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11. 发明申请

WO1995017345A2 PROCESS FOR PRODUCING HYDROGEN PEROXIDE, C1 TO C4 MONOPERCARBOXYLIC ACID AND C4 TO C18 DIPERCARBOXYLIC ACID COMPLEXES BY THE FLUIDISED BED PROCESS 审中-公开
标题翻译：用于生产过氧化氢，C1至C4 C4MONOPERCARBONSÄURE-AND至C18 dipercarboxylic酸COMPLEX IN流化床工艺
公开(公告)号：WO1995017345A2
公开(公告)日：1995-06-29
申请号：PCT/EP1994004115
申请日：1994-12-10
申请人： BASF AKTIENGESELLSCHAFT , BREITENBACH, Jörg , GRABOWSKI, Sven , SANNER, Axel
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C01B15/037
CPC分类号： C07C407/00 , C01B15/01 , C07C409/24 , C07C409/26
摘要： The production of hydrogen peroxide, C1 to C4 monopercarboxylic acid and C4 to C18 dipercarboxylic acid complexes by the fluidised bed process by the addition of a solution of hydrogen peroxide, C1 to C4 monopercarboxylic acid, C4 to C18 dipercarboxylic acid or a mixture thereof in water or carboxylic acids to a powdered or pregranulated matrix in or outside the fluidised bed and simultaneously or successively drying of the fluidised bed, in which use is made as a matrix of: A) N-vinyl caprolactam homopolymer, B) N-vinyl caprolactam copolymers with N-vinyl pyrrolidone, N-vinyl imidazole, acryl or methacryl amidopropyl-3-sulphonic acid, acrylic or methacrylic acid or mixtures thereof as comonomers in the proportion by weight of N-vinyl caprolactam to comonomers of 20:1 to 1:20, C) N-vinyl pyrrolidone copolymer with N-vinyl imidazole, acrylic or methacrylic acid or mixtures thereof as comonomers in the proportion by weight of N-vinyl pyrrolidone to comonomers of 20:1 to 1:20, D) N-vinyl imidazole homopolymers which may be substituted in the heterocyclic ring by up to three C1 to C4 alkyl radicals and may be present in C1 to C4 alkyl N-quaternised form, E) mixtures of monosaccharides, oligosaccharides, polysaccharides or derivatives thereof with the polymers A to D in the proportion by weight of 1:99 to 90:10, F) mixtures of monosaccharides, oligosaccharides, starches, starch decomposition products or derivatives thereof with N-vinyl pyrrolidone homopolymers in the proportion by weight of 1:99 to 90:10, G) mixtures of trehalose, saccharose, glucose, alpha or beta or gamma cyclodextrins or derivatives of said cyclodextrins or mixtures thereof with polymers A to D or with N-vinyl pyrrolidone homopolymers in the proportion by weight of 1:99 to 100:0 or H) in the case of C1 to C4 monopercarboxylic acid and C4 to C18 dipercarboxylic acid complexes, N-vinyl pyrrolidone homopolymers.
摘要翻译：生产过氧化氢的，C1至C4Monopercarbonsäure-和C4通过施加氢溶液C18在流化床工艺dipercarboxylic酸络合物，C1至C4Monopercarbonsäuren，C4至C18 dipercarboxylic酸或水或其混合物或羧酸为粉状或在或流化床和同时或随后流化床干燥使用作为基体中的外预颗粒化矩阵）N-乙烯基己内酰胺的均聚物，具有N-乙烯基吡咯烷酮，N-乙烯基咪唑，丙烯酸或甲基丙烯B）N-乙烯基己内酰胺共聚物 -3-磺酸，丙烯酸或甲基丙烯酸或如在N-乙烯基己内酰胺的从20的共聚单体的重量比共聚单体及其混合物：1至1:20，C）N-乙烯基吡咯烷酮共聚物具有N-乙烯基咪唑，丙烯酸或甲基丙烯酸或它们的混合物共聚单体在N-乙烯基吡咯烷酮的重量比为共聚单体从20：1至1:20，D）N-Vin的这可以被最多三个C1-C4烷基杂环上取代的和可以通过C1-C4烷基可以存在于N-季铵化形式，E）的单糖，寡糖，多糖或其衍生物与基咪唑的均聚物及其混合物，聚合物A至D在1:99至90:10的重量比，F）的单糖，低聚糖，淀粉，淀粉降解产物或其衍生物与为1:99的重量比N-乙烯基吡咯烷酮的均聚物，以90:10的混合物，G）海藻糖的混合物，蔗糖，葡萄糖，α - ，β - 或γ-环糊精或这些环糊精的衍生物或与聚合物A至D或与重量比的N-乙烯基吡咯烷酮均聚物或其混合物从1:99至100:0或H）的情况下使用C1至C4和C4与N-乙烯基吡咯烷酮的均聚物的C18Monopercarbonsäure-dipercarboxylic酸络合物。

12. 发明申请

WO1995009194A1 PYRROLIDONE-GROUP-CONTAINING POLYESTERS AND POLYAMIDES 审中-公开
标题翻译： PYRROLIDONGRUPPENHALTIGE聚酯和聚酰胺
公开(公告)号：WO1995009194A1
公开(公告)日：1995-04-06
申请号：PCT/EP1994003141
申请日：1994-09-20
申请人： BASF AKTIENGESELLSCHAFT , NGUYEN KIM, Son , BREITENBACH, Jörg , SANNER, Axel , HÖSSEL, Peter , LANG, Siegfried
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C08G63/685
CPC分类号： A61K8/85 , A61K8/88 , A61K47/34 , A61Q5/12 , C08G63/6852 , C08G63/6856 , C08G69/26 , C08G69/44 , Y10T428/2969
摘要： The invention concerns pyrrolidone-group-containing polyesters and polyamides of the formulae (I) to (III) in which R is hydrogen or C1-C4 alkyl, whereby two R groups may be bound to each other to form a six-membered ring, X is oxygen or an -NR- group, A is C1-C20 alkylene, which may include in the carbon chain one or more non-adjacent oxygen atoms, sulphur atoms or -NR- groups (in which the N-atom may be protonated or quaternarized), -CO-, -CO-O, -CO-NR, -SO- or -SO2- and may carry additional -COOH or -SO3H functional groups, C6-C20 cycloalkylene, C6-C20 arylene, or a mixture of such groups; Z is a group of the formula (IV) in which B is C1-C20 alkylene, which may include in the carbon chain one or more non-adjacent oxygen atoms, sulphur atoms or -NR- groups (in which the N-atom may be protonated or quaternarized), -CO-, -CO-O-, -CO-NR, -SO- or -SO2- an may carry additional -COOH or SO3H functional groups, C6-C20 cycloalkylene or a mixture of such groups, or a mixture of groups of formula IV and A groups; n is a number from 5 to 500. Compounds of the formulae (I) to (III) are suitable for use as film-forming agents and conditioners in cosmetic preparations for the hair, to stabilize aqueous solutions of hydrogen peroxide, as an iodine-complexing agent, as a binder in tablets and as a component of film coatings for pharmaceutical preparations, to stabilize enzyme and bleach additives in washing and cleaning agents, as an auxiliary in the manufacture and finishing of textiles, as a solubilizer and protective colloid in the manufacture and stabilization of polymer dispersions and as a raw material for adhesives.
摘要翻译： Pyrrolidongruppenhaltige聚酯和聚酰胺（I）至（III），其中R是氢或C1-C4烷基，其中两个基团R可被连接在一起以形成一个六元环，X表示氧或基团-NR甲 C1至C20亚烷基，其可被一个或多个不相邻的氧原子间隔，硫原子或官能团-NR-，其中氮原子被质子化或季铵化，-CO - ， - CO-O - ， - CO-NR- ， - SO-或-SO 2 - 被中断，并且可以携带额外的官能团COOH或-SO 3 H，C 6至C 20 - 亚环烷基，C6至C20亚芳基，其通过氧，硫或基团-NR-，-SO 可能被中断或-SO 2 - 和携带额外的官能团COOH或-SO 3 H，或这些基团的混合物，Z是式的基团（IV）其中的B是C1至C20亚烷基，其被一个或多个 - 非相邻的氧原子，硫原子或官能团 - NR-，其中所述N-原子被质子化或-CO-，-CO-O-，-CO-O - ， - CO-NR - ， - SO-或-SO 2 - 可以被季铵化，被中断，并且另外的官能团 - 可以携带COOH或-SO 3 H，C 6至C 20 - 亚环烷基，或这些基团的混合物是，或（IV）按组指定一个式的基团的混合物，n为5至500看台的数。型（I）至（III）的化合物作为在发用化妆品制剂剂和调理剂，在水溶液中过氧化氢的稳定化，对于碘络合，作为片剂粘合剂和作为药物制剂的薄膜包衣的成分成膜，酶和漂白剂稳定化有用在洗涤和清洁制剂，如在制造和在纺织品整理中的助剂，如在制备增溶剂和保护性胶体和聚合物分散体的稳定化，以及作为粘接剂的原料。

13. 发明申请

WO2008055965A1 MELT-PROCESSED IMATINIB DOSAGE FORM 审中-公开
标题翻译： MELT-PROCESSED IMATINIB剂型
公开(公告)号：WO2008055965A1
公开(公告)日：2008-05-15
申请号：PCT/EP2007/062100
申请日：2007-11-08
申请人： ABBOTT GMBH & CO. KG , NOVARTIS AG , BREITENBACH, Jörg , STEIGER, Norbert , HACH, Harald , WESTEDT, Ulrich , KNOBLOCH, Martin , ALTENBURGER, Ralf , LOGGIA, Nicoletta , OGORKA, Jörg
发明人： BREITENBACH, Jörg , STEIGER, Norbert , HACH, Harald , WESTEDT, Ulrich , KNOBLOCH, Martin , ALTENBURGER, Ralf , LOGGIA, Nicoletta , OGORKA, Jörg
IPC分类号： A61K9/20 , A61K31/505
CPC分类号： A61K9/2095 , A61K9/2054
摘要： The invention provides a dosage form, comprising a melt-processed mixture of (a) a pharmaceutically effective amount of imatinib or a salt thereof, (b) at least one polymeric binder, and (c) at least one pharmaceutically acceptable non-ionic surfactant. The invention provides imatinib dosage forms with high drug loading which can be prepared in a simple and efficient manner, imatinib dosage forms from which the active principle is released in an essentially pH-independent fashion, and extended release imatinib dosage forms.
摘要翻译：本发明提供了一种剂型，其包含（a）药学有效量的伊马替尼或其盐的熔融加工混合物，（b）至少一种聚合物粘合剂，和（c）至少一种药学上可接受的非离子表面活性剂。本发明提供具有高药物负荷的伊马替尼剂型，其可以以简单和有效的方式制备，以基本上不依赖于pH的方式释放活性成分的伊马替尼剂型和延长释放的伊马替尼剂型。

14. 发明申请

WO1998023722A1 PROCEDURE FOR THE PRODUCTION OF SOLID, FORMED DETERGENT FORMULATIONS 审中-公开
标题翻译：方法生产固体，形成了洗涤剂配方
公开(公告)号：WO1998023722A1
公开(公告)日：1998-06-04
申请号：PCT/EP1997006431
申请日：1997-11-18
申请人： KNOLL AKTIENGESELLSCHAFT , GRÜNHAGEN, Hans-Heinrich , BREITENBACH, Jörg , ROSENBERG, Joerg
发明人： KNOLL AKTIENGESELLSCHAFT
IPC分类号： C11D11/00
CPC分类号： C11D17/065 , C11D11/0082
摘要： Method for the production of high density detergent formulations that decompose quickly in the washing bath, characterized in that the feed material mixture is subjected to a kneading and mixing process, followed by forming by application of compressed-air.
摘要翻译：一种用于洗涤剂配方，在洗涤液体中的高密度和快速崩解的制备方法，其特征在于，所述起始材料的混合物进行捏合和混合处理，然后通过压缩空气三通成形邻接。

15. 发明申请

WO1998015291A1 1,3-BIS-(N-LACTAMYL) PROPANE AND THE PHARMACEUTICAL AND COSMETIC USE THEREOF 审中-公开
标题翻译： 1,3-双（N-lactamyl）丙烷和它们的药物和化妆品用途
公开(公告)号：WO1998015291A1
公开(公告)日：1998-04-16
申请号：PCT/EP1997005499
申请日：1997-10-07
申请人： BASF AKTIENGESELLSCHAFT , BREITENBACH, Jörg , LANG, Siegfried , KRATZ, Detlef
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： A61K47/22
CPC分类号： A61K9/0014 , A61K8/49 , A61K8/4906 , A61K8/4913 , A61K8/4926 , A61K9/0019 , A61K47/22 , A61Q19/00 , C07D207/267 , C07D211/40
摘要： The invention relates to 1,3-bis-(N-lactamyl) propane having general formula (I), wherein radicals R ,R ,R ,R ,R ,R , (NLac) and (NLac') have the meaning cited in the description, and the use thereof as a solvent in pharmaceutical and cosmetic agents.
摘要翻译：本发明涉及1,3-双（N-lactamyl）通式（I）其中基团R <1>，R <2>，R <3>，R <4>，R <5>的丙烷，R拥有和<6>（NLac）和（NLac“）在它们的在药物和化妆品的溶剂使用的说明书中给出的含义。

16. 发明申请

WO1997026866A2 PREPARATIONS OF NON-STEROIDAL ANALGESICS 审中-公开
标题翻译：非类固醇的筹备镇痛
公开(公告)号：WO1997026866A2
公开(公告)日：1997-07-31
申请号：PCT/EP1997000185
申请日：1997-01-17
申请人： BASF AKTIENGESELLSCHAFT , BREITENBACH, Jörg , ROSENBERG, Joerg
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： A61K09/20
CPC分类号： A61K31/192 , A61K9/2013 , A61K9/2027 , A61K9/2095
摘要： The invention concerns preparation of non-steroidal analgesics with antipyretic and antiphlogistic effect, obtained through extrusion and moulding of a melt containing in addition one or more substances in a mixture of: a) 40 to 99.5 wt% of a homopolymer of N -vinylpyrrolidone with a K value according to Fikentscher of 30; b) 0.25 to 59.75 wt% of a water-soluble copolymer of N-vinylpyrr olidone; and c) 0.25 to 10 wt% of one or more physiologically ac ceptable sodium or potassium salts, where the quantities refer to the total of the components a), b) and c).
摘要翻译：本发明涉及一种具有解热和抗炎作用的非甾体止痛剂，通过挤出获得的，熔体的成形的制品，其特征在于，除了一种或多种活性成分的混合物：a）40至99.5重量具有K A N-乙烯基吡咯烷酮的均聚物的％根据30 Fikentscher，值b）0.25至59.75重量的N-乙烯基吡咯烷酮的水溶性共聚物的％和钠或钾的一种或多种生理上可接受的盐C）0.25至10重量％其中给出的量是指组分的总和），b）和c）。

17. 发明申请

WO1997015291A1 METHOD OF PRODUCING MEDICAMENTS IN SOLID FORM 审中-公开
标题翻译：用于固体药物剂型的研制
公开(公告)号：WO1997015291A1
公开(公告)日：1997-05-01
申请号：PCT/EP1996004585
申请日：1996-10-22
申请人： BASF AKTIENGESELLSCHAFT , BREITENBACH, Jörg , HÄRTL, Axel, Paul , ROSENBERG, Joerg , SCHIESSL, Michael , ZETTLER, Hans, Dieter
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： A61K09/20
CPC分类号： A61K9/2095
摘要： The invention concerns a method of producing medicaments in solid form by mixing and melting at least one pharmacologically acceptable polymer binder, at least one pharmaceutical active substance and optionally conventional pharmaceutical additives in the absence of a solvent to form a plastic mixture, and shaping the mixture to form the desired medicament, mixing and melting being carried out in separate stages. The method according to the invention enables high-quality medicaments to be produced in a simple and careful manner.
摘要翻译：本发明涉及一种用于通过至少一种药理学上可接受的聚合物粘合剂，至少一种药物活性成分和任选的常规的药物添加剂的混合和熔化，在不存在溶剂的，在塑料混合物制备固体剂型，塑造成所需的剂型，其中所述混合物进行在分开的阶段的混合和熔融。本发明的方法允许简单和温和的生产具有高产品质量的剂型。

18. 发明申请

WO1997007786A2 USE OF LIPIDS AS ADJUVENTS IN THE PRODUCTION OF SOLID MEDICINAL FORMS BY THE MELT EXTRUSION PROCESS 审中-公开
标题翻译：脂质作为工具使用中的固体药用形式的熔化过程中挤出后的生产
公开(公告)号：WO1997007786A2
公开(公告)日：1997-03-06
申请号：PCT/EP1996003667
申请日：1996-08-21
申请人： BASF AKTIENGESELLSCHAFT , ROSENBERG, Joerg , BREITENBACH, Jörg
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： A61K09/20
CPC分类号： A61K9/2054 , A61K9/2013 , A61K9/2018 , A61K9/2095
摘要： Use of lipids as adjuvents in the production of solid medicinal forms by the melt extrusion process.
摘要翻译：使用脂质作为生产的通过熔融挤出法进行固体药物形式助剂。

19. 发明申请

WO1996025151A1 SOLID ACTIVE AGENT PREPARATIONS 审中-公开
标题翻译：积极准备节日
公开(公告)号：WO1996025151A1
公开(公告)日：1996-08-22
申请号：PCT/EP1996000417
申请日：1996-02-01
申请人： BASF AKTIENGESELLSCHAFT , GRABOWSKI, Sven , BREITENBACH, Jörg , ROSENBERG, Joerg , SANNER, Axel
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： A61K09/22
CPC分类号： A61K9/2054 , A61K9/2095
摘要： Solid preparations obtainable by the melt extrusion of A) at least one active agent, B) a mixture of B1) 10 to 90 wt.% of a water-soluble, thermoplastic polymer and B2) 10 to 90 wt.% of a low-substituted hydroxypropyl cellulose and C) 0 to 50 wt.% in relation to the total quantity of the preparation of common pharmaceutical auxiliaries.
摘要翻译：由A的熔融挤出）至少一种活性化合物，B）B1的混合物）10至90重量的水溶性，热塑性聚合物和B2）10〜90重量的低取代羟丙基纤维素的％％，和C获得的固体制剂）0至50重量％，基于制剂常规的药物赋形剂，总量。

20. 发明申请

WO1996019964A1 METHOD OF PRODUCING LENTICULAR TABLETS BY MELT CALENDERING 审中-公开
标题翻译：受理并熔体中制造LENS粒形
公开(公告)号：WO1996019964A1
公开(公告)日：1996-07-04
申请号：PCT/EP1995005119
申请日：1995-12-22
申请人： BASF AKTIENGESELLSCHAFT , ROSENBERG, Joerg , MAIER, Werner , BREITENBACH, Jörg
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： A61J03/10
CPC分类号： A61J3/10 , A61J2200/20 , A61K9/2072 , B30B11/165
摘要： The invention concerns a method of producing lenticular tablets by melt calendering, using form cylinders provided with ellipsoid-segment recesses. The proposed method produces tablets which are easy to trim and in which any misalignement between the top and bottom halves of the tablet is such that only a small residue needs to be ground off.
摘要翻译：本发明涉及一种用于通过熔融压延生产双凸透镜片，其特征在于，一个使用具有凹陷ellipsoidsegmentartigen成型辊。片剂本发明的方法的结果，其是容易被去除毛刺，并且其中在上和下半片之间的偏移量的片剂残余低的磨损。

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