专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

WO2008073764A3 SUBSTANTIALLY PURE FLUORESCEIN 审中-公开
标题翻译：大量纯白色荧光素
公开(公告)号：WO2008073764A3
公开(公告)日：2009-07-30
申请号：PCT/US2007086390
申请日：2007-12-04
申请人： ALCON RES LTD , BYDLINSKI GREGORY , HARRIS GREGG ROBERT , SCOTT BRITT S
发明人： BYDLINSKI GREGORY , HARRIS GREGG ROBERT , SCOTT BRITT S
IPC分类号： C07D493/10
CPC分类号： C07D311/82 , A61K31/352 , Y10T436/142222
摘要： The present invention is directed to an improved process for producing substantially pure fluorescein, as well as to substantially pure fluorescein compositions prepared by the process. The invention is particularly directed to the provision of pharmaceutical compositions for use in angiography. The substantially pure fluorescein produced by the process of the present invention is low in color, low in sodium chloride content, and substantially free of pyridine.
摘要翻译：本发明涉及用于生产基本上纯的荧光素以及通过该方法制备的基本上纯的荧光素组合物的改进方法。本发明特别涉及提供用于血管造影术的药物组合物。通过本发明方法生产的基本上纯的荧光素颜色低，氯化钠含量低，并且基本上不含吡啶。

12. 发明申请

WO2009079046A2 SYSTEMS AND METHODS FOR CONTROL OF ENGINE EXHAUST FLOW 审中-公开
标题翻译：用于控制发动机排气流量的系统和方法
公开(公告)号：WO2009079046A2
公开(公告)日：2009-06-25
申请号：PCT/US2008/076857
申请日：2008-09-18
申请人： THE BOEING COMPANY , SHMILOVICH, Arvin , YADLIN, Yoram , GREGG, Robert, D., III , CLARK, Roger, W.
发明人： SHMILOVICH, Arvin , YADLIN, Yoram , GREGG, Robert, D., III , CLARK, Roger, W.
IPC分类号： B64C21/04 , B64C3/28
CPC分类号： B64C21/04 , B64C9/38 , Y02T50/166
摘要： Coanda Effect and lift produced along a surface of an airfoil are increased by ducting compressed fluid from the engine to the surface of the airfoil. An engine produces exhaust gases that are predominantly directed toward an aft end of the aircraft by a cowling or other structure as an exhaust plume. One or more internal ducts extend from the engine to the surface of the airfoil to thereby transmit a compressed fluid from the engine to the surface in order to suppress flow separation along the surface, thereby causing the engine exhaust flow to remain attached to the surface over a wider span. Such structures and techniques may find particular use in aircraft designed to exploit upper surface blowing (USB) techniques and structures for short takeoff and landing (STOL) performance.
摘要翻译：通过将压缩流体从发动机引导到翼型件的表面，沿着翼型件的表面产生的附壁效应和升力增加。发动机产生主要通过整流罩或其他结构作为排气羽流朝向飞行器后端的废气。一个或多个内部管道从发动机延伸到翼面的表面，从而将压缩的流体从发动机传递到表面，以便抑制沿着表面的流动分离，从而使发动机排气流保持附着在表面上更宽的跨度这种结构和技术可以在设计用于利用上表面吹风（USB）技术和用于短起飞和着陆（STOL））性能的结构的飞机中发现。

13. 发明申请

WO2008060767A3 MACROCYCLIC BENZOFUSED PYRIMIDINE DERIVATIVES 审中-公开
公开(公告)号：WO2008060767A3
公开(公告)日：2008-05-22
申请号：PCT/US2007/080133
申请日：2007-10-02
申请人： ABBOTT LABORATORIES , ALTENBACH, Robert J , LIU, Huaqing , DRIZIN, Irene , COWART, Marlon D , WISHART, Neil , BABINSKI, David J , GREGG, Robert J , ESBENSHADE, Timothy A , HSIEH, Gin C , BRIONI, Jorge D , HONORE, Marie P , BLACK, Lawrence A , ZHAO, Chen , WAKEFIELD, Brian D.
发明人： ALTENBACH, Robert J , LIU, Huaqing , DRIZIN, Irene , COWART, Marlon D , WISHART, Neil , BABINSKI, David J , GREGG, Robert J , ESBENSHADE, Timothy A , HSIEH, Gin C , BRIONI, Jorge D , HONORE, Marie P , BLACK, Lawrence A , ZHAO, Chen , WAKEFIELD, Brian D.
IPC分类号： C07D491/04 , C07D493/04 , C07H17/04
摘要： Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.

14. 发明申请

WO2008060766A2 A METHOD FOR PAIN TREATMENT 审中-公开
标题翻译：一种疼痛治疗方法
公开(公告)号：WO2008060766A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/080132
申请日：2007-10-02
申请人： ABBOTT LABORATORIES , COWART, Marlon D , ALTENBACH, Robert J , LIU, Huaqing , DRIZIN, Irene , WISHART, Neil , BABINSKI, David J , GREGG, Robert J , ESBENSHADE, Timothy A , HSIEH, Gin C , BRIONI, Jorge D , HONORE, Marie P , BLACK, Lawrence A , ZHAO, Chen , WAKEFIELD, Brian D
发明人： ALTENBACH, Robert J , LIU, Huaqing , DRIZIN, Irene , WISHART, Neil , BABINSKI, David J , GREGG, Robert J , ESBENSHADE, Timothy A , HSIEH, Gin C , BRIONI, Jorge D , HONORE, Marie P , BLACK, Lawrence A , ZHAO, Chen , WAKEFIELD, Brian D
CPC分类号： A61K31/506 , A61K31/417 , A61K31/496 , A61K45/06
摘要： This invention discloses a method of treating pain by administering histamine H 4 receptor ligands and compositions comprising the same.
摘要翻译：本发明公开了一种通过施用组胺H 4受体配体和包含其的组合物来治疗疼痛的方法。

15. 发明申请

WO2007100990A3 OCTAHYDRO-PYRROLO[3,4-B] PYRROLE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTOR LIGANDS 审中-公开
公开(公告)号：WO2007100990A3
公开(公告)日：2007-09-07
申请号：PCT/US2007/062329
申请日：2007-02-16
申请人： ABBOTT LABORATORIES , COWART, Marlon, D. , ZHAO, Chen , SUN, Minghua , BLACK, Lawrence, A. , ZHENG, Guo Zhu , GREGG, Robert, J. , ZHANG, Geoff, G.Z. , SHEIKH, Ahmad, Y. , LOU, Xiaochun , HENRY, Rodger, F. , BARNES, David, M. , KOLACZKOWSKI, Lawrence , HAIGHT, Anthony, R. , CHANG, Sou-Jen , WITTENBERGER, Steven, J. , FICKES, Michael, G.
发明人： COWART, Marlon, D. , ZHAO, Chen , SUN, Minghua , BLACK, Lawrence, A. , ZHENG, Guo Zhu , GREGG, Robert, J. , ZHANG, Geoff, G.Z. , SHEIKH, Ahmad, Y. , LOU, Xiaochun , HENRY, Rodger, F. , BARNES, David, M. , KOLACZKOWSKI, Lawrence , HAIGHT, Anthony, R. , CHANG, Sou-Jen , WITTENBERGER, Steven, J. , FICKES, Michael, G.
IPC分类号： C07D487/04 , A61K31/407
摘要： Octahydro-pyrrolo[3,4-b]pyrrole derivatives or a pharmaceutically acceptable salt, ester, amide, prodrug, or radiolabeled form thereof, wherein R 1 is alkyl, C 3 -C 5 cycloalkyl. or (C 3 -C 5 cycloalkyl)methyl; R 2a , R 2b , R 2c , R 2d , R 2e , and R 2f each are independently hydrogen, methyl, or fluoromethyl; R 3a , R 3b , R 3c , and R 3d each are independently hydrogen, alkyl, fluoroalkyl, fluoroalkoxy, alkoxy, thioalkoxy, halogen, or nitrile, with the proviso that when one or more of R 3a , R 3b , R 3c , and R 3d are alkyl, then at least one of R 3a , R 3b , R 3c , and R 3d is fluoroalkyl, fluoroalkoxy, alkoxy, thioalkoxy, halogen, or nitrile; L 1 is a bond, oxygen, sulfur, carbonyl, alkylene,. alkylcarbonyl, alkylamino, -C(=N-Oalkyl)-, NR 4 , -C(=O) NR 4 -, or -NR4C(=O)-; R 4 is hydrogen or alkyl; Cy 1 is aryl, cycloalkyl, cycloalkenyl, heteroaryl, or heterocycle; Z is a substituent R 6 or a group represented by -L 3 -Cy 3 ; R 6 is hydrogen, acyl, acyloxy, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxyimino, alkoxysulfonyl, alkyl, alkylcarbonyl, alkylsulfonyl, alkynyl, amido, carboxy, cyano, cycloalkyl, fiuoroalkoxy, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, mercapto, nitro, alkylthio, amino, NHR 7 , NR 7 R 8 , -N(R 7 )C(=O)R 9 , -C(=O)NR 7 R 8 , or N(R 7 )SO 2 (R 10 ); L 3 is a bond, oxygen, sulfur, carbonyl, alkylene, alkylcarbonyl, alkylamino, -C(=N-Oalkyl)-, NR 11 , -C(=O) NR 11 -, or -NR 11 C(=O)-;Cy 3 is aryl, cycloalkyl, cycloalkenyl, heteroaryl, or heterocycle; R 7 , R 8 , R 9 , R 10 , and R 11 at each occurrence are independently hydrogen,C 1-4 alkyl, C 3 -C 4 cycloalkyl, or a (C 3 -C 4 cycloalkyl)amine; are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.

16. 发明申请

WO2007100990A2 OCTAHYDRO-PYRROLO[3,4-B]PYRROLE DERIVATIVES 审中-公开
标题翻译： OCTAHYDRO-PYRROLO [3,4-B]吡咯烷酮衍生物
公开(公告)号：WO2007100990A2
公开(公告)日：2007-09-07
申请号：PCT/US2007062329
申请日：2007-02-16
申请人： ABBOTT LAB , COWART MARLON D , ZHAO CHEN , SUN MINGHUA , BLACK LAWRENCE A , ZHENG GUO ZHU , GREGG ROBERT J , ZHANG GEOFF G Z , SHEIKH AHMAD Y , LOU XIAOCHUN , HENRY RODGER F , BARNES DAVID M , KOLACZKOWSKI LAWRENCE , HAIGHT ANTHONY R , CHANG SOU-JEN , WITTENBERGER STEVEN J , FICKES MICHAEL G
发明人： COWART MARLON D , ZHAO CHEN , SUN MINGHUA , BLACK LAWRENCE A , ZHENG GUO ZHU , GREGG ROBERT J , ZHANG GEOFF G Z , SHEIKH AHMAD Y , LOU XIAOCHUN , HENRY RODGER F , BARNES DAVID M , KOLACZKOWSKI LAWRENCE , HAIGHT ANTHONY R , CHANG SOU-JEN , WITTENBERGER STEVEN J , FICKES MICHAEL G
IPC分类号： C07D487/04 , A61K31/407
CPC分类号： C07D487/04
摘要： Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
摘要翻译：八氢吡咯并[3,4-b]吡咯衍生物可用于治疗组胺-3受体配体预防或改善的病症或病症。八氢吡咯并[3,4-b]吡咯化合物，使用这些化合物的方法，制备它们的组合物和制备这些化合物的方法在本文中公开。

17. 发明申请

WO2004099154A3 PYRAZOLE-AMIDES AND SULFONAMIDES AS SODIUM CHANNEL MODULATORS 审中-公开
标题翻译：作为钠通道调节剂的吡唑胺和磺酰胺
公开(公告)号：WO2004099154A3
公开(公告)日：2005-04-14
申请号：PCT/US2004013530
申请日：2004-04-29
申请人： ABBOTT LAB , ATKINSON ROBERT N , DRIZEN IRENE , GREGG ROBERT J , GROSS MICHAEL F , KORT MICHAEL E , SHI LEI
发明人： ATKINSON ROBERT N , DRIZEN IRENE , GREGG ROBERT J , GROSS MICHAEL F , KORT MICHAEL E , SHI LEI
IPC分类号： A61K31/416 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/24 , C07D401/04 , C07D401/12 , A61K31/415
CPC分类号： C07D401/04 , A61K31/416 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/24 , C07D401/12
摘要： Compounds of formula (I) or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, wherein R1 is alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, heterocycle, heterocyclealkyl, heteroaryl, or heteroarylalkyl; R4 is formula (Ia), formula (Ib), formula (Ic), formula (Id), formula (Ie) or formula (If); or formula (II), or a pharmaceutically acceptable salt, amide, ester or prodrug thereof, wherein R14 is formula (III), formula (IV), formula (V), formula (VI), formula (VII), formula (VIII), formula (IX), formula (X), formula (XI), or formula (XII); modulate PN3 in mammals and are useful in treating pain in mammals.
摘要翻译：式（I）化合物或其药学上可接受的盐，酰胺，酯或前药，其中R 1是烷基，芳基，芳基烷基，环烷基，环烷基烷基，卤代烷基，杂环，杂环烷基，杂芳基或杂芳基烷基; R4是式（Ia），式（Ib），式（Ic），式（Id），式（Ie）或式（If）; 或其药学上可接受的盐，酰胺，酯或前药，其中R 14为式（III），式（IV），式（V），式（VI），式（Ⅶ），式），式（IX），式（X），式（XI）或式（XII）; 调节哺乳动物中的PN3，可用于治疗哺乳动物的疼痛。

18. 发明申请

WO1999001079A1 LASER EXCISIONAL NEW ATTACHMENT PROCEDURE 审中-公开
标题翻译：激光彻底的新附件程序
公开(公告)号：WO1999001079A1
公开(公告)日：1999-01-14
申请号：PCT/US1997011307
申请日：1997-07-01
申请人： GREGG, Robert, H. , MCCARTHY, Delwin, K.
IPC分类号： A61C03/00
CPC分类号： A61C19/043 , A61B2017/22082 , A61C1/0046
摘要： A method for removing deep gingival pockets (20) provides for excise of disease while providing for reconnection of the tissue-tooth connection. Steps in the process include creating a gingival through in the pocket (20) with a contact laser fiber, excising the pocket epithelium (60) while selectively removing sulcular (10B) and pocket epithelium (60) and granulation tissue fully around the targeted tooth (10) to the full depth without breaking through the mucogingival junction (50), scaling the root surfaces to the full depth ultrasonically, lasing the pocket (20) to remove granulation tissue and to disinfect the tissue, assist in hemostatis, cauterize free nerve endings, seal lymphatics, prepare the tissue for welding and desensitize the tooth (10), and compressing the gingival tissue (5) against the tooth surface (10A) until adhesion is achieved.
摘要翻译：用于去除深牙龈袋（20）的方法提供疾病的消除，同时提供组织 - 牙齿连接的重新连接。该过程的步骤包括通过接触式激光纤维在口袋（20）中产生牙龈，切除口腔上皮（60），同时选择性地将全部（10B）和口袋上皮（60）和造粒组织完全围绕目标牙齿 10）完全深度而不破坏粘膜下龈交界处（50），将根表面超声波地定位到全部深度，激发口袋（20）以去除肉芽组织并消毒组织，帮助止血，烧灼自由神经末梢，密封淋巴管，准备用于焊接和使牙齿（10）脱敏的组织，并且将牙龈组织（5）压在牙齿表面（10A）上直到达到粘合。

19. 发明申请

WO2017132531A1 LASER-ASSISTED PERIODONTICS 审中-公开
标题翻译：激光辅助牙周病学
公开(公告)号：WO2017132531A1
公开(公告)日：2017-08-03
申请号：PCT/US2017/015380
申请日：2017-01-27
申请人： MILLENNIUM HEALTHCARE TECHNOLOGIES, INC. , GREGG, Robert, H. , GREGG, Dawn
发明人： GREGG, Robert, H. , GREGG, Dawn
IPC分类号： A61C1/00 , A61C19/04 , A61B18/20 , A61N5/06
CPC分类号： A61C1/0046 , A61B5/4547 , A61B18/22 , A61B34/25 , A61B2017/00482 , A61B2018/00023 , A61B2018/00565 , A61B2018/00577 , A61B2018/00589 , A61B2018/00595 , A61B2018/00601 , A61B2018/00625 , A61B2018/00642 , A61B2018/00708 , A61B2018/00779 , A61B2018/00815 , A61B2018/00863 , A61B2018/00988 , A61B2018/202 , A61B2018/22853 , A61B2034/252 , A61B2034/254 , A61B2034/256 , A61B2218/002 , A61C1/0015 , A61C8/0006 , A61C17/0202 , A61C17/036 , A61C19/043 , A61C19/063 , A61M19/00 , A61M2210/0631 , A61N5/062 , A61N5/0624 , A61N2005/0606 , A61N2005/063 , A61N2005/0651 , A61N2005/0662 , A61N2005/0663 , A61N2005/067
摘要： There is a need for a minimally invasive surgical treatment method for periodontitis for the removal of deep pockets, elimination of disease, creation of reattachment of the gingiva to the tooth surface and true regeneration of the attachment apparatus (new cementum, new periodontal ligament, and new alveolar bone) on a previously diseased root surface. The PerioLase® MVP-7™ including eGUI or another device capable of laser dosimetry, such as an original MVP-7™ type laser without the eGUI, achieves this with the LANAP protocol (laser-assisted new attachment procedure) and the LENAP protocol (laser excisional new attachment procedure).
摘要翻译：需要一种用于牙周炎的微创外科治疗方法，用于去除深袋，消除疾病，产生牙齿到牙齿表面的再附着以及附着装置的真正再生（新的牙骨质，新的牙周韧带和新的牙槽骨）在先前患病的根表面上。 PerioLase＆reg; MVP-7™包括eGUI或其他能够进行激光剂量测定的设备，例如没有eGUI的原始MVP-7™型激光，通过LANAP协议（激光辅助新附件程序）和LENAP协议（激光切除新型附件程序）。

20. 发明申请

WO2009058488A1 METHOD AND APPARATUS FOR ENHANCING ENGINE-POWERED LIFT IN AN AIRCRAFT 审中-公开
标题翻译：用于增强飞机上发动机起动的方法和装置
公开(公告)号：WO2009058488A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/076950
申请日：2008-09-19
申请人： THE BOEING COMPANY , SHMILOVICH, Arvin , YADLIN, Yoram , GREGG, Robert, D., III , CLARK, Roger, W.
发明人： SHMILOVICH, Arvin , YADLIN, Yoram , GREGG, Robert, D., III , CLARK, Roger, W.
IPC分类号： B64C3/58 , B64C9/00 , B64C21/04
CPC分类号： B64C9/38 , B64C3/58 , B64C7/00 , B64C21/04 , B64C2230/04 , Y02T50/166
摘要： Lift produced by an airfoil of an aircraft is increased by suppressing fluid detachment from the surface of the airfoil. An engine cowling (102) extends outwardly from the surface of the airfoil that has an exit plane (202) configured for directing exhaust gases toward a rear of the aircraft. Fences (106, 107, 108, 109) extending outwardly from the surface and proximate to the exit plane of the engine cowling are configured to guide the exhaust gases along at least a portion of the airfoil surface, thereby restricting spanwise movement of the gases and increasing the Coanda Effect exhibited by the gases, thereby increasing the amount of lift produced along the surface of the airfoil. Such techniques may be used in short take-off and landing (STOL) aircraft.
摘要翻译：由飞机的翼型产生的升力通过抑制从翼型的表面的流体分离而增加。发动机整流罩（102）从具有出口平面（202）的翼型件的表面向外延伸，该出口平面（202）构造成用于将废气引导到飞行器的后部。从表面向外延伸并靠近发动机整流罩的出口平面的围栏（106,107,108,109）构造成沿着翼面表面的至少一部分引导废气，从而限制气体的翼展运动，增加气体所展示的附壁效应，从而增加沿翼面表面产生的升力量。这种技术可以用于短时起飞（STOL）飞机。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式