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91. 发明申请

WO2018217921A1 TETHERED IMPLANTABLE DEVICE HAVING A VORTICAL INTRACARDIAC VELOCITY ADJUSTING BALLOON 审中-公开
公开(公告)号：WO2018217921A1
公开(公告)日：2018-11-29
申请号：PCT/US2018/034177
申请日：2018-05-23
申请人： HARMONY DEVELOPMENT GROUP, INC.
发明人： WILSON, John , SEGUIN, Christopher
IPC分类号： A61B17/00 , A61F2/00 , A61F2/02 , A61F2/24
CPC分类号： A61F2/2487 , A61B17/00234 , A61B17/12122 , A61B17/12136 , A61B2017/00017 , A61B2017/00022 , A61B2017/00221 , A61B2017/00243 , A61B2017/00539 , A61B2017/00557 , A61B2017/3425 , A61B2090/036 , A61F2/2412 , A61F2/2433 , A61F2/2442 , A61F2002/068 , A61F2002/482 , A61F2002/485 , A61F2210/009 , A61F2220/0008 , A61F2220/0033 , A61F2220/0091 , A61F2230/0013 , A61F2250/0003 , A61F2250/0013 , A61F2250/0065 , A61F2250/0069
摘要： An implant system for restoring and improving physiological intracardiac flow in a human heart is provided including an expandable balloon defining a fluid reservoir for positioning in a chamber of the human heart; a therapeutic apical base plate assembly attachable to the apex of the heart; and a tether assembly connected between the implant and the therapeutic apical base plate assembly.

92. 发明申请

WO2018217919A1 TETHERED IMPLANTABLE DEVICE HAVING AN APICAL BASE PLATE WITH A HYDRAULIC INTRACARDIAC ADJUSTING MECHANISM 审中-公开
公开(公告)号：WO2018217919A1
公开(公告)日：2018-11-29
申请号：PCT/US2018/034174
申请日：2018-05-23
申请人： HARMONY DEVELOPMENT GROUP, INC.
发明人： WILSON, John , SEGUIN, Christopher
IPC分类号： A61F2/00 , A61F2/02 , A61F2/24 , A61M1/10 , A61M1/12 , A61N1/362
CPC分类号： A61F2/2487 , A61B17/00234 , A61B17/12122 , A61B17/12136 , A61B2017/00017 , A61B2017/00022 , A61B2017/00221 , A61B2017/00243 , A61B2017/00539 , A61B2017/00557 , A61B2017/3425 , A61B2090/036 , A61F2/2412 , A61F2/2433 , A61F2/2442 , A61F2002/068 , A61F2002/482 , A61F2002/485 , A61F2210/009 , A61F2220/0008 , A61F2220/0033 , A61F2220/0091 , A61F2230/0013 , A61F2250/0003 , A61F2250/0013 , A61F2250/0065 , A61F2250/0069
摘要： An implant system for restoring and improving physiological intracardiac flow in a human heart is provided including an implant for positioning at least partially within a human heart; an apical base plate assembly attachable to the apex of the heart; a tether assembly comprising a tether connected between the implant and the therapeutic apical base plate assembly, and an adjustment assembly connected to the tether assembly to permit longitudinal movement of the tether assembly and implant relative to the base plate assembly.

93. 发明申请

WO2018167059A1 A TRANSAPICAL HEART PORT FOR INSERTION INTO A HEART OF A HUMAN OR AN ANIMAL SUBJECT 审中-公开
公开(公告)号：WO2018167059A1
公开(公告)日：2018-09-20
申请号：PCT/EP2018/056238
申请日：2018-03-13
申请人： ACADEMISCH ZIEKENHUIS MAASTRICHT , UNIVERSITEIT MAASTRICHT
发明人： SARDARI NIA, Peyman
IPC分类号： A61B17/34
CPC分类号： A61B17/3421 , A61B17/3423 , A61B2017/3425
摘要： Transapical heart port for insertion into a heart of a human or an animal subject, said transapical heart port comprising: a port housing (11) having a length dimension and a diameter dimension and comprising a first, proximal housing end and a housing second, distal housing end, wherein said port housing defines a housing channel extending along said length dimension between said first, proximal housing end and said second, distal housing end, wherein said port housing is configured to be inserted with said first, proximal housing end into a heart of a human or animal subject at the apex of said heart, whereas said second, distal housing end of said port housing is configured to remain outside said heart of a human or animal subject, wherein said housing channel is configured to provide repeated access to the interior of said housing heart through said housing channel, and wherein a hemostatic valve (25) attached to said housing and located within said channel, said hemostatic valve being configured to reduce blood loss from said heart through said channel, wherein said second, distal housing end comprises a securing portion (20) configured to secure said second, distal housing end to an exterior region of said heart, said securing portion being configured as a slab-like element of a flexible material extending away from said second, distal housing end, wherein said flexible slab-like element is arranged to be sutured to said exterior region of said heart.

94. 发明申请

WO2017127682A1 TRANSATRIAL ACCESS FOR INTRACARDIAC THERAPY 审中-公开
标题翻译：心动过速治疗的跨境访问
公开(公告)号：WO2017127682A1
公开(公告)日：2017-07-27
申请号：PCT/US2017/014341
申请日：2017-01-20
申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人： BADHWAR, Vinay , D'AMORE, Antonio , WAGNER, William, R.
IPC分类号： A61B17/34 , A61F2/24 , A61L31/06
CPC分类号： A61B17/34 , A61B17/3423 , A61B2017/00858 , A61B2017/00951 , A61B2017/3425 , A61B2217/007 , A61F2/2427 , A61L31/06
摘要： Disclosed herein are devices and methods for accessing the interior of the heart through a wall thereof. The device includes a main body, a flange at an end thereof, and a passage therethrough to allow for access to the interior of the heart when the device is placed on an outer surface thereof. The device can be formed of any suitable biocompatible and/or biodegradable material, and can have a passage sized to allow for transmittance of tools/devices normally used for interventions in the interior of the heart therethrough.
摘要翻译：这里公开了用于通过其壁进入心脏内部的装置和方法。该装置包括主体，在其端部处的凸缘以及贯穿其中的通道，以允许当该装置放置在其外表面上时进入心脏内部。该装置可以由任何合适的生物相容性和/或生物可降解材料形成，并且可以具有通道，其尺寸允许透过通常用于心脏内部介入的工具/装置通过。

95. 发明申请

WO2016066180A8 TRANSMYOCARDIAL INSERTION UNIT AND ITS USE 审中-公开
标题翻译：心肌梗塞单位及其使用
公开(公告)号：WO2016066180A8
公开(公告)日：2017-07-13
申请号：PCT/EP2014002915
申请日：2014-10-30
申请人： PETER OSYPKA STIFTUNG
IPC分类号： A61B17/34 , A61M1/10 , A61N1/05
CPC分类号： A61B17/3423 , A61B2017/00252 , A61B2017/00867 , A61B2017/3425 , A61B2017/3441 , A61B2017/3488 , A61F2/2427 , A61F2/243 , A61F2/2487 , A61F2/2493 , A61F2/82 , A61M1/1008 , A61M1/101 , A61M1/122 , A61M1/125 , A61N1/056 , A61N1/0587
摘要： The invention relates to an insertion device that for the first time allows gaining access to the left ventricle of the heart, via the tissue forming the wall of the right ventricle and via the ventricular septum. The insertion unit comprises a tubular shaft (5) with a lumen (8) extending there through, said shaft comprising distal, proximal and central sections, whereby the distal and proximal sections are disc-shaped extended thus forming each a double disc (1), (2) resp. (3) (4) and whereby the central section (50) links the distally placed double disc (1), (2) with the proximally placed double disc (3), (4), and whereby pressure valve (6) resp. (7) are fixed inside the shaft preferably on its distal and proximal end. The invention also relates to devices using said insertion unit.
摘要翻译：本发明涉及一种插入装置，其首次允许经由形成右心室壁的组织和经由心室隔膜进入心脏的左心室。插入单元包括具有延伸穿过其中的内腔（8）的管状轴（5），所述轴包括远侧部分，近侧部分和中央部分，由此远侧部分和近侧部分是盘形延伸的，因此形成每个双盘（1），（2）（3），（4）并且由此中央部分（50）将远侧放置的双层盘（1），（2）与近侧放置的双层盘（3），（4）连接，并且由此压力阀（6）（7）优选在其远端和近端固定在轴内。本发明还涉及使用所述插入单元的设备。

96. 发明申请

WO2016196933A1 APICAL CONTROL OF TRANSVASCULAR DELIVERY OF PROSTHETIC MITRAL VALVE 审中-公开
标题翻译：前列腺门静脉输送的临床控制
公开(公告)号：WO2016196933A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035719
申请日：2016-06-03
申请人： TENDYNE HOLDINGS, INC.
发明人： KOVALSKY, Igor , TEGELS, Zachary J. , VIDLUND, Robert M. , VIDLUND, Zach
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61B17/0401 , A61B17/3478 , A61B2017/00247 , A61B2017/00358 , A61B2017/0404 , A61B2017/3425 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2/2457 , A61F2002/9534 , A61F2002/9665 , A61F2210/0014 , A61F2220/0008 , A61F2220/0075 , A61F2230/0054
摘要： Apparatus and methods are described herein for use in the delivery and deployment of a prosthetic mitral valve. In some embodiments, after a prosthetic valve (1500) has been at least partially delivered from a delivery sheath into the left atrium of a heart, a valve positioning device can be used to engage with and position the prosthetic valve within the mitral annulus. The valve positioning device can include a alignment member (1576) configured to engage with a prosthetic valve such that the alignment member can control the distal, proximal, lateral and/or rotational movement of the prosthetic valve. The prosthetic valve can include a tether (1536) that can be inserted or threaded through the alignment member such that the alignment member can be moved along the tether into engagement with the prosthetic valve.
摘要翻译：本文描述的装置和方法用于递送和展开假体二尖瓣。在一些实施例中，在假体瓣膜（1500）至少部分地从输送护套输送到心脏的左心房之后，阀定位装置可以用于与二尖瓣环内的假体瓣接合并定位。瓣膜定位装置可以包括配置成与假性瓣膜接合的对准构件（1576），使得对准构件可以控制人造瓣膜的远侧，近侧，侧向和/或旋转运动。假体瓣膜可以包括可以插入或穿过对准构件的系绳（1536），使得对准构件可以沿着系绳移动以与假性瓣膜接合。

97. 发明申请

WO2016126942A3 EXPANDABLE EPICARDIAL PADS AND DEVICES AND METHODS FOR THEIR DELIVERY 审中-公开
标题翻译：可扩展的EPICARDIAL PADS及其设备及其交付方法
公开(公告)号：WO2016126942A3
公开(公告)日：2016-09-29
申请号：PCT/US2016016567
申请日：2016-02-04
申请人： TENDYNE HOLDINGS INC
发明人： VIDLUND ROBERT M , KOVALSKY IGOR , TEGELS ZACHARY J , EKVALL CRAIG A
IPC分类号： A61F2/24 , A61B17/04
CPC分类号： A61F2/2418 , A61B17/0401 , A61B2017/0443 , A61B2017/3425 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2/2457 , A61F2220/0016 , A61F2220/0041 , A61F2220/0075 , A61F2220/0083 , A61F2230/0093 , A61F2250/0039 , A61F2250/0063 , A61F2250/0098
摘要： Apparatus and methods are described herein for use in the delivery of a prosthetic mitral valve. In some embodiments, an apparatus includes an epicardial pad (1639) configured to engage an outside surface of a heart to secure a prosthetic heart valve in position within the heart. The epicardial pad defines a lumen configured to receive therethrough a tether (1619) extending from the prosthetic valve. The epicardial pad is movable between a first configuration in which the epicardial pad has a first outer perimeter and is configured to be disposed within a lumen of a delivery sheath and a second configuration in which the epicardial pad has a second outer perimeter greater than the first outer perimeter. The epicardial pad can be disposed against the outside surface of the heart when in the second configuration to secure the prosthetic valve and tether in a desired position within the heart.
摘要翻译：本文描述了用于递送假性二尖瓣的装置和方法。在一些实施例中，一种装置包括构造成接合心脏的外表面以将假心脏瓣膜固定在心脏内的适当位置的心外膜垫（1639）。心外膜限定了被配置为从其接收通过从假肢瓣延伸的系绳（1619）的内腔。心外膜垫可以在其中心外膜具有第一外周边并被构造成设置在输送护套的内腔内的第一构型和第二构型之间移动，其中心外膜垫具有大于第一外周边的第二外周边外围。当处于第二构造中时，心外膜可以抵靠心脏的外表面设置，以将人造瓣膜和系绳固定在心脏内的期望位置。

98. 发明申请

WO2016066180A1 TRANSMYOCARDIAL INSERTION UNIT AND ITS USE 审中-公开
标题翻译：转移插入单元及其使用
公开(公告)号：WO2016066180A1
公开(公告)日：2016-05-06
申请号：PCT/EP2014/002915
申请日：2014-10-30
申请人： PETER OSYPKA STIFTUNG
发明人： PETER OSYPKA STIFTUNG
IPC分类号： A61B17/34 , A61M1/10 , A61N1/05
CPC分类号： A61B17/3423 , A61B2017/00252 , A61B2017/00867 , A61B2017/3425 , A61B2017/3441 , A61B2017/3488 , A61F2/2427 , A61F2/243 , A61F2/2487 , A61F2/2493 , A61F2/82 , A61M1/1008 , A61M1/101 , A61M1/122 , A61M1/125 , A61N1/056 , A61N1/0587
摘要： The invention relates to an insertion device that for the first time allows gaining access to the left ventricle of the heart, via the tissue forming the wall of the right ventricle and via the ventricular septum. The insertion unit comprises a tubular shaft (5) with a lumen (8) extending there through, said shaft comprising distal, proximal and central sections, whereby the distal and proximal sections are disc-shaped extended thus forming each a double disc (1), (2) resp. (3) (4) and whereby the central section (50) links the distally placed double disc (1), (2) with the proximally placed double disc (3), (4), and whereby pressure valve (6) resp. (7) are fixed inside the shaft preferably on its distal and proximal end. The invention also relates to devices using said insertion unit.
摘要翻译：本发明涉及一种插入装置，其首次允许通过形成右心室的壁并通过心室隔膜的组织进入心脏的左心室。所述插入单元包括管状轴（5），所述管状轴（5）具有在其中延伸的内腔（8），所述轴包括远端，近端和中心区段，由此所述远端和近端区段是圆盘状延伸的，从而形成每个双盘（1），（2）（3）（4），并且由此中心部分（50）将远端放置的双盘（1），（2）与近端放置的双盘（3），（4）连接，并且由此将压力阀（6）（7）优选地在其远端和近端固定在轴内。本发明还涉及使用所述插入单元的装置。

99. 发明申请

WO2016018434A1 CORING DILATOR FOR DEFINING AN APERTURE IN A TISSUE WALL 审中-公开
标题翻译：用于在组织墙中定义孔的CORING DILATOR
公开(公告)号：WO2016018434A1
公开(公告)日：2016-02-04
申请号：PCT/US2014/049457
申请日：2014-08-01
申请人： VADOVATIONS, INC.
发明人： STANFIELD, Ryan, J. , LONG, James, W.
IPC分类号： A61B17/34 , A61M29/00 , A61M1/10
CPC分类号： A61B17/3423 , A61B17/3468 , A61B17/3478 , A61B2017/00252 , A61B2017/3425 , A61B2017/3458 , A61B2017/349 , A61M1/1008 , A61M1/101 , A61M1/12 , A61M1/122 , A61M29/00
摘要： A coring tool and a dilator for defining an aperture in a tissue is presented. The system is preferably configured for generating an aperture within a ventricular wall for a method of implantation of ventricular assist devices (VAD's). The insertion tool/system includes a conduit device including a detachable dilator-coring tool and cuff which secures within a defined aperture in the tissue.
摘要翻译：提出了一种用于限定组织中孔径的取芯工具和扩张器。该系统优选地构造成用于在心室辅助装置（VAD）的植入方法中产生心室壁内的孔。插入工具/系统包括导管装置，该管道装置包括可拆卸的扩张器取芯工具和在组织中限定的孔内固定的套囊。

100. 发明申请

WO2014207699A8 ORIENTATION DEVICE FOR USE IN MITRAL VALVE REPAIR 审中-公开
标题翻译：用于麻醉阀维修的定位装置
公开(公告)号：WO2014207699A8
公开(公告)日：2015-08-06
申请号：PCT/IB2014062630
申请日：2014-06-26
申请人： STRAIT ACCESS TECHNOLOGIES HOLDINGS PTY LTD
发明人： GERHARDT THOMAS , COUSINS MICHAEL ALAN , HAW PETER RUDI , JARMAN JEREMY DOUGLAS , MUDGE EDWARD CHARLES , COOMBES HEATHER MADELEINE , BEZUIDENHOUT DEON , ZILLA PETER PAUL
IPC分类号： A61B17/34 , A61B17/00
CPC分类号： A61B17/00234 , A61B5/02158 , A61B17/3468 , A61B2017/00022 , A61B2017/00243 , A61B2017/00327 , A61B2017/00557 , A61B2017/00867 , A61B2017/22068 , A61B2017/22098 , A61B2017/3425 , A61B2017/3488 , A61B2090/064
摘要： An orientation device (200) for use in mitral valve repair surgery is provided and includes a catheter (202) catheter insertable percutaneously through the mitral valve into a chamber of a heart. At least one pressure sensor (216, 218) and two generally arcuate commissural arms (208, 210) are provided at or near the distal end (204) of the catheter (202). The arms (208, 210) are deployable from a stowed condition, in which the catheter (202) can be introduced percutaneously into the heart, to an operative condition in which they extend outwardly in generally opposite directions. Each arm (208, 210) is shaped to be locatable within a mitral valve commissure and has an indentation (212) shaped to extend, in use, at least partially about a mitral valve commissure to limit movement of the device (200) relative to the mitral valve in the axial direction of the catheter (202).
摘要翻译：提供了用于二尖瓣修复手术的定向装置（200），并且包括可经由二尖瓣经皮插入到心脏腔室中的导管（202）导管。至少一个压力传感器（216,218）和两个大体上弓形的连合臂（208,210）设置在导管（202）的远端（204）处或附近。臂（208,210）可以从收起的状态展开，其中导管（202）能够经皮地引入心脏中，使其在大致相反的方向上向外延伸的操作状态。每个臂（208,210）成形为可定位在二尖瓣合并中，并且具有成形为在使用中至少部分地围绕二尖瓣连接延伸的凹陷（212），以限制装置（200）相对于二尖瓣在导管（202）的轴向上。

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