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11. 发明申请

WO2009057847A1 SUSTAINED-RELEASE NANOPARTICLE AND THE COSMETIC COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：持续释放纳米颗粒和含有它们的化妆品组合物
公开(公告)号：WO2009057847A1
公开(公告)日：2009-05-07
申请号：PCT/KR2007/005994
申请日：2007-11-26
申请人： AMOREPACIFIC CORPORATION , KIM, Do Hoon , SHIM, Jongwon , PARK, Chang Man , KIM, Jin Woong , KIM, Junch , KANG, Byung-Young
发明人： KIM, Do Hoon , SHIM, Jongwon , PARK, Chang Man , KIM, Jin Woong , KIM, Junch , KANG, Byung-Young
IPC分类号： A61K8/02
CPC分类号： A61K8/345 , A61K8/11 , A61K2800/412 , A61Q19/00
摘要： The present invention relates to a sustained-release nanoparticle and a cosmetic composition comprising the nanoparticle. Specifically, the present invention relates to a sustained-release nanoparticle that is prepared using phytantriol to inhibit an initial burst release of drugs or active ingredients and slowly release the drugs or active ingredients, and to a cosmetic composition comprising the nanoparticle.
摘要翻译：本发明涉及包含纳米颗粒的缓释纳米颗粒和化妆品组合物。具体地说，本发明涉及使用植物三醇制备抑制药物或活性成分的初始爆发释放并缓慢释放药物或活性成分的缓释纳米颗粒，以及包含纳米颗粒的化妆品组合物。

12. 发明申请

WO2007145399A1 ASSOCIATIVE POLYMERIC THICKENER AND SURFACTANT 审中-公开
标题翻译：相关聚合物增稠剂和表面活性剂
公开(公告)号：WO2007145399A1
公开(公告)日：2007-12-21
申请号：PCT/KR2006/004470
申请日：2006-10-31
申请人： AMOREPACIFIC CORPORATION , KIM, Do Hoon , KIM, Yong Jin , PARK, Chang Man , KIM, Jin Woong , KIM, Jun Oh , KIM, Chae Wook
发明人： KIM, Do Hoon , KIM, Yong Jin , PARK, Chang Man , KIM, Jin Woong , KIM, Jun Oh , KIM, Chae Wook
IPC分类号： C08G69/02
CPC分类号： C08G69/44 , A61K8/88 , A61K2800/52 , A61Q19/00 , C08G18/10 , C08G18/4833 , C08G18/755 , C08G18/2825
摘要： Disclosed herein are the use as a thickener and surfactant of an associative polymer represented by formula 1, and a cosmetic composition containing the polymer as an active ingredient. More specifically, disclosed are the use as a thickener and surfactant of the associative polymer (formula 1), which is obtained by allowing a polyisocyanate compound represented by R 2 - (NCO) 2 to react with polyethylene glycol HO(CH 2 CH 2 O) n CH 2 CH 2 OH (n= 100-3000), and then allowing the reaction product to react with a monoalcohol represented by R 1 -OH, as well as the use of the associative polymer as a surfactant, and a cosmetic composition containing the associative polymer as an active ingredient. Because the associative polymer represented by formula 1 has hydrophilic and lipophilic groups, it can be used alone to prepare an emulsion. In addition, because the associative polymer can maintain viscosity even in conditions of various pHs and salts, the use of the associative polymer as an active ingredient makes it possible to prepare an excellent cosmetic composition, which is stable and shows no decrease in viscosity.
摘要翻译：本文公开了用作由式1表示的缔合聚合物的增稠剂和表面活性剂以及含有聚合物作为活性成分的化妆品组合物的用途。更具体地，公开了作为缔合聚合物（式1）的增稠剂和表面活性剂的用途，其通过使由R 2 - （NCO）2表示的多异氰酸酯化合物（NCO）使其与聚乙二醇HO（CH 2 CH 2 CH 2）2反应， 2 OH（n = 100-3000），然后使反应产物与由R 1 -OH表示的一元醇反应，以及使用缔合聚合物作为表面活性剂和含有缔合聚合物作为有效成分的化妆品组合物。由于由式1表示的缔合聚合物具有亲水性和亲油性基团，因此可单独使用以制备乳液。此外，由于缔合聚合物即使在各种pH和盐的条件下也能保持粘度，所以使用缔合聚合物作为活性成分使得可以制备稳定且粘度不降低的优异的化妆品组合物。

13. 发明申请

WO2004106534A1 THE ENZYMATIC METHOD OF MAKING 1,2-DIOL DERIVATIVES AND THEIR ESTERS WITH SUCCINE ANHYDRIDE 审中-公开
标题翻译：制备1,2-二醇衍生物的方法及其与无水异氰酸酯的酯化
公开(公告)号：WO2004106534A1
公开(公告)日：2004-12-09
申请号：PCT/KR2004/001313
申请日：2004-06-02
申请人： ENZYTECH, LTD. , HWANG, Soon Ook , KIM, Do Hoon , RYU, Hye Youn , LEE, Tae Im , CHUNG, Sun Ho
发明人： HWANG, Soon Ook , KIM, Do Hoon , RYU, Hye Youn , LEE, Tae Im , CHUNG, Sun Ho
IPC分类号： C12P41/00
CPC分类号： C12P7/62 , C12P7/04 , C12P41/004
摘要： The present invention relates to a new process for the preparation of optically active alcohols represented by the general formula 2 and their esters represented by the general formula 3 in scheme 1. In more detail, this invention relates to the process for the preparation of optically active alcohols and their esters which are used as pharmaceutical intermediates by reacting the hydroxyl group stereospecifically by lipase after adding racemic alcohols represented by the general formula 1 and succinic anhydride as an acylating agent to the organic solvent. According to this invention, the primary hydroxyl group of 1,2-diols is transformed by other functional group and the secondary hydroxyl group is esterified stereospecifically with succinic anhydride as an acylating agent. Optically active alcohols and their esters of high optical purity in high yield can be produced by using succinic anhydride as an acylating agent because alcohols can be separated from their esters more easily than those of other conventional methods.
摘要翻译：本发明涉及制备由通式2表示的光学活性醇的新方法及其在方案1中由通式3表示的酯。更详细地说，本发明涉及制备光学活性的方法醇和它们的酯，其通过在将通式1表示的外消旋醇和琥珀酸酐作为酰化剂加入到有机溶剂中之后通过脂肪酶立体特异性地使羟基反应而用作药物中间体。根据本发明，1,2-二醇的伯羟基被其它官能团转变，仲羟基与琥珀酸酐作为酰化剂立体特异性酯化。通过使用琥珀酸酐作为酰化剂可以生产高产率的高光学纯度的光学活性醇及其酯，因为与其它常规方法相比，可以更容易地将醇与其酯分离。

14. 发明申请

WO2004097026A1 THE ENZYMATIC METHOD OF MAKING 1,2-DIOL DERIVATIVES AND THEIR ESTERS 审中-公开
标题翻译：制备1,2-二醇衍生物及其酯的方法
公开(公告)号：WO2004097026A1
公开(公告)日：2004-11-11
申请号：PCT/KR2004/001005
申请日：2004-04-30
申请人： ENZYTECH, LTD. , HWANG, Soon Ook , KIM, Do Hoon , RYU, Hye Youn
发明人： HWANG, Soon Ook , KIM, Do Hoon , RYU, Hye Youn
IPC分类号： C12P41/00
CPC分类号： C12P7/02 , C12P7/62 , C12P41/004
摘要： The present invention relates to a new process for the preparation of optically active alcohols represented by the general formula 2 and their esters represented by the general formula 3 by enzymatic method from racemic alcohols represented by the general formula 1 in scheme 1. In more details, this invention relates to a process for producing optically active alcohols and their esters which are used as pharmaceutical intermediates from alcohols represented by the general formula 1 by stereospecific transesterification of secondary hydroxyl group using lipases as catalyst with acyl donors in organic solvent or with acyl donors only without using organic solvent. According to this invention, optically active alcohols and esters of high optical purity in high yield can be produced by transforming the primary hydroxyl group of 1,2-diols by tosyl group and transesterifying the secondary hydroxyl group stereospecifically by lipase.
摘要翻译：本发明涉及由方案1中通式1表示的外消旋醇通过酶法由制备由通式2表示的光学活性醇及其由通式3表示的酯的新方法。更具体地，本发明涉及一种用于制备光学活性醇及其酯的方法，其通过使用脂肪酶作为催化剂的有机溶剂中的酰基供体的催化剂或仅与酰基供体的立体特异性酯交换作为由通式1表示的醇用作药物中间体不使用有机溶剂。根据本发明，可以通过将1,2-二醇的伯羟基转化成甲苯磺酰基并通过脂肪酶立体特异性酯交换酯化，可以制备高产率的高光学纯度的光学活性醇和酯。

15. 发明申请

WO2004020561A1 A COMPOSITION FOR DISINFECTING OR WASHING MEDICAL INSTRUMENTS AND A PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：用于消毒或洗涤医疗仪器的组合物及其制备方法
公开(公告)号：WO2004020561A1
公开(公告)日：2004-03-11
申请号：PCT/KR2003/001741
申请日：2003-08-28
申请人： LEE, Jin-Sik , LEE, Jin-Tae , KIM, Do-Hoon , JEONG, Chan-Ho
发明人： LEE, Jin-Sik , LEE, Jin-Tae , KIM, Do-Hoon , JEONG, Chan-Ho
IPC分类号： C11D3/36
CPC分类号： C11D3/042 , C11D3/2075 , C11D3/361 , C11D3/3707 , C11D3/3947
摘要： A composition for disinfecting or cleaning a medical instrument and a preparation process thereof are provided. The composition includes 1.0 to 1.6% by weight of peracetic acid, 0.1 to 20% by weight of acetic acid, 1 to 6% by weight of hydrogen peroxide, 0.1 to 20% by weight of phosphoric acid, 0.1 to 5% by weight of 1, 1-diphosphonic acid, 0.001 to 10% by weight of a surfactant with alcoholic groups at both terminals, and the remainder of the total composition being distilled water, reverse osmosis water or deionized water.
摘要翻译：提供了用于消毒或清洁医疗器械的组合物及其制备方法。该组合物包含1.0至1.6重量％的过乙酸，0.1至20重量％的乙酸，1至6重量％的过氧化氢，0.1至20重量％的磷酸，0.1至5重量％的过氧乙酸 1,1-二膦酸，0.001至10重量％的两端具有醇基的表面活性剂，总组合物的剩余部分为蒸馏水，反渗透水或去离子水。

16. 发明申请

WO2012087062A3 SUSTAINED-RELEASE POLYMERIC MICROPARTICLES CONTAINING POORLY WATER-SOLUBLE DRUG AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：含有水难溶性药物的持续释放型聚合物微粒及其制备方法
公开(公告)号：WO2012087062A3
公开(公告)日：2012-08-23
申请号：PCT/KR2011010030
申请日：2011-12-23
申请人： SAMYANG BIOPHARMACEUTICALS , LEE SA WON , KIM DO HOON , KIM BONG OH , SEO MIN HYO
发明人： LEE SA WON , KIM DO HOON , KIM BONG OH , SEO MIN HYO
IPC分类号： A61K9/16 , A61K9/22 , A61K47/14 , A61K47/36
CPC分类号： A61K47/34 , A01N25/28 , A61K9/1635 , A61K9/1647 , A61K9/1694 , A61K31/175 , A61K31/27 , A61K31/436 , A61K31/485 , A61K31/519 , A61K31/554 , A61K31/565 , A61K31/57
摘要： Disclosed are sustained-release polymeric microparticles containing a poorly water-soluble drug and a method for preparing the same.
摘要翻译：公开了含有难溶于水的药物的持续释放聚合物微粒及其制备方法。

17. 发明申请

WO2012091357A3 COMPOSITION FOR PREVENTION OF NAUSEA OR VOMITING 审中-公开
标题翻译：防止鼻孔或呕吐的组合物
公开(公告)号：WO2012091357A3
公开(公告)日：2012-08-16
申请号：PCT/KR2011009908
申请日：2011-12-21
申请人： SAMYANG BIOPHARMACEUTICALS , SEO MIN HYO , LEE SA WON , KIM DO HOON
发明人： SEO MIN HYO , LEE SA WON , KIM DO HOON
IPC分类号： A61K31/4178 , A61K31/4184 , A61K31/573 , A61P1/08
CPC分类号： A61K31/573 , A61K9/0019 , A61K31/4178 , A61K31/4184 , A61K45/06 , A61K47/12 , A61K2300/00
摘要： Provided is a composition for preventing nausea or vomiting, including a 5-HT3 receptor antagonist and a corticosteroid, and having a pH adjusted to 3.0-6.0. Provided also is a method for preparing a composition for preventing nausea or vomiting, including: mixing a 5-HT3 receptor antagonist with a corticosteroid; and adjusting pH of the mixture obtained from the preceding operation to 3.0-6.0.
摘要翻译：本发明提供一种用于预防恶心或呕吐的组合物，包括5-HT 3受体拮抗剂和皮质类固醇，pH调节至3.0-6.0。还提供了一种制备用于预防恶心或呕吐的组合物的方法，包括：将5-HT 3受体拮抗剂与皮质类固醇混合; 并将从前述操作获得的混合物的pH调节至3.0-6.0。

18. 发明申请

WO2011053007A3 COMPOSITION FOR SUPPRESSING PORE SHRINKAGE OR SEBUM SECRETION WHICH COMPRISES POTENTILLA CHINENSIS EXTRACT 审中-公开
标题翻译：用于抑制含有POTENTILLA CHINENSIS提取物的孔收缩或分布的组合物
公开(公告)号：WO2011053007A3
公开(公告)日：2011-09-29
申请号：PCT/KR2010007465
申请日：2010-10-28
申请人： AMOREPACIFIC CORP , KOH HYUN JU , KIM DO-HOON , PARK WON SEOK , KIM JEONG-HWAN , KIM HYOUNG JUN , SHIN HONG-JU , PARK JONG HEE , YI CHANG-GEUN
发明人： KOH HYUN JU , KIM DO-HOON , PARK WON SEOK , KIM JEONG-HWAN , KIM HYOUNG JUN , SHIN HONG-JU , PARK JONG HEE , YI CHANG-GEUN
IPC分类号： A61K36/73 , A61K8/97 , A61P17/08 , A61Q19/00
CPC分类号： A61K36/73 , A61K8/97 , A61K2800/75 , A61K2800/782 , A61Q19/008 , A61Q19/08
摘要： The present invention relates to a composition for suppressing pore shrinkage or sebum secretion which comprises Potentilla chinensis extract as an active ingredient. The Potentilla chinensis extract which constitutes an active ingredient comprised in the composition according to the present invention has been confirmed to be able to inhibit the formation of complexes of SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) and to inhibit the release of neurotransmitters and can therefore suitably be used as an active ingredient in compositions for suppressing pore shrinkage or sebum secretion.
摘要翻译：本发明涉及一种抑制孔收缩或皮脂分泌的组合物，其包含中华提取物作为活性成分。确认构成根据本发明的组合物的活性成分的中华根植物提取物已被证实能够抑制SNARE（可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体）的复合物的形成并抑制神经递质，因此可适当地用作抑制孔收缩或皮脂分泌的组合物中的活性成分。

19. 发明申请

WO2010010985A1 MULTI-LAYERED LAMELLAR GRANULE AND SKIN EXTERNAL APPLICATION COMPOSITION CONTAINING SAME 审中-公开
标题翻译：多层蓝宝石颗粒和皮肤外用应用组合物
公开(公告)号：WO2010010985A1
公开(公告)日：2010-01-28
申请号：PCT/KR2008/005143
申请日：2008-09-02
申请人： AMOREPACIFIC CORPORATION , KIM, Do Hoon , AN, Eun Jung , HWANG, Jae Sung , SHIN, Hong Ju , PARK, Won Seok , YI, Chang Geun , PARK, Jong Hee , KIM, Jeong Hwan , KIM, Jin Woong , SEO, Jung A , KIM, Yong Jin , SHIM, Jong Won , KIM, Mi Jin
发明人： KIM, Do Hoon , AN, Eun Jung , HWANG, Jae Sung , SHIN, Hong Ju , PARK, Won Seok , YI, Chang Geun , PARK, Jong Hee , KIM, Jeong Hwan , KIM, Jin Woong , SEO, Jung A , KIM, Yong Jin , SHIM, Jong Won , KIM, Mi Jin
IPC分类号： A61K9/16 , A61K45/00 , A61K9/127
CPC分类号： A61K9/5078 , A61K8/0245 , A61K8/68 , A61K9/0014 , A61K9/10 , A61K2800/412 , A61K2800/614 , A61Q19/007
摘要： Provided are: a multi-layered lamellar granule comprising a nucleating agent, a ceramide-containing artificial stratum corneum lipid lamellar layer which encases the nucleating agent and a polymer layer disposed on the artificial stratum corneum lipid lamellar layer; and an external skin application composition comprising the same. The external skin application composition shows improved moisturizing and barrier repair capabilities when applied to the skin, which can be advantageously used in cosmetics and pharmaceuticals.
摘要翻译：提供：包含成核剂，包含成核剂的含神经酰胺的人造角质层脂质层层和设置在人造角质层脂层上的聚合物层的多层片状颗粒; 和包含其的外用皮肤应用组合物。外用皮肤应用组合物在施用于皮肤时显示改善的保湿和屏障修复能力，其可有利地用于化妆品和药物中。

20. 发明申请

WO2009041789A2 NOVEL 3-CHLORO-5-SUBSTITUTED-QUINOXALINE-2-AMINE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARATION, THERAPEUTIC AGENT FOR INFLAMMATORY DISEASE INDUCED BY SPC ACTIVITY CONTAINING 3-CHLORO-5-SUBSTITUTED-QUINOXALINE-2-AMINE DERIVATIVES AS AN EFFECTIVE INGREDIENT 审中-公开
标题翻译：新型3-氯代-5-取代的喹喔啉-2-胺衍生物及其药学上可接受的盐，其制备方法，由含有3-氯代 - 喹啉-2-胺的SPC活性诱导的炎症疾病的治疗剂
公开(公告)号：WO2009041789A2
公开(公告)日：2009-04-02
申请号：PCT/KR2008/005725
申请日：2008-09-26
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , AMOREPACIFIC CORPORATION , GONG, Young-Dae , CHO, Heeyeong , JEON, Moon-Kook , LEE, Taeho , CHOI, Gildon , KONG, Jae-Yang , PARK, Woo-Kyu , HWANG, Soon-Hee , KIM, Jung Ju , LEE, Chang-hoon , KO, Jaeyoung , NOH, Minsoo , HAN, Eun Sil , KIM, Hyuk , YUN, Jun-Won , MOH, Joo Hyun , KIM, Do Hoon
发明人： GONG, Young-Dae , CHO, Heeyeong , JEON, Moon-Kook , LEE, Taeho , CHOI, Gildon , KONG, Jae-Yang , PARK, Woo-Kyu , HWANG, Soon-Hee , KIM, Jung Ju , LEE, Chang-hoon , KO, Jaeyoung , NOH, Minsoo , HAN, Eun Sil , KIM, Hyuk , YUN, Jun-Won , MOH, Joo Hyun , KIM, Do Hoon
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： Provided are a 3-chloro-5-substiuted-quinoxalin-2-amine derivative represented by the following Chemical Formula 1, a pharmaceutically acceptable salt thereof, a method for preparation thereof, and a use thereof as an effective ingredient in a therapeutic agent for inflammatory disease induced by activity of sphingosyl phosphorylcholine (SPC) receptor. The 3-chloro-5-substiuted-quinoxalin-2-amine derivative of the present invention has been confirmed to have superior inhibition activity against SPC receptor in an animal experiment using human-derived endothelial cells and mice. Thus, a therapeutic agent for inflammatory disease containing the 3- chloro-5-substiuted-quinoxalin-2-amine derivative or a pharmaceutically acceptable salt thereof as an effective ingredient may be useful for treating inflammation, itching or skin infection associated with atopic dermatitis or other disease induced by activity of SPC receptor.
摘要翻译：本发明提供由以下化学式1表示的3-氯-5-取代喹喔啉-2-胺衍生物，其药学上可接受的盐，其制备方法及其作为治疗剂的有效成分的用途由鞘氨醇磷酰胆碱（SPC）受体活性引起的炎性疾病。在使用人源性内皮细胞和小鼠的动物实验中，已经证实本发明的3-氯-5-取代喹喔啉-2-胺衍生物对SPC受体具有优异的抑制活性。因此，含有3-氯-5-取代的喹喔啉-2-胺衍生物或其药学上可接受的盐作为有效成分的炎性疾病治疗剂可用于治疗与特应性皮炎相关的炎症，瘙痒或皮肤感染或其他由SPC受体活性引起的疾病。

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