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91. 发明申请

WO2010061991A1 VEGF-SPECIFIC HUMAN ANTIBODY 审中-公开
标题翻译： VEGF特异性人抗体
公开(公告)号：WO2010061991A1
公开(公告)日：2010-06-03
申请号：PCT/KR2008/007045
申请日：2008-11-28
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , PARK, Young Woo , CHOI, So-Young , SONG, Eun-Jung , YU, Jung , SOHN, Myung-Ho , JEON, Jae Won , JUNG, Joon-Goo , JANG, Myeoung Hee , KIM, Sungsub
发明人： PARK, Young Woo , CHOI, So-Young , SONG, Eun-Jung , YU, Jung , SOHN, Myung-Ho , JEON, Jae Won , JUNG, Joon-Goo , JANG, Myeoung Hee , KIM, Sungsub
IPC分类号： C07K16/18
CPC分类号： C07K16/22 , C07K2317/21 , C07K2317/622 , C07K2317/76
摘要： The present invention relates to a vascular endothelial growth factor (VEGF) -specific human antibody, and more particularly to a human antibody including a complementarity determining region (CDR) and a framework region (FR) derived from a human antibody specifically bound to VEGF. The VEGF- specific human antibody of the present invention may be used in diagnosis of diseases caused by the VEGF-overexpression, classification of the diseases, visualization, treatment, and prognostic evaluation.
摘要翻译：本发明涉及血管内皮生长因子（VEGF）特异性人抗体，更具体地涉及包含衍生自特异性结合VEGF的人抗体的互补决定区（CDR）和构架区（FR）的人抗体。本发明的VEGF特异性人抗体可用于诊断由VEGF过表达，疾病分类，可视化，治疗和预后评估引起的疾病。

92. 发明申请

WO2010032899A2 ENO1-SPECIFIC HUMAN ANTIBODY 审中-公开
标题翻译： ENO1特异性人体抗体
公开(公告)号：WO2010032899A2
公开(公告)日：2010-03-25
申请号：PCT/KR2008/006116
申请日：2008-10-16
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , PARK, Young Woo , HOE, Kwang-Lae , CHOI, So-Young , PARK, Ji Hyun , SONG, Eun-Jung , YU, Jung , SOHN, Myung-Ho , KIM, Sungsub , JANG, Myeoung Hee , KIM, Dong-Jin
发明人： PARK, Young Woo , HOE, Kwang-Lae , CHOI, So-Young , PARK, Ji Hyun , SONG, Eun-Jung , YU, Jung , SOHN, Myung-Ho , KIM, Sungsub , JANG, Myeoung Hee , KIM, Dong-Jin
IPC分类号： C07K16/18
CPC分类号： C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/622
摘要： The present invention relates to an alpha-endolase (ENO1) -specific human antibody, and more particularly to a human antibody including a complementarity determining region (CDR) and a framework region (FR) derived from a human antibody specifically bound to ENO1. The ENO1-specific human antibody expressed in the various kinds of cancer cells of the present invention may be used in diagnosis of the cancer, classification of the disease, visualization, treatment, and prognostic evaluation.
摘要翻译：本发明涉及α-端粒酶（ENO1）特异性人抗体，并且更具体地涉及包含互补决定区（CDR）和源自其的框架区（FR）的人抗体与ENO1特异性结合的人抗体。在本发明的各种癌细胞中表达的ENO1特异性人抗体可用于癌症的诊断，疾病的分类，可视化，治疗和预后评估。

93. 发明申请

WO2010030081A2 PAPER FORMWORK WITH SEMICYLINDRIC PAPER TUBE 审中-公开
标题翻译：带半导体纸管的纸模板
公开(公告)号：WO2010030081A2
公开(公告)日：2010-03-18
申请号：PCT/KR2009/004585
申请日：2009-08-17
申请人： EPI LIMITED , JOE, Jeong-hoon
发明人： JOE, Jeong-hoon
IPC分类号： E04G13/02 , E01D19/02 , E04G9/00
CPC分类号： E04G13/021 , E04G9/021
摘要： Provide is paper formwork formed with two layers of semicylindric paper tubes. The paper formwork includes a pair of semicylindric inner paper tubes, and a pair of semicylindric outer paper tubes pressed against an exterior of the semicylindric inner paper tubes. The paper formwork is formed of a plurality of semicylindric paper tubes that facilitate its transportation and workability, can be applied to SRC construction as well as RC construction, is fabricated from paper and is easy to work with so that construction time and cost can be reduced to maximize profits for construction companies, and is environmentally-friendly because it can be reused as paper material after use to reduce environmental pollution.
摘要翻译：提供的是由两层半圆柱形纸管形成的纸模板。该纸模板包括一对半圆柱内纸管和一对半圆柱外纸管，该一对半圆柱外纸管压在半圆柱内纸管的外部。纸模板由多个半圆柱形纸管形成，便于运输和施工，可应用于钢筋混凝土结构和钢筋混凝土结构，由纸制成，易于加工，从而减少施工时间和成本最大限度地提高建筑公司的利润，并且环保，因为它可以在使用后作为纸质材料重复使用，以减少环境污染。

94. 发明申请

WO2010021435A1 ELECTROMAGNETIC MULTI-AXIS ACTUATOR 审中-公开
标题翻译：电磁多轴致动器
公开(公告)号：WO2010021435A1
公开(公告)日：2010-02-25
申请号：PCT/KR2008/007630
申请日：2008-12-24
申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY , CHO, Young-Ho , SEO, Dae Geon
发明人： CHO, Young-Ho , SEO, Dae Geon
IPC分类号： H02N2/02
CPC分类号： H02K33/16
摘要： The present invention relates to an electromagnetic multi-axis actuator, which can realize small size, light weight and low power consumption while being capable of performing multi-axis motion by overcoming limitations in a driving range, compared to a typical electrostatic actuation scheme or a typical electric motor actuating scheme. The electromagnetic multi-axis actuator includes an actuating unit (1) capable of being driven in a multi-axis manner, one or more elastic parts (2) connected to the actuating unit and made of a conductive material, and one or more coil substrates (3) disposed either above or below or both above and below the elastic parts and provided with conductive coils formed thereon to form magnetic fields around the elastic parts. The multi-axis actuator having the above construction can realize high response speed while having a driving range of high power caused by low power consumption, a large displacement, and multiple axes.
摘要翻译：电磁多轴致动器技术领域本发明涉及一种电磁多轴致动器，其能够通过克服驱动范围内的限制而能够实现小尺寸，轻量化和低功耗，同时能够执行多轴运动，与典型的静电致动方案或典型的电动机驱动方案。电磁多轴致动器包括能够以多轴方式驱动的致动单元（1），连接到致动单元并由导电材料制成的一个或多个弹性部件（2）和一个或多个线圈基板（3）设置在弹性部件的上方或下方或两者的上下，并且设置有形成在其上的导电线圈，以在弹性部件周围形成磁场。具有上述结构的多轴致动器可以实现高响应速度，同时具有由低功耗，大位移和多轴引起的高功率驱动范围。

95. 发明申请

WO2010013925A2 PHARMACOLOGICAL COMPOSITION FOR PREVENTION AND TREATMENT OF RESPIRATORY DISEASE CONTAINING PYRAZOLOPYRIMIDINONE COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF 审中-公开
标题翻译：用于预防和治疗含吡唑并嘧啶二甲基嘧啶酮化合物或其药用可接受盐的呼吸道疾病的药理组合物
公开(公告)号：WO2010013925A2
公开(公告)日：2010-02-04
申请号：PCT/KR2009/004188
申请日：2009-07-28
申请人： DONG-A PHARMACEUTICAL. CO., LTD. , LEE, Chan Ho , CHOI, Seul Min , KIM, Dong Hwan , KANG, Kyung Koo , KIM, Dong Seong , AHN, Byoung Ok , YOO, Moohi
发明人： LEE, Chan Ho , CHOI, Seul Min , KIM, Dong Hwan , KANG, Kyung Koo , KIM, Dong Seong , AHN, Byoung Ok , YOO, Moohi
IPC分类号： C07D487/04 , C07D487/02 , A61K31/519 , A61P11/00
CPC分类号： A61K31/519 , A61K9/0075 , A61K9/0078 , A61K9/2018 , A61K9/4858 , C07D487/04
摘要： Disclosed herein is composition for prevention and treatment of respiratory disease containing a pyrazolopyrimidinone compound or pharmaceutically acceptable salts thereof as an active ingredient.
摘要翻译：本文中公开了用于预防和治疗呼吸道疾病的组合物，其含有吡唑并嘧啶酮化合物或其药学上可接受的盐作为活性成分。

96. 发明申请

WO2009154425A2 MULTIMODAL IMAGING METHOD USING NANO-EMULSION COMPRISING OPTICAL NANO-PARTICLES AND PERFLUOROCARBONS 审中-公开
标题翻译：使用包含光学纳米颗粒和全氟化碳的纳米乳液的多模式成像方法
公开(公告)号：WO2009154425A2
公开(公告)日：2009-12-23
申请号：PCT/KR2009/003308
申请日：2009-06-19
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , CHUNG, Bong Hyun , LIM, Yong Taik
发明人： CHUNG, Bong Hyun , LIM, Yong Taik
IPC分类号： A61K49/06
CPC分类号： A61K49/0078 , A61K49/0002 , A61K49/0017 , A61K49/0067 , A61K49/1806
摘要： The present invention relates to a multimodal imaging method using a nano-emulsion comprising optical nano-particles and perfluorocarbons, and more particularly, to a method of obtaining multimodal images using a nano-emulsion consisted of perfluorocarbons for multispectral magnetic resonance imaging (MRI) and nano-particles for multicolor fluorescent detection. In the multimodal imaging method, various multispectral MRI images and multicolor fluorescent rays can be obtained by varing the kind and combination of perfluorocarbons and the kind and combination of optical nano-particles, so that multiplexed analysis is possible. Accordingly, the multimodal imaging method can be applied to various fields, including biological and medical fields in which studies on cell molecular imaging has been conducted.
摘要翻译：本发明涉及一种使用包含光学纳米颗粒和全氟化碳的纳米乳液的多模式成像方法，更具体地说，涉及使用由全氟化碳构成的纳米乳液用于多光谱磁共振成像（MRI）和用于多色荧光检测的纳米颗粒。在多模式成像方法中，可以通过改变全氟化碳的种类和组合以及光学纳米颗粒的种类和组合来获得各种多光谱MRI图像和多色荧光光谱，从而可以进行多重分析。因此，多模式成像方法可以应用于已经进行细胞分子成像研究的生物和医学领域的各个领域。

97. 发明申请

WO2009151190A1 COMBINED ORGANIC SEWAGE DISPOSAL INSTALLATION USING EFFECTIVE MICROORGANISM 审中-公开
标题翻译：使用有效的微生物组合有机污水处理安装
公开(公告)号：WO2009151190A1
公开(公告)日：2009-12-17
申请号：PCT/KR2008/006992
申请日：2008-11-27
申请人： KIM, Hyung Jong
发明人： KIM, Hyung Jong
IPC分类号： C02F3/20
CPC分类号： C02F3/301 , C02F2103/20 , C02F2201/003 , C02F2209/02 , C02F2209/06 , C02F2209/08 , C02F2209/10 , C02F2209/22 , C02F2303/24
摘要： The invention provides a combined organic waste water treatment system which can efficiently degrade and treat organic waste water such as livestock waste water by combining several organic waste water unit treating tanks, each of which includes a space charged with aerobic microbes and another space charged with facultative anaerobic microbes and anaerobic microbes, and by making a living environment suitable for the respective microbes. The organic waste water unit treating tank includes an outer cylinder provided in the upper portion thereof with inlet and outlet pipes for introduction of discharge of organic waste water, an inner cylinder concentrically provided in the outer cylinder to be connected with the inlet pipe and partially opened at a lowermost portion, and an aerator provided in the lower portion of the inner cylinder. The inner cylinder serves as an aerobic tank charged with aerobic microbes, and the annular space between the outer cylinder and the inner cylinder serves as an anaerobic tank charged with facultative anaerobic microbes and anaerobic microbes.
摘要翻译：本发明提供了一种组合的有机废水处理系统，其可以通过组合几个有机废水单元处理罐来有效降解和处理诸如家畜废水的有机废水，每个处理罐包括带有需氧微生物的空间和装有兼性的另外的空间厌氧微生物和厌氧微生物，以及适合各微生物的生活环境。有机废水处理槽包括在其上部设置有用于引入有机废水排出的入口管和外筒，外筒同心地设置在外筒中以与入口管连接并部分打开并且设置在内筒的下部的充气器。内筒用作装有需氧微生物的需氧罐，外筒与内筒之间的环形空间用作装有兼性厌氧微生物和厌氧微生物的厌氧池。

98. 发明申请

WO2009093774A1 METHOD FOR TREATMENT OF ANXIETY DISORDER BY REGULATING T-TYPE CALCIUM CHANNEL 审中-公开
标题翻译：通过调节T型钙通道治疗无效性疾病的方法
公开(公告)号：WO2009093774A1
公开(公告)日：2009-07-30
申请号：PCT/KR2008/001983
申请日：2008-04-08
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , SHIN, Hee-Sup , LEE, Sukchan , KIM, Huisu
发明人： SHIN, Hee-Sup , LEE, Sukchan , KIM, Huisu
IPC分类号： A61K31/41
CPC分类号： A61K31/41
摘要： The present invention relates to a composition for the prevention and treatment of anxiety disorder containing a T-type calcium channel blocker, and a method for the prevention and treatment of anxiety disorder by administering the said composition into mediodorsal thalamus (MD) of a subject with anxiety disorder. When the T-type calcium channel blocker mibefradil is administered into MD of the phospholipaseβ4 (PLCβ4, expressed mainly in MD) knock-out mouse, fear memory extinction which has been reduced is restored to normal level. When mibefradil and efonidipine are administered into MD of the wild type mouse, fear memory is lost faster than usual and fear memory recall is retarded. Therefore, a T-type calcium channel blocker can be effectively used for the prevention and treatment of anxiety disorder.
摘要翻译：本发明涉及一种用于预防和治疗含有T型钙通道阻滞剂的焦虑症的组合物，以及通过将所述组合物施用于受试者的中度丘脑（MD），预防和治疗焦虑症的方法，焦虑症当T型钙通道阻滞剂mibefradil被施用于磷脂酶β4（PLCβ4，主要表达于MD）敲除小鼠的MD中时，已经减少的恐惧记忆丧失恢复到正常水平。当mibefradil和efonidipine被施用于野生型小鼠的MD时，恐惧记忆丧失比平常更快，并且恐惧记忆回忆被延迟。因此，T型钙通道阻滞剂可以有效地用于预防和治疗焦虑症。

99. 发明申请

WO2009078586A1 COMPOSITION FOR PREVENTION AND TREATMENT OF CANCER CONTAINING PHENYL-AMINO-THIAZOLONE DERIVATIVES INHIBITING ACTIVITY OF PROTEIN PHOSPHATASES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS AN ACTIVE INGREDIENT 审中-公开
标题翻译：用于预防和治疗含有苯基 - 氨基噻唑酮衍生物的癌症组合物抑制蛋白磷酸酶的活性或其作为活性成分的药物可接受的盐
公开(公告)号：WO2009078586A1
公开(公告)日：2009-06-25
申请号：PCT/KR2008/006716
申请日：2008-11-14
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , RYU, Seong Eon , PARK, Hwang Seo , JUNG, Suk Kyeong , JEONG, Dae Gwin , LEE, Sang Hyeup , KIM, Seung Jun , BAHN, Young Jae
发明人： RYU, Seong Eon , PARK, Hwang Seo , JUNG, Suk Kyeong , JEONG, Dae Gwin , LEE, Sang Hyeup , KIM, Seung Jun , BAHN, Young Jae
IPC分类号： A61K31/426
CPC分类号： A61K31/426
摘要： The present invention relates to a composition for the prevention and treatment of various cancers, which inhibits protein phosphatases, containing a phenyl-amino-thiazolone derivative as an active ingredient. The phenyl-amino-thiazolone derivatives according to the present invention effectively inhibit the activities of protein phosphatases, such as Cdc25A and Cdc25B, and may be useful in the prevention and treatment of breast cancer, rectal cancer, non-Hodgkin's lymphoma, prostate cancer, pancreatic ductal adenocarcinoma, lung cancer, bone marrow cancer, and the like.
摘要翻译：本发明涉及用于预防和治疗各种癌症的组合物，其抑制含有苯基 - 氨基 - 噻唑酮衍生物作为活性成分的蛋白质磷酸酶。根据本发明的苯基 - 氨基 - 噻唑酮衍生物有效抑制蛋白磷酸酶如Cdc25A和Cdc25B的活性，可用于预防和治疗乳腺癌，直肠癌，非霍奇金淋巴瘤，前列腺癌，胰腺导管腺癌，肺癌，骨髓癌等。

100. 发明申请

WO2009072687A1 COMPOSITION FOR INHIBITION OF TRASPLANT REJECTION CONTAINING THE PHELLINUS LINTEUS MYCELLIA EXTRACT AS AN ACTIVE INGREDIENT 审中-公开
标题翻译：含有嗜酸乳杆菌MYCELLIA提取物作为活性成分的移植物排斥抑制组合物
公开(公告)号：WO2009072687A1
公开(公告)日：2009-06-11
申请号：PCT/KR2007/006355
申请日：2007-12-07
申请人： HANKOOK PHARM. CO., INC. , HAN, Man Woo , YOO, Jae Kuk , HUR, Chang-Uk , KIM, Hwan-Chul , KIM, Jin Pyo
发明人： HAN, Man Woo , YOO, Jae Kuk , HUR, Chang-Uk , KIM, Hwan-Chul , KIM, Jin Pyo
IPC分类号： A61K36/07 , A61P17/00
CPC分类号： A61K36/07
摘要： Disclosed is a composition for the inhibition of transplant rejection and the prevention and treatment of skin diseases, comprising a Phellinus sp. mycelial extract as an active ingredient. The Phellinus sp. mycelial extract significantly suppresses the production of antibodies to transplants without side effects, such as weight change. Based on natural material, the composition is non-toxic and harmless to the human body and thus can be used as an immunosuppressant for organ transplantation. Also, it stops oozing from sores and is applicable to the prevention and treatment of skin diseases, including atopy, allergic reactions, decubitus ulcers, and smallpox.
摘要翻译：公开了用于抑制移植排斥和预防和治疗皮肤病的组合物，其包含桑黄（Phellinus sp。），菌丝体提取物作为有效成分。桑黄菌丝体提取物显着抑制了没有副作用例如体重变化的抗体产生。基于天然材料，该组合物对人体无毒且无害，因此可用作器官移植的免疫抑制剂。此外，它不会从疮口渗出，适用于皮肤疾病的预防和治疗，包括特应性，过敏反应，褥疮溃疡和天花。

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