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11. 发明申请

WO2012170677A1 METHODS OF TREATMENT 审中-公开
标题翻译：治疗方法
公开(公告)号：WO2012170677A1
公开(公告)日：2012-12-13
申请号：PCT/US2012/041333
申请日：2012-06-07
申请人： PARION SCIENCES, INC. , BOUCHER, Richard , JOHNSON, Michael Ross , THELIN, William R. , BUTTON, Brian , NAVRATIL, Tomas
发明人： BOUCHER, Richard , JOHNSON, Michael Ross , THELIN, William R. , BUTTON, Brian , NAVRATIL, Tomas
IPC分类号： A61K9/12
CPC分类号： A61M11/003 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61M11/002 , A61M11/005 , A61M11/06 , A61M15/0085 , A61M15/0086 , A61M16/0057 , A61M16/06 , A61M16/0666 , A61M16/12 , A61M16/14 , A61M16/16 , A61M2202/0275 , A61M2206/14 , A61M2206/16
摘要： Methods, compositions and apparatus for administering active agents to the lungs of a subject. A method of enhancing mucus clearance from the lungs of a subject in need thereof, comprising: administering an osmolyte to airway surfaces of the lungs of said subject in an amount (i) sufficient to hydrate said lung airway mucus secretions and (ii) insufficient to substantially dehydrate lung airway epithelial cells there beneath, said administering step being carried out and for a time sufficient to enhance mucus clearance from the lungs of said subject. In some embodiments, the administering step is carried out by administering said subject an aerosol comprising said osmolyte such as saline or hypertonic saline.
摘要翻译：用于向受试者的肺部施用活性剂的方法，组合物和装置。一种提高有需要的受试者肺部粘液清除率的方法，其特征在于包括：向所述受试者肺部的气道表面施用量足以使所述肺呼吸道粘液分泌物水合的量（i）基本上脱水下面的肺气道上皮细胞，所述施用步骤进行并足以增强从所述受试者的肺部的粘液清除的时间。在一些实施方案中，施用步骤通过对所述受试者施用包含所述渗透液的气溶胶，例如盐水或高渗盐水进行。

12. 发明申请

WO2012149223A2 COMPOSITE CODE WITH DYNAMIC LINKING TO INTERNET ADDRESSES 审中-公开
标题翻译：具有动态链接到互联网地址的复合代码
公开(公告)号：WO2012149223A2
公开(公告)日：2012-11-01
申请号：PCT/US2012/035303
申请日：2012-04-26
申请人： JOHNSON, Michael
发明人： JOHNSON, Michael
IPC分类号： G06K9/18 , G06K7/10
CPC分类号： G06F17/30887 , G06Q30/02 , G06Q50/16
摘要： A composite code 202 is created from an image and a tag that is searchable by an Internet search engine. The composite code 202 is dynamically linked to one or more of a plurality of Internet addresses. When data about a composite code 202 is received from a user computing device 116, one of the linked Internet addresses is selected based on a predetermined rule and sent back to the user computing device 116.
摘要翻译：从图像和可由因特网搜索引擎搜索的标签创建复合代码202。复合代码202动态链接到多个因特网地址中的一个或多个。当从用户计算设备116接收关于复合代码202的数据时，基于预定规则来选择所链接的因特网地址之一，并将其发送回用户计算设备116。

13. 发明申请

WO2012112261A3 SAND SCREEN, EXPANDABLE SCREEN AND METHOD OF MAKING 审中-公开
标题翻译： SAND屏幕，可扩展屏幕和制作方法
公开(公告)号：WO2012112261A3
公开(公告)日：2012-10-26
申请号：PCT/US2012022318
申请日：2012-01-24
申请人： BAKER HUGHES INC , GUEST RANDALL V , JOHNSON MICHAEL H , HUBER KIRK J
发明人： GUEST RANDALL V , JOHNSON MICHAEL H , HUBER KIRK J
IPC分类号： B01D39/02 , B01D29/11 , B01D35/02 , B01D39/10 , B01D39/14
CPC分类号： B21F27/18 , B01D39/12 , B21F45/008
摘要： An expandable screen includes, a body constructed of one or more strands of a shape memory material randomly distributed in a mat structure, the body is stable at a first volume and expandable to a second volume upon a change in environment.
摘要翻译：可膨胀屏幕包括由随机分布在垫结构中的形状记忆材料的一股或多股构成的主体，所述身体在第一体积下是稳定的，并且在环境变化时可扩展到第二体积。

14. 发明申请

WO2012112246A2 POLYMERIC COMPONENT AND METHOD OF MAKING 审中-公开
标题翻译：聚合物组分和制备方法
公开(公告)号：WO2012112246A2
公开(公告)日：2012-08-23
申请号：PCT/US2012/021273
申请日：2012-01-13
申请人： BAKER HUGHES INCORPORATED , GUEST, Randall V. , JOHNSON, Michael H. , HUBER, Kirk J.
发明人： GUEST, Randall V. , JOHNSON, Michael H. , HUBER, Kirk J.
IPC分类号： D04H3/16 , D04H3/14 , D04H3/10
CPC分类号： B32B5/02 , B32B27/12 , D04H3/12 , D04H3/14 , D04H3/16 , Y10T428/2481
摘要： A method of making a polymeric component includes, extruding one or more strands of a polymer, halting curing of the one or more strands, forming a mat with the extruded one or more strands, bonding the one or more strands to one another at points of contact therebetween, and curing the one or more strands.
摘要翻译：制造聚合物组分的方法包括挤出一股或多股聚合物，停止一根或多根股线的固化，用挤出的一根或多根股线形成垫子，将一根或多根股线粘合或在它们之间的接触点处彼此更多的股线，以及固化一个或多个股线。

15. 发明申请

WO2012092119A1 GEL SEALING CORROSION PREVENTION TAPE 审中-公开
标题翻译： GEL密封防腐胶带
公开(公告)号：WO2012092119A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/066806
申请日：2011-12-22
申请人： 3M INNOVATIVE PROPERTIES COMPANY , JOHNSON, Michael A. , FALTEISEK, Steven L.
发明人： JOHNSON, Michael A. , FALTEISEK, Steven L.
IPC分类号： C08G18/28 , C08G18/79 , C08G18/69 , C08K7/28 , C08K9/06
CPC分类号： C09J109/00 , C08F136/06 , C08G18/2825 , C08G18/69 , C08G18/792 , C08G2190/00 , C08K7/28 , C08K9/06 , C08L75/14
摘要： A deformable tacky polyurethane polymer is provided which is the reaction product of a polyisocyanate, a polyol, and a mono-hydroxy tackifier. In addition, compositions pare provided comprising a polymer according to the present diclosure and one or more of: surface modified silica nanoparticles, glass bubbles and fiber filler particles. In addition, a flexible gasketing tape is provided comprising a polymer according to the present disclosure or a composition according to the present disclosure.
摘要翻译：提供了可变形的粘性聚氨酯聚合物，其是多异氰酸酯，多元醇和单羟基增粘剂的反应产物。此外，提供的组合物包含根据本说明书的聚合物和一种或多种：表面改性的二氧化硅纳米颗粒，玻璃泡和纤维填料颗粒。此外，提供了柔性衬垫带，其包括根据本公开的聚合物或根据本公开的组合物。

16. 发明申请

WO2012082576A1 INTERPENETRATED POLYMER LAYER 审中-公开
标题翻译：嵌入式聚合物层
公开(公告)号：WO2012082576A1
公开(公告)日：2012-06-21
申请号：PCT/US2011/064318
申请日：2011-12-12
申请人： 3M INNOVATIVE PROPERTIES COMPANY , JOHNSON, Michael A. , GALUSH, Thomas B. , KORBA, Gary A. , SETH, Jayshree , KUMAR, Kanta
发明人： JOHNSON, Michael A. , GALUSH, Thomas B. , KORBA, Gary A. , SETH, Jayshree , KUMAR, Kanta
IPC分类号： C08J7/16
CPC分类号： C08J7/04 , C08J7/047 , C08J7/16 , C08J2375/04 , C08J2433/00 , C08J2483/04 , Y02P20/582 , Y10T428/24802 , Y10T428/2495 , Y10T428/265
摘要： Structures having an interpenetrated polymer layer are described. The interpenetrating layer (230) comprises a mixture of a first component (211) and a second component (212), wherein the concentrations of the first component and the second component vary inversely across the thickness of the interpenetrating layer. Both interpenetrated surface layers (210, 220) and interpenetrated bonding layers (230) are described. Methods of forming an interpenetrated layer are also disclosed.
摘要翻译：描述了具有互穿聚合物层的结构。互穿层（230）包括第一组分（211）和第二组分（212）的混合物，其中第一组分和第二组分的浓度跨越互穿层的厚度反向变化。描述了互穿表面层（210,220）和互穿结合层（230）。还公开了形成互穿层的方法。

17. 发明申请

WO2012061696A1 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS 审中-公开
标题翻译：作为PI3K-DELTA抑制剂的5-氰基-4,6-二氨基嘧啶或6-氨基嘌呤衍生物
公开(公告)号：WO2012061696A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/059309
申请日：2011-11-04
申请人： AMGEN INC. , FISHER, Benjamin , JOHNSON, Michael G. , LUCAS, Brian , SHIN, Youngsook , KAIZERMAN, Amy
发明人： FISHER, Benjamin , JOHNSON, Michael G. , LUCAS, Brian , SHIN, Youngsook
IPC分类号： C07D401/12 , C07D401/14 , C07D473/34 , C07D239/48 , C07D403/12 , A61K31/506 , A61K31/52 , A61K31/505 , A61P29/00 , A61P19/02 , A61P35/00 , A61P37/00
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D473/34
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention aLso enables methods for treating cancers that are mediated, dependent on or associated with pi 105 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo- dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译：取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状本发明aLso 包括但不限于白血病，如急性骨髓性白血病（AML）骨髓增生异常综合征（MDS）骨髓增殖性疾病（MPD）慢性骨髓性白血病（CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

18. 发明申请

WO2012005979A3 WELLBORE CENTRALIZER FOR TUBULARS 审中-公开
标题翻译：井式集中器用于管件
公开(公告)号：WO2012005979A3
公开(公告)日：2012-04-26
申请号：PCT/US2011041789
申请日：2011-06-24
申请人： BAKER HUGHES INC , BARNARD JASON J , HORNER DONALD N , JOHNSON MICHAEL H
发明人： BARNARD JASON J , HORNER DONALD N , JOHNSON MICHAEL H
IPC分类号： E21B17/10
CPC分类号： E21B17/1078 , E21B17/10
摘要： A tubular centralizer is secured to the tubular for run in. The profile for run in is small so that damage to the centralizer is minimized during run in. When the string is in position the centralizer is actuated to change shape or volume to engage the surrounding borehole to centralize the tubular for subsequent operations such as cementing or in the case of screens for gravel packing. The centralizer can be a shape memory material that is initially compressed at above its transition temperature to hold the smaller shape. At the desired location after run in it is brought above the transition temperature and changes back to the original shape or volume to centralize the tubular string. The structure can be spaced ring segments or a cohesive ring structure with an undulating profile or radiating blades to create flow spaces in the annulus where it is deployed for flow of a sealing material or gravel, for example.
摘要翻译：一个管状扶正器固定在管道上以便进入。用于运行的轮廓很小，因此在运行期间对扶正器的损坏最小化。当绳索处于适当位置时，扶正器被致动以改变形状或体积以接合周围钻孔以将管状物集中以用于随后的操作，例如固井或用于砾石充填的筛网。扶正器可以是形状记忆材料，其最初在其转变温度以上被压缩以保持较小的形状。在运行之后，在所需的位置处，其在转变温度以上并且变回到原始形状或体积以集中管柱。例如，该结构可以是具有波状轮廓的间隔环段或粘性环结构或辐射叶片，以便在其中部署用于密封材料或砾石的流动的环形空间中产生流动空间。

19. 发明申请

WO2011112627A8 METHODS, BIOLOGICAL OILS, BIOFUELS, UNITS, AND ORGANISMS RELATED TO USE IN COMPRESSION ENGINES 审中-公开
标题翻译：方法，生物油，生物燃料，单位和与压缩机使用有关的机构
公开(公告)号：WO2011112627A8
公开(公告)日：2012-04-26
申请号：PCT/US2011027610
申请日：2011-03-08
申请人： BP BIOFUELS UK LTD , PFEIFER JOSEPH W III , BEHRENS PAUL W , JOHNSON MICHAEL A , HANSEN JON M , APT KIRK E , BARCLAY WILLIAM R , MARTIN DAVID CHRISTIAN , BORDEN JACOB
发明人： PFEIFER JOSEPH W III , BEHRENS PAUL W , JOHNSON MICHAEL A , HANSEN JON M , APT KIRK E , BARCLAY WILLIAM R , MARTIN DAVID CHRISTIAN , BORDEN JACOB
IPC分类号： C12P7/64 , C12N1/14 , C12N1/16 , C12R1/645 , C12R1/74
CPC分类号： C12R1/645 , C12P7/6463 , C12P7/649 , C12R1/74 , Y02E50/13
摘要： Methods, biological oils, biofuels, units, and/or organisms directed to use in compression engines. A method of producing biological oils includes producing an organism and having the organism consume a feedstock. The organism includes a lipid containing fatty acids. The organism meets or exceeds at least two metrics. The metrics include: A) a eel! density of at least about 115 grams per liter; B) a fatty acid content of at least about 49 percent on a dry mass basis; C) a fatty acid productivity of at least about 15 grams per liter per day; D) a fatty acid yield of at least about 0.175 grams of fatty acids produced per grams of the feedstock consumed; E) a 24 hour peak fatty acid productivity of at least about 30 grams per liter per day: F) an extraction efficiency on a percent of total fatty acid content basis of at least about 50 percent; and/or G) yield of fatty acids on oxygen of more than about 0.4 as grams of fatty acids produced per gram of oxygen consumed basis.
摘要翻译：方法，生物油，生物燃料，单位和/或指导用于压缩发动机的生物。生产生物油的方法包括生产有机体并使生物体消耗原料。生物体包含含脂质的脂肪酸。生物达到或超过至少两个指标。指标包括：A）鳗鱼！至少约115克/升的密度; B）以干质量计至少约49％的脂肪酸含量; C）每天至少约15克/升的脂肪酸生产率; D）每克消耗的原料产生的至少约0.175克脂肪酸的脂肪酸产率; E）每天至少约30克/升的24小时峰值脂肪酸生产率：F）至少约50％的总脂肪酸含量百分比的提取效率; 和/或G）在氧上的脂肪酸的产量大于约0.4，作为克消耗的每克消耗的基础上生产的脂肪酸的克数。

20. 发明申请

WO2012009098A3 BALL SEAT HAVING COLLAPSIBLE HELICAL SEAT 审中-公开
标题翻译：球座具有可折叠螺旋座椅
公开(公告)号：WO2012009098A3
公开(公告)日：2012-04-12
申请号：PCT/US2011040803
申请日：2011-06-17
申请人： BAKER HUGHES INC , KORKMAZ LALE , JOHNSON MICHAEL H , PORTER ANDRE J
发明人： KORKMAZ LALE , JOHNSON MICHAEL H , PORTER ANDRE J
IPC分类号： E21B34/14 , E21B34/06 , E21B34/10
CPC分类号： F16K15/044 , E21B23/04 , F16K15/183 , F16K17/0406
摘要： Apparatuses for restricting fluid flow through a well conduit comprise a tubular member having a helically-shaped seat member disposed within the tubular member. The helically-shaped seat member comprises first and second ends, a first position in which the first and second ends relative to each other to provide a first diameter opening through the helically-shaped seat member for receiving a plug element, and a second position in which the second end is disposed axially below and radially outward relative to the first end to provide a second diameter opening through the helically seat member, the second diameter being greater than the first diameter thereby facilitating the plug element passing through the helically-shaped seat.
摘要翻译：用于限制通过井导管的流体流动的装置包括管状构件，该管状构件具有布置在管状构件内的螺旋形座椅构件。螺旋形座椅构件包括第一端和第二端，第一位置中第一端和第二端相对于彼此以提供穿过螺旋形座构件的第一直径开口以用于接收插塞元件，并且第二位置在第一位置所述第二端相对于所述第一端在轴向下方且径向向外布置，以提供穿过所述螺旋形座部件的第二直径开口，所述第二直径大于所述第一直径，由此便于所述插塞元件穿过所述螺旋形座。

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