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101. 发明申请

WO1996040760A2 IODINE-CONTAINING PEPTIDES AND THEIR USE AS X-RAY CONTRAST MEDIA 审中-公开
标题翻译：含碘物质及其用作X射线对比介质
公开(公告)号：WO1996040760A2
公开(公告)日：1996-12-19
申请号：PCT/EP1996002450
申请日：1996-06-06
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , KRAUSE, Werner , NITECKI, Danute , MAIER, Franz , SCHUMANN-GIAMPIERI, Gabriele , PRESS, Wolf-Rüdiger , MUSCHICK, Peter , BIANCALANA, Sara
IPC分类号： C07K14/00
CPC分类号： A61K49/0442 , A61K38/00 , C07K14/001
摘要： Iodine-containing peptides of general formula (I) in which R , R , R , R , a, m and q have the meanings indicated in the description, agents containing these compounds, the use of compounds as contrast media as well as processes for their production are described.
摘要翻译：其中R 1，R 2，R 3，R 4，a，m和q具有通式（I）的含碘的肽具有说明书中指出的含义，含有这些化合物的试剂，描述了使用化合物作为造影剂及其生产方法。

102. 发明申请

WO1996037193A1 TOPICALLY APPLICABLE AGENTS FOR TREATING AND PREVENTING ALOPECIA 审中-公开
标题翻译：局部应用装置，用于预防和治疗脱发
公开(公告)号：WO1996037193A1
公开(公告)日：1996-11-28
申请号：PCT/EP1996002195
申请日：1996-05-22
申请人： SCHERING AKTIENGESELLSCHAFT , LIPP, Ralph , RIEDL, Jutta , SACHSE, Andreas , RÖSSLING, Georg
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61K09/127
CPC分类号： A61K31/593 , A61K8/14 , A61K8/67 , A61K9/127 , A61K31/59 , A61Q7/00
摘要： The invention relates to topically applicable agents for the treatment and prevention of alopecia characterised by a content of vitamin D analogues encapsulated in liposomes.
摘要翻译：本发明涉及一种用于治疗脱发和预防，其特征在于，脂质体包封的维生素D类似物的含量局部应用剂。

103. 发明申请

WO1996032392A1 ANELLATED 'beta'-CARBOLINES 审中-公开
标题翻译：融合的β-咔啉
公开(公告)号：WO1996032392A1
公开(公告)日：1996-10-17
申请号：PCT/DE1996000632
申请日：1996-04-03
申请人： SCHERING AKTIENGESELLSCHAFT , SEIDELMANN, Dieter , HUTH, Andreas , OLESEN, Preben, H. , OTTOW, Eckhard , TURNER, Jonathan , HILLMANN, Margrit , COLE, Belinda
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07D471/14
CPC分类号： C07D471/04 , C07D471/14 , C07D513/14
摘要： Described are compounds of formula (I), wherein A is a 5-6 membered unsaturated ring in which 1-2 C atoms can be substituted by N, O and/or S and which can be substituted with R and R , and the method for preparing them. Because of their affinity for benzodiazepine receptors, the compounds of formula (I) as well as their salts can be used as drugs. They have different intrinsic efficacy (i.e. agonistic, antagonistic and/or inversely agonistic efficacy) with different isoforms of the GABA benzodiazepine receptor.
摘要翻译：是其中1-2个C原子可以被N，O和/或S和R <5>和R <6来代替式（I）其中A代表5-6元不饱和环，化合物可>取代的描述和它们的制备过程。式（I）和它们的盐的化合物是由于它们的亲合性苯并二氮杂向受体作为药物是有用的。它们对GABA苯并二氮杂受体的各种亚型不同的固有活性（即激动剂，拮抗剂和/或反向激动剂活性）。

104. 发明申请

WO1996028415A1 RADIOGRAPHIC CONTRASTING AGENT FOR COMPUTERISED TOMOGRAPHY AND UROGRAPHY 审中-公开
标题翻译：射线造影剂计算并尿路造影
公开(公告)号：WO1996028415A1
公开(公告)日：1996-09-19
申请号：PCT/EP1996000735
申请日：1996-02-21
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , BLASZKIEWICZ, Peter , SPECK, Ulrich , KRAUSE, Werner
IPC分类号： C07C237/46
CPC分类号： A61K49/0433 , C07C237/46
摘要： A radiographic contrasting agent having the formula (I) based on triiodinated isophthalic acid amide is disclosed, as well as its use and a process for preparing the same. In the formula, R stands for the methyl residue and R for the 2,3-dihydroxypropyl residue or R and R stand each for a 2-hydroxyethyl residue.
摘要翻译：本发明涉及的基础上，通式（I）的X射线造影剂trijodierterIsophthalsäureamide，它们的其制备方法，其特征在于为R <1>使用和过程是甲基基团并且R <2>或R为2,3-二羟基丙基<1 >和R <2>分别为2-羟乙基基团。

105. 发明申请

WO1996025392A1 NOVEL BORNEOL DERIVATIVES, METHODS OF MANUFACTURING THEM, AND THEIR PHARMACEUTICAL USE 审中-公开
标题翻译：新BORNEOLDERIVATE，PROCESS FOR THEIR和制药用
公开(公告)号：WO1996025392A1
公开(公告)日：1996-08-22
申请号：PCT/DE1996000297
申请日：1996-02-19
申请人： SCHERING AKTIENGESELLSCHAFT , KLAR, Ulrich , GRAF, Hermann , NEEF, Günter , BLECHERT, Siegfried
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07C271/22
CPC分类号： C07D303/16 , C07C271/22 , C07C2603/86
摘要： The invention concerns borneol derivatives of general formula (I), wherein: R represents C(O)-CH(OR )-CH(NR R )-R , C(O)-CH(OR )-CH[NH(C(O)-CH(OR )-CH(NR R )-R )] -R ; R and R are identical or different and the same as R ; R and R are identical or different and the same as R ; R is -C(O)R , -SO2R , -C(O)OR , -C(O)SR , -C(O)NHR , -C(O)NR R , (a), alkyl; R is phenyl; R and R are identical or different and stand for alkyl, cycloalkyl, aryl or aralkyl; R are identical or different and stand for hydrogen, alkyl, aryl, acyl, aralkyl, -SO2R , -P(O) (OH)2; R stands for hydrogen, alkyl, aryl, aralkyl. The invention also concerns salts of the said compounds with physiologically tolerable bases, alpha -, beta - or gamma -cyclodextrine clathrates of the said compounds and compounds of formula (I) encapsulated with liposomes. The compounds are active as tubulin polymerisation antagonists.
摘要翻译：本发明betrfifft Borneolderivate通式（I）其中R <1>（O）-CH（OR <6>）C - CH（NR <7A> - [R <7B>） - R的<8>，C（O） -CH（OR <6>） - CH [NH（（O）-CH（OR <6B>）C - CH（NR <7A> - [R <7B>） - R的<8>）] - R的<8>， [R <6A>，R <6B>是相同的或不同的并且R <6>，R <7A>，R <7B>是相同的或不同的并且R <7>，R <7> -C（O）R <12>，-SO 2 R <12>，-C（O）OR <12>，-C（O）SR <12>，-C（O）NHR <9D>，-C（O）NR <9D>ř <9A>中，（a）烷基，R <8>是苯基，R ，R <12>是相同的或不同的并且是烷基，环烷基，芳基，芳烷基，R <6>是相同的或不同的，是氢烷基，芳基，酰基，芳烷基，-SO 2 R <9C>，-P（O）（OH）指2，R <13>为氢，烷基，芳基，芳烷基，以及与生理上可耐受的碱，以及它们的α它们的盐 - ，β - 或伽马-Cyclodextrinclathrate和平均封装有通式（I）的脂质体的化合物。该化合物作为活性聚合的微管蛋白拮抗剂。

106. 发明申请

WO1996023503A1 PROGESTERONE ANTAGONISTS USEFUL FOR PREPARING MEDICAMENTS FOR TREATING DYSFUNCTIONAL UTERINE BLEEDING 审中-公开
标题翻译：孕激素拮抗剂药物的出血功能失调性子宫出血的治疗PRODUCTION
公开(公告)号：WO1996023503A1
公开(公告)日：1996-08-08
申请号：PCT/EP1995000394
申请日：1995-02-02
申请人： SCHERING AKTIENGESELLSCHAFT , CHWALSZ, Kristof , STÖCKEMANN, Klaus
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61K31/57
CPC分类号： A61K31/57 , A61K31/575 , Y10S514/899
摘要： Competitive progesterone antagonists (antigestagenes) are useful to prepare medicaments for treating dysfunctional uterine bleeding (metrorrhagia, menorrhagia, hypermenorrhea).
摘要翻译：有竞争力的孕酮拮抗剂（antigestagens）适合于生产药物用于功能性子宫出血的出血合适的治疗（子宫出血，月经过多，月经过多）。

107. 发明申请

WO1996016928A1 NOVEL SUBSTITUTED DTPA DERIVATIVES, THEIR METAL COMPLEXES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPLEXES AND THEIR USE IN DIAGNOSIS AND THERAPY 审中-公开
标题翻译：创新取代DTPA衍生物，它们的金属络合物，这种复杂的制药含有它们的它们在诊断和治疗
公开(公告)号：WO1996016928A1
公开(公告)日：1996-06-06
申请号：PCT/EP1995004548
申请日：1995-11-20
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , MAIER, Franz-Karl , BAUER, Michael , KRAUSE, Werner , SPECK, Ulrich , SCHUHMANN-GIAMPIERI, Gabriele , MÜHLER, Andreas , BALZER, Thomas , PRESS, Wolf-Rüdiger
IPC分类号： C07C229/76
CPC分类号： A61K49/04 , A61K49/0002 , A61K49/0004 , A61K49/103 , Y10S514/836 , Y10T436/24
摘要： The invention concerns novel diethylenetriamine pentaacetic acid (DTPA) derivatives, their complexes and complex salts, containing an element of the atomic numbers 20 - 32, 39 - 51 or 57 - 83. The invention further concerns pharmaceutical compositions containing these compounds, their preparation and their use as contrast media and antidotes.
摘要翻译：本发明涉及新的Diethylentriaminpentaessigsäurederivate，它们的复合物和含有原子序数20的元件配盐 - 32 39 - 51或57-83，包含这些化合物的药物组合物，它们的制备和它们作为造影剂和解毒剂的用途。

108. 发明申请

WO1996016677A2 USE OF METAL COMPLEXES AS LIVER AND GALL BLADDER RADIODIAGNOSIS AGENTS IN COMPUTER TOMOGRAPHY 审中-公开
标题翻译：金属络合物的AS肝胆光诊断在计算机使用
公开(公告)号：WO1996016677A2
公开(公告)日：1996-06-06
申请号：PCT/DE1995001644
申请日：1995-11-20
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , MAIER, Franz-Karl , BAUER, Michael , KRAUSE, Werner , SPECK, Ulrich , SCHUHMANN-GIAMPIERI, Gabriele , MÜHLER, Andreas , BALZER, Thomas , PRESS, Wolf-Rüdiger
IPC分类号： A61K49/00
CPC分类号： A61K49/04 , A61K49/0002 , A61K49/0004 , A61K49/103 , Y10S514/836 , Y10T436/24
摘要： Metal complexes consisting of a metal of atomic number 39-42, 44-51 or 56-83, and a complexing agent are used to produce X-ray contrast media for use in enhanced-contrast computed tomography of the liver and the bile ducts.
摘要翻译：使用的，包括原子序数39-42，44-51或56-83的金属和用于生产X射线造影介质用于在肝和胆道对比增强计算机断层摄影中使用的配位剂的金属配合物。

109. 发明申请

WO1996013289A2 PROCESS FOR FILLING WITH A FLUID AND CLOSING DISPOSABLE SYRINGES THAT ARE TO BE STERILISED 审中-公开
标题翻译：填充和与FLUIDEM目录合闸方式，需要消毒的一次性注射器
公开(公告)号：WO1996013289A2
公开(公告)日：1996-05-09
申请号：PCT/DE1995001523
申请日：1995-10-27
申请人： SCHERING AKTIENGESELLSCHAFT , SPECK, Ulrich
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61M05/28
CPC分类号： A61M5/34 , A61M5/001 , A61M5/1782 , A61M5/28 , A61M5/3134 , A61M5/315 , A61M5/31505 , A61M5/32 , A61M2005/3104 , A61M2005/3118 , A61M2005/3139 , A61M2005/3279 , A61M2207/00 , B65B3/003
摘要： A process is disclosed for filling with a fluid and closing disposable plastic syringes that are to be sterilised. The disposable syringes have an injection cylinder (11) with a shaped front nozzle part (20), a piston or piston plug (30) in at least one piece and a piston stop element (40) arranged in the area of the cylinder gripping plate (12). After inserting the piston (30) into the empty injection cylinder (11), together or not with its own piston rod, the piston is fully pushed up to the front end of the cylinder. The fluid medium is then fed under pressure into the injection cylinder (11) through the nozzle part (20) and pushes the piston (30) in the direction of the piston rod up to the piston stop element (40). After the syringe is filled, the front area (25) of the nozzle part (20) is closed by plastic deformation. This process allows a previously filled disposable syringe to be sterilised in a standard autoclave without any risk of the syringe inner pressure plastically deforming parts of the syringe.
摘要翻译：本发明涉及一种用于填充密封一个与fluidem内容的方法来进行灭菌由塑料制成的，一次性注射器，其中所述一次性注射器注射器筒（11），其具有前整体形成的喷嘴部分（20），一个至少单件式活塞或柱塞止动件（30）和一个在所述范围内气缸把手板（12）位于活塞止挡元件（40）。所述活塞（30）被完全插入时，插入空的注射器筒（11）具有或不具有其自己的活塞杆到其前端之后。随后，经由注射器筒（11）在喷嘴部（20）压力下的流体介质被按压，其中，所述流体介质推动活塞（30）朝向所述活塞杆侧到活塞止挡元件（40）向前。填充喷嘴部分的前部（25）后（20）由塑性变形封闭。使用本发明的方法中，预填充的一次性注射器可在Standardautoklaven进行灭菌而不会由于内压注射器针筒部件有的塑性变形的危险。

110. 发明申请

WO1996012494A1 COMPETITIVE PROGESTERONE ANTAGONISTS FOR REGULATING FEMALE FERTILITY AS REQUIRED 审中-公开
标题翻译：竞争孕激素拮抗剂需求为导向女性生育控制
公开(公告)号：WO1996012494A1
公开(公告)日：1996-05-02
申请号：PCT/EP1995004191
申请日：1995-10-24
申请人： SCHERING AKTIENGESELLSCHAFT , CHWALISZ, Kristof , STÖCKEMANN, Klaus , SCHMIDT-GOLLWITZER, Karin , KLEMANN, Walter
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61K31/56
CPC分类号： A61K31/567 , A61K31/00 , A61K31/569 , A61K31/575 , A61K31/58 , Y10S514/843
摘要： The present invention concerns the novel use of competitive progesterone antagonists in the preparation of a drug for regulating female fertility as required (pill to be taken as required). This drug can be administered in a single dose at any time during the menstrual cycle, its dosage being less than the ovulation-inhibiting dosage.
摘要翻译：本发明描述了用于面向需求的雌性节育药物（按需丸），它可以不考虑施加的月经周期的时间的制造中的新用途的竞争孕酮拮抗剂，所述剂量是在一个单次剂量给药的排卵抑制剂量以下单元。

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