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91. 发明申请

WO1997011185A1 DszD UTILIZATION IN DESULFURIZATION OF DBT BY RHODOCOCCUS sp. IGTS8 审中-公开
标题翻译： DszD通过RHODOCOCCUS对DBT的脱硫利用 IGTS8
公开(公告)号：WO1997011185A1
公开(公告)日：1997-03-27
申请号：PCT/US1995015864
申请日：1995-12-05
申请人： ENERGY BIOSYSTEMS CORPORATION , GRAY, Kevin, A. , SQUIRES, Charles, H. , MONTICELLO, Daniel, J.
发明人： ENERGY BIOSYSTEMS CORPORATION
IPC分类号： C12N15/53
CPC分类号： C12N1/20 , C10G31/00 , C10G32/00 , C12N9/0004 , C12N9/0006 , C12N15/52 , C12P1/00 , C12R1/01
摘要： The invention relates to the discovery that the rate of reaction of the desulfurization of fossil fuels is enhanced by the addition of an oxidoreductase to the biocatalyst. The invention is drawn to a method for enhancing the rate of desulfurizing a fossil fuel containing organic sulfur compounds, comprising the steps of: a) contacting the fossil fuel with an aqueous phase containing a biocatalyst capable of cleaving carbon-sulfur bonds and a rate-enhancing amount of an oxidoreductase, thereby forming a fossil fuel and aqueous phase mixture; b) maintaining the mixture of step (a) under conditions sufficient for cleavage of the carbon-sulfur bonds of the organic sulfur molecules by the biocatalyst, thereby resulting in a fossil fuel having a reduced organic sulfur content; and c) separating the fossil fuel having a reduced organic sulfur content from the resulting aqueous phase. The invention also relates to a recombinant microorganism containing one or more recombinant DNA molecules which encode a biocatalyst capable of desulfurizing a fossil fuel containing organic sulfur molecules and which encode an oxidoreductase. The invention also relates to a composition comprising (a) a biocatalyst capable of desulfurizing a fossil fuel containing organic sulfur molecules and (b) an oxidoreductase.
摘要翻译：本发明涉及通过向生物催化剂中加入氧化还原酶来提高化石燃料脱硫反应速率的发现。本发明涉及提高含有机硫化合物的化石燃料脱硫速率的方法，包括以下步骤：a）使化石燃料与含有能够裂解碳 - 硫键的生物催化剂的水相接触，增加氧化还原酶的量，从而形成化石燃料和水相混合物; b）将步骤（a）的混合物保持在足以通过生物催化剂裂解有机硫分子的碳 - 硫键的条件下，从而导致具有降低的有机硫含量的化石燃料; 和c）从所得水相中分离具有降低的有机硫含量的化石燃料。本发明还涉及含有一种或多种重组DNA分子的重组微生物，所述重组DNA分子编码能够使含有机硫分子的化石燃料脱硫并编码氧化还原酶的生物催化剂。本发明还涉及一种组合物，其包含（a）能够使含有机硫分子的化石燃料脱硫的生物催化剂和（b）氧化还原酶。

92. 发明申请

WO1996023061A2 SURFACTANT-BASED ENZYME EXTRACTION PROCESS 审中-公开
标题翻译：基于表面活性剂的酶萃取过程
公开(公告)号：WO1996023061A2
公开(公告)日：1996-08-01
申请号：PCT/US1996000878
申请日：1996-01-25
申请人： GENENCOR INTERNATIONAL, INC.
发明人： GENENCOR INTERNATIONAL, INC. , BRAUNSTEIN, Edit, L. , BECKER, Nathaniel, T. , GANSHAW, Grant, C. , GRAYCAR, Thomas, P.
IPC分类号： C12N09/00
CPC分类号： C11D3/046 , C11D3/386 , C11D11/0082 , C12N9/00 , C12N9/54 , C12P1/00 , Y10S435/816
摘要： There are disclosed processes for the recovery of a desired fermentation product, the process using a salt and surfactant mixture to form a two-phase system wherein one phase is a surfactant-rich phase containing the desired product and the second phase is a salt-rich phase. The recovery process is particularly useful for whole or clarified fermentation broths comprising hydrophilic products.
摘要翻译：公开了回收所需发酵产物的方法，使用盐和表面活性剂混合物的方法形成两相体系，其中一相是含有所需产物的富表面活性剂相，第二相是富含盐的相。回收方法对于包含亲水性产品的全部或澄清的发酵液特别有用。

93. 发明申请

WO1996018719A1 APPARATUS AND METHOD FOR BIOTRANSFORMATIONS 审中-公开
标题翻译：生物传感器的装置和方法
公开(公告)号：WO1996018719A1
公开(公告)日：1996-06-20
申请号：PCT/GB1995002958
申请日：1995-12-18
申请人： IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE , LIVINGSTON, Andrew , BOAM, Andrew, Timothy , STUCKEY, David, Campbell , LEAK, David, Jonathon
发明人： IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE
IPC分类号： C12M01/12
CPC分类号： C12M29/04 , C12P1/00 , C12P17/02
摘要： A method of effecting a liquid phase biotransformation of precursor to product comprising a step of contacting an aqueous phase containing a biocatalyst with an organic phase containing the precursor across a selectively permeable polymeric membrane, allowing permeation of precursor through that membrane, allowing reaction to take place whereby precursor is at least partly transformed into product in said aqueous phase, and said product permeating back into the organic phase through said membrane. Apparatus for carrying the method into effect is also disclosed and can be "closed" modular or "open" with a gas/liquid interface with a receptacle for one of the liquid phases.
摘要翻译：一种将前体液相生物转化成产物的方法，包括使含有生物催化剂的水相与含有前体的有机相穿过选择性可渗透的聚合物膜接触的步骤，允许前体渗透该膜，允许反应发生由此前体在所述水相中至少部分地转化成产物，并且所述产物通过所述膜渗透回有机相。还公开了用于承载该方法的装置，并且可以与用于一个液相的容器的气体/液体界面“封闭”模块化或“开放”。

94. 发明申请

WO1996011256A1 PROCESS FOR THE CONTINUOUS ENZYMATIC EXTRACTION OF HYDROPHOBIC PRODUCTS AND DEVICE SUITABLE THEREFOR 审中-公开
标题翻译：方法对疏水性的产品和合适的设备的不断酶法提取
公开(公告)号：WO1996011256A1
公开(公告)日：1996-04-18
申请号：PCT/DE1995001399
申请日：1995-10-07
申请人： FORSCHUNGSZENTRUM JÜLICH GMBH , KRUSE, Wolfgang , KRAGL, Udo , WANDREY, Christian
发明人： FORSCHUNGSZENTRUM JÜLICH GMBH
IPC分类号： C12M01/40
CPC分类号： C12P1/00 , C12M21/18 , C12M29/04 , C12M29/18 , C12P7/04 , C12P7/26 , Y02P20/582 , Y10S435/813 , Y10S435/817
摘要： The invention concerns the extraction, into an organic solvent, of hydrophobic products from the aqueous product-containing reaction mixture (product flow) of a continuous enzyme-catalyzed process through a microporous product-permeable membrane, whilst the reaction mixture depleted of product is recycled for production purposes. The enzyme-catalyzed reaction occurs in particular in a reactor containing an immobilised enzyme, preferably in the enzyme membrane reactor. In order to separate the product, the product-containing reaction mixture preferably passes through a hollow fibre membrane bundle around which the product-solvent flows externally, in particular in counterflow. The effective pore size of the membrane ranges in particular from 5 to 500 mu m and the process is performed in particular at a differential pressure between the aqueous phase and organic solvent of 0.5 to 5 bars. A production circuit incorporating an extraction cartridge, in particular in the form of a hollow fibre membrane bundle, with a product-permeable porous membrane is suitable as a device for carrying out the process.
摘要翻译：疏水性的产品是由通过在有机溶剂中的产物可渗透微孔膜的连续酶催化过程的水性含产物的反应混合物（产物流）萃取，而produktverarmte反应混合物被再循环到生产中。酶催化反应，特别是与其中的固定化酶的反应器中进行，优选在酶膜反应器。将含产物的反应混合物优选通过来自外部的中空纤维膜束发送到产物的分离 - 是由产品溶剂围绕流动 - 尤其是在逆流。膜的有效孔径是特别是在5〜500微米的范围内，并且其与水相和有机溶剂之间从0.5到5巴的特定压力差工作。特别是在Holfasermembranbündels的形式 - - 与产品可渗透多孔膜结合作为一种用于执行所述方法，一个产生电路，其中的采样盒是合适的。

95. 发明申请

WO9611072A2 MICROBIOLOGICAL PARTS WASHER 审中-公开
标题翻译：微生物部件清洗机
公开(公告)号：WO9611072A2
公开(公告)日：1996-04-18
申请号：PCT/US9513042
申请日：1995-09-29
申请人： ADVANCED BIOREMEDIATION SYSTEM , MCCLURE JAMES C , MEARS ERIC L , WHITEMAN G ROB
发明人： MCCLURE JAMES C , MEARS ERIC L , WHITEMAN G ROB
IPC分类号： B08B3/08 , A61L2/18 , B01D39/14 , B01L99/00 , B08B3/00 , B08B7/00 , C02F3/04 , C02F3/10 , C02F3/34 , C12M1/00 , C12N1/00 , C12P1/00 , C12S9/00 , B08B3/02
CPC分类号： C02F3/344 , B08B3/006 , B08B7/00 , C02F3/04 , C02F3/10 , C02F3/34 , C02F3/343 , C02F2103/44 , C12P1/00 , C12R1/00 , Y02W10/15
摘要： An apparatus includes a first mechanical component for cleaning parts by contacting the parts with a fluid, and a second mechanical component for biodegrading the organic matter removed from the parts. The first mechanical component is in communication with the second mechanical component so that the fluid recirculates between the first and second mechanical components. A method of washing parts including the steps of placing an article in a first chamber, circulating a washing liquid from a second reservoir to the first reservoir to wash the surfaces of the article in contact with the liquid, passing the washing liquid through a porous medium, draining the washing liquid from the first chamber into the second chamber, removing organic matter in the washing liquid and recirculating the washing liquid from the second chamber to the first chamber, is also provided.
摘要翻译：一种装置包括用于通过使部件与流体接触来清洁部件的第一机械部件和用于对从部件去除的有机物进行生物降解的第二机械部件。第一机械部件与第二机械部件连通，使得流体在第一和第二机械部件之间循环。一种洗涤部件的方法，包括以下步骤：将物品放置在第一室中，将洗涤液体从第二储存器循环到第一储存器以洗涤与液体接触的物品表面，使洗涤液体通过多孔介质将洗涤液从第一室排出到第二室中，除去洗涤液中的有机物质并将洗涤液从第二室再循环至第一室。

96. 发明申请

WO1994024314A1 RANDOM CHEMISTRY FOR THE GENERATION OF NEW COMPOUNDS 审中-公开
标题翻译：新化合物生成的随机化学
公开(公告)号：WO1994024314A1
公开(公告)日：1994-10-27
申请号：PCT/US1994004314
申请日：1994-04-19
申请人： KAUFFMAN, Stuart, A. , REBEK, Julius, Jr.
IPC分类号： C12Q01/68
CPC分类号： C12N15/1093 , C07K1/047 , C12N9/0002 , C12P1/00 , C12P19/34 , C12Q1/6811 , C40B40/10 , C40B50/06
摘要： Methods for the generation of new compounds are disclosed. The present invention eliminates the need to know in advance the structure or chemical composition of a compound having a desired property. The disclosure of the present invention provides that diversity of unknown compounds may be produced by "random" chemistry, and such a diversity of unknown compounds may be screened for one or more desired properties to detect the presence of suitable compounds. In one aspect, a starting group of organic compounds is caused to undergo a series of chemical reactions to create a diversity of new organic compounds that are screened for the presence of organic compounds having the desired property. In another aspect of the present invention, a diversity of compounds is generated from a group of substrates which are subjected to a group of enzymes representing a diversity of catalytic activities.
摘要翻译：公开了生成新化合物的方法。本发明不需要预先知道具有所需性质的化合物的结构或化学组成。本发明的公开内容提供了通过“随机”化学可以产生未知化合物的多样性，并且可以筛选出这些多种未知化合物的一种或多种所需性质以检测合适化合物的存在。在一个方面，使有机化合物的起始基团经历一系列化学反应，以产生多种新的有机化合物，其筛选出具有所需性质的有机化合物的存在。在本发明的另一方面，由代表多种催化活性的一组酶的底物组产生多种化合物。

97. 发明申请

WO1993016190A1 BACTERIAL MACROMOLECULE EXTRACT, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITION CONTAINING SAID EXTRACT 审中-公开
标题翻译：细菌大分子提取物，其制备方法和含有提取物的药物组合物
公开(公告)号：WO1993016190A1
公开(公告)日：1993-08-19
申请号：PCT/CH1993000029
申请日：1993-02-03
申请人： LABORATORIES OM SA , BAUER, Jacques , HIRT, Pierre , SCHULTHESS, Adrian
发明人： LABORATORIES OM SA
IPC分类号： C12P21/00
CPC分类号： C07K14/245 , A61K38/00 , C12P1/00 , C12R1/19 , Y02A50/473 , Y10S435/822 , Y10S435/849 , Y10S435/851 , Y10S435/852 , Y10S435/871 , Y10S435/885 , Y10S435/886
摘要： A modified bacterial protein-based extract comprising a mixture of acidic bacterial polyanions having a molecular weight of 10,000-1,000,000 and an isoelectric point of 2.5-5.5, wherein the sum of the constituent amino acids represents at least 50 wt % of said extract. Said protein extract is prepared by cultivating bacteria in an aqueous medium, subjecting the bacterial suspension to alkaline extraction and purifying the protein extract. Alkaline extraction is performed in the presence of a dilute aqueous source of OH ions and at a pH of 11-13, with the pH decrease during said extraction being no greater than 0.4. The resulting protein extract may be used as an active ingredient in a pharmaceutical composition.
摘要翻译：一种经修饰的细菌蛋白质提取物，其包含分子量为10,000-1,000,000和等电点为2.5-5.5的酸性细菌聚阴离子的混合物，其中组成氨基酸的总和占所述提取物的至少50重量％。所述蛋白质提取物通过在水性介质中培养细菌，使细菌悬浮液进行碱提取和纯化蛋白质提取物来制备。碱性萃取是在稀盐酸水溶液存在下进行的，pH为11-13，所述提取过程中pH值降低不大于0.4。所得到的蛋白质提取物可以用作药物组合物中的活性成分。

98. 发明申请

WO1993016173A1 DECOLORIZATION AND DEODORIZATION OF FERMENTATION BROTH BY TREATMENT WITH STRONGLY BASIC EXTRACTANTS 审中-公开
标题翻译：通过用强碱性提取物处理发酵丝的脱胶和脱色
公开(公告)号：WO1993016173A1
公开(公告)日：1993-08-19
申请号：PCT/US1992001048
申请日：1992-02-10
申请人： COGNIS, INC. , STIERMAN, Thomas, J. , MAURER, Karl-Heinz , WEISS, Albrecht
发明人： COGNIS, INC.
IPC分类号： C12N09/00
CPC分类号： C12N9/54 , C12N1/005 , C12N9/00 , C12P1/00
摘要： Fermentation broths can be decolorized and deodorized by treatment with strongly basic extractants.
摘要翻译：发酵液可用强碱性萃取剂处理脱色脱臭。

99. 发明申请

WO1993009184A1 BIODEGRADABLE PLASTIC 审中-公开
标题翻译：可生物降解塑料
公开(公告)号：WO1993009184A1
公开(公告)日：1993-05-13
申请号：PCT/JP1992001411
申请日：1992-10-30
申请人： KABUSHIKI KAISHA KOBE SEIKO SHO , DEGUCHI, Tetsuya , NISHIDA, Tomoaki , TAKAHARA, Yoshimasa
发明人： KABUSHIKI KAISHA KOBE SEIKO SHO
IPC分类号： C08L101/00
CPC分类号： C08K5/0033 , C08L101/00 , C08L2201/06 , C12P1/00 , C12R1/00 , C08L77/00 , C08L23/02
摘要： A biodegradable plastic containing a substance which imparts hydrophilicity in such an amount as to give a wettability of 70 DEG or below in terms of the contact angle of the plastic surface with water and being improved in the degradability by basidiomycetes, products of culture thereof and/or products of treatment thereof. A process for decomposing the plastic under the condition where the amount of nitrogen and/or carbon is restricted. The invention makes it possible to decompose efficiently those plastics which have hitherto been difficult to decompose.
摘要翻译：一种可生物降解的塑料，其含有使塑性表面与水的接触角以70度以下的润湿性赋予亲水性的物质，并且通过担子菌，其培养物及/ 或其治疗产品。在限制氮和/或碳的量的条件下分解塑料的方法。本发明使得能够有效地分解迄今为止难以分解的那些塑料。

100. 发明申请

WO1993000439A1 IN VIVO DELIVERY OF ACTIVE FACTORS BY CO-CULTURED CELL IMPLANTS 审中-公开
标题翻译：通过共培养的细胞植入物传递活性因子
公开(公告)号：WO1993000439A1
公开(公告)日：1993-01-07
申请号：PCT/US1992005390
申请日：1992-06-25
申请人： BROWN UNIVERSITY RESEARCH FOUNDATION
发明人： BROWN UNIVERSITY RESEARCH FOUNDATION , AEBISCHER, Patrick , WINN, Shelley, R.
IPC分类号： C12P01/00
CPC分类号： A61F2/022 , A61K9/0024 , A61K9/0085 , A61K9/0092 , A61K35/22 , A61K35/30 , A61K38/185 , A61M31/002 , A61M2210/0687 , A61M2210/0693 , B01J13/02 , C12N5/0012 , C12N5/0614 , C12N5/0619 , C12N5/0676 , C12N11/04 , C12N2533/30 , C12N2533/74 , C12P1/00 , A61M2230/005 , A61K2300/00
摘要： Methods and devices are disclosed for the delivery of an active factor from an implanted co-culture of an active factor-secreting cell obtained from a first source and an augmentary substance-secreting cell obtained from a second source different from the first source, to a target region in a subject. The co-culture is maintained within a biocompatible, semipermeable membrane in which the augmentary substance secreted by the augmentary substance-producing cells stimulates the active factor-producing cells to secrete active factor. The semipermeable membrane permits the diffusion of the active factor therethrough while excluding detrimental agents present in the external environment from gaining access to the co-culture.
摘要翻译：公开了用于从从第一来源获得的活性因子分泌细胞和从不同于第一来源的第二源获得的增生物质分泌细胞的植入共培养物递送活性因子的方法和装置，受试者的目标区域。共培养保持在生物相容的半透膜中，其中由增生物质产生细胞分泌的增殖物质刺激活性因子产生细胞分泌活性因子。半透膜允许活性因子的扩散通过，同时排除存在于外部环境中的有害剂以获得共培养物质。

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