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1. 发明申请

WO2009093774A1 METHOD FOR TREATMENT OF ANXIETY DISORDER BY REGULATING T-TYPE CALCIUM CHANNEL 审中-公开
标题翻译：通过调节T型钙通道治疗无效性疾病的方法
公开(公告)号：WO2009093774A1
公开(公告)日：2009-07-30
申请号：PCT/KR2008/001983
申请日：2008-04-08
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , SHIN, Hee-Sup , LEE, Sukchan , KIM, Huisu
发明人： SHIN, Hee-Sup , LEE, Sukchan , KIM, Huisu
IPC分类号： A61K31/41
CPC分类号： A61K31/41
摘要： The present invention relates to a composition for the prevention and treatment of anxiety disorder containing a T-type calcium channel blocker, and a method for the prevention and treatment of anxiety disorder by administering the said composition into mediodorsal thalamus (MD) of a subject with anxiety disorder. When the T-type calcium channel blocker mibefradil is administered into MD of the phospholipaseβ4 (PLCβ4, expressed mainly in MD) knock-out mouse, fear memory extinction which has been reduced is restored to normal level. When mibefradil and efonidipine are administered into MD of the wild type mouse, fear memory is lost faster than usual and fear memory recall is retarded. Therefore, a T-type calcium channel blocker can be effectively used for the prevention and treatment of anxiety disorder.
摘要翻译：本发明涉及一种用于预防和治疗含有T型钙通道阻滞剂的焦虑症的组合物，以及通过将所述组合物施用于受试者的中度丘脑（MD），预防和治疗焦虑症的方法，焦虑症当T型钙通道阻滞剂mibefradil被施用于磷脂酶β4（PLCβ4，主要表达于MD）敲除小鼠的MD中时，已经减少的恐惧记忆丧失恢复到正常水平。当mibefradil和efonidipine被施用于野生型小鼠的MD时，恐惧记忆丧失比平常更快，并且恐惧记忆回忆被延迟。因此，T型钙通道阻滞剂可以有效地用于预防和治疗焦虑症。

2. 发明申请

WO2009093772A1 PLC BETA4 MUTANT MICE AS A MODEL FOR TESTING ANXIETY DISORDER DRUGS 审中-公开
标题翻译： PLC BETA4 MUTANT MICE作为测试麻醉药物的模型
公开(公告)号：WO2009093772A1
公开(公告)日：2009-07-30
申请号：PCT/KR2008/001275
申请日：2008-03-06
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , SHIN, Hee Sup , LEE, Sukchan , KIM, Hui-su , CHOI, Sukwoo , HONG, Ingie
发明人： SHIN, Hee Sup , LEE, Sukchan , KIM, Hui-su , CHOI, Sukwoo , HONG, Ingie
IPC分类号： A01K67/027
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0356
摘要： The present invention relates to a use of a PLCβ4 (Phospholipaseβ4 ) knock-out animal, more precisely, a use or a method of using a PLCβ4 knock-out animal as an anxiety disorder animal model and a method for screening a preventive and therapeutic agent for treating anxiety disorder using the animal model. The mouse model for anxiety disorder of the present invention has normal learning ability, long-term memory and living activity but has a severe defect in memory extinction, therefore it can be effectively used for the screening of a therapeutic agent for anxiety disorder.
摘要翻译：本发明涉及使用PLCß4（Phospholipase4）敲除动物，更确切地说，涉及使用或使用PLCβ4敲除动物作为焦虑症动物模型的方法和用于筛选预防和治疗剂的方法用于使用动物模型治疗焦虑症。本发明的焦虑症小鼠模型具有正常的学习能力，长期记忆力和生活活动性，但是在记忆丧失方面存在严重的缺陷，因此可以有效地用于筛查焦虑症的治疗剂。

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