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    • 13. 发明申请
    • SMART FAIMS SENSOR
    • SMART FAIMS传感器
    • WO2008094299A2
    • 2008-08-07
    • PCT/US2007/073717
    • 2007-07-17
    • OWLSTONE NANOTECH, INC.BOYLE, PaulRUSH, MartynRUIZ-ALONSO, DavidKOEHL, AndrewPARRIS, RussellWILKS, Ashley
    • BOYLE, PaulRUSH, MartynRUIZ-ALONSO, DavidKOEHL, AndrewPARRIS, RussellWILKS, Ashley
    • G01N27/624
    • A smart FAIMS sensor system and method includes an array of two or more FAIMS sensors and a controller configured to control independently each of the FAIMS sensors in the array. In a preferred embodiment, the sensor array is normally operated with one FAIMS sensor operating in a high sensitivity mode while the remaining sensors are turned off. When the high sensitivity FAIMS sensor detects a possible event, each of the remaining sensors is turned on in sequence to confirm the possible event. Each of the remaining sensors is operated in a different selectivity mode that together forms a characteristic signature of a target analyte. The characteristic signature is more robust against false positives and an alarm is registered only when all remaining sensors confirm the possible event detected by the high sensitivity sensor. In another embodiment, a smart FAIMS sensor system and method includes a 2/2-electrode filter that pumps the ions through the system and separates the ionic species, a detector for collecting the separated ions and generating a detector signal in response to the collected ions, and a controller configured to change the operating parameters of the system in response to changes in the sensor's environment detected by the sensor. The ability to dynamically change the operating parameters of the sensor enables the sensor to maintain high sensitivity to environmental threats while decreasing the incidences of false positive events.
    • 智能FAIMS传感器系统和方法包括两个或更多个FAIMS传感器的阵列和被配置为独立地控制阵列中的每个FAIMS传感器的控制器。 在优选实施例中,传感器阵列通常以一个在高灵敏度模式下运行的FAIMS传感器工作,而剩下的传感器被关闭。 当高灵敏度FAIMS传感器检测到可能的事件时,依次打开每个剩余的传感器以确认可能的事件。 每个剩余的传感器以不同的选择性模式操作,共同形成目标分析物的特征。 只有当所有剩余传感器确认高灵敏度传感器检测到的可能事件时,特征识别才能抵抗误报,而且只能报警。 在另一个实施例中,智能FAIMS传感器系统和方法包括:2/2电极过滤器,其通过系统泵送离子并分离离子物质;用于收集分离离子的检测器,并响应于所收集的离子产生检测器信号 以及控制器,被配置为响应于由传感器检测到的传感器的环境的变化而改变系统的操作参数。 动态改变传感器工作参数的能力使传感器能够保持对环境威胁的高度敏感性,同时减少假阳性事件的发生率。