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11. 发明申请

WO2007128987A3 THERAPY TARGETING CATHEPSIN S 审中-公开
公开(公告)号：WO2007128987A3
公开(公告)日：2007-11-15
申请号：PCT/GB2007/001312
申请日：2007-04-10
申请人： FUSION ANTIBODIES LIMITED , OLWILL, Shane , SCOTT, Christopher , GORMLEY, Julie , THOMAS, Jaquin , BURDEN, Roberta , MCMEEL, Darragh , JOHNSTON, James
发明人： OLWILL, Shane , SCOTT, Christopher , GORMLEY, Julie , THOMAS, Jaquin , BURDEN, Roberta , MCMEEL, Darragh , JOHNSTON, James
IPC分类号： C07K16/28 , C07K16/40 , A61K39/395 , A61K31/00 , A61P35/00 , G01N33/573 , C12N9/54
摘要： The invention relates to a method of inhibiting chemotherapy induced upregulation of Cathepsin S on the surface of tumour cells, the method comprising the administration of a Cathepsin S inhibitor to said cells. Also provided is a therapy comprising an anti Cathepsin S antibody, in particular an anti-Cathepsin S antibody which does not inhibit the proteolytic effect of Cathepsin S but nevertheless inhibits angiogenesis and a combination treatment comprising a Cathepsin S inhibitor and a therapeutic agent.

12. 发明申请

WO2006078176A1 NANO-STRUCTURED SILICATE, FUNCTIONALISED FORMS THEREOF, PREPARATION AND USES 审中-公开
标题翻译：纳米结构硅酸盐，其功能形式，制备和使用
公开(公告)号：WO2006078176A1
公开(公告)日：2006-07-27
申请号：PCT/NZ2006/000003
申请日：2006-01-17
申请人： VICTORIA LINK LIMITED , JOHNSTON, James, Howard , MCFARLANE, Andrew, James , BORRMANN, Thomas
发明人： JOHNSTON, James, Howard , MCFARLANE, Andrew, James , BORRMANN, Thomas
IPC分类号： C01B33/24
CPC分类号： C01B33/24 , B01D53/02 , B01D2253/106 , B01D2257/60 , B01J20/10 , B01J20/28007 , B82Y30/00 , C01P2004/03 , C01P2006/12 , C01P2006/19 , C01P2006/82 , C09C1/0018 , C09C1/28 , Y02W10/37 , Y10T428/259
摘要： This invention relates to the preparation, functionalisation and use of a novel nano structured silicate, generally a calcium silicate which may be hydrated. It also relates to novel methods of producing nano structured silicates. The novel nano-structured silicate material comprises a calcium silicate in the form of platelets of about 5-10 nm thick and about 50-500 nm wide or wider stacked together in a poorly ordered framework type structure as illustrated in Figure 1. The novel material can be prepared by reacting a calcium ion containing solution with a silicate containing solution under controlled conditions and then allowing the calcium silicate to age. The novel silicate has pores of a high volume and which are readily accessible. This provides a high oil absorption capacity and high surface area. Novel nano-structured silicate materials are produced by the invention having an oil absorption capacity up to 700g.oil.100g -1 silicate and a surface area up to 600m2g -1 . The novel material can be functionalised to yield a material having a variety of uses.
摘要翻译：本发明涉及新型纳米结构硅酸盐的制备，官能化和用途，通常为可水合的硅酸钙。它还涉及生产纳米结构硅酸盐的新方法。新型纳米结构的硅酸盐材料包括如图1所示的具有约5-10nm厚和约50-500nm宽或更宽的血小板形式的硅酸钙，其以非常有序的骨架类型结构堆叠在一起。该新型材料可以通过使含钙离子的溶液与含硅酸盐的溶液在受控条件下反应然后使硅酸钙老化来制备。新型硅酸盐具有大体积的孔，并且易于接近。这提供了高吸油能力和高表面积。通过本发明生产新型纳米结构硅酸盐材料，其吸油能力高达700g·0.01g-1硅酸盐，表面积高达600m2g -1 -1。该新型材料可以被功能化以产生具有多种用途的材料。

13. 发明申请

WO2005049818A3 GENES ENCODING HUMAN DEUBIQUITINATING ENZYMES 审中-公开
标题翻译：编码人体免疫酶的基因
公开(公告)号：WO2005049818A3
公开(公告)日：2006-01-05
申请号：PCT/GB2004004820
申请日：2004-11-12
申请人： UNIV BELFAST , BURROWS JAMES , MCGRATTAN MICHAEL , JOHNSTON JAMES
发明人： BURROWS JAMES , MCGRATTAN MICHAEL , JOHNSTON JAMES
IPC分类号： C12N9/48 , C12N15/12 , G01N33/53
CPC分类号： C12N9/48
摘要： Described is a novel human deubiquitinating enzyme, DUB-3, (SEQ ID NO: 1), and variants and fragments thereof. Also described are nucleic acid molecules encoding the enzyme, and use of the polypeptide and nucleic acid molecules in treatment of cancer, assays.
摘要翻译：描述了一种新的人类去泛素化酶DUB-3（SEQ ID NO：1）及其变体和片段。还描述了编码该酶的核酸分子，以及多肽和核酸分子在癌症治疗中的应用。

14. 发明申请

WO2005038528A3 METHOD OF COATING A MULTILAYERED ELEMENT 审中-公开
标题翻译：涂层多层元件的方法
公开(公告)号：WO2005038528A3
公开(公告)日：2005-09-01
申请号：PCT/US2004033751
申请日：2004-10-12
申请人： EASTMAN KODAK CO , YAU HWEI-LING , JOHNSTON JAMES LYNN , WANG YONGCAI , PAWLAK JOHN LAWRENCE , AXTELL DOUGLAS HALTON
发明人： YAU HWEI-LING , JOHNSTON JAMES LYNN , WANG YONGCAI , PAWLAK JOHN LAWRENCE , AXTELL DOUGLAS HALTON
IPC分类号： G03C1/00 , G03C1/74 , G03F7/09 , G03F7/16
CPC分类号： G03C1/74 , G03C1/002 , G03C2001/7492 , G03C2200/60 , Y10S430/136
摘要： This invention relates to a method of coating multiple layers on a support comprising a) taking a support; b) simultaneously coating on said support a chill settable layer and a non-chill settable layer; c) lowering the temperature of the layers to immobilize said layers; and d) drying said layers. It further relates to imaging elements made by this process.
摘要翻译：本发明涉及一种在支撑体上涂覆多层的方法，包括：a）承载; b）同时在所述支撑体上涂覆冷却可固化层和非冷却可固化层; c）降低层的温度以固定所述层; 和d）干燥所述层。它还涉及通过该方法制造的成像元件。

15. 发明申请

WO2004046452A3 FORMULIERUNGEN ZUR OBERFLÄCHENBEHANDLUNG VON SUBSTRATEN 审中-公开
公开(公告)号：WO2004046452A3
公开(公告)日：2004-06-03
申请号：PCT/EP2003/050772
申请日：2003-10-31
申请人： GE BAYER SILICONES GMBH & CO. KG , LANGE, Horst , ROOS, Christopher , WAGNER, Roland , KROPFGANS, Martin , GRAYDON, Andrew, Russell , HARTSHORN, Richard, Timothy , BOUTIQUE, Jean-Pol , DELPLANQUE, Patrick, Firmin, August , JOHNSTON, James, Pyott
发明人： LANGE, Horst , ROOS, Christopher , WAGNER, Roland , KROPFGANS, Martin , GRAYDON, Andrew, Russell , HARTSHORN, Richard, Timothy , BOUTIQUE, Jean-Pol , DELPLANQUE, Patrick, Firmin, August , JOHNSTON, James, Pyott
IPC分类号： D06M15/643
摘要： Die Erfindung betrifft Formulierungen enthaltend mindestens eine stickstofffreie Polysiloxan-Verbindung, mindestens eine Polyamino- und/oder Polyammonium-Polysiloxan-Verbindung und/oder mindestens eine Amino- und/oder Ammonium-Polysiloxan-Verbindung, sowie gegebenenfalls ein silikonfreies kationisches Tensid, einen Koazervatphasenbildner und Trägersubstanzen, ein Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von natürlichen und synthetischen faserartigen Materialien.

16. 发明申请

WO2004041912A1 LINEARE POLYAMINO- UND/ODER POLYAMMONIUM-POLYSILOXANCOPOLYMERE I 审中-公开
标题翻译： LINEAR聚和/或铵 - 聚硅氧烷我
公开(公告)号：WO2004041912A1
公开(公告)日：2004-05-21
申请号：PCT/EP2003/050775
申请日：2003-10-31
申请人： GE BAYER SILICONES GMBH & CO. KG , LANGE, Horst , WITOSSEK, Anita , WAGNER, Roland , STACHULLA, Karl-Heinz , GRAYDON, Andrew, Russell , HARTSHORN, Richard, Timothy , BOUTIQUE, Jean-Pol , DELPLANQUE, Patrick, Firmin, August , JOHNSTON, James, Pyott , SOCKEL, Karl-Heinz
发明人： LANGE, Horst , WITOSSEK, Anita , WAGNER, Roland , STACHULLA, Karl-Heinz , GRAYDON, Andrew, Russell , HARTSHORN, Richard, Timothy , BOUTIQUE, Jean-Pol , DELPLANQUE, Patrick, Firmin, August , JOHNSTON, James, Pyott , SOCKEL, Karl-Heinz
IPC分类号： C08G77/54
CPC分类号： A61Q19/00 , A61K8/898 , A61Q5/02 , A61Q19/10 , C08G73/02 , C08G73/0226 , C08G73/0273 , C08G73/0616 , C08G73/0633 , C08G77/54 , C11D3/3723 , C11D3/3742 , D06M15/6436 , D06M2200/20
摘要： Die Erfindung betrifft lineare Polyamino- und/oder Polyammonium- Polysiloxancopolymere, insbesondere hydrophile polyquaternäre Polysiloxancopolymere und deren Verwendung in kosmetischen Formulierungen, in Waschmitteln oder zur Oberflächenbehandlung von Substraten.
摘要翻译：本发明涉及一种线性聚和/或多铵聚硅氧烷共聚物，特别是聚季亲水聚硅氧烷共聚物和它们在化妆品制剂中使用时，在衣物洗涤剂或用于表面处理的基板。

17. 发明申请

WO0248039A8 CATALYSTS AND THE HYDROFORMYLATION OF OLEFINS 审中-公开
标题翻译：催化剂和烯烃的加氢反应
公开(公告)号：WO0248039A8
公开(公告)日：2002-07-18
申请号：PCT/NZ0100280
申请日：2001-12-12
申请人： VICTORIA LINK LTD , BORRMANN THOMAS , JOHNSTON JAMES HOWARD
发明人： BORRMANN THOMAS , JOHNSTON JAMES HOWARD
IPC分类号： B01J21/08 , B01J23/02 , B01J23/46 , B01J31/22 , C07C45/50 , C01B33/46 , B01J23/58 , B01J23/60 , B01J23/62
CPC分类号： B01J31/1616 , B01J21/08 , B01J23/02 , B01J23/464 , B01J31/1683 , B01J31/223 , B01J31/26 , B01J31/30 , B01J31/4046 , B01J2231/321 , B01J2531/56 , B01J2531/62 , B01J2531/64 , B01J2531/72 , B01J2531/822 , B01J2531/842 , B01J2531/845 , C07C45/50 , Y02P20/584 , C07C47/02
摘要： The invention discloses novel homogeneous catalysts for hydroformylation reactions comprising or including: a) a substantially amorphous silicate host, and b) a plurality of metal cationic species (preferably Rh(III) species) capable of catalysing a hydroformylation reaction, coordinated or otherwise bound to the host. The invention also discloses methods for making such a catalyst and applications for the catalyst.
摘要翻译：本发明公开了用于加氢甲酰基化反应的新型均相催化剂，其包含或包括：a）基本无定形的硅酸盐主体，和b）能够催化加氢甲酰化反应的多种金属阳离子物质（优选Rh（III）），其协同或以其他方式结合主人。本发明还公开了制备这种催化剂的方法和催化剂的应用。

18. 发明申请

WO1997025841A1 COMPONENT FOR AND METHOD OF MAKING COPPER CLAD SUBSTRATES 审中-公开
标题翻译：制造铜箔基板的组件和方法
公开(公告)号：WO1997025841A1
公开(公告)日：1997-07-17
申请号：PCT/US1997000216
申请日：1997-01-06
申请人： JOHNSON & JOHNSTON ASSOCIATES, INC. , JOHNSTON, James, A. , BURGUN, Albert, H.
发明人： JOHNSON & JOHNSTON ASSOCIATES, INC.
IPC分类号： H05K03/02
CPC分类号： B32B37/06 , B32B2309/60 , B32B2457/08 , H05K3/0097 , H05K3/022 , H05K3/4611
摘要： A component (30) is disclosed for use in manufacturing articles such as printed circuit boards which comprises a laminate constructed of two sheets of copper foil (33, 35) which, in a finished printed circuit board, constitutes functional elements and a sheet of aluminum (31) which constitutes a discardable element. One surface of each of the copper sheets and both surfaces of the aluminum sheet are essentially uncontaminated and engagable with each other at interfaces. Each of the uncontaminated interfaces of the sheets have central zones inwardly of the edges of the sheets. A margin on each of the copper foil sheets extends beyond each of two edges of the aluminum sheet. Adhesive (40) is located between the sheets outwardly of the central zones to maintain the essentially uncontaminated character of the central zones. The margins of the copper sheets are electrically joined (83) in a pattern such that when there are a multiplicity of components assembled with dielectric material in a book to make printed circuit boards and when electric current is passed through the copper sheets, the book is heated uniformly to melt and cure the resin.
摘要翻译：公开了用于制造诸如印刷电路板的制品的部件（30），该印刷电路板包括由两片铜箔（33,35）构成的层叠体，该铜箔在成品印刷电路板中构成功能元件和一片铝（31）构成可废弃元件。每个铜板的一个表面和铝板的两个表面基本上没有污染并且在界面处彼此可接合。片材的每个未污染的界面在片材边缘的内侧具有中心区域。每个铜箔片上的边缘延伸超过铝板的两个边缘中的每一个。粘合剂（40）位于中央区域之外的片材之间，以保持中央区域基本上没有污染的特征。铜片的边缘以图案电连接（83），使得当一本书中有多个与电介质材料组装的部件以制造印刷电路板时，并且当电流通过铜片时，该书是均匀加热熔融固化树脂。

19. 发明申请

WO1995020032A1 DETERGENT COMPOSITIONS INHIBITING DYE TRANSFER 审中-公开
标题翻译：洗涤剂组合物抑制转染
公开(公告)号：WO1995020032A1
公开(公告)日：1995-07-27
申请号：PCT/US1995000626
申请日：1995-01-13
申请人： THE PROCTER & GAMBLE COMPANY , FREDJ, Abdennaceur , WILLEY, Alan, David , JOHNSTON, James, Pyott , HARDY, Frederick, Edward , THOEN, Christiaan, Arthur, Jacques, Kamiel
发明人： THE PROCTER & GAMBLE COMPANY
IPC分类号： C11D03/37
CPC分类号： C11D3/3792 , C11D3/0021
摘要： A dye transfer inhibiting composition comprising a mixture of polyamine N-oxide polymers having a low and high oxidation degree, said polyamine N-oxide polymers containing units having structural formula (I), wherein P is a polymerisable unit, whereto the N-O group can be attached to or wherein the N-O group forms part of the polymerisable unit. A is (a), (b), (c), -O-, -S-, (d); x is 0 or 1; R are aliphatic, ethoxylated, aliphatic, aromatic, heterocyclic or alicyclic groups whereto the nitrogen of the N-O group can be attached or wherein the nitrogen of the N-O group is part of these groups.
摘要翻译：一种染料转移抑制组合物，其包含具有低和高氧化度的聚胺N-氧化物聚合物的混合物，所述聚胺N-氧化物聚合物含有结构式（I）的单元，其中P是可聚合单元，其中NO基团可以是附着于或其中NO基团形成可聚合单元的一部分。 A是（a），（b），（c），-O - ， - S - ，（d） x为0或1; R是脂族，乙氧基化，脂族，芳族，杂环或脂环族基团，其中N-O基团的氮可以连接或其中N-O基团的氮是这些基团的一部分。

20. 发明申请

WO1994011479A1 DETERGENTS CONTAINING NON-IRON METALLOCATALYST AND BLEACH TO INHIBIT DYE TRANSFER IN WASHING 审中-公开
标题翻译：含有非铁金属化合物的洗涤剂和漂洗剂可以在洗涤中抑制转染
公开(公告)号：WO1994011479A1
公开(公告)日：1994-05-26
申请号：PCT/US1993010548
申请日：1993-11-03
申请人： THE PROCTER & GAMBLE COMPANY , FREDJ, Abdennaceur , BUSCH, Alfred , CONVENTS, Andre, Christian , JOHNSTON, James, Pyott , LABEQUE, Regine , THOEN, Christiaan, Arthur, J., K.
发明人： THE PROCTER & GAMBLE COMPANY
IPC分类号： C11D03/28
CPC分类号： C11D3/3932 , C11D3/0021
摘要： A non-iron metallocatalyst selected from a) non-iron metalloporphin and water-soluble or water-dispersable derivatives thereof; b) non-iron metalloporphyrin and water-soluble or water-dispersable derivatives thereof; c) non-iron metallophthalocyanine and water-soluble or water-dispersable derivatives thereof; an efficient amount of a quick releasing bleaching agent, the bleaching agent being in such form that it is released into the wash solution within the first five minutes after the composition has been dissolved or dispersed in water.
摘要翻译：一种非铁金属催化剂，其选自：a）非铁金属蛋白酶及其水溶性或水分散性衍生物; b）非铁金属卟啉及其水溶性或水分散性衍生物; c）非铁金属酞菁及其水溶性或水分散性衍生物; 有效量的快速释放漂白剂，漂白剂的形式使得其在组合物溶解或分散在水中之后的最初五分钟内释放到洗涤溶液中。

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