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91. 发明申请

WO2005078118A1 OXIDIZABLE SPECIES AS AN INTERNAL REFERENCE FOR BIOSENSORS AND METHOD OF USE 审中-公开
标题翻译：可氧化物种作为生物传感器的内部参考和使用方法
公开(公告)号：WO2005078118A1
公开(公告)日：2005-08-25
申请号：PCT/US2005/003622
申请日：2005-02-04
申请人： BAYER HEALTHCARE LLC , BEER, Greg, P. , WU, Huan-Ping , YIP, Kin-Fai
发明人： BEER, Greg, P. , WU, Huan-Ping , YIP, Kin-Fai
IPC分类号： C12Q1/00
CPC分类号： G01N27/3273 , C12Q1/004 , C12Q1/006 , G01N27/3271 , G01N27/3272 , G01N27/3274 , G01N33/54373
摘要： A biosensor (102) for determining the presence or amount of a substance in a sample and methods of use of the biosensor (102) are provided. The biosensor (102) for receiving a user sample to be analyzed includes a mixture for electrochemical reaction with an analyte. The mixture includes an enzyme, a mediator and an oxidizable species as an internal reference.
摘要翻译：提供了一种用于确定样品中物质的存在或量的生物传感器（102）和所述生物传感器（102）的使用方法。用于接收待分析的用户样品的生物传感器（102）包括用于与分析物的电化学反应的混合物。该混合物包括酶，介体和可氧化物质作为内部参考。

92. 发明申请

WO2005040784A1 試料分析方法、および試料分析装置审中-公开
标题翻译：样本分析方法和样本分析设备
公开(公告)号：WO2005040784A1
公开(公告)日：2005-05-06
申请号：PCT/JP2004/015415
申请日：2004-10-19
申请人：アークレイ株式会社 , 川相拓司
发明人：川相拓司
IPC分类号： G01N27/416
CPC分类号： G01N27/3273 , Y10T436/11 , Y10T436/112499 , Y10T436/115831 , Y10T436/12 , Y10T436/144444
摘要：　本発明は、分析用具(２)からの出力に相関した物理量を出力する２重積分回路(11)を利用して試料を分析する技術に関する。本発明では、２重積分回路(11)に対する分析用具(２)の出力の入力開始から２重積分回路(11)からの物理量の出力開始までの時間間隔を、分析用具(２)に試料が供給されたことを確認する前後において異なったものとした。
摘要翻译：一种样本分析方法和用于通过利用输出与分析仪器（2）的输出相关的物理量的双积分电路（11）来分析样本的样本分析装置。从分析仪器（2）输出到双积分电路（11）的输入开始之间的时间间隔和从它们之前和之后获得的来自双积分电路（11）的物理量的输出开始确认供给到分析用具（2）的样品彼此不同。

93. 发明申请

WO98035225A1 SMALL VOLUME IN VITRO ANALYTE SENSOR 审中-公开
标题翻译：体积分析传感器的小体积
公开(公告)号：WO98035225A1
公开(公告)日：1998-08-13
申请号：PCT/US1998/002652
申请日：1998-02-06
IPC分类号： G01N33/483 , A61B5/00 , A61B5/145 , A61B5/1473 , A61B5/1486 , A61B5/15 , A61B5/151 , A61B5/157 , C12M1/34 , C12Q1/00 , G01N21/76 , G01N21/78 , G01N27/28 , G01N27/327 , G01N27/42 , G01N27/49 , G01N33/487 , G01N33/543 , G01N33/66
CPC分类号： G01N27/3272 , A61B5/1411 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/150022 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15105 , A61B5/15113 , A61B5/15144 , A61B5/157 , A61B2560/0223 , A61B2562/0295 , C12Q1/001 , C12Q1/004 , C12Q1/006 , G01N27/3273 , G01N33/5438 , G01N2333/904
摘要： A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 mu L. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between the analyte and the electrode. In addition, a second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. The redox mediator is typically a redox compound bound to a polymer. The preferred redox mediators are airoxidizable. The amount of analyte can be determined by coulometry. One particular coulometric technique includes the measurement of the current between the working electrode and a counter or reference electrode at two or more times. The charge passed by this current to or from the analyte is correlated with the amount of analyte in the sample. Other electrochemical detection methods, such as amperometric, voltammetric, and potentiometric techniques, can also be used. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is provided as a second electron transfer agent.
摘要翻译：设计用于确定体积小于约1μL的样品中分析物的量和浓度的传感器。传感器具有涂覆有不可浸出的氧化还原介体的工作电极。氧化还原介体作为分析物和电极之间的电子转移剂。此外，可以加入第二电子转移剂，例如酶，以促进分析物的电氧化或电还原。氧化还原介体通常是与聚合物结合的氧化还原化合物。优选的氧化还原介体是可氧化的。分析物的量可以通过库仑法测定。一种特定的库仑技术包括两次或更多次测量工作电极与计数器或参考电极之间的电流。通过该电流流向或来自分析物的电荷与样品中分析物的量相关。还可以使用其他电化学检测方法，例如电流，伏安和电位技术。本发明可用于测定生物流体如血液或血清中生物分子如葡萄糖或乳酸盐的浓度。提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

94. 发明申请

WO1994029705A1 BIOSENSING METER WHICH DETECTS PROPER ELECTRODE ENGAGEMENT AND DISTINGUISHES SAMPLE AND CHECK STRIPS 审中-公开
标题翻译：检测正确的电极参与和检测的生物传感器样品和检查条带
公开(公告)号：WO1994029705A1
公开(公告)日：1994-12-22
申请号：PCT/US1994005322
申请日：1994-05-13
申请人： BOEHRINGER MANNHEIM CORPORATION
发明人： BOEHRINGER MANNHEIM CORPORATION , WHITE, Bradley, E. , PARKS, Robert, A. , RITCHIE, Paul, G.
IPC分类号： G01N27/26
CPC分类号： G01N27/3273
摘要： A biosensing meter (50) receives a biomedical sample strip (10) which includes electrically isolated excitation (14) and sense (12) electrodes or, alternatively, a check strip. The biosensing meter includes first and second contacts (C, D) that are connected by a sense electrode upon insertion of a sample strip. An operational amplifier circuit has first and second inputs respectively connected to the first contact and a reference potential, the first input manifesting the reference potential as a result of a feedback within the operational amplifier. A processor (60) is coupled to the second contact and determines the presence of the reference potential at the second contact when an inserted sense electrode connects the first and second contacts. The processor also distinguishes between sample and check strips and tests for a proper impedance between the sense and excitation electrodes of a sample strip, thus enabling operation of the biosensing meter upon sample strip dosing.
摘要翻译：生物传感仪（50）接收生物医学样品条（10），其包括电隔离的激发（14）和感测（12）电极，或者替代地，检查条。生物传感计包括在插入样品条时由感测电极连接的第一和第二接触（C，D）。运算放大器电路具有分别连接到第一触点和参考电位的第一和第二输入，作为运算放大器内的反馈的结果，第一输入表现出参考电位。当插入的感测电极连接第一和第二触点时，处理器（60）耦合到第二触点并确定在第二触点处存在参考电位。处理器还区分样品和检查条，并测试样品条的感测电极和激发电极之间的适当阻抗，从而使样品条带计量后的生物传感计可进行操作。

95. 发明申请

WO1991009316A1 BIOSENSOR ELECTRODE EXCITATION CIRCUIT 审中-公开
标题翻译：生物传感器电极激励电路
公开(公告)号：WO1991009316A1
公开(公告)日：1991-06-27
申请号：PCT/US1990007501
申请日：1990-12-14
申请人： BOEHRINGER MANNHEIM CORPORATION
发明人： BOEHRINGER MANNHEIM CORPORATION , PARKS, Robert, A.
IPC分类号： G01R27/02
CPC分类号： G01N27/3273
摘要： A circuit is described for applying a potential to an electrode (12) of a biosensing test cell (10), which electrode, when properly inserted in a female connector (20), is contacted by a pair spaced apart contacts (A, B). The circuit includes a source of excitation potential (Ve) and an operational amplifier (52) having one input (62) connected to the source of excitation potential (Ve). A switching circuit (54) is coupled between the operational amplifier (52) and a first one of the spaced apart contacts (B), with the switch means exhibiting an impedance (56). A feedback circuit (60) is connected between the second of the spaced-apart contacts (A) and another input to the operational amplifier (62), to feed back a potential appearing at the second contact (A). The feedback is for the purpose of maintaining the output of the operational amplifier (52) at a level which compensates for impedance losses in the switching circuit (54). The feedback circuit enables the output of the operational amplifier (52) to be varied so that the potential applied to the electrode (B) is equal to the source of excitation potential (Ve). A further circuit is connected to the feedback circuit (60) for sensing when an open or high impedance state exists between the spaced-apart contacts (A, B).

96. 发明申请

WO2019113085A1 ELECTROCHEMICAL DETECTION SYSTEMS AND COMPONENTS THEREOF 审中-公开
公开(公告)号：WO2019113085A1
公开(公告)日：2019-06-13
申请号：PCT/US2018/063866
申请日：2018-12-04
申请人： LAXMI THERAPEUTIC DEVICES, INC.
发明人： GARNER, Logan, Earl , THEOGARAJAN, Luke Satish, Kumar , VAN ANTWERP, William
IPC分类号： C12Q1/00 , C08F122/38
CPC分类号： G01N33/54313 , A61B5/14514 , A61L31/145 , C08F120/60 , C08L33/24 , C08L2203/02 , C12Q1/001 , C12Q1/006 , G01N27/3273 , G01N27/4166 , G01N33/5438 , G01N2333/902
摘要： The invention is directed to electrochemical detection systems, components thereof, materials and methods for making the systems and components thereof, and methods for detecting analytes with the systems. The systems include electrochemical cells containing hydrogels. The hydrogels include polymers with amine-containing pendant groups. The polymers can be cross-linked via the amine-containing pendant groups. The polymers can also or alternatively include enzymes and/or electron shuttles tethered thereto via amine-containing pendant groups. Monomers for making the polymers are provided. The systems can be used to detect analytes such as glucose.

97. 发明申请

WO2017117469A1 DIFFUSION RESISTANCE LAYER FOR ANALYTE SENSORS 审中-公开
标题翻译：用于分析传感器的扩散阻抗层
公开(公告)号：WO2017117469A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/069342
申请日：2016-12-29
申请人： DEXCOM, INC.
发明人： ZOU, Jiong , BOOCK, Robert, J. , DENNIS, Andrew, Trinin , LEE, Ted, Tang , SURI, Jeff, T. , SZE, David , TAPSAK, Mark, A. , WANG, Shanger , ZHANG, Huashi
IPC分类号： A61B5/1473 , A61B5/1486
CPC分类号： G01N27/3273 , A61B5/0004 , A61B5/002 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B2562/12 , A61K31/045 , A61K31/137 , A61K31/46 , A61K31/465 , A61K31/485 , A61K31/515 , A61K31/56 , A61K33/00 , A61K36/185 , A61K38/28 , C08G18/0828 , C08G18/12 , C08G18/3857 , C08G18/4018 , C08G18/44 , C08G18/4833 , C08G18/755 , C08L39/06 , C08L69/00 , C08L75/04 , C12N11/08 , C12Q1/002 , C12Q1/006 , G01N27/3275 , G01N33/66 , C08G18/3234
摘要： Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.
摘要翻译：公开了用于确定分析物浓度的装置（例如葡萄糖）。这些装置包括配置为产生与分析物浓度相关的信号的传感器和位于传感器上的传感膜。传感膜包含酶层，其中酶层包含酶和包含聚氨酯和/或聚脲段和一个或多个两性离子重复单元的聚合物。酶层保护酶并防止其从传感膜渗入宿主或失活。

98. 发明申请

WO2017045601A9 METHOD AND APPARATUS FOR IMPROVING USABILITY AND ACCURACY FOR PHYSIOLOGICAL MEASUREMENT ON MOBILE DEVICE 审中-公开
标题翻译：提高移动设备上生理测量的可用性和准确性的方法和设备
公开(公告)号：WO2017045601A9
公开(公告)日：2017-04-20
申请号：PCT/CN2016098971
申请日：2016-09-14
申请人： IXENSOR CO LTD
发明人： CHEN YENYU , TSAI TUNGMENG , CHEN CHIEH HSIAO , TSAI YAUCHING , LIU TANGAN
IPC分类号： G01N33/53 , H04M1/725
CPC分类号： G01N33/48785 , G01N27/3273 , H04M1/21
摘要： An accessory (800) is provided for a mobile device (102) to measure characteristics of a test strip (808).The accessory (800) includes a test strip adapter (806), a phone adapter (802), and a coupler (804). The test strip adapter (806) includes a test strip attachment for a test strip type and a first interlock shared with other test strip adapters for other test strip types. The phone adapter (802) includes a phone attachment for a mobile device model and a second interlock shared with other phone adapters for other mobile device models. The coupler (804) includes a third interlock that forms a first mating pair with the first interlock of the test strip adapter (806), and a fourth interlock that forms a second mating pair with the second interlock of the phone adapter (802).
摘要翻译：提供用于移动设备（102）以测量测试条（808）的特性的附件（800）。附件（800）包括测试条适配器（806），电话适配器（802）和耦合器 804）。测试条适配器（806）包括用于测试条类型的测试条附件和与用于其他测试条类型的其他测试条适配器共享的第一互锁。电话适配器（802）包括用于移动设备型号的电话附件和与用于其他移动设备型号的其他电话适配器共享的第二互锁。耦合器（804）包括与测试条适配器（806）的第一互锁形成第一配对对的第三互锁，以及与电话适配器（802）的第二互锁形成第二配对对的第四互锁。

99. 发明申请

WO2016203266A1 METHOD, APPARATUS AND ELECTROCHEMICAL TEST DEVICE 审中-公开
标题翻译：方法，装置和电化学测试装置
公开(公告)号：WO2016203266A1
公开(公告)日：2016-12-22
申请号：PCT/GB2016/051829
申请日：2016-06-17
申请人： INSIDE BIOMETRICS LIMITED
发明人： SAINI, Selwayan , RODGERS, James , BASKEYFIELD, Damian
IPC分类号： C12Q1/00 , C12Q1/26 , G06F19/00
CPC分类号： C12Q1/005 , C12Q1/006 , C12Q1/26 , C12Q1/32 , C12Q1/54 , C12Y101/0103 , C12Y101/03004 , C12Y113/12004 , G01N27/3273 , G01N27/3277 , G01N2333/90241 , G01N2333/904 , G01N2800/042 , G06F3/04817 , G06F3/0482 , G06F19/00 , G16H10/40
摘要： A method of processing data from a test device is provided. The method comprises determining a concentration of a first analyte in a fluid sample using first sensing chemistry, wherein the first analyte is an acidosis-related analyte; determining a concentration of a second analyte in the fluid sample using second sensing chemistry, wherein the second analyte is glucose; displaying a first indication related to the determined concentration of the second analyte; if the determined concentration of the first analyte is equal to or greater than a first threshold, providing a user-selectable option to display a second indication related to the determined concentration of the first analyte.
摘要翻译：提供了一种从测试设备处理数据的方法。该方法包括使用第一感测化学测定流体样品中的第一分析物的浓度，其中第一分析物是酸中毒相关分析物; 使用第二感测化学确定流体样品中第二分析物的浓度，其中第二分析物是葡萄糖; 显示与所确定的第二分析物的浓度相关的第一指示; 如果所确定的第一分析物的浓度等于或大于第一阈值，则提供用户可选择的选项以显示与所确定的第一分析物浓度相关的第二指示。

100. 发明申请

WO2016120212A1 REFERENCE ELECTRODE ERROR TRAP DETERMINED FROM A SPECIFIED SAMPLING TIME AND A PRE-DETERMINED SAMPLING TIME 审中-公开
标题翻译：从指定的采样时间和预先确定的采样时间确定的参考电极错误捕捉
公开(公告)号：WO2016120212A1
公开(公告)日：2016-08-04
申请号：PCT/EP2016/051455
申请日：2016-01-25
申请人： LIFESCAN SCOTLAND LIMITED
发明人： MACKINTOSH, Stephen , SMITH, Antony
IPC分类号： G01N27/327
CPC分类号： G01N27/3274 , G01N27/3272 , G01N27/3273
摘要： Various embodiments for a method that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic of the sample and determining whether a counter or reference electrode is causing an error by monitoring the working electrodes and flagging an error if the signal outputs of the working electrodes do not meet certain thresholds.
摘要翻译：用于通过确定样品的至少一个物理特性来允许用生物传感器更准确的分析物浓度的方法的各种实施方案，并且通过监测工作电极并且如果信号标记错误来确定计数器或参考电极是否引起误差，工作电极的输出不满足某些阈值。

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