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11. 发明申请

WO2011036597A1 BINDING ASSAY WITH MULTIPLE MAGNETICALLY LABELLED TRACER BINDING AGENTS. 审中-公开
标题翻译：具有多个磁性标签的追踪器绑定代理的绑定测试。
公开(公告)号：WO2011036597A1
公开(公告)日：2011-03-31
申请号：PCT/IB2010/054094
申请日：2010-09-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NIEUWENHUIS, Jeroen, Hans , EVERS, Toon, Hendrik
发明人： NIEUWENHUIS, Jeroen, Hans , EVERS, Toon, Hendrik
IPC分类号： G01N33/543
CPC分类号： G01N33/54326 , G01N27/745
摘要： The present invention relates to a cartridge (1) for the detection of an analyte (2) in a binding assay with magnetic labels (3), the cartridge comprising at least one capture binding agent (4) against a binding site on the analyte and comprising at least two magnetically labelled tracer binding agents (51 and 52) against further different binding sites on the analyte, characterised in that the cartridge comprises at least two regions (61 and 62) wherein a first region (61) comprises the at least one capture binding agent (4) and a first magnetically labelled tracer binding agent (51) and wherein a second region (62) comprises at least one capture binding agent (4) and a second magnetically labelled tracer binding agent (52). Herein the first region (61) does not comprise a magnetically labelled tracer binding agent other than the first magnetically labelled tracer bind agent (51) and wherein the second region (62) does not comprise a magnetically labelled tracer binding agent other than the second magnetically labelled tracer binding agent (52).
摘要翻译：本发明涉及一种用于在具有磁性标签（3）的结合测定中检测分析物（2）的盒（1），所述盒包含针对分析物上的结合位点的至少一种捕获结合剂（4）包括至少两个磁性标记的示踪剂结合剂（51和52），其抵抗所述分析物上的另外不同的结合位点，其特征在于，所述盒包括至少两个区域（61和62），其中第一区域（61）包括所述至少一个捕获结合剂（4）和第一磁性标记的示踪剂结合剂（51），并且其中第二区域（62）包含至少一种捕获结合剂（4）和第二磁性标记示踪剂结合剂（52）。本文中，第一区域（61）不包含除了第一磁性标记的示踪剂结合剂（51）之外的磁性标记的示踪剂结合剂，并且其中第二区域（62）不包括除了第二磁性标记的磁性标记的示踪剂结合剂标记示踪剂结合剂（52）。

12. 发明申请

WO2008001263A3 MAGNETIC SENSOR DEVICE WITH FIELD GENERATORS AND SENSOR ELEMENTS 审中-公开
标题翻译：具有现场发电机和传感器元件的磁传感器装置
公开(公告)号：WO2008001263A3
公开(公告)日：2008-08-21
申请号：PCT/IB2007052327
申请日：2007-06-18
申请人： KONINKL PHILIPS ELECTRONICS NV , NIEUWENHUIS JEROEN HANS , ZON HANS , KAHLMAN JOHANNES ARNOLDUS HENR
发明人： NIEUWENHUIS JEROEN HANS , ZON HANS , KAHLMAN JOHANNES ARNOLDUS HENR
IPC分类号： G01R33/09 , G01N15/06 , G01R33/12
CPC分类号： G01R33/12 , B82Y25/00 , G01R33/093 , G01R33/1269
摘要： The invention relates to a magnetic sensor device (10) comprising (a) excitation wires (11, 13) for generating a magnetic excitation field (B) that magnetizes particles (2) in an investigation region (5), and (b) a magnetic sensor element, for example a GMR sensor (12), for detecting reaction fields (B') generated by the magnetized particles (2). The excitation wires (11, 13) and the GMR element (12) are driven by current pulses such that the average power dissipation is kept constant while the signal-to-noise ratio is optimized. The sampling frequency of said pulses is preferably larger than the thermal time constant (t) of the magnetic sensor device (10).
摘要翻译：本发明涉及一种磁传感器装置（10），它包括：（a）用于产生在调查区域（5）中磁化颗粒（2）的磁激励场（B）的激励线（11,13），以及（b）磁传感器元件，例如GMR传感器（12），用于检测由磁化颗粒（2）产生的反应场（B'）。励磁线（11,13）和GMR元件（12）由电流脉冲驱动，使得平均功率损耗保持恒定，同时信噪比优化。所述脉冲的采样频率优选大于磁传感器装置（10）的热时间常数（t）。

13. 发明申请

WO2007132384A3 MAGNETIC SENSOR DEVICE WITH FIELD GENERATORS AND SENSORS 审中-公开
标题翻译：具有现场发电机和传感器的磁传感器装置
公开(公告)号：WO2007132384A3
公开(公告)日：2008-01-24
申请号：PCT/IB2007051640
申请日：2007-05-02
申请人： KONINKL PHILIPS ELECTRONICS NV , NIEUWENHUIS JEROEN HANS , VAN ZON HANS , KAHLMAN JOSEPHUS ARNOLDUS HENR
发明人： NIEUWENHUIS JEROEN HANS , VAN ZON HANS , KAHLMAN JOSEPHUS ARNOLDUS HENR
IPC分类号： G01R33/09 , G01N15/06 , G01N33/543
CPC分类号： G01N33/54326 , B82Y25/00 , G01N15/0656 , G01N27/745 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： The invention relates to a magnetic sensor device (10) comprising magnetic field generators (11, 13) for generating a magnetic excitation field (B) in an investigation region and a magnetic sensor element (12) for measuring magnetic reactions fields (B') generated by magnetized particles (2) that are bound to binding sites (3) in the investigation region. Both the magnetic field generators (11, 13) and the magnetic sensor element (12) are driven with electrical power, wherein the ratio of the power that is dissipated in said components is kept in a predetermined interval. The magnetic field generators may preferably be realized by excitation wires (11, 13) and the sensor element (12) by a magneto-resistive element, for example a GMR element. In this case, it is preferred that about equal amounts of power are dissipated in the excitation wires (11, 13) and the GMR element (12).
摘要翻译：本发明涉及一种磁传感器装置（10），包括用于在调查区域中产生磁场（B）的磁场发生器（11,13）和用于测量磁反应场（B'）的磁传感器元件（12）由在调查区域中与结合位点（3）结合的磁化颗粒（2）产生。磁力发生器（11,13）和磁性传感器元件（12）都用电力驱动，其中在所述部件中耗散的功率的比率保持在预定的间隔。磁场发生器可以优选地通过激磁线（11,13）和传感器元件（12）由磁阻元件（例如GMR元件）来实现。在这种情况下，优选在激励线（11,13）和GMR元件（12）中消耗大约相等的功率。

14. 发明申请

WO2012147000A1 SENSOR SYSTEM WITH AN EXCHANGEABLE CARTRIDGE AND A READER 审中-公开
标题翻译：具有可交换盒和读取器的传感器系统
公开(公告)号：WO2012147000A1
公开(公告)日：2012-11-01
申请号：PCT/IB2012/051801
申请日：2012-04-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BEERLING, Bernardus Jozef Maria , NIEUWENHUIS, Jeroen Hans , VAN LANKVELT, Petrus Johannes Wilhelmus , MEERTENS, Wendela , ZUIDEMA, Patrick
发明人： BEERLING, Bernardus Jozef Maria , NIEUWENHUIS, Jeroen Hans , VAN LANKVELT, Petrus Johannes Wilhelmus , MEERTENS, Wendela , ZUIDEMA, Patrick
IPC分类号： G01N21/03 , G01N21/55 , B01L3/00 , G01N33/543
CPC分类号： G01N1/28 , G01N21/0332 , G01N21/552 , G01N21/648 , G01N2201/0221
摘要： The invention relates to a sensor system (100) comprising a reader (150) with a sensor unit (155, 156) and an accommodation space(151) for an exchangeable cartridge (110). The cartridge(110) is held in said accommodation space (151) by at least one contact element (111) which has an increased thermal resistance and/or a contact area of reduced size. Thus a more homogenous temperature distribution can be achieved within the cartridge (110), reducing distortions which might adversely affect optical measurements.
摘要翻译：本发明涉及一种传感器系统（100），其包括具有传感器单元（155,156）的读取器（150）和用于可更换盒（110）的容纳空间（151）。盒（110）通过至少一个接触元件（111）保持在所述容纳空间（151）中，该接触元件具有增加的热阻和/或减小尺寸的接触面积。因此，可以在盒（110）内实现更均匀的温度分布，减少可能不利地影响光学测量的失真。

15. 发明申请

WO2009024916A1 VENT DESIGN FOR BIOSENSOR CARTRIDGE 审中-公开
标题翻译：生物传感器盒的通风设计
公开(公告)号：WO2009024916A1
公开(公告)日：2009-02-26
申请号：PCT/IB2008/053303
申请日：2008-08-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NIEUWENHUIS, Jeroen Hans , VERHOECKX, Godefridus Johannes
发明人： NIEUWENHUIS, Jeroen Hans , VERHOECKX, Godefridus Johannes
IPC分类号： B01L3/00
CPC分类号： B01L3/502723 , B01L2200/0684 , B01L2200/141 , B01L2300/0816 , B01L2300/0825 , B01L2400/0688
摘要： The invention provides a cartridge for receiving a liquid. In the cartridge, the liquid is applied to a receiving opening and flows to a sample chamber, preferably driven by capillary action. A venting hole (13) connecting the sample chamber (12) with the outside of the cartridge allows the liquid flow through the cartridge. The venting hole (13) is arranged in a recess (14) which has a substantially larger diameter than the venting hole (13). The cartridge may advantageously be used in a biosensor device or a bioreactor, e.g. a magnetic sensor device such as a magnetic sensor device for measuring the presence of an agent in the liquid based on molecular capture and labeling with magnetic beads.
摘要翻译：本发明提供一种用于接收液体的盒。在墨盒中，将液体施加到接收开口并流动到样品室，优选地通过毛细作用驱动。将样品室（12）与盒的外部连接的排气孔（13）允许液体流过盒。排气孔（13）布置在具有比通气孔（13）大得多的直径的凹槽（14）中。该盒可有利地用于生物传感器装置或生物反应器中，例如，磁传感器装置，例如磁传感器装置，用于基于用磁珠的分子捕获和标记来测量液体中的试剂的存在。

16. 发明申请

WO2008102218A1 A SENSOR DEVICE FOR AND A METHOD OF SENSING MAGNETIC PARTICLES 审中-公开
标题翻译：一种用于感测磁性颗粒的传感器装置和方法
公开(公告)号：WO2008102218A1
公开(公告)日：2008-08-28
申请号：PCT/IB2007/052449
申请日：2007-06-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN LANKVELT, Petrus Johannes Wilhelmus , NIEUWENHUIS, Jeroen Hans , IMMINK, Albert Hendrik Jan , KAHLMAN, Josephus Arnoldus Henricus Maria
发明人： VAN LANKVELT, Petrus Johannes Wilhelmus , NIEUWENHUIS, Jeroen Hans , IMMINK, Albert Hendrik Jan , KAHLMAN, Josephus Arnoldus Henricus Maria
IPC分类号： G01N33/543 , G01R33/06
CPC分类号： G01N33/54373 , B82Y25/00 , G01N27/745 , G01N33/54326 , G01R33/07 , G01R33/093 , G01R33/12 , G01R33/1269 , G01R33/1276
摘要： A sensor device (50) for sensing magnetic particles (15), the sensor device (50) comprising a substrate (25) and a sensing unit (11, 20) provided on and/or in and/or near the substrate (25) and being adapted for sensing a detection signal indicative of the presence of the magnetic particles (15), and a magnetic field control unit (30 to 34) provided off the substrate (25) and being adapted for generating a time-dependent magnetic field for interaction with the magnetic particles (15).
摘要翻译：一种用于感测磁性颗粒（15）的传感器装置（50），所述传感器装置（50）包括衬底（25）和设置在衬底（25）上和/或之中和/或附近的感测单元（11,20）适于感测表示磁性粒子（15）的存在的检测信号，以及设置在基板（25）之外的磁场控制部（30〜34），适于产生时间依赖性的磁场，与磁性颗粒（15）的相互作用。

17. 发明申请

WO2008072149A2 A MAGNETIC SYSTEM FOR BIOSENSORS OR A BIOSYSTEM 审中-公开
标题翻译：生物传感器或生物体系的磁系统
公开(公告)号：WO2008072149A2
公开(公告)日：2008-06-19
申请号：PCT/IB2007/054967
申请日：2007-12-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , KAHLMANN, Josephus Arnoldus Henricus Maria , IMMINK, ALBERT HENDRIK JAN , NIEUWENHUIS, Jeroen Hans , VAN DER WIJK, Thea , DE THEIJE, FEMKE KARINA
发明人： KAHLMANN, Josephus Arnoldus Henricus Maria , IMMINK, ALBERT HENDRIK JAN , NIEUWENHUIS, Jeroen Hans , VAN DER WIJK, Thea , DE THEIJE, FEMKE KARINA
IPC分类号： G01N35/00 , G01N33/543 , H01F7/00
CPC分类号： G01N27/745 , G01N33/54333 , G01N35/0098 , H01F7/0273
摘要： The invention relates to a magnetic System for biosensors or a biosystem. In order to achieve a compact and effective biosensor System, magnetic particles that interact with molecules of the biomaterial are brought into a magnetic field, in order to be influenced by magnetic attraction or repulsion forces, wherein the sensor or at least the sensor surface is movable relatively with respect to the magnetic poles of at least one magnet.
摘要翻译：本发明涉及用于生物传感器或生物系统的磁系统。为了实现紧凑且有效的生物传感器系统，与生物材料的分子相互作用的磁性颗粒被带入磁场，以受到磁吸引力或排斥力的影响，其中传感器或至少传感器表面是可移动的相对于至少一个磁体的磁极。

18. 发明申请

WO2008035252A3 A SENSOR DEVICE FOR AND A METHOD OF SENSING PARTICLES 审中-公开
标题翻译：用于传感颗粒的传感器装置和方法
公开(公告)号：WO2008035252A3
公开(公告)日：2008-05-29
申请号：PCT/IB2007053679
申请日：2007-09-12
申请人： KONINKL PHILIPS ELECTRONICS NV , NIEUWENHUIS JEROEN HANS , PRINS MENNO WILLEM JOSE
发明人： NIEUWENHUIS JEROEN HANS , PRINS MENNO WILLEM JOSE
IPC分类号： G01N15/06 , G01N33/49 , G01N33/543 , G01N35/00 , G01R33/09
CPC分类号： G01N15/12 , G01N15/0656 , G01N15/1056 , G01N2015/1087
摘要： A GMR based sensor device (100) for sensing first particles (504, 505) e.g. magnetic beads for immuno assay of a sample comprising the first particles (504, 505) and second particles (503) e.g. red blood cells, the sensor device (100) comprising a detection unit (11, 12) adapted to detect a signal which depends on a quantity of the first particles (504, 505) and which depends on a quantity of the second particles (503)" based on a measurement performed with the sample comprising the first particles (504, 505) and the second particles (503), an estimation unit (30) for estimating information indicative of the quantity of the second particles (503) e.g. haematocrit based on an impedance measurement, and a determining unit (20) adapted for determining the quantity of the first particles (504, 505) based on the detected signal under consideration of the estimated information. The advantage of this arrangement is that whole blood samples may be used.
摘要翻译：用于感测第一颗粒（504,505）的基于GMR的传感器装置（100）用于免疫测定包含第一颗粒（504,505）和第二颗粒（503）的样品的磁珠。所述传感器装置（100）包括检测单元（11,12），所述检测单元适于检测取决于所述第一颗粒（504,505）的量并且取决于所述第二颗粒（503）的量的信号）基于使用包含第一颗粒（504,505）和第二颗粒（503）的样品进行的测量，估计单元（30），用于估计指示第二颗粒（503）的量的信息，例如基于血细胞比容以及确定单元（20），其适于基于在所述估计信息下考虑的所述检测信号来确定所述第一粒子（504,505）的量，所述排列的优点在于，全血样品可以是用过的。

19. 发明申请

WO2007132384A2 MAGNETIC SENSOR DEVICE WITH FIELD GENERATORS AND SENSORS 审中-公开
标题翻译：具有现场发电机和传感器的磁传感器装置
公开(公告)号：WO2007132384A2
公开(公告)日：2007-11-22
申请号：PCT/IB2007/051640
申请日：2007-05-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , NIEUWENHUIS, Jeroen Hans , VAN ZON, Hans , KAHLMAN, Josephus Arnoldus Henricus Maria
发明人： NIEUWENHUIS, Jeroen Hans , VAN ZON, Hans , KAHLMAN, Josephus Arnoldus Henricus Maria
IPC分类号： G01R33/09 , G01N15/06 , G01N33/543
CPC分类号： G01N33/54326 , B82Y25/00 , G01N15/0656 , G01N27/745 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： The invention relates to a magnetic sensor device (10) comprising magnetic field generators (11, 13) for generating a magnetic excitation field (B) in an investigation region and a magnetic sensor element (12) for measuring magnetic reactions fields (B') generated by magnetized particles (2) that are bound to binding sites (3) in the investigation region. Both the magnetic field generators (11, 13) and the magnetic sensor element (12) are driven with electrical power, wherein the ratio of the power that is dissipated in said components is kept in a predetermined interval. The magnetic field generators may preferably be realized by excitation wires (11, 13) and the sensor element (12) by a magneto-resistive element, for example a GMR element. In this case, it is preferred that about equal amounts of power are dissipated in the excitation wires (11, 13) and the GMR element (12).
摘要翻译：本发明涉及一种磁传感器装置（10），包括用于在调查区域中产生磁场（B）的磁场发生器（11,13）和用于测量磁反应场（B'）的磁传感器元件（12）由在调查区域中与结合位点（3）结合的磁化颗粒（2）产生。磁力发生器（11,13）和磁性传感器元件（12）都用电力驱动，其中在所述部件中耗散的功率的比率保持在预定的间隔。磁场发生器可以优选地通过激磁线（11,13）和传感器元件（12）由磁阻元件（例如GMR元件）来实现。在这种情况下，优选在激励线（11,13）和GMR元件（12）中消耗大约相等的功率。

20. 发明申请

WO2011128807A1 HEATING OF MAGNETIC PARTICLES IN A BIOSENSOR CARTRIDGE 审中-公开
标题翻译：在生物传感器盒中加热磁性颗粒
公开(公告)号：WO2011128807A1
公开(公告)日：2011-10-20
申请号：PCT/IB2011/051452
申请日：2011-04-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VEEN, Jeroen , NIEUWENHUIS, Jeroen Hans
发明人： VEEN, Jeroen , NIEUWENHUIS, Jeroen Hans
IPC分类号： H05B6/06 , H05B6/10
CPC分类号： H05B6/10
摘要： The present invention relates to a biosensor and method of heating a liquid contained in a measurement chamber (10) of a biosensor, wherein a time-varying magnetic field is provided by electromagnets (20) in the measurement chamber (10). The time-varying magnetic field is applied in a manner to obtain an at least substantially spatial homogenous distribution of the time-varying magnetic field in the measurement chamber (10). Thereby, the temperature or shell temperature of particles (e.g. labels or beads) provided in the liquid of the measurement chamber can be directly increased to effectively heat the liquid and control the temperature of bio-chemical reactions on or near the particle label surfaces.
摘要翻译：本发明涉及一种生物传感器和生物传感器的测量室（10）中包含的液体的加热方法，其中在测量室（10）中由电磁体（20）提供时变磁场。施加时变磁场以获得测量室（10）中的时变磁场的至少基本上空间均匀的分布。因此，可以直接增加设置在测量室的液体中的颗粒（例如标签或珠）的温度或壳温度，以有效地加热液体并控制颗粒标签表面上或附近的生物化学反应的温度。

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