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91. 发明申请

WO00035508A1 A NOVEL COMPOSITE AND ITS USE 审中-公开
标题翻译：一种新型复合材料及其使用
公开(公告)号：WO00035508A1
公开(公告)日：2000-06-22
申请号：PCT/FI1999/000960
申请日：1999-11-19
IPC分类号： A61L27/00 , A61K6/033 , A61L27/10 , A61L27/30 , A61L27/32 , C03C3/097 , C03C4/00 , C03C12/00 , C03C17/25
CPC分类号： A61L27/32 , A61L27/10 , A61L27/306 , C03C3/097 , C03C4/0007 , C03C12/00 , C03C17/25
摘要： The invention relates to a porous composite which comprises particles made from a bioactive material, the particles being sintered together to form a porous composite. It is characteristic that the particles have one or more recesses or throughgoing holes, or that the particles provided with an unbroken surface layer are hollow.
摘要翻译：本发明涉及一种多孔复合材料，其包含由生物活性材料制成的颗粒，所述颗粒被烧结在一起以形成多孔复合材料。特征在于，颗粒具有一个或多个凹槽或通孔，或者具有不间断表面层的颗粒是中空的。

92. 发明申请

WO99066966A1 THIN-FILM COATING FOR A BONE IMPLANT 审中-公开
标题翻译：薄膜涂层用于骨头植入
公开(公告)号：WO99066966A1
公开(公告)日：1999-12-29
申请号：PCT/EA1998/000002
申请日：1998-06-22
IPC分类号： A61L27/30 , A61L27/00
CPC分类号： A61L27/306 , A61L27/06 , A61L27/10 , A61L27/40
摘要： The present invention pertains to the field of medical techniques and can be used in traumatology and in orthopedics for placing hip-joint endoprostheses. The thin-film coating of the present invention includes a non-porous titanium sub-layer resting on a base, a bioactive layer as well as an intermediate layer comprising a mixture of the materials used in the compositions of the sub-layer and the bioactive layer. This invention is characterised in that the bioactive layer essentially comprises titanium oxides having a different stoichiometric composition, e.g. TiO2, TiO and Ti2O3. The surface of the base has an excess number of active atoms, while the concentration of titanium oxides in the intermediate layer increases from the sub-layer towards the bioactive layer. Aluminium and zirconium oxides are further provided between the titanium oxides, wherein the concentration of said aluminium and zirconium oxides decreases from the sub-layer towards the bioactive layer. The use in traumatology and in orthopedics of a bone implant provided with this thin-film coating increases the adhesion to the base as well as the coating density, the corrosion resistance, the bio-compatibility and the bioactivity.
摘要翻译：本发明涉及医疗技术领域，并且可用于创伤学和整形外科用于放置髋关节内假体。本发明的薄膜涂层包括搁置在基底上的无孔钛亚层，生物活性层以及包含用于亚层组合物和生物活性物质的混合物的中间层层。本发明的特征在于生物活性层基本上包含具有不同化学计量组成的钛氧化物， TiO 2，TiO和Ti 2 O 3。碱的表面具有过量的活性原子，而中间层中的氧化钛的浓度从亚层向生物活性层增加。在氧化钛之间进一步提供铝和锆氧化物，其中所述铝和锆氧化物的浓度从子层朝向生物活性层降低。在具有这种薄膜涂层的骨植入物的创伤学和整形外科中的使用增加了对基底的粘附性以及涂层密度，耐腐蚀性，生物相容性和生物活性。

93. 发明申请

WO99065537A1 SUPERFICIAL IMPLANT AND SURFACE COATING FOR STENTS AND OTHER IMPLANTS 审中-公开
标题翻译：表面植入物和表面涂层的支架或其他植入物
公开(公告)号：WO99065537A1
公开(公告)日：1999-12-23
申请号：PCT/EP1999/003919
申请日：1999-06-08
IPC分类号： A61F2/82 , A61L27/30 , A61L31/08 , A61L27/00 , A61L31/00 , A61L33/00
CPC分类号： A61L27/306 , A61F2/82 , A61L31/088
摘要： A superficial implant or surface coating made of a material differing from that of the base material is provided for stents or other implants that are to be permanently or temporarily lodged in the human or animal body and that have a different basic body shape made of a base material owing to mechanical or geometric requirements. The invention makes it possible to combine the favorable mechanical properties of the base material with the biocompatible properties of tantalum or niobium due to the fact that the surface coating is made of tantalum or niobium.
摘要翻译：对于支架或其它植入物中，以上在人体或动物体永久地暂时保持，并且由于其具有基材机械或几何要求基体上的形成，表面植入物或表面涂层是由不同的材料比基体材料所提供。其特征在于，所述表面或表面涂层是由钽或铌构成，在基材的与钽或铌的生物相容性质可连接良好的机械性能。

94. 发明申请

WO99058167A1 IMPLANT WITH COMPOSITE COATING 审中-公开
标题翻译：植入复合涂料
公开(公告)号：WO99058167A1
公开(公告)日：1999-11-18
申请号：PCT/US1999/008456
申请日：1999-04-16
IPC分类号： A61F2/00 , A61F2/30 , A61F2/36 , A61F2/38 , A61L27/30 , A61L27/00
CPC分类号： A61F2/30767 , A61F2/3094 , A61F2/30965 , A61F2/36 , A61F2/3662 , A61F2/367 , A61F2/3859 , A61F2002/30016 , A61F2002/30906 , A61F2002/30925 , A61F2002/30929 , A61F2002/30968 , A61F2002/3097 , A61F2002/3098 , A61F2002/30981 , A61F2002/3611 , A61F2002/3625 , A61F2002/3631 , A61F2002/365 , A61F2250/0019 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00179 , A61F2310/00407 , A61F2310/00485 , A61F2310/00491 , A61F2310/00538 , A61F2310/00544 , A61F2310/00574 , A61F2310/0058 , A61F2310/00796 , A61F2310/00976 , A61L27/306
摘要： Systems and methods are described for implants with composite coatings to promote tissue in-growth and/or on-growth. An implant includes: a substrate; a structured surface formed on at least a portion of the substrate; and a biocompatible coating deposited on at least a fraction of the structured surface. The systems and methods provide advantages in that the implant has good biocompatibility while the biocompatible coating has good strength.
摘要翻译：描述了具有复合涂层的植入物以促进组织生长和/或生长的系统和方法。植入物包括：基底; 形成在所述基板的至少一部分上的结构化表面; 以及沉积在结构化表面的至少一部分上的生物相容性涂层。该系统和方法提供了优点，因为植入物具有良好的生物相容性，而生物相容性涂层具有良好的强度。

95. 发明申请

WO99046780A1 IONTOPHORETIC MATERIAL 审中-公开
标题翻译：静电材料
公开(公告)号：WO99046780A1
公开(公告)日：1999-09-16
申请号：PCT/US1999/004095
申请日：1999-02-25
IPC分类号： A61F2/00 , A61F2/28 , A61F2/30 , A61F2/36 , A61L27/30 , A61L27/44 , A61L27/54 , A61L29/10 , A61L29/12 , A61L29/16 , A61L31/08 , A61L31/12 , A61L31/16 , A61N1/05 , A61N1/20 , A61N1/30 , H01B1/22 , A61M5/00 , B05D1/02 , B05D1/18 , H01B1/24
CPC分类号： A61N1/20 , A61F2/30767 , A61F2/36 , A61F2/3662 , A61F2002/2821 , A61F2002/30064 , A61F2310/0052 , A61F2310/00574 , A61L27/303 , A61L27/306 , A61L27/443 , A61L27/446 , A61L27/54 , A61L29/103 , A61L29/106 , A61L29/126 , A61L29/16 , A61L31/084 , A61L31/086 , A61L31/126 , A61L31/128 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/108 , A61L2300/404 , A61L2300/62 , A61L2300/80 , A61N1/056 , A61N1/303 , A61N1/306 , Y10T428/249954
摘要： A material is provided that uses controlled electrical current derived from two dissimilar galvanic materials to drive oligodynamic metal ions (36) into solution. Exemplary materials include carbon and silver (32).
摘要翻译：提供了一种材料，其使用由两种不同的电偶材料得到的受控电流以将低分子量金属离子（36）驱动到溶液中。示例性材料包括碳和银（32）。

96. 发明申请

WO99037246A1 BIOCOMPATIBLE STRUCTURE COMPRISING MEANS FOR ENHANCED FIBROVASCULAR INGROWTH 审中-公开
标题翻译：包括增强血管生成的手段的生物化学结构
公开(公告)号：WO99037246A1
公开(公告)日：1999-07-29
申请号：PCT/US1999/001148
申请日：1999-01-20
IPC分类号： A61F2/14 , A61L27/30 , A61L27/34 , A61L27/56
CPC分类号： A61L27/56 , A61F2/141 , A61L27/306 , A61L27/34 , A61L2430/16 , C08L67/04
摘要： A porous structure for implantation into the orbital cavity of a mammal who has had an ocular enucleation, evisceration or who needs to have an orbital implant replaced, the structure comprising pores having a mean size of less than 200 micrometers. Also disclosed is a surgical method for placing an implant into a mammal who has had an ocular enucleation, evisceration or who needs implant replacement, whereby the implant obtains rapid ingrowth of connective and vascular tissues, said method comprising: selecting a porous ocular implant comprising pores with a mean size of less than 200 micrometers; and, placing the implant into an orbital cavity of a mammal.
摘要翻译：用于植入到具有眼睛摘除，掏膛内或需要具有眼眶植入物的哺乳动物的眼眶腔中的多孔结构，所述结构包括平均尺寸小于200微米的孔。还公开了一种用于将植入物放置在哺乳动物中的手术方法，所述哺乳动物具有眼睛摘除，取内脏或需要植入物置换，由此植入物获得结缔组织和血管组织的快速向内生长，所述方法包括：选择包含孔的多孔眼植入体平均尺寸小于200微米; 并将植入物放置在哺乳动物的轨道腔中。

97. 发明申请

WO99001089A1 IMPLANTABLE PROSTHETIC DEVICES COATED WITH BIOACTIVE MOLECULES 审中-公开
标题翻译：用生物活性分子涂覆的可植入的前置装置
公开(公告)号：WO99001089A1
公开(公告)日：1999-01-14
申请号：PCT/US1998/013792
申请日：1998-07-01
IPC分类号： A61L27/28 , A61L27/30 , A61L27/34 , A61L33/12 , A61F2/06
CPC分类号： A61L33/12 , A61L27/22 , A61L27/227 , A61L27/28 , A61L27/30 , A61L27/306 , A61L27/34 , A61L27/54 , A61L27/56 , C08L89/00 , A61L33/128 , A61L33/022
摘要： Coated implantable prosthetic devices are disclosed. The device is a prosthetic having a gold layer on the surface to which bioactive molecules are attached through a gold-sulfhydryl bond. The devices are easy and convenient to prepare. Gold coated implantable devices are also disclosed herein. The gold coated implantable device is a prosthetic device formed of a porous non-fabric material having a surface with projections and indentations and the gold layer on the surface of the porous non-fabric material forms a uniform layer across the material such that the gold layer also forms projections and indentations.
摘要翻译：公开了涂覆的可植入假体装置。该装置是在生物活性分子通过金 - 巯基键附着的表面上具有金层的假体。这些设备易于准备。本文还公开了镀金可植入装置。金涂覆的可植入装置是由具有突起和凹陷的表面的多孔非织物材料形成的假体装置，并且多孔非织物材料的表面上的金层在整个材料上形成均匀的层，使得金层也形成预测和缩进。

98. 发明申请

WO1998017331A1 SILVER IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：银色植入式医疗器械
公开(公告)号：WO1998017331A1
公开(公告)日：1998-04-30
申请号：PCT/US1997019188
申请日：1997-10-23
申请人： COOK INCORPORATED , MED INSTITUTE, INC.
发明人： COOK INCORPORATED , MED INSTITUTE, INC. , BATES, Brian, L. , OSBORNE, Thomas, A. , ROBERTS, Joseph, W. , FEARNOT, Neal, E. , KOZMA, Thomas, G. , RAGHEB, Anthony, O. , VOORHEES, William, D., III
IPC分类号： A61L29/00
CPC分类号： A61L29/085 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L33/022 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2300/61 , A61N5/1002
摘要： A silver implantable medical device (29) includes a structure (12) adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer (18) of a bioactive material deposited on one surface of structure (12); and at least one porous layer (20) deposited over the bioactive material layer (18) deposited on one surface of structure (12) and the bioactive-material-free surface. Also included is a layer or impregnation of silver (45). Preferably, the structure (12) is a coronary stent. The porous layer (20) is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Silver is included as a base material, coating or included in a carrier, drug, medicament material utilized with the implantable stent.
摘要翻译：银可植入医疗装置（29）包括适于引入血管系统，食道，气管，结肠，胆道或尿道的结构（12）; 沉积在结构（12）的一个表面上的生物活性材料的至少一层（18）; 以及沉积在沉积在结构（12）的一个表面上的生物活性材料层（18）上的至少一个多孔层（20）和不含生物活性材料的表面。还包括一层或浸渍银（45）。优选地，结构（12）是冠状动脉支架。多孔层（20）由优选通过蒸汽或等离子体沉积施加的聚合物构成，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，其仅通过单体蒸气的冷凝而无溶剂，热或催化剂沉积。银包含作为基材，涂层或包含在与可植入支架一起使用的载体，药物，药物材料中。

99. 发明申请

WO1996022796A1 BIODEGRADABLE AND/OR COMPOSTABLE POLYMERS MADE FROM CONJUGATED DIENES SUCH AS ISOPRENE AND 2,3-DIMETHYL-1,3-BUTADIENE 审中-公开
标题翻译：可连接的和/或可组合的聚合物，从偶联的二烯如异丙苯和2,3-二甲基-1,3-丁二烯
公开(公告)号：WO1996022796A1
公开(公告)日：1996-08-01
申请号：PCT/US1996000081
申请日：1996-01-11
申请人： THE PROCTER & GAMBLE COMPANY , SHELL OIL COMPANY
发明人： THE PROCTER & GAMBLE COMPANY , SHELL OIL COMPANY , DYER, John, Collins , HIRD, Bryn , WONG, Pui, Kwan
IPC分类号： A61L15/24
CPC分类号： A61L27/10 , A61L15/24 , A61L15/425 , A61L15/48 , A61L15/62 , A61L27/306 , C08F2/32 , C08F236/04 , C08J9/28 , C08J2300/00 , F02B2075/027 , Y10T428/249953 , Y10T428/249984 , C08L33/06
摘要： Biodegradable and/or compostable polymers are made from isoprene, 2,3-dimethyl-1,3-butadiene or like conjugated dienes and a cross-linking agent having a cleavable linking group such as ethylene glycol dimethacrylate. These polymers can be used to make absorbent foams that are useful in absorbent articles such as diapers, as well as other biodegradable articles such as films, and latexes useful as binders and adhesives.
摘要翻译：可生物降解和/或可堆肥的聚合物由异戊二烯，2,3-二甲基-1,3-丁二烯或类似的共轭二烯和具有可切割连接基团的交联剂如乙二醇二甲基丙烯酸酯制成。这些聚合物可用于制备可用于吸收制品如尿布的吸收性泡沫，以及其它可生物降解的制品如膜，以及可用作粘合剂和粘合剂的胶乳。

100. 发明申请

WO1995013100A1 BONE SUBSTITUTE MATERIAL AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：骨替代材料及其生产方法
公开(公告)号：WO1995013100A1
公开(公告)日：1995-05-18
申请号：PCT/JP1994001885
申请日：1994-11-07
申请人： THE FOUNDATION FOR THE PROMOTION OF ION ENGINEERING
发明人： THE FOUNDATION FOR THE PROMOTION OF ION ENGINEERING , KOKUBO, Tadashi
IPC分类号： A61L27/00
CPC分类号： A61L27/306 , A61F2/28 , A61F2310/00796 , A61L27/06 , A61L27/32 , A61L2430/02
摘要： A bone substitute material comprising a base material comprising titanium or its alloy and, formed on the surface thereof, a coating containing a titanium oxide phase and a noncrystalline alkali titanate phase; and a process for producing the same by immering a base material comprising titanium or its alloy in an alkali solution and heating the material to temperature lower than the transition point of titanium or its alloy. The invention material comprises a titanium and apatite bonded to each other firmly, has both of the fracture toughness of titanium and the bioactivity of apatite, and is available at a low cost.
摘要翻译：一种骨替代材料，其包含包含钛或其合金的基材，并且在其表面上形成包含氧化钛相和非结晶性钛酸钛相的涂层; 以及通过将含有钛或其合金的基材浸渍在碱溶液中并将材料加热到低于钛或其合金的转变点的温度来制造该方法。本发明材料包括彼此牢固结合的钛和磷灰石，具有钛的断裂韧性和磷灰石的生物活性，并且可以低成本获得。

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