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91. 发明申请

WO1991018594A1 THE PHARMACOLOGICAL USE OF CERTAIN CYSTINE DERIVATIVES 审中-公开
标题翻译：某些CYSTINE衍生物的药理学应用
公开(公告)号：WO1991018594A1
公开(公告)日：1991-12-12
申请号：PCT/SE1991000388
申请日：1991-06-03
申请人： AKTIEBOLAGET ASTRA , ANDERSSON, Carl-Magnus, Alexander , BERGSTRAND, Sten, Håkan, Axel , HALLBERG, Anders, Rudolf , SÄRNSTRAND, Bengt, Olof , TUNEK, Per, Anders, Sigvard
发明人： AKTIEBOLAGET ASTRA
IPC分类号： A61K31/195
CPC分类号： A61K31/198 , A61K31/195 , A61K31/22 , A61K31/225 , C07C323/59
摘要： A method for the treatment of diseases due to defects in the immune system using certain cystine derivatives and a pharmaceutical preparation comprising these derivatives.
摘要翻译：一种用于治疗由于使用某些胱氨酸衍生物的免疫系统缺陷引起的疾病的方法和包含这些衍生物的药物制剂。

92. 发明申请

WO1991014448A1 NEW PROTEINS, PEPTIDES AND CORRESPONDING DNA OR RNA SEQUENCES AND PROBES USEFUL FOR DIAGNOSING TUBERCULOSIS 审中-公开
标题翻译：新蛋白，肽和相应的DNA或RNA序列和探针有助于诊断TUBCCOSOSIS
公开(公告)号：WO1991014448A1
公开(公告)日：1991-10-03
申请号：PCT/SE1991000225
申请日：1991-03-22
申请人： AKTIEBOLAGET ASTRA
发明人： AKTIEBOLAGET ASTRA , CHINNASWAMY, Jagannath , MEENAKSHI, Balganesh , BACHALLY, Ramasastry, Srinivasa
IPC分类号： A61K39/04
CPC分类号： C07K16/1289 , A61K38/00 , A61K39/00 , C07K14/35 , C07K2317/34
摘要： Disclosed are the immunochemical properties of a 17 kDa protein antigen fractionated, purified and sequenced for amino acids from Mycobacterium tuberculosis (South Indian isolate, SII 1) which causes human tuberculosis worldwide among 16 million patients. The 17 kDa protein antigen which has an N-terminus of A T T L P V Q R (aa 1-8) has at least three specific antibody binding epitopes located on linear peptides of sequences, R A T Y D K R Y E V R (aa 91-101) and S E F A Y G S F V R (aa 68-77) which were useful in a micro ELISA for the early diagnosis of human tuberculosis by the detection of specific antibodies. The 17 kDa protein antigen which was mitogenic for human tuberculous peripheral blood lymphocytes was found to carry three predicted T-cell epitopes on linear peptides of sequences, S E F A Y G S F V R (aa 68-77) and A E L P G V D P D C D V C I T R (aa 107-122). The 17 kDa antigen of M. tuberculosis (SII 1) which thus had both B and T cell reactive properties was found to contain 131 amino acids and potentially applicable in the immuno diagnosis, immuno therapy and immuno prophylaxis of human tuberculosis.
摘要翻译：披露了分离，纯化和测序结核分枝杆菌（南印度分离株，SII 1）的氨基酸的17kDa蛋白质抗原的免疫化学性质，其在全世界1600万患者中引起人类结核病。具有ATTLPVQR（aa 1-8）N末端的17kDa蛋白抗原具有位于序列的线性肽RATYDKRYEVR（aa 91-101）和SEFAYGSFVR（aa 68-77）上的至少三个特异性抗体结合表位，其中通过检测特异性抗体在微型ELISA中可用于人类结核病的早期诊断。发现对于结核性外周血淋巴细胞有丝分裂的17kDa蛋白抗原在序列的线性肽S E F A Y G S F V R（aa 68-77）和A E L P G V D P D C D V C I T R（aa 107-122）上携带三个预测的T细胞表位。发现具有B和T细胞反应性的结核分枝杆菌（SII 1）的17kDa抗原含有131个氨基酸，并且可能适用于人结核病的免疫诊断，免疫治疗和免疫预防。

93. 发明申请

WO1991013894A1 METHOD FOR THE SYNTHESIS OF TRISODIUM PHOSPHONOFORMATE HEXAHYDRATE 审中-公开
标题翻译：合成磷酸三钙HEXAHYDRATE的方法
公开(公告)号：WO1991013894A1
公开(公告)日：1991-09-19
申请号：PCT/SE1991000172
申请日：1991-03-06
申请人： AKTIEBOLAGET ASTRA , JAKUPOVIC, Edib , STENHEDE, Urban
发明人： AKTIEBOLAGET ASTRA
IPC分类号： C07F09/38
CPC分类号： C07F9/3886
摘要： The present invention relates to a method for the synthesis of foscarnet, i.e. trisodium phosphonoformate hexahydrate, comprising the steps of adding sodium hydroxide to water, heating the aqueous sodium hydroxide solution to 50 °C, adding triethyl phosphonoformate to said solution at 50 °C, heating the reaction mixture to reflux for about 1 hour, cooling of the reaction mixture and filtering-off of the product.

94. 发明申请

WO1991009845A1 SUBSTITUTED 4-PHENYL-4-PIPERIDINECARBOXAMIDES WITH BOTH LOCAL ANAESTHETIC AND ANALGESIC EFFECT AS WELL AS PROCESSES FOR THEIR PREPARATION 审中-公开
标题翻译：取代的4-苯基-4-哌啶甲酰胺，具有两种本地麻醉和有效的作用，作为其制备方法
公开(公告)号：WO1991009845A1
公开(公告)日：1991-07-11
申请号：PCT/SE1990000818
申请日：1990-12-17
申请人： AKTIEBOLAGET ASTRA
发明人： AKTIEBOLAGET ASTRA , ASK, Anna-Lena , SANDBERG, Rune
IPC分类号： C07D211/64
CPC分类号： C07D211/64
摘要： Compounds of formula (IV) for use as local anaesthetica and analgetica, as well as a method for their preparation, their pharmaceutical preparations and their use.

95. 发明申请

WO1991006330A1 A NOVEL DISSOLUTION SYSTEM 审中-公开
标题翻译：一个新的解散系统
公开(公告)号：WO1991006330A1
公开(公告)日：1991-05-16
申请号：PCT/SE1990000698
申请日：1990-10-26
申请人： AKTIEBOLAGET ASTRA , BERGLUND, Bengt, Göran
发明人： AKTIEBOLAGET ASTRA
IPC分类号： A61M05/00
CPC分类号： A61M5/1409
摘要： The invention provides a device for mixing a pharmaceutical from a solid supply into a parenterally acceptable liquid flowing through a set for parenteral administration of the liquid to a patient, said device comprising a first compartment defining a mixing space through which the liquid flows in a defined flow direction and in which the liquid mixes with the pharmaceutical in liquid solution. The device is characterized in said mixing space (15) being limited in an upper part thereof, by a generally horizontal partition (4) parallel to the flow direction in the mixing space, and a second compartment (12) extending generally vertically above said partition and being in liquid communication with the mixing space via perforations in said partition, said second compartment being closed and gas impervious in its upper end and defining a space for dissolution of the pharmaceutical in liquid penetrating through the perforations, and said second compartment further comprising a storage space where undissolved solid pharmaceutical (5) is held surrounded by entrapped gas.
摘要翻译：本发明提供了一种用于将药物从固体供应混合到流过用于肠胃外给予患者的组的胃肠外可接受液体的装置，所述装置包括限定混合空间的第一隔室，液体通过该混合空间流动，流动方向，其中液体与药物在液体溶液中混合。该装置的特征在于，所述混合空间（15）在其上部通过在混合空间中平行于流动方向的大致水平的隔板（4）限制，以及第二隔室（12），其大致垂直地延伸在所述隔板并且通过所述分隔件中的穿孔与所述混合空间液体连通，所述第二隔室在其上端是封闭的并且气体不可渗透并且限定了药物溶解在穿透穿孔的液体中的空间，并且所述第二隔室还包括存储空间，其中未溶解的固体药物（5）被夹带的气体包围。

96. 发明申请

WO1990000390A1 NEW SYNERGISTIC PREPARATIONS CONTAINING DEZOCINE AND A LOCAL ANAESTHETIC AND A NEW METHOD OF ALLEVIATION OF PAIN 审中-公开
标题翻译：含有DEZOCINE和本地麻醉剂的新型协同制剂和一种新的疼痛评估方法
公开(公告)号：WO1990000390A1
公开(公告)日：1990-01-25
申请号：PCT/SE1989000348
申请日：1989-06-19
申请人： AKTIEBOLAGET ASTRA , POST, Claes, Tomas
发明人： AKTIEBOLAGET ASTRA
IPC分类号： A61K31/135
CPC分类号： A61K31/7004 , A61K31/445 , A61K31/13 , A61K31/135 , A61K2300/00
摘要： A pharmaceutical preparation for spinal analgesia, which alleviates postoperative or chronic pain containing dezocine or a physiologically acceptable salt thereof together with a local anaesthetic, such as bupivacaine or a physiologically acceptable salt thereof, a method for obtaining said preparation and a method of obtaining analgesia by administering said preparation to a patient in the need of analgesia.
摘要翻译：一种用于脊髓止痛的药物制剂，其与含有替佐啶或其生理学上可接受的盐的局部麻醉剂如布比卡因或其生理学上可接受的盐一起减轻术后或慢性疼痛，获得所述制剂的方法和通过以下步骤获得镇痛的方法：对需要镇痛的患者给予所述制剂。

97. 发明申请

WO1989007928A1 A HANDLING DEVICE FOR DRUG DOSAGE UNITS 审中-公开
标题翻译：用于药物剂量单位的处理装置
公开(公告)号：WO1989007928A1
公开(公告)日：1989-09-08
申请号：PCT/SE1989000091
申请日：1989-03-01
申请人： AKTIEBOLAGET ASTRA , EEK, Arne, Torsten , LUNDHOLM, Nils, Åke , LÖFMAN, Claes, Peter
发明人： AKTIEBOLAGET ASTRA
IPC分类号： A61J0
CPC分类号： A61J1/035
摘要： A handling device for dosage units of drugs comprising a sheet (1, 101) of shape-stable material provided with one or more holes (2, 102), and a number of blister packs (8, 9, 10, 108, 109, 110) placed such that the blisters (11, 111) thereof project through at least some of the holes is described. It is characterized in, that each of the last mentioned holes closely embraces, at least at two opposing portions of the periphery thereof, a blister at the base (124) thereof and that the blister has one or more zones (123) laterally extended beyond the base, to overlie the closely embracing portions of the hole, which extended zone(s) are permitted to pass through the hole by flexible deformation of the blister thereby locking the blister packs in the holes. A process for preparing the device and a means therefor are also described.
摘要翻译：一种用于药物剂量单位的处理装置，包括具有一个或多个孔（2,102）的形状稳定材料的片材（1,101）和多个泡罩包装（8,9,10,108,109， 110），使得其泡罩（11,111）突出穿过至少一些孔。其特征在于，每个最后提到的孔至少在其周边的两个相对的部分处紧密地包围在其底部（124）处的泡罩，并且泡罩具有横向延伸超过的一个或多个区域（123）该基部覆盖孔的紧密包围的部分，该延伸区允许通过泡罩的柔性变形而穿过孔，从而将泡罩包装锁定在孔中。还描述了一种用于制备该装置的方法及其装置。

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