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11. 发明申请

WO2010096733A3 LUMINESCENT POROUS SILICON NANOPARTICLES, METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：发光多孔硅纳米粒子，其制造方法和使用方法
公开(公告)号：WO2010096733A3
公开(公告)日：2010-11-18
申请号：PCT/US2010024848
申请日：2010-02-20
申请人： UNIV CALIFORNIA , SAILOR MICHAEL J , GU LUO , PARK JI-HO
发明人： SAILOR MICHAEL J , GU LUO , PARK JI-HO
IPC分类号： C09K11/59 , A61K49/00 , B82B1/00 , B82B3/00 , C09K11/02
CPC分类号： C09K11/59 , A61K49/0017 , A61K49/0067 , A61K49/0093 , C09K11/02 , C09K11/025 , Y10T428/2982
摘要： The disclosure relates to imaging agents and drug delivery systems.
摘要翻译：本公开涉及成像剂和药物递送系统。

12. 发明申请

WO2009009563A9 MATERIALS AND METHODS FOR DELIVERING COMPOSITIONS TO SELECTED TISSUES 审中-公开
公开(公告)号：WO2009009563A9
公开(公告)日：2009-01-15
申请号：PCT/US2008/069474
申请日：2008-07-09
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , FREEMAN, William, R. , SAILOR, Michael, J. , CHENG, Lingyun
发明人： FREEMAN, William, R. , SAILOR, Michael, J. , CHENG, Lingyun
摘要： This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or electronics.

13. 发明申请

WO2009005848A1 SYSTEM AND METHOD FOR REMOTE, FREE-SPACE OPTICAL DETECTION OF POTENTIAL THREAT AGENT 审中-公开
标题翻译：用于遥感，自由空间光学检测潜在威胁剂的系统和方法
公开(公告)号：WO2009005848A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/051553
申请日：2008-01-21
申请人： THE BOEING COMPANY , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , DORVEE, Jason, R. , LINK, Jamie, R. , SAILOR, Michael, J. , HAGER, Harold, E. , SHERMAN, William, D.
发明人： DORVEE, Jason, R. , LINK, Jamie, R. , SAILOR, Michael, J. , HAGER, Harold, E. , SHERMAN, William, D.
IPC分类号： G01N21/78 , G01N33/00
CPC分类号： G01N21/39 , G01N21/783 , G01N2015/0088 , G01N2021/1793 , G01N2021/7773 , G01N2021/7796 , G01N2201/0214 , G01N2201/06113
摘要： A system and method for free space, optical remote sensing of a potential threat agent using spectrally responsive sensor material. In one example the sensor material is formed by particles, which in one particular form are porous photonic crystals. The particles are dispersed into an area being monitored for the presence of the potential threat agent. A pair of lasers is used to generate optical light beams that are directed at the sensor particles after the particles have been dispersed. The light reflected by the sensor particles is then analyzed. The presence of the potential threat agent causes a shift in the spectral peak of light reflected from the sensor particles that can be sensed using photo detectors and a processing subsystem. The system can be tuned to remotely detect for specific chemical, biological or environmental agents that may be present within a given area.
摘要翻译：使用光谱响应传感器材料的自由空间，潜在威胁剂的光学遥感的系统和方法。在一个示例中，传感器材料由颗粒形成，其在一种特定形式中是多孔光子晶体。颗粒被分散到正在监测的潜在威胁剂的存在的区域中。使用一对激光器在颗粒分散之后产生指向传感器颗粒的光束。然后分析由传感器颗粒反射的光。潜在威胁剂的存在导致从可以使用光电检测器和处理子系统感测的传感器颗粒反射的光的光谱峰值的偏移。该系统可以被调整以远程检测可能存在于给定区域内的特定化学，生物或环境因素。

14. 发明申请

WO2007082075A2 OPTICAL SENSOR FOR DETECTING CHEMICAL REACTION ACTIVITY 审中-公开
标题翻译：用于检测化学反应活性的光学传感器
公开(公告)号：WO2007082075A2
公开(公告)日：2007-07-19
申请号：PCT/US2007/000912
申请日：2007-01-10
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SAILOR, Michael, J. , OROSCO, Manuel, M. , PACHOLSKI, Claudia , MISKELLY, Gordon, M.
发明人： SAILOR, Michael, J. , OROSCO, Manuel, M. , PACHOLSKI, Claudia , MISKELLY, Gordon, M.
IPC分类号： H01R9/16
CPC分类号： G01N33/552 , Y10S435/808 , Y10S435/973 , Y10S436/805
摘要： The invention provides an optical sensor for detecting chemical reaction activity, including, e.g., enzyme activity and catalytic or reactive molecule activity. An optical sensor of the invention includes a porous photonic film (12) that produces a predetermined spectral reflectance response. In preferred embodiments, the film has a chemical coating (such as a hydrophobic layer) within its pores with an affinity for the reaction product(s) of the catalytic or otherwise reactive analyte. A coating can also act as a protective layer in preferred embodiment. A thin substrate (14) susceptible to reaction by at least one analyte of interest is on the surface of the thin film to block pores of the thin film. A method of detecting chemical reaction activity of the invention exposes the optical sensor to an analyte of interest, such as an enzyme or otherwise catalytic or reactive molecule. The optical sensor is subjected to light and the reflectivity spectrum of the optical sensor is monitored for a change indicative of reaction activity. Monitoring can include observation for a visible change or data acquisition via instruments such as a spectrometer for monitoring for a change in interferometric reflectance spectra.
摘要翻译：本发明提供用于检测化学反应活性的光学传感器，其包括例如酶活性和催化或反应性分子活性。本发明的光学传感器包括产生预定光谱反射响应的多孔光子膜（12）。在优选实施方案中，膜在其孔中具有对催化反应产物或反应分析物的反应产物具有亲和性的化学涂层（例如疏水层）。在优选实施例中，涂层也可以用作保护层。易受至少一种感兴趣分析物反应的薄基底（14）位于薄膜的表面上以阻挡薄膜的孔。检测本发明的化学反应活性的方法使光学传感器暴露于感兴趣的分析物，例如酶或其他催化或反应性分子。对光学传感器进行光照并监测光学传感器的反射率光谱的变化以指示反应活性。监测可以包括观察可见变化或通过仪器如光谱仪获取数据，以监测干涉反射光谱的变化。

15. 发明申请

WO2007008211A9 MAGNETIC POROUS PHOTONIC CRYSTAL PARTICLES AND METHOD OF MAKING 审中-公开
标题翻译：磁性多孔光子晶体颗粒及其制备方法
公开(公告)号：WO2007008211A9
公开(公告)日：2007-02-22
申请号：PCT/US2005025383
申请日：2005-07-18
申请人： UNIV CALIFORNIA , SAILOR MICHAEL J , LI YANGYANG , TRUJILLO NATHAN , DORVEE JASON
发明人： SAILOR MICHAEL J , LI YANGYANG , TRUJILLO NATHAN , DORVEE JASON
IPC分类号： H01L31/0256
CPC分类号： G01N21/31 , B22F1/0003 , B22F1/025 , B22F2998/10 , B82Y20/00 , G02B6/1225 , G02B26/004 , G02F1/09 , H01F1/0063 , Y10S977/838 , Y10S977/96 , Y10S977/962 , Y10T428/29 , Y10T428/2982 , Y10T428/2991 , Y10T428/31 , Y10T428/32 , B22F3/114 , B22F9/04
摘要： The invention provides porous particles that produce a predetermined optical response and that may be manipulated magnetically. A preferred particle of the invention has a porous structure (12, 12a, 18) that produces a predetermined optical response and magnetic material (14) adhered to the particle. Another preferred particle is amphiphilic. The optical response provided by a particle of the invention enables particles of the invention to be used in sensing, labeling, signaling, display and many other applications. The magnetic nature of the present magnetic particles permits the particles themselves to be manipulated, e.g., vibrated, moved and re-oriented. The porous particles can also be used to control, move, and/or deliver small volumes of liquids and solids associated with the particles.
摘要翻译：本发明提供产生预定光学响应且可以磁性操作的多孔颗粒。本发明的优选颗粒具有产生预定光学响应的多孔结构（12,12a，18）和粘附到颗粒上的磁性材料（14）。另一个优选的颗粒是两亲性的。由本发明的颗粒提供的光学响应使得本发明的颗粒可用于感测，标记，信号传递，显示和许多其它应用。本磁性颗粒的磁性使颗粒本身受到操纵，例如振动，移动和重新取向。多孔颗粒也可用于控制，移动和/或传送与颗粒相关的小体积的液体和固体。

16. 发明申请

WO2007008211A2 MAGNETIC POROUS PHOTONIC CRYSTAL PARTICLES AND METHOD OF MAKING 审中-公开
标题翻译：磁性多孔光子晶体颗粒及其制备方法
公开(公告)号：WO2007008211A2
公开(公告)日：2007-01-18
申请号：PCT/US2005/025383
申请日：2005-07-18
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SAILOR, Michael, J. , LI, Yangyang , TRUJILLO, Nathan , DORVEE, Jason
发明人： SAILOR, Michael, J. , LI, Yangyang , TRUJILLO, Nathan , DORVEE, Jason
IPC分类号： H01L31/0256
CPC分类号： G01N21/31 , B22F1/0003 , B22F1/025 , B22F2998/10 , B82Y20/00 , G02B6/1225 , G02B26/004 , G02F1/09 , H01F1/0063 , Y10S977/838 , Y10S977/96 , Y10S977/962 , Y10T428/29 , Y10T428/2982 , Y10T428/2991 , Y10T428/31 , Y10T428/32 , B22F3/114 , B22F9/04
摘要： The invention provides porous particles that produce a predetermined optical response and that may be manipulated magnetically. A preferred particle of the invention has a porous structure (12, 12a, 18) that produces a predetermined optical response and magnetic material (14) adhered to the particle. Another preferred particle is amphiphilic. The optical response provided by a particle of the invention enables particles of the invention to be used in sensing, labeling, signaling, display and many other applications. The magnetic nature of the present magnetic particles permits the particles themselves to be manipulated, e.g., vibrated, moved and re-oriented. The porous particles can also be used to control, move, and/or deliver small volumes of liquids and solids associated with the particles.
摘要翻译：本发明提供了产生预定光学响应并且可以被磁性操纵的多孔颗粒。本发明的优选颗粒具有产生预定光学响应的多孔结构（12,12a，18）和粘附于颗粒的磁性材料（14）。另一种优选的颗粒是两亲性的。由本发明的颗粒提供的光学响应使本发明的颗粒能够用于感测，标记，信号传导，显示和许多其他应用。本磁性粒子的磁性允许粒子本身被操纵，例如振动，移动和重新定向。多孔颗粒也可用于控制，移动和/或递送与颗粒相关的少量液体和固体。

17. 发明申请

WO2005034725A2 PHOTONIC SENSOR PARTICLES AND FABRICATION METHODS 审中-公开
标题翻译：光子传感器粒子及其制备方法
公开(公告)号：WO2005034725A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/026572
申请日：2004-08-13
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LINK, Jamie, R. , SAILOR, Michael, J.
发明人： LINK, Jamie, R. , SAILOR, Michael, J.
IPC分类号： A61B
CPC分类号： B29D11/00663 , B82Y20/00 , G01N21/4788 , G01N21/774 , G02B6/1225 , Y10T428/249969
摘要： The invention is related to optical particles (10), use of optical particles in sensing applications, and methods of fabricating optical particles that can target a desired analyte. The invention is also related to the self assembly of individual optical particles. An advantage of the invention is that it includes self-assembling individual photonic crystal sensors onto a target. In an embodiment of the invention, a processed sensor structure having two generally opposing surfaces is provided, wherein each of the opposing surfaces have different surface affinities, with a first optical structure formed on one of the opposing surfaces, and a second optical structure formed on the other of the opposing surfaces. The chemically and optically asymmetric opposing surfaces will spontaneously align at an organic liquid/water interface. Changes in the optical response of at least one of the opposing surfaces indicate the presence of a particular analyte for sensing applications.
摘要翻译：本发明涉及光学颗粒（10），在感测应用中使用光学颗粒，以及制造可靶向期望分析物的光学颗粒的方法。本发明还涉及自我与害羞; 单个光学粒子的组装。本发明的优点是它包括将各个光子晶体传感器自组装到目标上。在本发明的一个实施例中，提供了具有两个大致相对的表面的经处理的传感器结构，其中每个相对的表面具有不同的表面亲和性，其中第一光学结构形成在相对表面中的一个上，并且第二光学结构形成在另一个相对的表面。化学和光学不对称的相对表面将在有机液体/水界面处自发排列。至少一个相对表面的光学响应变化表明用于感测应用的特定分析物的存在。

18. 发明申请

WO2004058841A2 SYNTHESIS AND USE OF INORGANIC POLYMER SENSOR FOR DETECTING NITROAROMATIC COMPOUNDS 审中-公开
标题翻译：无机聚合物传感器用于检测硝基化合物的合成和使用
公开(公告)号：WO2004058841A2
公开(公告)日：2004-07-15
申请号：PCT/US2003/031600
申请日：2003-10-06
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SAILOR, Michael, J. , TROGLER, William, C. , SOHN, Honglae , TOAL, Sarah, J.
发明人： SAILOR, Michael, J. , TROGLER, William, C. , SOHN, Honglae , TOAL, Sarah, J.
IPC分类号： C08G
CPC分类号： C08G79/00 , C07F7/0896 , C07F7/30 , C08G77/60 , G01N21/643 , G01N33/0049 , G01N2021/6432 , G01N2021/7786
摘要： A dehydrocoupling polycondensation method for synthesizing polymetalloles including obtaining a dihydrometallole that includes silicon or germanium atoms, designating a reducing agent for preparation of dihydrometallole monomer, measuring a predetermined molar percentage of the reducing agent corresponding to a molar amount of the dihydrometallole, selecting a catalyst, and reacting the catalyst with the dihydrometallole to obtain a polymetallole. A method for detecting an analyte that may be present in ambient air or complex aqueous media including providing a polymer or copolymer containing a metalloid-metalloid backbone, exposing the polymer or copolymer to a suspected analyte or a system suspected of including the analyte, and measuring a quenching of photoluminescence of the metallole polymer or copolymer exposed to the system.
摘要翻译：一种用于合成多元醇的脱氢缩合缩聚方法，包括获得包含硅或锗原子的二羟基醇，指定用于制备二羟基醇单体的还原剂，测量对应于二羟基醇的摩尔量的预定摩尔百分数的还原剂，选择催化剂，并使催化剂与二水合醇反应以获得多元醇。用于检测可能存在于环境空气或复合水性介质中的分析物的方法，包括提供含有准金属 - 准金属主链的聚合物或共聚物，将聚合物或共聚物暴露于可疑分析物或怀疑包含分析物的体系，并测量暴露于体系的金属聚合物或共聚物的光致发光的淬灭。

19. 发明申请

WO2003067231A1 OPTICALLY ENCODED PARTICLES 审中-公开
标题翻译：光学编码颗粒
公开(公告)号：WO2003067231A1
公开(公告)日：2003-08-14
申请号：PCT/US2003/003040
申请日：2003-01-31
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SAILOR, Michael, J. , SCHMEDAKE, Thomas , CUNIN, Frederique , LINK, Jamie
发明人： SAILOR, Michael, J. , SCHMEDAKE, Thomas , CUNIN, Frederique , LINK, Jamie
IPC分类号： G01N21/64
CPC分类号： G06K19/06084 , B05D1/00 , B05D2451/00 , G01N21/31 , G01N21/45 , G06K19/0614 , G09F3/00 , Y10T436/13 , Y10T436/143333 , Y10T436/144444
摘要： The invention concerns a particle (10, 10a) having a code embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum.
摘要翻译：本发明涉及具有通过粒子的不同区域之间的折射率变化嵌入物理结构中的代码的粒子10,10a。在优选实施例中，薄膜具有以产生在反射率谱中可检测的代码的方式变化的孔隙率。

20. 发明申请

WO2012050966A3 CARBON AND CARBON/SILICON COMPOSITE NANOSTRUCTED MATERIALS AND CASTING FORMATION METHOD 审中-公开
标题翻译：碳与碳/硅复合纳米结构材料与铸造成形方法
公开(公告)号：WO2012050966A3
公开(公告)日：2012-08-16
申请号：PCT/US2011053965
申请日：2011-09-29
申请人： UNIV CALIFORNIA , SAILOR MICHAEL J , KELLY TIMOTHY L
发明人： SAILOR MICHAEL J , KELLY TIMOTHY L
IPC分类号： B82B3/00 , B82B1/00 , C01B31/02
CPC分类号： C01B31/022 , B82B1/00 , B82Y30/00 , B82Y40/00 , C01B32/158 , C01B32/16 , C01B32/166 , D01D5/00 , D01F9/14 , G02B1/005 , Y10T428/249994 , Y10T428/2918
摘要： The invention provides nanostructure composite porous silicon and carbon materials, and also provides carbon nanofiber arrays having a photonic response in the form of films or particles. Composite materials or carbon nanofiber arrays of the invention are produced by a templating method of the invention, and the resultant nanomaterials have a predetermined photonic response determined by the pattern in the porous silicon template, which is determined by etching conditions for forming the porous silicon. Example nanostructures include rugate filters, single layer structures and double layer structures. In a preferred method of the invention, a carbon precursor is introduced into the pores of a porous silicon film. Carbon is then formed from the carbon precursor. In a preferred method of the invention, liquid carbon-containing polymer precursor is introduced into the pores of an porous silicon film. The precursor is thermally polymerized to form a carbon-containing polymer in the pores of the porous silicon film, which is then thermally carbonized to produce the nanostructured composite material. A carbon nanofiber array is obtained by dissolving the porous silicon. A carbon nanofiber array can be maintained as a film in liquid, and particles can be formed by drying the material.
摘要翻译：本发明提供纳米结构复合多孔硅和碳材料，并且还提供具有膜或颗粒形式的光子响应的碳纳米纤维阵列。本发明的复合材料或碳纳米纤维阵列通过本发明的模板化方法生产，并且所得到的纳米材料具有由多孔硅模板中的图案确定的预定光子响应，所述图案由用于形成多孔硅的蚀刻条件确定。示例性纳米结构包括皱纹滤波器，单层结构和双层结构。在本发明的优选方法中，碳前体被引入到多孔硅膜的孔中。然后由碳前体形成碳。在本发明的优选方法中，将液体含碳聚合物前体引入到多孔硅膜的孔中。将前体热聚合以在多孔硅膜的孔中形成含碳聚合物，然后将其热碳化以制备纳米结构复合材料。碳纳米纤维阵列通过溶解多孔硅而获得。碳纳米纤维阵列可以作为膜保持在液体中，并且可以通过干燥材料来形成粒子。

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