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11. 发明申请

WO2012129548A2 IN SITU EXPRESSION OF LIPASE FOR ENZYMATIC PRODUCTION OF ALCOHOL ESTERS DURING FERMENTATION 审中-公开
标题翻译：脂肪酶在发酵过程中用于酶水解生产醇酯的原位表达
公开(公告)号：WO2012129548A2
公开(公告)日：2012-09-27
申请号：PCT/US2012/030468
申请日：2012-03-23
申请人： BUTAMAX(TM) ADVANCED BIOFUELS LLC , DICOSIMO, Robert , KRUCKEBERG, Arthur Leo , VAN AKEN, Thomas Edwin
发明人： DICOSIMO, Robert , KRUCKEBERG, Arthur Leo , VAN AKEN, Thomas Edwin
IPC分类号： C12N1/19 , C12N15/55 , C12N1/38 , C12P7/16
CPC分类号： C12N9/20 , C12P7/06 , C12P7/16 , C12P7/649 , Y02E50/13 , Y02E50/17
摘要： Disclosed herein are methods of producing alcohol esters during a fermentation by providing alcohol-producing microorganisms which further comprise an engineered polynucleotide encoding a polypeptide having lipase activity.
摘要翻译：本发明公开了通过提供生产醇的微生物在发酵期间生产醇酯的方法，所述生产醇的微生物还包含编码具有脂肪酶活性的多肽的工程化多核苷酸。

12. 发明申请

WO2012039759A3 MULTIMEDIA EVALUATION OF BUTANOL-CONTAINING FUELS 审中-公开
公开(公告)号：WO2012039759A3
公开(公告)日：2012-03-29
申请号：PCT/US2011/001622
申请日：2011-09-20
申请人： BUTAMAX (TM) ADVANCED BIOFUELS LLC , BOYD, Dennis, P. , DOBEL, Theresa, M. , GERMANO, Don , GRACE, Robert, S. , GREENE, Phillip, R. , KIMURA, Ken , LULHAM, Geoffrey , SCHUBERT, Adam , STEVENS, Ronald, D.
发明人： BOYD, Dennis, P. , DOBEL, Theresa, M. , GERMANO, Don , GRACE, Robert, S. , GREENE, Phillip, R. , KIMURA, Ken , LULHAM, Geoffrey , SCHUBERT, Adam , STEVENS, Ronald, D.
IPC分类号： G01N33/22 , C10L1/182
摘要： The present invention is related to hydrocarbon compositions comprising butanol that have substantially the same or improved performance properties than comparable hydrocarbon compositions comprising ethanol and to methods for identifying such compositions.

13. 发明申请

WO2012033832A2 INTEGRATION OF A POLYNUCLEOTIDE ENCODING A POLYPEPTIDE THAT CATALYZES PYRUVATE TO ACETOLACTATE CONVERSION 审中-公开
标题翻译：将多核苷酸编码多肽的催化剂聚合成乙酰胆碱酯转化酶
公开(公告)号：WO2012033832A2
公开(公告)日：2012-03-15
申请号：PCT/US2011/050689
申请日：2011-09-07
申请人： BUTAMAX(TM) ADVANCED BIOFUELS LLC , ANTHONY, Larry, Cameron , MAGGIO-HALL, Lori, Ann , PAUL, Brian, James
发明人： ANTHONY, Larry, Cameron , MAGGIO-HALL, Lori, Ann , PAUL, Brian, James
IPC分类号： C12N1/21 , C12N15/52 , C12N15/63 , C12P7/16
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/1022 , C12N9/88 , C12N15/52 , C12P7/18 , C12P7/26 , C12P7/649 , C12Y101/01001 , C12Y101/01002 , C12Y101/01086 , C12Y101/01265 , C12Y202/01006 , C12Y401/01001 , C12Y401/01072 , C12Y402/01009 , Y02E50/10 , Y02E50/13
摘要： The invention relates to recombinant host cells having at least one integrated polynucleotide encoding a polypeptide that catalyzes a step in a pyruvate-utilizing biosynthetic pathway, e.g ., pyruvate to acetolactate conversion. The invention also relates to methods of increasing the biosynthetic production of isobutanol, 2,3-butanediol, 2-butanol or 2-butanone using such host cells.
摘要翻译：本发明涉及具有至少一种编码多肽的整合多核苷酸的重组宿主细胞，所述多肽催化丙酮酸利用生物合成途径中的步骤，例如丙酮酸至乙酰乳酸转化。本发明还涉及使用这种宿主细胞增加异丁醇，2,3-丁二醇，2-丁醇或2-丁酮的生物合成生产的方法。

14. 发明申请

WO2011160030A2 METHODS AND SYSTEMS FOR REMOVING UNDISSOLVED SOLIDS PRIOR TO EXTRACTIVE FERMENTATION IN THE PRODUCTION OF BUTANOL 审中-公开
标题翻译：在丁醇生产中提取发酵前除去未溶解固体的方法和系统
公开(公告)号：WO2011160030A2
公开(公告)日：2011-12-22
申请号：PCT/US2011/040899
申请日：2011-06-17
申请人： BUTAMAX(TM) ADVANCED BIOFUELS LLC , ROESCH, Brian, Michael , BURLEW, Keith, H. , HALLAM, John, W. , LOWE, David, J. , ZAHER, Joseph, J.
发明人： ROESCH, Brian, Michael , BURLEW, Keith, H. , HALLAM, John, W. , LOWE, David, J. , ZAHER, Joseph, J.
IPC分类号： C12P7/16 , C07C29/86 , B01D21/26 , C12M1/00
CPC分类号： C12N1/38 , B01D21/262 , C07C29/86 , C12N9/88 , C12P7/16 , Y02E50/10 , Y02E50/16 , Y02E50/17 , C07C31/12
摘要： A method and system for efficiently producing a fermentative product alcohol such as butanol utilizing in situ product extraction are provided. The efficiency is obtained through separating undissolved solids after liquefying a given feedstock to create a feedstock and prior to fermentation, for example, through centrifugation. Removal of the undissolved solids avoids problems associated with having the undissolved solids present during in situ production extraction, and thereby increases the efficiency of the alcohol production.
摘要翻译：提供了利用原位产物提取有效地生产发酵产物醇如丁醇的方法和系统。通过在液化给定原料以产生原料并且在发酵之前，例如通过离心分离未溶解的固体，获得效率。去除未溶解的固体避免了在原位生产提取期间存在未溶解固体的问题，从而提高了醇生产的效率。

15. 发明申请

WO2011100299A2 PROCESS TO REMOVE PRODUCT ALCOHOL FROM A FERMENTATION BY VAPORIZATION UNDER VACUUM 审中-公开
标题翻译：在真空下通过蒸发从发酵中除去产物醇的方法
公开(公告)号：WO2011100299A2
公开(公告)日：2011-08-18
申请号：PCT/US2011/024159
申请日：2011-02-09
申请人： BUTAMAX(TM) ADVANCED BIOFUELS LLC , GRADY, Michael, Charles , PARTEN, William, D. , SYLVESTER, Robert W. , ZAHER, Joseph, J.
发明人： GRADY, Michael, Charles , PARTEN, William, D. , SYLVESTER, Robert W. , ZAHER, Joseph, J.
IPC分类号： B01D3/14 , B01D1/00 , B01D3/06
CPC分类号： C07C29/80 , B01D3/002 , B01D53/1475 , B01D53/1487 , B01D2251/306 , B01D2251/606 , B01D2252/2025 , B01D2252/20484 , B01D2252/20489 , B01D2257/504 , B01D2257/704 , B01D2257/708 , B01D2257/80 , C07C29/76 , Y02C10/06 , Y02P20/152 , Y02P70/34 , C07C31/12
摘要： A fermentation liquid feed including water and a product alcohol and optionally CO 2 is at least partially vaporized such that a vapor stream is produced. The vapor stream is contacted with an absorption liquid under suitable conditions wherein an amount of the product alcohol is absorbed. The portion of the vapor stream that is absorbed can include an amount of each of the water, the product alcohol and optionally the CO 2 . The temperature at the onset of the absorption of the vapor stream into the absorption liquid can be greater than the temperature at the onset of condensation of the vapor stream in the absence of the absorption liquid. The product alcohol can be separated from the absorption liquid whereby the absorption liquid is regenerated. The absorption liquid can include a water soluble organic molecule such as an amine.
摘要翻译：包含水和产物醇和任选CO 2的发酵液体进料至少部分地蒸发，从而产生蒸气流。蒸汽流在其中吸收了一定量的产物醇的合适条件下与吸收液接触。被吸收的蒸气流部分可以包括一定量的水，产物醇和任选的CO 2。蒸汽流吸收到吸收液中的开始时的温度可以大于不存在吸收液时蒸汽流开始凝结时的温度。产物醇可以从吸收液体中分离出来，由此吸收液体被再生。吸收液体可以包括水溶性有机分子如胺。

16. 发明申请

WO2011040901A2 ENHANCED PYRUVATE TO ACETOLACTATE CONVERSION IN YEAST 审中-公开
标题翻译：在酵母中增强的乙醛酸转化为乙酰转移酶
公开(公告)号：WO2011040901A2
公开(公告)日：2011-04-07
申请号：PCT/US2009/046226
申请日：2009-07-20
申请人： BUTAMAX(TM) ADVANCED BIOFUELS LLC. , ANTHONY, Larry, Cameron , MAGGIO-HALL, Lori, Ann
发明人： ANTHONY, Larry, Cameron , MAGGIO-HALL, Lori, Ann
IPC分类号： C12N1/00
CPC分类号： C12P7/16 , C12N9/88 , C12N15/81 , C12P7/04 , C12Y202/01006 , Y02E50/10 , Y02P20/52
摘要： A high flux in conversion of pyruvate to acetolactate was achieved in yeast through expression of acetolactate synthase in the cytosol in conjunction with reduction in pyruvate decarboxylase activity. Additional manipulations to improve flux to acetolactate are reduced pyruvate dehydrogenase activity and reduced glycerol-3-phosphate dehydrogenase activity. Production of compounds having acetolactate as an upstream intermediate benefit from the increased conversion of pruvate to acetolactate in the described strains.
摘要翻译：通过在胞质溶胶中表达乙酰乳酸合酶并结合丙酮酸脱羧酶活性的降低，在酵母中达到丙酮酸转化为乙酰乳酸的高通量。改善向乙酰乳酸流量的其他操作是降低丙酮酸脱氢酶活性并降低甘油-3-磷酸脱氢酶活性。生产具有乙酰乳酸的化合物作为上游中间体受益于所述菌株中丙酮酸转化为乙酰乳酸的增加。

17. 发明申请

WO2011008924A2 RECOVERY OF BUTANOL FROM A MIXTURE OF BUTANOL, WATER, AND AN ORGANIC EXTRACTANT 审中-公开
标题翻译：丁醇从丁醇，水和有机提取物的混合物中恢复
公开(公告)号：WO2011008924A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/042092
申请日：2010-07-15
申请人： BUTAMAX(TM) ADVANCED BIOFUELS LLC , XU, Yihui, Tom , PARTEN, William, D.
发明人： XU, Yihui, Tom , PARTEN, William, D.
IPC分类号： C07C31/12
CPC分类号： B01D3/143 , B01D3/002 , C07C29/80 , C07C29/84 , C07C29/86 , C07C31/12
摘要： A process for recovering butanol from a mixture comprising a water-immiscible organic extractant, water, butanol, and optionally a non-condensable gas, is provided. The butanol is selected from 1-butanol, isobutanol, and mixtures thereof. An overhead stream from a first distillation column is decanted into two liquid phases. The wet butanol phase is returned to the first distillation column as reflux. A bottom stream from the first distillation column is refined in a second distillation column to obtain a second overhead stream comprising butanol and a second bottoms stream comprising the extractant. The extractant comprises at least one solvent selected from the group consisting of C 7 to C 22 fatty alcohols, C 7 to C 22 fatty acids, esters of C 7 to C 22 fatty acids, C 7 to C 22 fatty aldehydes, and mixtures thereof.
摘要翻译：提供了一种从包含与水不混溶的有机萃取剂，水，丁醇和任选的不可冷凝气体的混合物中回收丁醇的方法。丁醇选自1-丁醇，异丁醇及其混合物。将来自第一蒸馏塔的塔顶物流倾析成两个液相。湿的丁醇相作为回流返回到第一蒸馏塔。来自第一蒸馏塔的塔底物流在第二蒸馏塔中精制，得到包含丁醇的第二塔顶物流和包含萃取剂的第二塔底物流。萃取剂包含至少一种选自C7至C22脂肪醇，C7至C22脂肪酸，C7至C22脂肪酸酯，C7至C22脂肪醛及其混合物的溶剂。

18. 发明申请

WO2010065582A1 IMPROVED STRAIN FOR BUTANOL PRODUCTION WITH INCREASED MEMBRANE UNSATURATED TRANS FATTY ACIDS 审中-公开
标题翻译：改进的葡萄糖生产菌株与增加的膜不饱和转发脂肪酸
公开(公告)号：WO2010065582A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/066327
申请日：2009-12-02
申请人： BUTAMAX(TM) ADVANCED BIOFUELS LLC , FLINT, Dennis , VAN DYK, Tina, K.
发明人： FLINT, Dennis , VAN DYK, Tina, K.
IPC分类号： C12N1/21 , C12N1/32 , C12N1/16
CPC分类号： C12P7/16 , C12N1/38 , C12N9/90 , Y02E50/10
摘要： Bacteria that are not natural butanol producers were found to have increased tolerance to butanol when the membrane content of unsaturated trans fatty acids was increased. Feeding cells with unsaturated trans fatty acids increased their concentration in the membrane, which may also be accomplished by expressing a fatty acid cistrans isomerase.
摘要翻译：发现当不饱和反式脂肪酸的膜含量增加时，不是天然丁醇生产者的细菌具有增加的对丁醇的耐受性。用不饱和反式脂肪酸喂养细胞增加其在膜中的浓度，这也可以通过表达脂肪酸顺反异构酶来实现。

19. 发明申请

WO2014106107A3 DHAD VARIANTS FOR BUTANOL PRODUCTION 审中-公开
公开(公告)号：WO2014106107A3
公开(公告)日：2014-07-03
申请号：PCT/US2013/078086
申请日：2013-12-27
申请人： BUTAMAX (TM) ADVANCED BIOFUELS LLC
发明人： MAGGIO-HALL, Lori Ann , PAUL, Brian James , ROTHMAN, Steven Cary , YE, Rick W.
IPC分类号： C12N9/88 , C12P7/16
摘要： Dihydroxy-acid dehydratase (DHAD) variants that display increased DHAD activity are disclosed. Such enzymes can result in increased production of compounds from DHAD requiring biosynthetic pathways. Also disclosed are isolated nucleic acids encoding the DHAD variants, recombinant host cells comprising the isolated nucleic acid molecules, and methods of producing butanol.

20. 发明申请

WO2014047412A1 A METHOD FOR PRODUCING BUTANOL USING TWO-PHASE EXTRACTIVE FERMENTATION AND RECYCLABLE EXTRACTANT COMPOSITIONS 审中-公开
标题翻译：使用两相萃取发酵和可回收的萃取剂组合物生产丁醇的方法
公开(公告)号：WO2014047412A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/060858
申请日：2013-09-20
申请人： BUTAMAX(TM) ADVANCED BIOFUELS LLC
发明人： ANTON, Douglas, Robert , DINER, Bruce, A. , DOIG, Steven, D.
IPC分类号： C12P7/16
CPC分类号： C07C29/86 , C12P7/04 , C12P7/16 , C12P21/06 , Y02E50/10
摘要： Provided herein are processes comprising providing a fermentation medium comprising a fermentable carbon source, a recombinant microorganism comprising an engineered butanol biosynthetic pathway, and butanol; contacting said fermentation medium with an extractant composition comprising an effective amount of antioxidant or antioxidant-like compound, whereby at least a portion of the butanol in the fermentation medium partitions into the extractant; recovering at least a portion of the butanol and extractant composition from the fermentation medium; recycling the extractant composition recovered in (c) one or more times in the fermentation medium; optionally adjusting the effective amount of antioxidant or antioxidant-like compound in the extractant composition, whereby the rate of oxidation or effet of oxidized products in the recycled extractant composition is substantially reduced and/or avoided such that the extractant composition may be recycled.
摘要翻译：本文提供的方法包括提供包含可发酵碳源的发酵培养基，包含工程丁醇生物合成途径的重组微生物和丁醇; 使所述发酵培养基与包含有效量的抗氧化剂或类似抗氧化剂的化合物的提取剂组合物接触，由此发酵培养基中的至少一部分丁醇分配到提取剂中; 从发酵培养基中回收至少一部分丁醇和提取剂组合物; 在（c）中回收的萃取剂组合物在发酵培养基中回收一次或多次; 可选地调节萃取剂组合物中抗氧化剂或抗氧化剂样化合物的有效量，从而大大减少和/或避免再循环的萃取剂组合物中的氧化产物的氧化或反应速率，从而使萃取剂组合物可循环使用。

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