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11. 发明申请

WO2012047437A3 TRIAXIAL INDUCTION CALIBRATION WITHOUT PRIOR KNOWLEDGE OF THE CALIBRATION AREA'S GROUND CONDUCTIVITY 审中-公开
标题翻译：未预先知道校准区域的地电导率的三轴感应校准
公开(公告)号：WO2012047437A3
公开(公告)日：2012-07-19
申请号：PCT/US2011050663
申请日：2011-09-07
申请人： BAKER HUGHES INC , PELEGRI LUIS M , MAURER HANS-MARTIN
发明人： PELEGRI LUIS M , MAURER HANS-MARTIN
IPC分类号： E21B47/00 , E21B47/12 , E21B49/00
CPC分类号： G01V13/00
摘要： Disclosed is a method for determining calibration factors of an induction tool that includes three receiver coils, each having a distinct orientation. The method includes: placing the induction logging tool in a first position at a first height above a surface of the earth; performing a first set of measurements of conductivity using the receiver coils with the induction logging tool in the first position at the first height; placing the induction logging tool in a second position at a second height above the surface of the earth; performing a second set of measurements of conductivity using the receiver coils with the induction logging tool in the second position at the second height; and determining the calibration factors that correct conductivity measurements performed by the induction logging tool in a borehole penetrating the earth using the first and second sets of measurements.
摘要翻译：公开了一种用于确定感应工具的校准因子的方法，该感应工具包括三个接收器线圈，每个接收器线圈具有不同的取向。该方法包括：将感应测井工具放置在地球表面上方第一高度的第一位置; 使用具有在第一高度处的第一位置中的感应测井工具的接收器线圈来执行第一组电导率的测量; 将感应测井工具放置在地球表面上方第二高度的第二位置; 使用所述感应测井工具在所述第二位置处的所述第二位置处的所述接收器线圈执行第二组电导率测量; 以及使用所述第一组测量和所述第二组测量确定校正由所述感应测井工具在穿透地球的钻孔中执行的电导率测量的所述校准因子。

12. 发明申请

WO2012092373A2 IN VIVO POLYNUCLEOTIDE DELIVERY CONJUGATES HAVING ENZYME SENSITIVE LINKAGES 审中-公开
标题翻译：生物多糖交付合并具有酶敏感性连接
公开(公告)号：WO2012092373A2
公开(公告)日：2012-07-05
申请号：PCT/US2011/067588
申请日：2011-12-28
申请人： ARROWHEAD RESEARCH CORPORATION , ROZEMA, David, B. , LEWIS, David, L. , WAKEFIELD, Darren, H. , KITAS, Eric, A. , HADWIGER, Philipp , WOLFF, Jon, A. , ROEHL, Ingo , MOHR, Peter , HOFFMANN, Torsten , JAHN-HOFMANN, Kerstin , MUELLER, Hans, Martin , OTT, Guenther , BLOKHIN, Andrei, V. , CARLSON, Jeffrey, C. , BENSON, Jonathan, D.
发明人： ROZEMA, David, B. , LEWIS, David, L. , WAKEFIELD, Darren, H. , KITAS, Eric, A. , HADWIGER, Philipp , WOLFF, Jon, A. , ROEHL, Ingo , MOHR, Peter , HOFFMANN, Torsten , JAHN-HOFMANN, Kerstin , MUELLER, Hans, Martin , OTT, Guenther , BLOKHIN, Andrei, V. , CARLSON, Jeffrey, C. , BENSON, Jonathan, D.
IPC分类号： A61K48/00 , C07C69/96 , C08G63/91
CPC分类号： C07K5/06034 , A61K47/58 , A61K47/60 , C07K5/06078 , C07K5/06104 , C07K5/06113 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , C12N2800/95 , C12N2810/10
摘要： The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active poiyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalentiy linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate.
摘要翻译：本发明涉及用于将RNA干扰（RNAi）多核苷酸递送至细胞体内的组合物。组合物包含用酶切割二肽 - 氨基苄基 - 碳酸酯掩蔽剂可逆地修饰的两亲性膜活性多胺。改性掩盖聚合物的膜活性，而可逆性提供生理反应性。可逆修饰的多胺（动态多偶联物或DPC）进一步共价连接到RNAi多核苷酸或与靶向RNAi多核苷酸靶向分子缀合物共同施用。

13. 发明申请

WO2012089602A1 SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE COMPOUNDS 审中-公开
标题翻译：用于细胞内递送生物活性化合物的小分子
公开(公告)号：WO2012089602A1
公开(公告)日：2012-07-05
申请号：PCT/EP2011/073718
申请日：2011-12-22
申请人： F. HOFFMANN-LA ROCHE AG , HADWIGER, Philipp , HOFFMANN, Torsten , JAHN-HOFMANN, Kerstin , KITAS, Eric A. , LEWIS, David L. , MOHR, Peter , MUELLER, Hans Martin , OTT, Guenther , ROEHL, Ingo , ROZEMA, David B.
发明人： HADWIGER, Philipp , HOFFMANN, Torsten , JAHN-HOFMANN, Kerstin , KITAS, Eric A. , LEWIS, David L. , MOHR, Peter , MUELLER, Hans Martin , OTT, Guenther , ROEHL, Ingo , ROZEMA, David B.
IPC分类号： C12N15/87 , C12N15/11 , A61K48/00 , A61K31/713 , A61K47/18
CPC分类号： A61K38/00 , A61K31/7088 , A61K47/60 , A61K47/65 , A61K48/00 , C07C69/96 , C07C271/20 , C07H15/04 , C07H15/20 , C07H15/26 , C07K7/02 , C07K2317/77 , C12N15/1138 , C12N15/87 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2310/351 , C12N2320/30
摘要： The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to a delivery polymer to achieve in vivo mRNA knock down are disclosed therein.
摘要翻译：本发明提供了用于递送生物活性物质的这些化合物的新化合物和缀合物。其中公开了当共价连接到递送聚合物以实现体内mRNA敲低时特别有用的化学稳定的siRNA的新颖设计标准。

14. 发明申请

WO2012089352A1 SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS 审中-公开
标题翻译：小分子共聚物用于细胞内输送核酸
公开(公告)号：WO2012089352A1
公开(公告)日：2012-07-05
申请号：PCT/EP2011/063436
申请日：2011-08-04
申请人： F. HOFFMANN-LA ROCHE AG , HADWIGER, Philipp , HOFFMANN, Torsten , JAHN-HOFMANN, Kerstin , KITAS, Eric A. , LEWIS, David L. , MOHR, Peter , MUELLER, Hans Martin , OTT, Guenther , ROEHL, Ingo , ROZEMA, David B.
发明人： HADWIGER, Philipp , HOFFMANN, Torsten , JAHN-HOFMANN, Kerstin , KITAS, Eric A. , LEWIS, David L. , MOHR, Peter , MUELLER, Hans Martin , OTT, Guenther , ROEHL, Ingo , ROZEMA, David B.
IPC分类号： C12N15/87 , C12N15/11 , A61K48/00 , A61K31/713 , A61K47/18
CPC分类号： A61K38/00 , A61K31/7088 , A61K47/60 , A61K47/65 , A61K48/00 , C07C69/96 , C07C271/20 , C07H15/04 , C07H15/20 , C07H15/26 , C07K7/02 , C07K2317/77 , C12N15/1138 , C12N15/87 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2310/351 , C12N2320/30
摘要： Use of compounds for the delivery of nucleic acids as well as conjugates of these compounds with nucleic acids, in particular siRNAs, are provided. Also discloses are stabilized siRNA that are useful when covalently bound to such compound and co- administered with a delivery polymer to achieve mRNA knock-down in vivo. In particular, the invention provides the use of a compound of formula (I) For the delivery of nucleic acids, wherein: Y is a linker group selected from -(CH 2 ) 3 or -C(0)-N-(CH 2 -CH 2 -0)p-CH 2 -CH 2 - R 1 is -(C1 -6) alkyl; -(CH 2 )-naphthyl; or -(CH 2 ) m -phenyl, which phenyl is unsubstituted or up to four times substituted with a substituent selected from: -N0 2 , -CN, Halogen, -0-(CH 2 )-phenyl, -0-(C1- 6) alkyl, or -C(0)-NH 2 R 2 is Hydrogen; -(CH 2 ) k -N-C(Ph) 3 , which phenyl rings are unsubstituted or independently substituted with -0-(Cl -4) alkyl; -(CH 2 )k-C(0)-NH 2 ; -(CH 2 )k-phenyl; -(C1 -6) alkyl, which is unsubstituted or once substituted with -S-CH 3 ; R 3 is -NH-phenyl, which phenyl group is further substituted with a substituent independently selected from -(CH 2 )-OH or -(CH 2 )-0-C(0)-0-(4-nitro-phenyl); k is 1, 2, 3, 4, 5, or 6; m is 1, 2, 3 or 4; n is 0 or 1; and p is an integer from 1 to 20.
摘要翻译：提供了化合物用于递送核酸以及这些化合物与核酸，特别是siRNA的缀合物的用途。还公开了当与这种化合物共价结合并与递送聚合物共同施用以在体内实现mRNA敲低时有用的稳定的siRNA。特别地，本发明提供式（I）化合物用于递送核酸，其中：Y是选自 - （CH 2）3或-C（O）-N-（CH 2 -CH 2 -O）p-CH 2 -CH 2 -R 1是 - （C 1-6）烷基; - （CH 2） - 萘基; 或 - （CH 2）m - 苯基，该苯基是未取代的或至多四次被选自：-NO 2，-CN，卤素，-O-（CH 2） - 苯基，-O-（C 1-6）烷基或-C（O）-NH 2 R 2是氢; - （CH 2）k-N-C（Ph）3，该苯环是未取代的或独立地被-O-（C 1-4）烷基取代; - （CH2）K-C（O）-NH 2; - （CH 2）K - 苯基; - （C 1-6）烷基，其未被取代或一次被-S-CH 3取代; R3是-NH-苯基，该苯基进一步被独立地选自 - （CH 2）-OH或 - （CH 2）-O-C（O）-O-（4-硝基 - 苯基）的取代基取代; k为1,2,3,4,5或6; m为1,2,3或4; n为0或1; p为1〜20的整数。

15. 发明申请

WO2011101794A3 THREE DIMENSIONAL RADAR SYSTEM 审中-公开
公开(公告)号：WO2011101794A3
公开(公告)日：2011-08-25
申请号：PCT/IB2011/050650
申请日：2011-02-16
申请人： ELBIT SYSTEMS LTD. , RST RADAR SYSTEMTECHNIK GMBH , BRAUN, Hans Martin , MAYDAN, Gadi , BAESSLER, Holger , JONAS, Carsten , KLEIN, Ofer
发明人： BRAUN, Hans Martin , MAYDAN, Gadi , BAESSLER, Holger , JONAS, Carsten , KLEIN, Ofer
IPC分类号： G01S13/89 , G01S13/94
摘要： A system and a method of generating a three-dimensional terrain model using one-dimensional interferometry of a rotating radar unit is provided herein. Height information is evaluated from phase differences between two echoes by applying a Kalman filter in relation to a phase confidence map that is generated from phase forward projections relating to formerly analyzed phase data. The radar system starts from a flat earth model and gathers height information of the actual terrain as the platform approaches it. Height ambiguities are corrected by removing redundant 2 π multiples from the unwrapped phase difference between the echoes.

16. 发明申请

WO2010069602A3 APPARATUS FOR THE DISTRIBUTION OF FLUIDS AND THE HEAT AND/OR MASS EXCHANGE THEREOF 审中-公开
标题翻译：设备用于流体的分布及其热和/或物质交换
公开(公告)号：WO2010069602A3
公开(公告)日：2011-01-13
申请号：PCT/EP2009009184
申请日：2009-12-21
申请人： FRAUNHOFER GES FORSCHUNG , HERMANN MICHAEL , BONGS CONSTANZE , HENNING HANS-MARTIN
发明人： HERMANN MICHAEL , BONGS CONSTANZE , HENNING HANS-MARTIN
IPC分类号： F28F13/06 , B01F5/06 , F28D9/00
CPC分类号： F28F13/06 , B01F5/0641 , F28D9/0018 , F28D2021/0052
摘要： The present invention relates to a fluid distributor (I) comprising, in the longitudinal direction, a first aperture (1) that has two concentric pipes (2, 3) within the cross-section thereof, and a second aperture (4) that has 2n sectors of a circle within the cross-section thereof. The inner pipe (2) encloses a first space A, while the outer pipe (3) and the inner pipe (2) enclose a space B. In the longitudinal direction, the inner pipe (2) includes n recesses (5) and n protuberances (6) between the first and the second aperture, said recesses (5) and protuberances (6) being alternately arranged around the circumference of the pipe (2).
摘要翻译：本发明涉及一种流体分配器（I）包括纵向第一孔（1）同心地布置在两个管的横截面（2,3），其中所述内管（2）包围的第一空间A，外（ 3）和内（2）管包围的空间B和具有在横截面中的2n圆的扇区的第二孔（4），其中（第一和所述内管的所述第二孔之间2）纵向地布置围绕管周 n具有切口（5）和布置成交替n个突起（6）。

17. 发明申请

WO2010149311A3 HAIR RELAXER 审中-公开
公开(公告)号：WO2010149311A3
公开(公告)日：2010-12-29
申请号：PCT/EP2010/003650
申请日：2010-06-17
申请人： COGNIS IP MANAGEMENT GmbH , HAAKE, Hans-Martin , BOHLANDER, Ralf , CECCHINI, Jessica , ALTUNOK, Mehmet , WEISS, Albrecht , BRANDS, Angela
发明人： HAAKE, Hans-Martin , BOHLANDER, Ralf , CECCHINI, Jessica , ALTUNOK, Mehmet , WEISS, Albrecht , BRANDS, Angela
IPC分类号： A61K8/25 , A61K8/43 , A61Q5/04
摘要： Vorgeschlagen wird ein Haarglättungsmittel, welches durch einen Gehalt an Wasserglas gekennzeichnet ist.

18. 发明申请

WO2010149311A2 HAIR RELAXER 审中-公开
标题翻译：头发松弛
公开(公告)号：WO2010149311A2
公开(公告)日：2010-12-29
申请号：PCT/EP2010003650
申请日：2010-06-17
申请人： COGNIS IP MAN GMBH , HAAKE HANS-MARTIN , BOHLANDER RALF , CECCHINI JESSICA , ALTUNOK MEHMET , WEISS ALBRECHT , BRANDS ANGELA
发明人： HAAKE HANS-MARTIN , BOHLANDER RALF , CECCHINI JESSICA , ALTUNOK MEHMET , WEISS ALBRECHT , BRANDS ANGELA
IPC分类号： A61Q5/06
CPC分类号： A61K8/25 , A61K8/062 , A61K8/19 , A61K8/345 , A61K8/43 , A61K8/604 , A61Q5/04
摘要： The invention relates to a hair smoothing agent characterized by a content of sodium silicate.
摘要翻译：本发明提供一种头发拉直剂，其特征在于水玻璃含量。

19. 发明申请

WO2010049294A1 METHOD OF SIGNALLING SYSTEM INFORMATION, METHOD OF RECEIVING SYSTEM INFORMATION, RADIO BASE STATION AND RADIO COMMUNICATION TERMINAL 审中-公开
标题翻译：信号系统信息的方法，接收系统信息的方法，无线电台站和无线电通信终端
公开(公告)号：WO2010049294A1
公开(公告)日：2010-05-06
申请号：PCT/EP2009/063604
申请日：2009-10-16
申请人： INFINEON TECHNOLOGIES AG , BIENAS, Maik , CHOI, Hyung-Nam , HANS, Martin , ZIMMERMANN, Manfred
发明人： BIENAS, Maik , CHOI, Hyung-Nam , HANS, Martin , ZIMMERMANN, Manfred
IPC分类号： H04W48/10 , H04W72/04 , H04W16/14
CPC分类号： H04W48/10 , H04W16/14 , H04W72/042
摘要： A method of signalling system information and a method of receiving system information are provided. The method of signalling system information includes broadcasting a piece of system information in a radio cell, the piece of system information indicating that a first portion of a frequency spectrum, the frequency spectrum being available for the radio cell, is assigned to a first radio mode, the piece of system information further indicating that a second portion of the frequency spectrum is assigned to a second radio mode, the second radio mode being different from the first radio mode. A radio base station is configured to perform the method of signalling system information. A radio communication terminal is configured to receive the broadcasted piece of system information.
摘要翻译：提供一种信令系统信息的方法和接收系统信息的方法。信令系统信息的方法包括在无线电小区中广播一系统信息，该系统信息指示频谱的第一部分（该无线电小区可用的频谱）被分配给第一无线电模式所述系统信息进一步指示所述频谱的第二部分被分配给第二无线电模式，所述第二无线电模式不同于所述第一无线电模式。无线基站被配置为执行信令系统信息的方法。无线通信终端被配置为接收广播的系统信息。

20. 发明申请

WO2008155073A3 SHAMPOO COMPOSITION HAVING IMPROVED CARE PROPERTIES 审中-公开
标题翻译：香波组合物具有改进的性能CARE
公开(公告)号：WO2008155073A3
公开(公告)日：2010-01-28
申请号：PCT/EP2008004801
申请日：2008-06-14
申请人： COGNIS IP MAN GMBH , HLOUCHA MATTHIAS , HAAKE HANS-MARTIN , MUELLER MICHAEL , KUESTERS ESTHER , MENZER JASMIN , EISFELD WOLF , SEIPEL WERNER , HENSEN HERMANN , BOETTCHER AXEL , GEHM ESTHER RICARDA
发明人： HLOUCHA MATTHIAS , HAAKE HANS-MARTIN , MUELLER MICHAEL , KUESTERS ESTHER , MENZER JASMIN , EISFELD WOLF , SEIPEL WERNER , HENSEN HERMANN , BOETTCHER AXEL , GEHM ESTHER RICARDA
IPC分类号： A61K8/06 , A61K8/60 , A61K8/73 , A61K8/81 , A61Q5/02 , A61Q5/12 , A61Q19/10
CPC分类号： A61K8/068 , A61K8/375 , A61K8/604 , A61K8/731 , A61K8/737 , A61K8/817 , A61K31/01 , A61K2800/34 , A61K2800/5426 , A61Q5/02 , A61Q5/12 , A61Q19/10
摘要： The invention relates to a cosmetic preparation that contains (a) at least one surfactant selected from anionic, zwitterionic or amphoteric surfactants, (b) a microemulsion and (c) at least one cationic polymer.
摘要翻译：化妆品制剂包含（a）提出选自阴离子，两性离子或两性表面活性剂中选择的至少一种表面活性剂，（b）中的微乳液和（c）至少一种阳离子聚合物。

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