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1. 发明申请

WO1989005624A1 TRI-SCORED DRUG TABLET 审中-公开
公开(公告)号：WO1989005624A1
公开(公告)日：1989-06-29
申请号：PCT/US1988004367
申请日：1988-12-12
申请人： THE UPJOHN COMPANY , NI, Phillip, F. , ODAR, Larry, F.
发明人： THE UPJOHN COMPANY
IPC分类号： A61J03/10
CPC分类号： A61J3/10 , A61K9/2072
摘要： A tri-scored drug tablet (10) having an elongated tablet body (11) with a length greater than its width. The body (11) has a bottom facing surface with a pair of concavities (23, 24) therein. Each concavity (23, 24) is equal in size and has parallel major and minor axes, each concavity (23, 24) further having a smooth and uninterrupted arcuate surface extending between the opposite longitudinal ends of said body (11) and a longitudinally central part of said tablet (10). The opposite longitudinal ends of the body (11) and the longitudinally central part are of a thicker dimension than the thickness of the body (11) measured at an apex of each of the concavities (23, 24). Aligned breaking grooves (21, 29, 31, 32) are formed in the top and bottom surfaces at both of the concavities (23, 24) and between the concavities (23, 24) at said longitudinally central part, each of breaking groove (21, 29, 31, 32) extending laterally across the width of said tablet (10) at said apex of each of said concavities (23, 24) at said longitudinally central part to divide the tablet (10) into four quarter sections (48, 49, 51, 52) of equal size.
摘要翻译：具有长度大于其宽度的细长片剂本体（11）的三片药片（10）。主体（11）具有底面朝向的表面，其中具有一对凹部（23,24）。每个凹部（23,24）的尺寸相等并且具有平行的主轴和短轴，每个凹部（23,24）还具有在所述主体（11）的相对的纵向端部之间延伸的平滑且不间断的弓形表面，并且纵向中心所述片剂（10）的一部分。主体（11）和纵向中心部分的相对的纵向端部具有比在每个凹部（23,24）的顶点处测量的主体（11）的厚度更大的尺寸。在两个凹部（23,24）的顶表面和底表面以及在所述纵向中心部分处的凹部（23,24）之间形成有分隔开的凹槽（21,29,31,32），每个断裂槽在所述纵向中心部分处，在每个所述凹部（23,24）的顶点处横向延伸穿过所述片剂（10）的宽度的横截面（21,29,31,32），以将片剂（10）分成四个四分之一部分，49,51,52）。

2. 发明申请

WO1995018595A1 PROCESS FOR PRODUCING TABLETS 审中-公开
标题翻译：用于生产片剂
公开(公告)号：WO1995018595A1
公开(公告)日：1995-07-13
申请号：PCT/DE1995000010
申请日：1995-01-04
申请人： VOSS, Gunter, M.
IPC分类号： A61J03/10
CPC分类号： B01J2/22 , B30B11/02 , B30B15/0011
摘要： A process is disclosed for producing tablets by using a press having at least one tablet bottom die movable in relation to a lubricant supply unit having at least one binary nozzle that applies lubricant on the compression chamber walls of the tablet bottom die as a hollow cone-shaped beam of lubricant. The invention is characterised in that the position of the beam of lubricant applied on the compression chamber walls changes in relation to the tablet bottom die at least between two successive tablet bottom dies to be supplied with lubricant.
摘要翻译：公开了一种用于使用压机制备片剂的方法，具有至少一个Tablettenmatrize其相对于润滑剂供应单元，其中至少提供一个双流体喷嘴，其将润滑剂施加到Tablettenmatrize的按压室壁中的中空圆锥形润滑剂束的形式移动。本发明的特征在于，施加到所述加压室壁上的润滑剂束的压力的位置是相变化到Tablettenmatrize至少之间两个连续的润滑剂以提供Tablettenmatrizen。

3. 发明申请

WO1996019963A1 METHOD OF PRODUCING COATED TABLETS 审中-公开
标题翻译：用于生产包衣片
公开(公告)号：WO1996019963A1
公开(公告)日：1996-07-04
申请号：PCT/EP1995005118
申请日：1995-12-22
申请人： BASF AKTIENGESELLSCHAFT , ROSENBERG, Joerg , MAIER, Werner , GRABOWSKI, Sven , BREITENBACH, Jörg
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： A61J03/10
CPC分类号： B30B11/34 , A61J1/035 , A61J3/005 , A61J3/10 , A61J2200/20 , A61K9/2072 , B30B11/16 , B65B9/04
摘要： The invention concerns a method of producing coated tablets by melt calendering, the melt containing the active substance being introduced into the form cylinders between two films of the coating material.
摘要翻译：本发明涉及一种用于制备包衣片通过熔融压延的方法，其中含有活性成分的熔体两片覆盖材料到模制辊之间引入的方法。

4. 发明申请

WO1995018596A1 PROCESS FOR PRODUCING TABLETS 审中-公开
标题翻译：用于生产片剂
公开(公告)号：WO1995018596A1
公开(公告)日：1995-07-13
申请号：PCT/DE1995000011
申请日：1995-01-04
申请人： VOSS, Gunter, M.
IPC分类号： A61J03/10
CPC分类号： B30B15/0011 , A61J3/10 , B01J2/20 , B01J2/22
摘要： A process is disclosed for producing tablets by using a press with at least one compression chamber with an upper ram and a bottom ram, as well as a lubricating device with at least one binary nozzle that projects the lubricant on the walls of the compression chamber as a spraying cone. This process is characterised in that at least one additive is added to the lubricant.
摘要翻译：公开的是用于制备使用具有具有上表面和下冲头的至少一个压力室的压片剂和具有至少一个双物质喷嘴，其发射上的喷雾锥压缩室壁上的润滑剂的润滑装置的方法。本发明的方法的特征在于，所述润滑剂是添加剂加入到至少。

5. 发明申请

WO1997015268A1 MOULDING STRIP CALENDER 审中-公开
标题翻译： FORMBANDKALANDER
公开(公告)号：WO1997015268A1
公开(公告)日：1997-05-01
申请号：PCT/EP1996004600
申请日：1996-10-23
申请人： KNOLL AKTIENGESELLSCHAFT , SPENGLER, Reinhard
发明人： KNOLL AKTIENGESELLSCHAFT
IPC分类号： A61J03/10
CPC分类号： B30B11/16 , A23P10/28 , A23P30/10 , A61J3/06 , A61J2200/20 , A61K9/2095 , B30B5/04
摘要： The invention concerns a method and device for producing flat blanks, in particular tablets, from a product mass containing an active substance by fusion calendering. To this end, a charging device delivers the product mass to at least one pair of rollers consisting of two calender rollers which can rotate in opposite senses. The device comprises a circulating moulding strip which is guided between the two rollers and comprises on its surface recesses for receiving the product mass.
摘要翻译：本发明涉及一种装置和用于制作薄片状坯件的方法，特别是片剂，从含有通过熔融压延的活性物质的产品质量。在此，进料装置导致的至少一对由两个反向转动的压延辊，产品质量的轧辊。该装置包括一成型循环带，在这两个辊之间进行，具有在其表面上的凹部成型带，用于接收的产品质量。

6. 发明申请

WO1996019962A1 METHOD OF MANUFACTURING DIVISIBLE TABLETS 审中-公开
标题翻译：用于生产分割药片
公开(公告)号：WO1996019962A1
公开(公告)日：1996-07-04
申请号：PCT/EP1995005117
申请日：1995-12-22
申请人： BASF AKTIENGESELLSCHAFT , ROSENBERG, Jörg , MAIER, Werner , FRICKE, Helmut , BREITENBACH, Jörg
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： A61J03/10
CPC分类号： B30B11/165 , A61J3/10 , A61K9/2072 , Y10S53/90
摘要： Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von teilbaren Tabletten durch Schmelzkalandrierung, wobei man zwei Formwalzen miteinander kombiniert, von denen mindestens eine Vertiefungen mit mindestens einem Steg aufweist, der sich bis zur Mantellinie der Formwalze erstreckt und die Formung einer Bruchrille bewirkt.
摘要翻译：本发明涉及制造由熔融压延整除片剂的方法，包括：两个表单汽缸组合，具有至少一个凹部与延伸直到所述滚筒的表面线并形成切断槽的至少一个脊的气缸中的一个，

7. 发明申请

WO1992022278A1 PROCESS FOR REMOVING TABLETS OR PILLS OR THE LIKE ISSUING FROM A TABLET PRESS AND PROCESSING THEM FURTHER AND DEVICE THEREFOR 审中-公开
标题翻译：从平板印刷机中取出片材或印刷品或类似印刷品的方法及其进一步处理及其设备
公开(公告)号：WO1992022278A1
公开(公告)日：1992-12-23
申请号：PCT/DE1992000468
申请日：1992-06-09
申请人： KRÄMER, Norbert
IPC分类号： A61J03/10
CPC分类号： A61J3/10 , B30B15/32
摘要： The invention relates to a process for removing tablets or pills or the like issuing from a tablet or pill press and processing them further in a plurality of containers (125, 126, 127) standing cramped on a restricted area. After leaving the tablet or pill press, the tablets or pills are conveyed upwards and, by gravity alone without the application of further energy, pass from top to bottom through an oblique deburring and dust-removing station (12) and a distributing guide (15) to divide the flow of tablets or pills into two partial streams which are taken to either a metal testing device (18) or a tablet or pill testing device (19) with a sample collector (22); the tablets or pills found to be faultless are taken further by gravity to a belt conveyor (107, 112) which takes the tablets or pills to and inserts them in a predetermined container (125, 126, 127).
摘要翻译：本发明涉及一种从片剂或药片压制机中除去片剂或丸剂等的方法，并且进一步在许多容纳在限制区域上的狭窄容器（125,126,127）中进行处理。在离开片剂或药丸按压机之后，片剂或丸剂被向上输送，并且通过重力单独而不施加进一步的能量，从顶部到底部通过倾斜去毛刺和除尘台（12）和分配引导件（15））将片剂或丸剂的流分成两个部分流，其被带到具有样品收集器（22）的金属测试装置（18）或片剂或丸剂测试装置（19）; 发现无缺陷的片剂或丸剂通过重力进一步被吸收到带式输送机（107,112）中，该带式输送机将片剂或药片吸入并将其插入预定的容器（125,126,127）中。

8. 发明申请

WO1996019964A1 METHOD OF PRODUCING LENTICULAR TABLETS BY MELT CALENDERING 审中-公开
标题翻译：受理并熔体中制造LENS粒形
公开(公告)号：WO1996019964A1
公开(公告)日：1996-07-04
申请号：PCT/EP1995005119
申请日：1995-12-22
申请人： BASF AKTIENGESELLSCHAFT , ROSENBERG, Joerg , MAIER, Werner , BREITENBACH, Jörg
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： A61J03/10
CPC分类号： A61J3/10 , A61J2200/20 , A61K9/2072 , B30B11/165
摘要： The invention concerns a method of producing lenticular tablets by melt calendering, using form cylinders provided with ellipsoid-segment recesses. The proposed method produces tablets which are easy to trim and in which any misalignement between the top and bottom halves of the tablet is such that only a small residue needs to be ground off.
摘要翻译：本发明涉及一种用于通过熔融压延生产双凸透镜片，其特征在于，一个使用具有凹陷ellipsoidsegmentartigen成型辊。片剂本发明的方法的结果，其是容易被去除毛刺，并且其中在上和下半片之间的偏移量的片剂残余低的磨损。

9. 发明申请

WO1996017579A1 N-VINYL LACTAM POLYMER CONTAINING TABLETS OF LOW FRIABILITY AND HIGH RATE OF DISSOLUTION 审中-公开
标题翻译：含有低可溶性和高溶解度的片剂的N-乙烯基-LACTAM聚合物
公开(公告)号：WO1996017579A1
公开(公告)日：1996-06-13
申请号：PCT/US1995015535
申请日：1995-11-29
申请人： ISP INVESTMENTS INC.
发明人： ISP INVESTMENTS INC. , NARAYANAN, Kolazi, S.
IPC分类号： A61J03/10
CPC分类号： A61K9/2013 , A01N25/34 , A61K9/2027
摘要： This invention relates to a coprecipitated binder composition used for the compression of pharmaceutically and agriculturally active components to provide a non-friable, readily soluble or dispersible pill or tablet. The invention also relates to the process for preparing the binder and to its incorporation in a formulation with the active ingredient.
摘要翻译：本发明涉及一种用于压制药用和农业活性组分以提供不易碎，易溶或可分散的丸剂或片剂的共沉淀粘合剂组合物。本发明还涉及制备粘合剂的方法及其与制剂中掺入活性成分的方法。

10. 发明申请

WO1990003776A1 LOW-MELTING MOLDABLE PHARMACEUTICAL EXCIPIENT AND DOSAGE FORMS PREPARED THEREWITH 审中-公开
标题翻译：低熔点可塑性药物制剂及其制剂
公开(公告)号：WO1990003776A1
公开(公告)日：1990-04-19
申请号：PCT/US1989004533
申请日：1989-10-12
申请人： ZETACHRON, INC.
发明人： ZETACHRON, INC. , SNIPES, Wallace, C.
IPC分类号： A61J03/10
CPC分类号： A61K9/02 , A61K9/006 , A61K9/2009 , A61K9/2013 , A61K9/2031
摘要： An excipient for a pharmaceutical compound which melts at body temperature but will not spontaneously deform at higher temperatures encountered in shipment and storage comprises: low MW polyethylene glycol (M.P. about 37°C) 75-90 %; medium to high MW polyethylene glycol 0-4 %; long chain saturated carboxylic acid 0-4 %; polyethylene oxide (MW 100,000 - 5,000,000) 0-4 %; colloidal silica 10-20 %. The excipient is particularly advantageous for the preparation of dosage forms for buccal administration of pharmaceutical compounds.

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