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1. 发明申请

WO1991014448A1 NEW PROTEINS, PEPTIDES AND CORRESPONDING DNA OR RNA SEQUENCES AND PROBES USEFUL FOR DIAGNOSING TUBERCULOSIS 审中-公开
标题翻译：新蛋白，肽和相应的DNA或RNA序列和探针有助于诊断TUBCCOSOSIS
公开(公告)号：WO1991014448A1
公开(公告)日：1991-10-03
申请号：PCT/SE1991000225
申请日：1991-03-22
申请人： AKTIEBOLAGET ASTRA
发明人： AKTIEBOLAGET ASTRA , CHINNASWAMY, Jagannath , MEENAKSHI, Balganesh , BACHALLY, Ramasastry, Srinivasa
IPC分类号： A61K39/04
CPC分类号： C07K16/1289 , A61K38/00 , A61K39/00 , C07K14/35 , C07K2317/34
摘要： Disclosed are the immunochemical properties of a 17 kDa protein antigen fractionated, purified and sequenced for amino acids from Mycobacterium tuberculosis (South Indian isolate, SII 1) which causes human tuberculosis worldwide among 16 million patients. The 17 kDa protein antigen which has an N-terminus of A T T L P V Q R (aa 1-8) has at least three specific antibody binding epitopes located on linear peptides of sequences, R A T Y D K R Y E V R (aa 91-101) and S E F A Y G S F V R (aa 68-77) which were useful in a micro ELISA for the early diagnosis of human tuberculosis by the detection of specific antibodies. The 17 kDa protein antigen which was mitogenic for human tuberculous peripheral blood lymphocytes was found to carry three predicted T-cell epitopes on linear peptides of sequences, S E F A Y G S F V R (aa 68-77) and A E L P G V D P D C D V C I T R (aa 107-122). The 17 kDa antigen of M. tuberculosis (SII 1) which thus had both B and T cell reactive properties was found to contain 131 amino acids and potentially applicable in the immuno diagnosis, immuno therapy and immuno prophylaxis of human tuberculosis.
摘要翻译：披露了分离，纯化和测序结核分枝杆菌（南印度分离株，SII 1）的氨基酸的17kDa蛋白质抗原的免疫化学性质，其在全世界1600万患者中引起人类结核病。具有ATTLPVQR（aa 1-8）N末端的17kDa蛋白抗原具有位于序列的线性肽RATYDKRYEVR（aa 91-101）和SEFAYGSFVR（aa 68-77）上的至少三个特异性抗体结合表位，其中通过检测特异性抗体在微型ELISA中可用于人类结核病的早期诊断。发现对于结核性外周血淋巴细胞有丝分裂的17kDa蛋白抗原在序列的线性肽S E F A Y G S F V R（aa 68-77）和A E L P G V D P D C D V C I T R（aa 107-122）上携带三个预测的T细胞表位。发现具有B和T细胞反应性的结核分枝杆菌（SII 1）的17kDa抗原含有131个氨基酸，并且可能适用于人结核病的免疫诊断，免疫治疗和免疫预防。

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