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11. 发明申请

WO2008044852A1 STABLE LIQUID COMPOSITIONS FOR TREATING STOMATITIS COMPRISING EPIDERMAL GROWTH FACTOR 审中-公开
标题翻译：稳定液体组合物，用于处理包含生物生长因子的STOMATITI
公开(公告)号：WO2008044852A1
公开(公告)日：2008-04-17
申请号：PCT/KR2007/004911
申请日：2007-10-09
申请人： DAEWOONG CO., LTD. , KIM, Sun-Hee , LEE, Sang-Kil , YOON, Chae-Ha , YANG, Sun-Mee , NAM, Sang-Hyun , SHIN, Kyeong-Sun , PARK, Seung-Kook , LEE, Sang-Wook
发明人： KIM, Sun-Hee , LEE, Sang-Kil , YOON, Chae-Ha , YANG, Sun-Mee , NAM, Sang-Hyun , SHIN, Kyeong-Sun , PARK, Seung-Kook , LEE, Sang-Wook
IPC分类号： A61K9/08 , A61K38/18
CPC分类号： A61K9/006 , A61K38/1808 , A61K47/10 , C07K14/485
摘要： Provided is a liquid composition for treating stomatitis, the liquid composition including: an epidermal growth factor; an adhesive polymer; and at least one stabilizer selected from the group consisting of ethylenediaminetetraacetic acid (EDTA) and salts thereof, histidine, lysine and inorganic acid salts thereof, arginin and inorganic acid salts thereof, and dextran. The liquid composition includes a stabilizer selected from EDTA (or salts thereof) and a certain amino acid (or inorganic acid salts thereof) and thus, physicochemical and biological stability of the epidermal growth factor can be substantially increased. Thus, the liquid composition can be stored and distributed for a long period of time. The stabilized composition includes an adhesive polymer, and thus, when ejected in a spray form in the mouth of a user, the liquid composition can be quickly attached to an inflammation site and exhibits effectiveness for a long period of time.
摘要翻译：本发明提供一种用于治疗口腔炎的液体组合物，所述液体组合物包括：表皮生长因子; 粘合剂聚合物; 和选自乙二胺四乙酸（EDTA）及其盐，组氨酸，赖氨酸及其无机酸盐，精氨酸及其无机酸盐和右旋糖酐的至少一种稳定剂。液体组合物包括选自EDTA（或其盐）和某些氨基酸（或其无机酸盐）的稳定剂，因此可以显着增加表皮生长因子的物理化学和生物学稳定性。因此，液体组合物可以长期储存和分配。稳定化的组合物包括粘合剂聚合物，因此当以使用者口中喷雾形式喷射时，液体组合物可以快速地附着于炎症部位并且长期显示出有效性。

12. 发明申请

WO2007120000A1 CONTAINER ASSEMBLY 审中-公开
标题翻译：集装箱装配
公开(公告)号：WO2007120000A1
公开(公告)日：2007-10-25
申请号：PCT/KR2007/001854
申请日：2007-04-17
申请人： DAEWOONG CO., LTD. , YUN, Jae Seung
发明人： YUN, Jae Seung
IPC分类号： B65D81/32
CPC分类号： B05B11/0081 , B05B11/0048 , B05B11/30
摘要： The present invention relates to a container assembly having a structure capableof upplying new liquid contents held in a second container to a first container without separating the members, to solve the above problems occurring in a container having a structure mixing two contents. The container assembly according to one embodiment of the present invention comprises a first container holding first contents; a rotating member disposed under the first container at a rotatable state; a guiding member disposed in the rotating member in a fixed state and including an upper guide and a lower guide having regular interval; a second container disposed in the guiding member; including a connecting member that penetrates an upper guide of the guiding member and is connected to the rotating member; thereby rising and rotating along the upper guide of the guiding member by rotation of the rotating member; and having an injecting member in its upper end; and a piston member disposed under the second container in the guiding member; including the connecting member that penetrates a lower guide of the guiding member and is connected to the rotating member; and so pressing the second container by rising and rotating along the lower guide of the guiding member by rotation of the rotating member.
摘要翻译：本发明涉及一种容器组件，其具有能够将容纳在第二容器中的新液体内容物提供到第一容器而不分离构件的结构，以解决在具有混合两种内容物的结构的容器中出现的上述问题。根据本发明的一个实施例的容器组件包括容纳第一内容物的第一容器; 旋转构件，其以可旋转状态设置在所述第一容器的下方; 引导构件，其以固定状态设置在所述旋转构件中，并且包括具有规则间隔的上引导件和下引导件; 设置在所述引导构件中的第二容器; 包括穿过所述引导构件的上引导件并连接到所述旋转构件的连接构件; 从而通过旋转构件的旋转沿引导构件的上引导件上升和旋转; 并在其上端具有注射构件; 以及活塞构件，其设置在所述引导构件的所述第二容器的下方; 包括连接构件，该连接构件穿过所述引导构件的下引导件并且连接到所述旋转构件; 并且因此通过旋转构件的旋转沿着引导构件的下引导件升高并旋转来挤压第二容器。

13. 发明申请

WO2007055481A1 SUSTAINED RELEASE FILM FORMULATION FOR HEALING WOUND COMPRISING EPIDERMAL GROWTH FACTOR 审中-公开
标题翻译：持续发布电影制作用于包围人造生长因子的治疗
公开(公告)号：WO2007055481A1
公开(公告)日：2007-05-18
申请号：PCT/KR2006/004401
申请日：2006-10-27
申请人： DAEWOONG CO., LTD. , KIM, Sun Hee , LEE, Sang Kil , LEE, Min Suk , HONG, Joon Pio
发明人： KIM, Sun Hee , LEE, Sang Kil , LEE, Min Suk , HONG, Joon Pio
IPC分类号： A61L27/20
CPC分类号： A61L26/0066 , A61L15/28 , A61L26/0023 , A61L26/0095 , C08L5/08
摘要： The present invention relates to a sustained release film formulation for healing wound comprising epidermal growth factor, chitosan, viscosity modifiers, plasticizers, and stabilizers. Specifically, the present invention relates to a sustained release film formulation for healing wound comprising epidermal growth factor as an effective ingredient and chitosan as a main base, and additionally comprising one or more antioxidants selected from the group consisting of EDTA and vitamin C; one or more viscosity modifiers selected from the group consisting of hydroxypropylmethylcellulose, gellan gum and pullulan; and one or more plasticizers selected from the group consisting of glycerin, propylene glycol, polyethylene glycol, polyvinyl alcohol and polyvinylpyrrolidone thereto. When the present film is attached to wound site, it absorbs exudation from wound site, and so is changed to hydrogel to keep wound site humid, which is good for wound-healing. And, the present film has superior attachment property to human body, and antifungal activity. Thus, the present film has more merits than simple ointment/cream formulation.
摘要翻译：本发明涉及用于治疗伤口的持续释放膜制剂，其包括表皮生长因子，壳聚糖，粘度调节剂，增塑剂和稳定剂。具体地，本发明涉及一种用于治疗伤口的持续释放膜制剂，其包含表皮生长因子作为有效成分和壳聚糖作为主要基质，并且还包含一种或多种选自EDTA和维生素C的抗氧化剂; 选自羟丙基甲基纤维素，结冷胶和支链淀粉的一种或多种粘度调节剂; 和一种或多种选自甘油，丙二醇，聚乙二醇，聚乙烯醇和聚乙烯吡咯烷酮的增塑剂。当本膜附着于伤口部位时，吸收伤口部位的渗出物，因此变为水凝胶，保持伤口部位湿润，有利于伤口愈合。而且，本发明的膜具有优异的人体附着性和抗真菌活性。因此，本发明的薄膜比简单的软膏/霜剂具有更多的优点。

14. 发明申请

WO2007037611A1 MARKERS FOR PREDICTING THE RESPONSE OF A PATIENT WITH ACUTE MYELOID LEUKEMIA TO ANTI-CANCER DRUGS 审中-公开
标题翻译：用于预防急性脑脊髓灰质炎患者对抗癌药物的反应的标记
公开(公告)号：WO2007037611A1
公开(公告)日：2007-04-05
申请号：PCT/KR2006/003822
申请日：2006-09-26
申请人： DIGITAL GENOMICS INC. , DAEWOONG CO., LTD. , YOON, Jeong Ho , KIM, Young joon , KIM, Se Nyun , SONG, Young-Hwa , PARK, Dong Yoon , KIM, Sung Han , LEE, Han yong , KIM, Dong-Wook , SHIN, InKyung , LEE, BONG YONG
发明人： YOON, Jeong Ho , KIM, Young joon , KIM, Se Nyun , SONG, Young-Hwa , PARK, Dong Yoon , KIM, Sung Han , LEE, Han yong , KIM, Dong-Wook , SHIN, InKyung , LEE, BONG YONG
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： Disclosed is a marker capable of predicting the response of AML (Acute Myeloid Leukemia) patients to anticancer therapy. Also, a kit equipped with a means for measuring the expression level of marker genes capable of predicting the response is provided for predicting the response of AML patients to anticancer drugs. Additionally, a method is provided for predicting the response of AML patients to anticancer drugs on the basis of the extent of expression of the marker genes. By applying a bio-specimen taken from AML patients to the kit to analyze the expression patterns of the genes, the response of AML patients to anticancer drugs can be predicted. The method can give information on suitable chemotherapy for AML patients, thereby improving the therapeutic effect of the anticancer drugs used and relieving the pain and economic burden of the patients.
摘要翻译：公开了能够预测AML（急性骨髓性白血病）患者对抗癌治疗的反应的标志物。此外，还提供了一种配备有测量能够预测反应的标记基因表达水平的方法的试剂盒，用于预测AML患者对抗癌药物的反应。另外，提供了一种基于标记基因表达程度来预测AML患者对抗癌药物的反应的方法。通过将AML患者的生物样本应用于试剂盒来分析基因的表达模式，可以预测AML患者对抗癌药物的反应。该方法可以提供适合AML患者化疗的信息，从而提高使用抗癌药物的治疗效果，缓解患者的疼痛和经济负担。

15. 发明申请

WO2017095062A1 METHOD FOR PRODUCING BOTULINUM TOXIN 审中-公开
标题翻译：生产肉毒杆菌毒素的方法
公开(公告)号：WO2017095062A1
公开(公告)日：2017-06-08
申请号：PCT/KR2016/013506
申请日：2016-11-23
申请人： DAEWOONG CO., LTD.
发明人： KIM, Kyoung-Yun , KIM, Chung Sei , KIM, Myung Seob , SUL, Hye-Young
IPC分类号： C07K14/33 , C07K1/16 , C07K1/18 , C07K1/30 , C07K1/34 , C07K1/36 , B01D15/36
CPC分类号： C07K14/33 , B01D15/363 , B01D61/145 , B01D61/147 , B01D61/58 , B01D2315/16
摘要： The present invention relates to a method for producing a botulinum toxin comprising :(a) treating a culture of a botulinum toxin-producing strain with acid to form a botulinum toxin-containing precipitate; (b) adding a buffer to the botulinum toxin-containing precipitate of step (a), followed by clarification by at least one method selected from the group consisting of depth filtration (DF), microfiltration (MF), ultrafiltration (UF), sterile filtration, membrane chromatography (MC) and centrifugation; (c) subjecting the botulinum toxin-containing solution of step (b) to UF diafiltration, ammonium sulfate precipitation or hydrochloric acid precipitation, and then diluting a retentate resulting from the UF diafiltration in a buffer or dissolving a precipitate resulting from the ammonium sulfate precipitation or hydrochloric acid precipitate in a buffer; and (d) subjecting the retentate dilution, ammonium sulfate precipitate solution or hydrochloric acid precipitate solution of step (c) to anion-exchange chromatography (AEX) to purify the botulinum toxin.
摘要翻译：本发明涉及肉毒杆菌毒素的制备方法，其包括：（a）用酸处理肉毒杆菌毒素生产菌株的培养物以形成含肉毒杆菌毒素的沉淀; （b）向步骤（a）的含肉毒杆菌毒素的沉淀物中加入缓冲液，然后通过选自深层过滤（DF），微滤（MF），超滤（UF），无菌过滤，膜层析（MC）和离心; （c）将步骤（b）的含肉毒毒素的溶液进行UF渗滤，硫酸铵沉淀或盐酸沉淀，然后将由UF渗滤得到的渗余物在缓冲液中稀释或溶解由硫酸铵沉淀产生的沉淀或盐酸在缓冲液中沉淀; （d）将步骤（c）的保留物稀释液，硫酸铵沉淀溶液或盐酸沉淀溶液进行阴离子交换层析（AEX）以纯化肉毒杆菌毒素。

16. 发明申请

WO2010027217A2 COMPOSITION FOR PREVENTING OR TREATING ALOPECIA CAUSED BY A CHEMOTHERAPEUTIC AGENT 审中-公开
标题翻译：用于预防或治疗由化学治疗剂引起的ALOPECIA的组合物
公开(公告)号：WO2010027217A2
公开(公告)日：2010-03-11
申请号：PCT/KR2009005018
申请日：2009-09-04
申请人： DAEWOONG CO LTD , HONG JOON PIO , KWON OH BYUNG , KIM WON CHUL , LIM SEON MOOK , PARK MIN SUN
发明人： HONG JOON PIO , KWON OH BYUNG , KIM WON CHUL , LIM SEON MOOK , PARK MIN SUN
IPC分类号： A61K8/14
CPC分类号： A61K8/553 , A61K8/14 , A61K9/0014 , A61K9/127 , A61Q7/00
摘要： The present invention relates to a topically applicable composition for preventing or treating alopecia caused by a chemotherapeutic agent, including a nanoliposome consisting of a liposome layer containing a lecithin, wherein the nanoliposome includes an epidermal growth factor. In addition, the present invention relates to a pharmaceutical combination which contains the above-described composition and chemotherapeutic agent such that the composition and the chemotherapeutic agent can be individually administered.
摘要翻译：本发明涉及用于预防或治疗由化学治疗剂引起的脱发的局部适用组合物，包括由含有卵磷脂的脂质体层组成的纳米脂质体，其中所述纳米脂质体包括表皮生长因子。此外，本发明涉及包含上述组合物和化学治疗剂的药物组合，使得组合物和化学治疗剂可以单独给药。

17. 发明申请

WO2008004717A1 A STABLE LIQUID FORMULATION OF HUMAN GROWTH HORMONE 审中-公开
标题翻译：稳定的液体配方人类生长激素
公开(公告)号：WO2008004717A1
公开(公告)日：2008-01-10
申请号：PCT/KR2006/002640
申请日：2006-07-06
申请人： DAEWOONG CO., LTD. , KIM, Sun hee , CHUNG, Yo kyung , CHANG, Jae young , LEE, Sang kil , LEE, Min suk , PARK, Seung kook
发明人： KIM, Sun hee , CHUNG, Yo kyung , CHANG, Jae young , LEE, Sang kil , LEE, Min suk , PARK, Seung kook
IPC分类号： A61K38/27 , A61K9/08 , A61P5/06
CPC分类号： A61K38/27 , A61K9/0019 , A61K9/19 , A61K47/10 , A61K47/183 , A61K47/26 , A61K47/34
摘要： Disclosed herein is a stable liquid formulation comprising human growth hormone; L-lysine, L-arginine or polyethylene glycol 300; and poly(oxyethylene) poly(oxypropylene) copolymer, polyethylene glycol- 15 polyoxystearate or polyethylene glycol-35 castor oil.
摘要翻译：本文公开了包含人生长激素的稳定液体制剂; L-赖氨酸，L-精氨酸或聚乙二醇300; 和聚（氧乙烯）聚（氧丙烯）共聚物，聚乙二醇-15聚氧乙烯硬脂酸酯或聚乙二醇-35蓖麻油。

18. 发明申请

WO2004039413A1 IMMUNE STIMULATING AND CONTROLLING COMPOSITION COMPRISING BACTERIAL CHROMOSOMAL DNA FRAGMENTS AND NON-TOXIC LIPOPOLYSACCHARIDES 审中-公开
标题翻译：包含细菌染色体DNA片段和非毒性脂多糖的免疫刺激和控制组合物
公开(公告)号：WO2004039413A1
公开(公告)日：2004-05-13
申请号：PCT/KR2002/001813
申请日：2002-09-26
申请人： EYEGENE INC , DAEWOONG CO., LTD. , AHN, Bo Young , CHO, Yang Je , YOO, Won Il , LEE, Sung Ho , PARK, Hye Ran , LEE, Dong Hyun , LEE, Na-Gyong , KIM, Doo Sik
发明人： AHN, Bo Young , CHO, Yang Je , YOO, Won Il , LEE, Sung Ho , PARK, Hye Ran , LEE, Dong Hyun , LEE, Na-Gyong , KIM, Doo Sik
IPC分类号： A61K48/00
CPC分类号： A61K39/39 , A61K31/739 , A61K39/00 , A61K2039/55561 , A61K2039/55572 , A61K2039/57
摘要： The present invention relates to immune stimulating and controlling composition comprising bacterial chromosomal DNA fragments and non-toxic lipopolysacchararides. The composition of the present invention can be industrially applied the effective materials for treating cancers and adjuvant.
摘要翻译：本发明涉及包含细菌染色体DNA片段和无毒性脂多糖的免疫刺激和控制组合物。本发明的组合物可以在工业上应用用于治疗癌症和佐剂的有效材料。

19. 发明申请

WO2004028563A1 A VACCINE ENHANCING THE PROTECTIVE IMMUNITY TO HEPATITIS C VIRUS USING PLASMID DNA AND RECOMBINANT ADENOVIRUS 审中-公开
标题翻译：一种疫苗可以增强使用PLASMID DNA和重组腺病毒的C型病毒的保护性免疫
公开(公告)号：WO2004028563A1
公开(公告)日：2004-04-08
申请号：PCT/KR2003/001951
申请日：2003-09-24
申请人： GENEXINE INC. , POSTECH FOUNDATION , DONG-A PHARM. CO., LTD. , DAEWOONG CO., LTD. , POSCO , SUNG, Young Chul , YOUN, Jin-Won , YANG, Se-Hwan , PARK, Su-Hyung , LEE, Chang Geun
发明人： SUNG, Young Chul , YOUN, Jin-Won , YANG, Se-Hwan , PARK, Su-Hyung , LEE, Chang Geun
IPC分类号： A61K39/29
CPC分类号： A61K39/12 , A61K39/29 , A61K2039/53 , A61K2039/545 , A61K2039/55522 , A61K2039/57 , C12N2710/10043 , C12N2770/24234
摘要： The present invention relates to a vaccine enhancing the protective immunity to Hepatitis C virus using plasmid DNA recombinant adenovirus, more particularly to a vaccine consisting of Δ core-E1-E2 expressing DNA vaccine, nonstructural protein NS3 and NS4 expressing DNA vaccine, nonstructural protein NS5 expressing DNA vaccine and recombinant adenovirus vaccine, and method for administration of the vaccine by priming with the DNA vaccines described above and boosting with the recombinant adenovirus vaccine thereby enhancing the protective immunity to Hepatitis C virus.
摘要翻译：本发明涉及使用质粒DNA重组腺病毒增强对丙型肝炎病毒的保护性免疫力的疫苗，更具体地说，涉及一种由表达三核心-E1-E2的DNA疫苗，非结构蛋白NS3和NS4表达DNA疫苗，非结构蛋白NS5 表达DNA疫苗和重组腺病毒疫苗，以及通过用上述DNA疫苗引发并用重组腺病毒疫苗加强疫苗来施用疫苗，从而增强对丙型肝炎病毒的保护性免疫力。

20. 发明申请

WO2003016170A1 CONTAINER PLUS SYRINGE SYSTEM 审中-公开
标题翻译：集装箱灌装系统
公开(公告)号：WO2003016170A1
公开(公告)日：2003-02-27
申请号：PCT/KR2002/001543
申请日：2002-08-13
申请人： BOO YOON TECH., INC. , DAEWOONG CO., LTD. , YOON, Yeo Saeng , PARK, Byoung Hoon
发明人： YOON, Yeo Saeng , PARK, Byoung Hoon
IPC分类号： B65D81/32
CPC分类号： A61J1/2096 , A61J1/201 , A61J1/2013 , A61J1/2051 , A61J1/2065
摘要： The present invention relates to a container plus syringe system which is easy to grab when used wherein a pharmaceutical composition contained in a syringe is easily introduced into a container by pushing the needle part in the needle case thereby mixing said pharmaceutical composition contained in a syringe with a pharmaceutical composition contained in said container followed by removing both said needle case part and said syringe part and storing said container containing said mixture in an upright position.
摘要翻译：本发明涉及一种容器加注射器系统，当使用时容易抓住，其中容纳在注射器中的药物组合物通过将针状部件中的针部分推入针壳容易地引入容器中，从而将包含在注射器中的药物组合物与包含在所述容器中的药物组合物，随后除去所述针壳部分和所述注射器部分，并将容纳所述混合物的容器储存在直立位置。

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