专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011106743A1 RECOMBINANT CDV COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：重组CDV组合物及其用途
公开(公告)号：WO2011106743A1
公开(公告)日：2011-09-01
申请号：PCT/US2011/026378
申请日：2011-02-25
申请人： MERIAL LIMITED , AUDONNET, Jean-christophe , MINKE, Jules
发明人： AUDONNET, Jean-christophe , MINKE, Jules
IPC分类号： A61K39/12 , A61K39/175 , A61K39/205 , A61K39/23 , C07K14/015 , C07K14/12 , C07K14/13 , C07K14/145 , C07K14/165 , C12N7/00 , C12N7/04 , C12N15/86
CPC分类号： A61K39/175 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/552 , A61K2039/55522 , A61N5/0613 , C07K14/005 , C07K14/535 , C12N7/00 , C12N2710/24043 , C12N2750/14334 , C12N2760/18422 , C12N2760/18434 , C12N2760/18471 , C12N2800/22
摘要： The present invention provides vectors that contain and express in vivo or in vitro CDV polypeptides or antigens that elicit an immune response in animal against CDV, compositions comprising said vectors and/or CDV polypeptides, and methods of vaccination against CDV. The invention further provides methods for inducing an immunogenic or protective response against CDV and other canine virus, as well as methods for preventing or treating CDV and other canine virus or disease state(s) caused by CDV and other canine virus.
摘要翻译：本发明提供载体，其含有体内或体外CDV多肽或在动物体内产生针对CDV的免疫应答的抗原，包含所述载体和/或CDV多肽的组合物，以及针对CDV的疫苗接种方法。本发明还提供了诱导针对CDV和其他犬病毒的免疫原性或保护性应答的方法，以及用于预防或治疗CDV和其他犬病毒或由CDV和其他犬病毒引起的疾病状态的方法。

2. 发明申请

WO00015785A2 GENE MODIFICATION IN THE GENE FOR THE DIE G beta 3-SUB-UNIT OF HUMAN G-PROTEIN 审中-公开
标题翻译：人类G蛋白Gβ3基因的一般变化
公开(公告)号：WO00015785A2
公开(公告)日：2000-03-23
申请号：PCT/EP1999/006534
申请日：1999-09-06
IPC分类号： A01K67/027 , A61K38/00 , A61K48/00 , A61P3/04 , A61P3/10 , A61P9/06 , A61P9/10 , A61P9/12 , A61P19/10 , A61P25/28 , A61P31/18 , A61P37/02 , A61P43/00 , C07K14/13 , C07K14/47 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/68 , A61K31/70 , C07K16/18 , C12N15/11
CPC分类号： C07K14/005 , A01K2217/05 , A61K48/00 , C07K14/4722 , C12N2760/18422 , C12Q1/6883 , C12Q2600/156 , G01N33/6893 , G01N2800/042
摘要： The invention relates to the use of a gene modification in the gene for the G beta 3-sub-unit of the human G-protein for determining the risk of a G-protein dysregulation-associated disease, cytosine being substituted by thymin in position 825 in anlage 2 and/or cytosine being substituted by thymin in position 1429 in anlage 2.
摘要翻译：本发明涉及一种使用在该基因的人G-蛋白的G-测试3亚基的基因改变的方法，其中在附录2位置825，存在通过胸腺嘧啶胞嘧啶的取代，和/或其中在附录2位置1429是胞嘧啶的取代通过胸腺嘧啶来确定与G蛋白管理不善有关的疾病的风险。

3. 发明申请

WO2020058341A1 INTRANASAL VECTOR VACCINE AGAINST PORCINE EPIDEMIC DIARRHEA 审中-公开
公开(公告)号：WO2020058341A1
公开(公告)日：2020-03-26
申请号：PCT/EP2019/075015
申请日：2019-09-18
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH
发明人： NIKOLIN, Veljko , GALLEI, Andreas
IPC分类号： A61K39/175 , A61K39/215 , A61P31/14 , C07K14/13 , A61K39/00
摘要： The present invention relates to the field of (vector) vaccines, and especially to a canine distemper virus (CDV) vector comprising a heterologous nucleotide sequence which encodes a porcine epidemic diarrhea virus (PEDV) antigen. Said PEDV antigen is preferably a PEDV spike (S) protein. The viral vector of the present invention is useful for producing an immunogenic composition or vaccine for intranasally immunizing sows, and thereby protecting piglets, suckled by said sows, against the clinical signs associated with a PEDV infection.

4. 发明申请

WO0200883A3 RESCUE OF CANINE DISTEMPER VIRUS FROM CDNA 审中-公开
标题翻译：来自CDNA的抗病毒病毒病毒
公开(公告)号：WO0200883A3
公开(公告)日：2003-02-06
申请号：PCT/US0120157
申请日：2001-06-22
申请人： AMERICAN CYANAMID CO , PARKS CHRISTOPHER L , SIDHU MOHINDERJIT S , WALPITA PRAMILA , KOVACS GERALD R , UDEM STEPHEN A
发明人： PARKS CHRISTOPHER L , SIDHU MOHINDERJIT S , WALPITA PRAMILA , KOVACS GERALD R , UDEM STEPHEN A
IPC分类号： C12N15/09 , A61K35/76 , A61K39/175 , A61P31/12 , A61P31/14 , C07K14/12 , C07K14/13 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/02 , C12N15/40 , C12N15/45 , C12N15/86
CPC分类号： C12N7/00 , A61K2039/5256 , C07K14/005 , C12N2760/18422 , C12N2760/18451
摘要： This invention relates to a method for recombinantly producing via rescue canine distemper virus, a nonsegmented, negative-sense, single-stranded RNA virus, and immunogenic compositions formed therefrom. Additional embodiments relate to methods of producing the canine distemper virus as an attenuated and/or infectious viruses. The recombinant viruses can be prepared from cDNA clones, and, accordingly, viruses having defined changes, including nucleotide/polynucleotide deletions, insertions, substitutions and rearrangements, in the genome can be obtained.
摘要翻译：本发明涉及通过救援犬瘟热病毒，非分段，负义的单链RNA病毒和由其形成的免疫原性组合重组生产的方法。另外的实施方案涉及生产犬瘟热病毒作为减毒和/或感染性病毒的方法。可以从cDNA克隆制备重组病毒，因此，可以获得在基因组中具有确定的变化（包括核苷酸/多核苷酸缺失，插入，取代和重排）的病毒。

5. 发明申请

WO0200694A3 MODIFIED MORBILLIVIRUS V PROTEINS 审中-公开
标题翻译：修饰的MORBILLIVIRUS V蛋白
公开(公告)号：WO0200694A3
公开(公告)日：2002-10-10
申请号：PCT/US0119806
申请日：2001-06-21
申请人： AMERICAN CYANAMID CO , PARKS CHRISTOPHER L
发明人： PARKS CHRISTOPHER L
IPC分类号： C12N15/09 , A61K39/155 , A61K39/165 , C07K14/12 , C12N7/00 , C12N7/02 , C12N7/04 , C07K14/115 , C07K14/13
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/165 , A61K2039/525 , A61K2039/5254 , C07K2319/00 , C12N7/00 , C12N2760/18422 , C12N2760/18434 , C12N2760/18461
摘要： Modified Morbilliviruses having at least one mutation in the region corresponding to amino acids 112-134 of the measles virus V protein are described wherein one or both of amino acids 113 or 114 is mutated. Such modified Morbilliviruses exhibit reduced repression of gene expression. Additional mutations or deletions in other regions of the genome may be included, including in the carboxy-terminal region.
摘要翻译：描述了在对应于麻疹病毒V蛋白的氨基酸112-134的区域中具有至少一个突变的修饰的马铃薯病毒，其中氨基酸113或114中的一个或两个突变。这种修饰的枯草芽孢杆菌表现出对基因表达的抑制减弱。可以包括基因组其他区域中的额外突变或缺失，包括在羧基末端区域。

6. 发明申请

WO00077043A2 DNA VACCINES FOR PETS AND SPORT ANIMALS 审中-公开
标题翻译：用于PETS和运动动物的DNA疫苗
公开(公告)号：WO00077043A2
公开(公告)日：2000-12-21
申请号：PCT/FR2000/001592
申请日：2000-06-08
IPC分类号： C12N15/09 , A61K35/74 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/175 , A61K39/193 , A61K39/205 , A61K39/215 , A61K39/23 , A61K39/245 , A61K39/265 , A61K39/27 , A61K39/295 , A61K39/39 , A61K48/00 , A61P31/12 , A61P31/16 , A61P31/22 , C07K14/535 , C07K14/13
CPC分类号： A61K39/265 , A61K39/12 , A61K39/155 , A61K39/175 , A61K39/245 , A61K39/27 , A61K2039/525 , A61K2039/53 , A61K2039/552 , A61K2039/70 , C07K14/535 , C07K2319/02 , C12N2710/16634 , C12N2710/16734 , C12N2760/18334 , C12N2760/18434 , C12N2760/18634
摘要： The invention aims at improving the efficacy and protection induced by DNA vaccination against viruses of the family of Paramyxoviridae and against the herpes virus, in pets and sport animals. The improvement of DNA vaccination is achieved either by formulating the vaccine with a cationic lipid containing a quaternary ammonium salt, DMRIE, or by modifications in the nucleotide sequence coding for the antigen of interest in particular of deletions of the fragment of the nucleotide sequence coding for the transmembrane domain of the antigen of interest, and/or insertions of introns and/or insertions of nucleotide sequences coding for the signal peptides, or by adding GM-CSF, or by combinations thereof. The invention also concerns the resulting vaccines.
摘要翻译：本发明旨在提高针对宠物和运动动物中的副粘病毒科和针对疱疹病毒的病毒的DNA疫苗接种所产生的功效和保护作用。通过用含有季铵盐的阳离子脂质DMRIE配制疫苗或通过编码感兴趣抗原的核苷酸序列的修饰，特别是编码所述抗原的核苷酸序列的片段的缺失来实现DNA接种的改善感兴趣的抗原的跨膜结构域，和/或内含子的插入和/或编码信号肽的核苷酸序列的插入，或通过添加GM-CSF或其组合。本发明还涉及所得的疫苗。

7. 发明申请

WO2021072284A2 CANINE DISTEMPER VIRUS HEMAGGLUTININ AND FUSION POLYPEPTIDES 审中-公开
公开(公告)号：WO2021072284A2
公开(公告)日：2021-04-15
申请号：PCT/US2020/055100
申请日：2020-10-09
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , RUSSELL, Stephen James , MUNOZ ALIA, Miguel A.
发明人： RUSSELL, Stephen James , MUNOZ ALIA, Miguel A.
IPC分类号： C07K14/13 , C12N7/00 , C12N15/11 , A61K38/16 , A61K35/766 , C07K14/005 , C07K16/2863 , C07K16/2896 , C07K2317/622 , C07K2319/00 , C12N15/86 , C12N2760/18422 , C12N2760/20232 , C12N2760/20243
摘要： This document provides methods and materials related to CDV H and/or CDV F polypeptides. For example, CDV H polypeptides, CDV F polypeptides, recombinant viruses (e.g., vesicular stomatitis viruses (VSVs)) containing CDV H polypeptides and/or CDV F polypeptides, nucleic acid molecules encoding a CDV H polypeptide and/or CDV F polypeptide, methods for making recombinant viruses (e.g., VSVs) containing CDV H polypeptides and/or CDV F polypeptides, and methods for using recombinant viruses (e.g., VSVs) containing CDV H polypeptides and/or CDV F polypeptides to treat cancer or infectious diseases are provided.

8. 发明申请

WO02000883A2 RESCUE OF CANINE DISTEMPER VIRUS FROM CDNA 审中-公开
标题翻译：来自CDNA的抗病毒病毒病毒
公开(公告)号：WO02000883A2
公开(公告)日：2002-01-03
申请号：PCT/US2001/020157
申请日：2001-06-22
IPC分类号： C12N15/09 , A61K35/76 , A61K39/00 , A61K39/175 , A61P31/12 , A61P31/14 , C07K14/12 , C07K14/13 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/02 , C12N15/40 , C12N15/45
CPC分类号： C12N7/00 , A61K2039/5256 , C07K14/005 , C12N2760/18422 , C12N2760/18451
摘要： This invention relates to a method for recombinantly producing via rescue canine distemper virus, a nonsegmented, negative-sense, single-stranded RNA virus, and immunogenic compositions formed therefrom. Additional embodiments relate to methods of producing the canine distemper virus as an attenuated and/or infectious viruses. The recombinant viruses can be prepared from cDNA clones, and, accordingly, viruses having defined changes, including nucleotide/polynucleotide deletions, insertions, substitutions and rearrangements, in the genome can be obtained.
摘要翻译：本发明涉及通过救援犬瘟热病毒，非分段，负义的单链RNA病毒和由其形成的免疫原性组合重组生产的方法。另外的实施方案涉及生产犬瘟热病毒作为减毒和/或感染性病毒的方法。可以从cDNA克隆制备重组病毒，因此，可以获得在基因组中具有确定的变化（包括核苷酸/多核苷酸缺失，插入，取代和重排）的病毒。

9. 发明申请

WO00046390A1 T HELPER CELL EPITOPES 审中-公开
标题翻译： T HELPER细胞病毒
公开(公告)号：WO00046390A1
公开(公告)日：2000-08-10
申请号：PCT/AU2000/000070
申请日：2000-02-07
IPC分类号： A61K38/00 , A61K20060101 , A61K38/09 , A61K39/00 , A61K39/165 , A61K39/175 , A61K39/39 , A61P37/04 , C07K14/13 , C07K14/705 , C12P20060101 , C12P21/02
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/57 , C07K2319/00 , C12N2760/18422
摘要： The present invention provides T helper cell epitopes and compositions for use in inducing an immune response comprising at least one of these epitopes. The epitopes are contained within a peptide sequence selected from the group consisting of SSKTQTHTQQDRPPQPS; QPSTELEETRTSRARHS; RHSTTSAQRSTHYDPRT; PRTSDRPVSYTMNRTRS; TRSRKQTSHRLKNIPVH; SHQYLVIKLIPNASLIE; IGTDNVHYKIMTRPSHQ; YKIMTRPSHQYLVIKLI; KLIPNASLIENCTKAEL; AELGEYEKLLNSVLEPI; KLLNSVLEPINQALTLM; EPINQALTLMTKNVKPL; FAGVVLAGVALGVATAA; GVALGVATAAQITAGIA; TAAQITAGIALHQSNLN; GIALHQSNLNAQAIQSL; NLNAQAIQSLRTSLEQS; QSLRTSLEQSNKAIEEI; EQSNKAIEEIREATQET; TELLSIFGPSLRDPISA; PRYIATNGYLISNFDES; CIRGDTSSCARTLVSGT; DESSCVFVSESAICSQN; TSTIINQSPDKLLTFIA, SPDKLLTFIASDTCPLV and SGRRQRRFAGVVLAGVA.
摘要翻译：本发明提供了用于诱导包含这些表位中的至少一个的免疫应答的T辅助细胞表位和组合物。表位包含在选自SSKTQTHTQQDRPPQPS; QPSTELEETRTSRARHS; RHSTTSAQRSTHYDPRT; PRTSDRPVSYTMNRTRS; TRSRKQTSHRLKNIPVH; SHQYLVIKLIPNASLIE; IGTDNVHYKIMTRPSHQ; YKIMTRPSHQYLVIKLI; KLIPNASLIENCTKAEL; AELGEYEKLLNSVLEPI; KLLNSVLEPINQALTLM; EPINQALTLMTKNVKPL; FAGVVLAGVALGVATAA; GVALGVATAAQITAGIA; TAAQITAGIALHQSNLN; GIALHQSNLNAQAIQSL; NLNAQAIQSLRTSLEQS; QSLRTSLEQSNKAIEEI; EQSNKAIEEIREATQET; TELLSIFGPSLRDPISA; PRYIATNGYLISNFDES; CIRGDTSSCARTLVSGT; DESSCVFVSESAICSQN; TSTIINQSPDKLLTFIA，SPDKLLTFIASDTCPLV和SGRRQRRFAGVVLAGVA。

10. 发明申请

WO0166568A3 USE OF RECOMBINANT ANTIGENS TO DETERMINE THE IMMUNE STATUS OF AN ANIMAL 审中-公开
标题翻译：使用重组抗原来确定动物的免疫状态
公开(公告)号：WO0166568A3
公开(公告)日：2003-01-23
申请号：PCT/US0107251
申请日：2001-03-07
申请人： HESKA CORP , UNIV COLORADO STATE RES FOUND , JENSEN WAYNE A , LAPPIN MICHAEL R , ROSEN DAVID K , ANDREWS JANET S
发明人： JENSEN WAYNE A , LAPPIN MICHAEL R , ROSEN DAVID K , ANDREWS JANET S
IPC分类号： C07K14/005 , C07K14/015 , C07K14/03 , C07K14/08 , C07K14/13 , C07K14/15 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , G01N33/53 , G01N33/536 , G01N33/569
CPC分类号： C07K14/005 , C12N2710/16722 , C12N2740/13022 , C12N2750/14322 , C12N2750/14343 , C12N2760/18422 , G01N33/56983
摘要： The present invention includes a method to determine the immune status of an animal that includes the steps of (a) contacting a biological specimen of the animal with a recombinant infectious agent antigen that is specific for detecting an antibody selective for that infectious agent, under conditions suitable for formation of a complex between the recombinant antigen and the antibody and (b) detecting the presence or absence of the complex, wherein presence or absence of a complex is indicative of the immune status of the animal. Preferably such a method indicates whether the animal should be vaccinated. The present invention also includes an assay comprising (a) a recombinant infectious agent antigen that is specific for detecting an antibody selective for that infectious agent; and (b) a means to detect an antibody that selectively binds to the recombinant antigen. Also included in the present invention are recombinant antigens and nucleic acid molecules encoding such antigens as well as methods to produce and use such nucleic acid molecule and recombinant antigens.
摘要翻译：本发明包括确定动物的免疫状态的方法，其包括以下步骤：（a）在条件下使动物的生物标本与特异于检测针对该感染因子的抗体的重组感染原体抗原接触适合于在重组抗原和抗体之间形成复合物，和（b）检测复合物的存在或不存在，其中复合物的存在或不存在指示动物的免疫状态。优选地，这种方法指示动物是否应该接种疫苗。本发明还包括一种测定法，其包含（a）特异于检测针对该感染因子的抗体的抗体的重组感染原体抗原; 和（b）检测选择性结合重组抗原的抗体的方法。本发明还包括编码这种抗原的重组抗原和核酸分子以及产生和使用这种核酸分子和重组抗原的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式