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121. 发明申请

WO1994026777A1 THROMBIN INHIBITORS 审中-公开
标题翻译：冷冻抑制剂
公开(公告)号：WO1994026777A1
公开(公告)日：1994-11-24
申请号：PCT/EP1994001404
申请日：1994-05-03
申请人： MERCK PATENT GMBH , HEMBERGER, Jürgen , SAWYER, Roy , WOLF, Sabine , DODT, Johannes
发明人： MERCK PATENT GMBH
IPC分类号： C07K07/10
CPC分类号： C07K14/815 , A61K38/00 , Y10S514/822 , Y10S530/855
摘要： The invention relates to novel polypeptides with antithrombin activity obtainable from extracts of tissues or secretions of leeches of the order Rhynchobdellida, particularly of the species Theromyzon tessulatum. The polypeptides have molecular weights of about 14 kD, 9 kD and 3 kD and can be used in pharmaceutical compositions for the treatment of thrombosis related disorders and events.
摘要翻译：本发明涉及具有抗凝血酶活性的新型多肽，其可获自组织提取物或Rhynchobdellida序列水蛭分泌物，特别是物种Theromyzon tessulatum。多肽具有约14kD，9kD和3kD的分子量，并且可用于治疗血栓形成相关疾病和事件的药物组合物中。

122. 发明申请

WO1994025595A2 CYTOLYSIN GENE AND GENE PRODUCT 审中-公开
标题翻译： CYTOLYSIN基因和基因产物
公开(公告)号：WO1994025595A2
公开(公告)日：1994-11-10
申请号：PCT/EP1994001262
申请日：1994-04-22
申请人： MERCK PATENT GMBH
发明人： MERCK PATENT GMBH , GOEBEL, Werner , HEFFRON, Fred, L. , LIBBY, Stephen, J.
IPC分类号： C12N15/31
CPC分类号： C07K14/255
摘要： A Salmonella gene, encoding a cytolysin, has been identified by screening for hemolysis on blood agar. The gene (slyA) is present in every strain of Salmonella examined in Shigella, and enteroinvasive Escherichia coli (EIEC) but not in other enterobacteriaceae. It is encoded near 28.5 minutes on the chromosome. A SlyA (salmolysin) has hemolytic and cytolytic activity and has a molecular weight predicted by the DNA sequence.
摘要翻译：通过筛选血琼脂上的溶血来鉴定编码细胞溶解素的沙门氏菌基因。基因（slyA）存在于在志贺氏菌和肠内侵袭性大肠杆菌（EIEC）中检测的沙门氏菌的每一个菌株中，但不在其他肠杆菌科中。在染色体28.5分钟附近编码。 SlyA（salmolysin）具有溶血和溶细胞活性，具有DNA序列预测的分子量。

123. 发明申请

WO1994023294A1 LIQUID CHROMATOGRAPHY CARTRIDGE 审中-公开
标题翻译：墨盒液体
公开(公告)号：WO1994023294A1
公开(公告)日：1994-10-13
申请号：PCT/EP1994000913
申请日：1994-03-23
申请人： MERCK PATENT GMBH , DELP, Axel , JUNGBLUT, Bernd , KINKEL, Joachim
发明人： MERCK PATENT GMBH
IPC分类号： G01N30/60
CPC分类号： B01D15/22 , B29C65/00 , B29C66/5432 , B29C66/612 , B29C66/71 , G01N30/6004 , G01N30/6039 , G01N30/6091 , G01N2030/085 , B29K2027/18
摘要： A novel liquid chromatography cartridge is disclosed, in particular for high pressure liquid chromatography (HPLC). A simplified endpiece with sieving means is introduced into a tubular cartridge and retained in the tubular cartridge by frictional forces. The endpiece is sealed by radial forces. In the dismounted state, the outer diameter of the endpiece is larger than the inner diameter of the tubular cartridge.

124. 发明申请

WO1994022574A1 IMMOBILIZED ENZYMES 审中-公开
标题翻译：固定化酶
公开(公告)号：WO1994022574A1
公开(公告)日：1994-10-13
申请号：PCT/EP1994000976
申请日：1994-03-28
申请人： MERCK PATENT GMBH , MÜLLER, Egbert , BADEL, Kerstin , MÜLLER, Andreas , HERBERT, Stefan , SEILER, Anja , HOLSCHUH, Karl
发明人： MERCK PATENT GMBH
IPC分类号： B01J20/32
CPC分类号： C12N9/22 , B01J20/261 , B01J20/264 , B01J20/265 , B01J20/28047 , B01J20/3204 , B01J20/3219 , B01J20/327 , B01J20/3278 , B01J20/328 , C12N11/08
摘要： Immobilized enzymes may be produced by reacting enzymes with activated substrates which contain as activated groups oxiran or azlactone groups as substituents in linear polymers. These immobilized enzymes are used in reaction with high molecular substrates. The immobilized proteinase K, for example, is suitable for inactivating other enzymes, in particular nucleic acid-modifying enzymes, for example restriction endonucleases.

125. 发明申请

WO1994013658A2 BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES 审中-公开
标题翻译：苯并噻唑啉，苯并吖庚因和苯并HI嗪
公开(公告)号：WO1994013658A2
公开(公告)日：1994-06-23
申请号：PCT/EP1993003445
申请日：1993-12-07
申请人： MERCK PATENT GMBH , BERTHELON, Jean-Jacques , BRUNET, Michel , NOBLET, Marc , DURBIN, Philippe , GUERRIER, Daniel , LUONG, Trong, Nghia
发明人： MERCK PATENT GMBH
IPC分类号： C07D313/08
CPC分类号： C07D213/30 , C07D213/57 , C07D213/89 , C07D405/04 , C07D409/04 , C07D493/04 , Y02P20/55
摘要： The subject of the invention is compounds of general formula (I), in which: X represents O or CHR; R1, R2, R3 and R4, which are identical or different, represent a hydrogen atom or a C1-C7 alkyl group, it being possible for R1 to additionally form a bond with R; R5 represents a hydrogen atom, a hydroxyl group or R5, taken together with R7, forms a bond or a O group; R6 represents a group of formula (a) in which R10 and R11, taken together with the carbon atom to which they are attached, form a nitrogenous heterocyclic group, and their N-oxides and pharmaceutically acceptable salts. These compounds are powerful activators of potassium channels.
摘要翻译：本发明的主题是通式（I）的化合物，其中：X表示O或CHR; R1，R2，R3和R4相同或不同，表示氢原子或C1-C7烷基，R1可以另外与R形成键; R5表示氢原子，羟基或R5，与R7一起形成键或 O基团; R 6表示其中R 10和R 11与它们所连接的碳原子一起形成含氮杂环基的式（a）基团及其N-氧化物和药学上可接受的盐。这些化合物是钾通道的强大激活剂。

126. 发明申请

WO1994012278A1 CO-ORDINATION CATALYST SYSTEM 审中-公开
标题翻译：配位催化剂体系
公开(公告)号：WO1994012278A1
公开(公告)日：1994-06-09
申请号：PCT/EP1993003204
申请日：1993-11-16
申请人： MERCK PATENT GMBH , POHL, Ludwig , POETSCH, Eike , HIRSCH, Hans-Ludwig , SCHUMANN, Herbert , WEISS, Karin , THIELE, Karl-Heinz
发明人： MERCK PATENT GMBH
IPC分类号： B01J31/14
CPC分类号： B01J31/143 , B01J31/0252 , B01J31/12 , B01J31/122 , B01J31/16 , B01J2231/12 , B01J2231/543 , B01J2231/546 , C07C6/02 , C07C6/04 , C07C2531/12 , C07C2531/14 , C07C2531/22 , C07F5/00 , C07F5/062 , C07F5/066 , C08F10/00 , C08F38/00 , C08F4/603 , C08F4/602
摘要： The invention concerns the use of cyclic metallic-organic bonds as components in co-ordination catalyst systems, corresponding co-ordination catalyst systems and a process for producing polymers by co-ordination polymerisation and unsaturated hydrocarbons by the catalysed metathesis of alkenes and alkines using such co-ordination catalyst systems.

127. 发明申请

WO1994007945A1 MOLDED BODIES MADE OF POLYESTER COTAINING COVALENT-BONDED OXIDE PARTICLES 审中-公开
标题翻译：成型聚酯共价结合氧化物粒子含有
公开(公告)号：WO1994007945A1
公开(公告)日：1994-04-14
申请号：PCT/EP1993002660
申请日：1993-09-30
申请人： HOECHST AKTIENGESELLSCHAFT , MERCK PATENT GMBH , DALLMANN, Herrmann , KINKEL, Joachim , MARQUARD, Kurt , POHL, Ludwig
发明人： HOECHST AKTIENGESELLSCHAFT , MERCK PATENT GMBH
IPC分类号： C08K03/22
CPC分类号： B82Y30/00 , C01P2004/32 , C01P2004/52 , C01P2004/61 , C01P2004/62 , C01P2004/64 , C01P2004/80 , C01P2006/90 , C08J5/18 , C08J2367/02 , C08K9/06 , C09C1/3081 , C09C3/12 , Y10T428/25 , Y10T428/256 , Y10T428/259 , Y10T428/2991 , Y10T428/2995 , Y10T428/31786 , C08L67/02
摘要： Described are molded bodies and their use, preferably molded bodies made of a polyester that contains oxide particles that have been subjected to surface modification with a silanizing agent of formula (I): (R1R2R3)Si-(CH2)I-X-R4, wherein R1 stands for Cl or alkoxy with 1-6 C atoms, R2, R3 alkyl with 1-6 C atoms or the meaning of R1, I the numbers 1-6, X a single bond, O, NH, CONH, NHCONH, R4 (a), with Y = CH or (b), Z = OR or two Z residues together with -O-, (c) and m, n the numbers 0-6 or (d), where X is a single bond, with R, R', R'' = H or alkyl with 1-6 C atoms.

128. 发明申请

WO1993022397A1 ELECTROOPTICAL LIQUID CRYSTAL SYSTEM 审中-公开
标题翻译：电液体水晶系统
公开(公告)号：WO1993022397A1
公开(公告)日：1993-11-11
申请号：PCT/EP1993000989
申请日：1993-04-23
申请人： MERCK PATENT GMBH , COATES, David , PARRI, Owain, Llyr , GREENFIELD, Simon , TILLIN, Martin, David , GOULDING, Mark, John , NOLAN, Patrick
发明人： MERCK PATENT GMBH
IPC分类号： C09K19/54
CPC分类号： C09K19/3469 , C09K19/12 , C09K19/14 , C09K19/2007 , C09K19/322 , C09K19/3444 , C09K19/38 , C09K19/544 , C09K2019/0448 , C09K2019/0481 , Y10T428/10 , Y10T428/1077
摘要： Electrooptical system with improved switching time especially at low temperatures: which between 2 electrode layers contains a PDLC film comprising a liquid crystal mixture forming microdroplets in an optically isotropic, transparent polymer matrix, the precursor of the PDLC film comprises one or more monomers, oligomers and/or prepolymers and a photoinitiator, and is cured photoradically, the liquid crystal mixture of which comprises one or more compounds of formula (I) in which Z and Z , independently of one another, are a single bond, -CH2CH2-, -COO-, -OCO- or -C=C-, (a) and (b), independently of one another, are trans-1,4-cyclohexylene, 1,4-phenylene, 2-fluoro-1,4-phenylene, 3-fluoro-1,4-phenylene, 2,3-difluoro-1,4-phenylene or 3,5-difluoro-1,4-phenylene and one of (a) and (b) may also be pyrimidine-2,5-diyl, pyridine-2,5-diyl or trans-1,3-dioxane-2,5-diyl, X and X , independently from one another, are H or F, Q is -CF2, -OCF2, -C2F4, -OC2F4 or a single bond, Y is -H, -F, -C1 or -CN, n is 0, 1 or 2 and R is alkyl having up to 13 C atoms, in which one or two non-adjacent CH2 groups can also be replaced by -O- and/or -CH=CH- and additionally one or more reactive liquid crystalline compounds preferably containing terminal ene-group.
摘要翻译：具有改善的切换时间，特别是在低温下的电光学系统：其中2个电极层之间包含PDLC膜，其包含在光学各向同性的透明聚合物基质中形成微滴的液晶混合物，PDLC膜的前体包含一种或多种单体，低聚物和光学引发剂，并且光电偶联地固化，其液晶混合物包含一种或多种式（I）化合物，其中Z 1和Z 2彼此独立地是单键， -CH 2 CH 2 - ， - COO-，-OCO-或-C = C - ，（a）和（b）彼此独立地为反式-1,4-亚环己基，1,4-亚苯基， 1,4-亚苯基，3-氟-1,4-亚苯基，2,3-二氟-1,4-亚苯基或3,5-二氟-1,4-亚苯基和（a）和（b）之一可以吡啶-2,5-二基或反式-1,3-二恶烷-2,5-二基，X 1和X 2彼此独立地为H或 F，Q是-CF 2，-OCF 2，-C 2 F 4，-OC 2 F 4或单键，Y是-H，-F， -C 1或-CN，n为0,1或2，R为具有多达13个C原子的烷基，其中一个或两个不相邻的CH 2基团也可以被-O-和/或-CH = CH- 以及另外一种或多种优选含有末端烯基的反应性液晶化合物。

129. 发明申请

WO1993021281A1 TN CELL WITH IMPROVED GREY-SHADE REPRESENTATION 审中-公开
标题翻译：具有改进的灰度PRESENTATION TN CELL
公开(公告)号：WO1993021281A1
公开(公告)日：1993-10-28
申请号：PCT/EP1993000857
申请日：1993-04-06
申请人： MERCK PATENT GMBH , PLACH, Herbert , BREDDELS, Paulus, Adrianus
发明人： MERCK PATENT GMBH
IPC分类号： C09K19/02
CPC分类号： G02F1/1396 , C09K19/0208 , C09K19/586 , G02F2203/30
摘要： The invention concerns a TN cell comprising a nematic liquid crystal with positive dielectric anisotropy and a twist angle of about 90° located between two substrates equipped with electrode and orientation films, the product of the distance between the substrate plates d and the optical anisotropy d.Δn being between 0.15 and 0.70 νm. The cell is characterized in that, to improve the grey-shade representation capacity, the liquid crystal contains a doping component so that the cell has a value for the interference-free quotient of the distance between the substrate plates d and the pitch length of the liquid crystal p within the range 0,1«d/p«0.5.

130. 发明申请

WO1993015712A1 USE OF BENZIMIDAZOLE DERIVATIVES AS PROTECTIVE LIGHT FILTERS 审中-公开
标题翻译：苯并咪唑衍生物作为保护性光过滤器的使用
公开(公告)号：WO1993015712A1
公开(公告)日：1993-08-19
申请号：PCT/EP1993000233
申请日：1993-02-02
申请人： MERCK PATENT GMBH , STEIN, Ingeborg , HEYWANG, Ulrich , PUTZ, Alexander , MARTIN, Roland
发明人： MERCK PATENT GMBH
IPC分类号： A61K07/42
CPC分类号： A61Q17/04 , A61K8/4946 , C07D235/18 , C07D235/20
摘要： The invention relates to the use of benzimidazole derivatives of formula (I), in which R , R , R , R and Ar have the meanings given in claim 1, as protective light filters in cosmetic preparations. At least one of the groups R to R or an alkyl or alkoxy substituent in group Ar has at least 4 C atoms.
摘要翻译：本发明涉及式（I）的苯并咪唑衍生物，其中R 1，R 2，R 3，R 4和Ar具有权利要求1中给出的含义作为保护性光过滤器在化妆品制剂中。基团R 1至R 4中的至少一个或基团Ar中的烷基或烷氧基取代基具有至少4个C原子。

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