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    • 9. 发明申请
    • USE OF RECOMBINANT ANTIGENS TO DETERMINE THE IMMUNE STATUS OF AN ANIMAL
    • 使用重组抗原来确定动物的免疫状态
    • WO01066568A2
    • 2001-09-13
    • PCT/US2001/007251
    • 2001-03-07
    • C07K14/005C07K14/015C07K14/03C07K14/08C07K14/13C07K14/15C12N1/15C12N1/19C12N1/21C12N5/10C12N15/09C12P21/02G01N33/53G01N33/536G01N33/569
    • C07K14/005C12N2710/16722C12N2740/13022C12N2750/14322C12N2750/14343C12N2760/18422G01N33/56983
    • The present invention includes a method to determine the immune status of an animal that includes the steps of (a) contacting a biological specimen of the animal with a recombinant infectious agent antigen that is specific for detecting an antibody selective for that infectious agent, under conditions suitable for formation of a complex between the recombinant antigen and the antibody and (b) detecting the presence or absence of the complex, wherein presence or absence of a complex is indicative of the immune status of the animal. Preferably such a method indicates whether the animal should be vaccinated. The present invention also includes an assay comprising (a) a recombinant infectious agent antigen that is specific for detecting an antibody selective for that infectious agent; and (b) a means to detect an antibody that selectively binds to the recombinant antigen. Also included in the present invention are recombinant antigens and nucleic acid molecules encoding such antigens as well as methods to produce and use such nucleic acid molecule and recombinant antigens.
    • 本发明包括确定动物的免疫状态的方法,其包括以下步骤:(a)在条件下使动物的生物标本与特异于检测针对该感染因子的抗体的重组感染原体抗原接触 适合于在重组抗原和抗体之间形成复合物,和(b)检测复合物的存在或不存在,其中复合物的存在或不存在指示动物的免疫状态。 优选地,这种方法指示动物是否应该接种疫苗。 本发明还包括一种测定法,其包含(a)特异于检测针对该感染因子的抗体的抗体的重组感染原体抗原; 和(b)检测选择性结合重组抗原的抗体的方法。 本发明还包括编码这种抗原的重组抗原和核酸分子以及产生和使用这种核酸分子和重组抗原的方法。