE JAN , PEYS ERIC , TAN HAI MENG , SE CHEA-YUN , RAMCHAND CHANIYILPARAMPU , VARGHESE JERRY
发明人： SAS BENEDIKT , VAN HEMEL JOHAN , VANDENKERCKHOVE JAN , PEYS ERIC , TAN HAI MENG , SE CHEA-YUN , RAMCHAND CHANIYILPARAMPU , VARGHESE JERRY
IPC分类号： A61K31/74
CPC分类号： A61K35/742 , A23L33/135 , A61K38/164 , C12R1/07 , C12R1/125
摘要： Bacteria of the sp. Bacillus that produce a lipopeptide are found to be effective in the treatment and prophylaxis of gastro-intestinal disease when administered as a probiotic. In particular, a strain of Bacillus bacteria identified as PB6 is useful for the treatment of Antibiotic Associated Diarrhea (AAD) or the more serious condition Clostridium difficile associated diarrhea (CDAD) when administered as a probiotic. Additionally, these bacteria have been found efficient for the treatment of immunorelated diseases such as Inflammatory Bowel Disease (IBD).
摘要翻译：细菌发现产生脂肽的芽孢杆菌在作为益生菌施用时可有效地治疗和预防胃肠道疾病。特别地，当作为益生菌施用时，鉴定为PB6的芽孢杆菌菌株可用于治疗抗生素相关性腹泻（AAD）或更严重的艰难梭菌相关性腹泻（CDAD）。另外，已经发现这些细菌对于治疗免疫反应性疾病如炎症性肠病（IBD）是有效的。

13. 发明申请

WO2007106041A1 POLYKETIDES AND USES THEREOF 审中-公开
标题翻译：多晶硅及其用途
公开(公告)号：WO2007106041A1
公开(公告)日：2007-09-20
申请号：PCT/SG2006/000057
申请日：2006-03-14
申请人： NATIONAL UNIVERSITY OF SINGAPORE , NGA, Been Hen , TAN, Hai Meng
发明人： NGA, Been Hen , TAN, Hai Meng
IPC分类号： C12N1/00 , C12N9/00 , C12N15/04 , C12P1/06
CPC分类号： C12N15/52 , C12P19/56 , C12R1/01
摘要： This invention relates to the discovery of two novel actinomycete strains and the production of antitumour anthracycline polyketide antibiotic compounds.
摘要翻译：本发明涉及两种新型放线菌株的发现和抗肿瘤蒽环类抗生素化合物的生产。

14. 发明申请

WO2007044340A2 PRODUCTION OF ORGANIC AND INORGANIC SELENIUM COMPOUNDS BY LACTIC ACID BACTERIA 审中-公开
标题翻译：有机酸和无机硒化合物的生产通过酸性细菌
公开(公告)号：WO2007044340A2
公开(公告)日：2007-04-19
申请号：PCT/US2006038652
申请日：2006-10-04
申请人： KEMIN IND INC , TEO ALEX YEOW-LIM , HON SOOK-MEI , SE CHEA-YUN , TAN HAI MENG
发明人： TEO ALEX YEOW-LIM , HON SOOK-MEI , SE CHEA-YUN , TAN HAI MENG
IPC分类号： A61K35/74 , C12N1/20
CPC分类号： C12R1/01 , A23K10/16 , A23K20/30 , A23K50/75 , A61K33/04 , A61K35/747 , C12N1/20
摘要： A novel strain of lactic acid bacteria was found to be heat resistant and able to grow in a sulfur-limiting medium (SLM) containing a high concentration of sodium selenite. The microorganism is a non-spore forming and Gram-positive coccus, which is identified with > 90% confidence using the API biochemical and sugar fermentation tests, ribotyoing and 16S rRNA sequencing as Pediococcus pentosaceus SP80. In the current study, P. pentosaceus SP80 grown on SLM containing 250 ppm sodium selenite produced both organic and inorganic forms of selenium. Selenium-enriched bacteria are useful as a source of selenium for supplementing the diets of animals and humans. Animals fed efficacious amounts of the selenium-enriched bacteria show improved feed conversion rates and higher levels of glutathione peroxidase activity in heart, kidney and liver tissues indicating an increased absorption and retention of selenium over control diets.
摘要翻译：发现一种新的乳酸菌菌株是耐热的，能够在含有高浓度亚硒酸钠的限硫介质（SLM）中生长。微生物是非孢子形成和革兰氏阳性球菌，其使用API生物化学和糖发酵测试，核糖体发酵和16S rRNA测序作为戊糖片球菌SP80鉴定为> 90％的置信度。在目前的研究中，在含有250ppm亚硒酸钠的SLM上生长的戊酸蜡状芽孢杆菌SP80产生有机和无机形式的硒。富含硒的细菌可用作补充动物和人类饮食的硒来源。喂食有效量的富硒细菌的动物显示出改善的饲料转化率和在心脏，肾脏和肝脏组织中更高水平的谷胱甘肽过氧化物酶活性，表明硒在对照饮食上的吸收和保留率增加。

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