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1. 发明申请

WO2019239428A1 ORAL MUCOSAL DELIVERY SYSTEMS COMPRISING MONOPHASIC CONCENTRATE OF TERIPARATIDE 审中-公开
公开(公告)号：WO2019239428A1
公开(公告)日：2019-12-19
申请号：PCT/IN2019/050444
申请日：2019-06-10
申请人： ZIM LABORATORIES LIMITED
发明人： DAUD, Anwar Siraj , SAPKAL, Nidhi Prakash , BONDE, Minal Nandkumar , DEVARAJAN, Padma Venkitachalam , KOTAK, Darsheen Jitendrabhai
IPC分类号： A61K9/00 , A61K38/29
摘要： This invention comprises a water free liquid composition comprising Teriparatide for transmucosal delivery that adheres to mucosa after coming in contact with mucosal surface and a system of making dosage form from the same and delivering to mucous mebrane at various locations though liquid drops, capsule or tablets. The liquid composition is characterized by being a monophasic composition. The liquid monophasic composition comprises a non-aqueous liquid as carrier, a penetration enhancer/ permeation enhancer, stabilizer and a surfactant. The liquid composition of Teriparatide intended to be dispensed to a mucosal membrane of oral/buccal cavity as liquid drops, or of oral/buccal cavity or nasal cavity as an oral or nasal spray or of oral/buccal cavity as an oral film; or of a part of alimentary canal as incorporated in a capsule or a tablet as an ingredient.

2. 发明申请

WO2016038623A2 TASTE MASKED STABLE PHARMACEUTICAL DOSAGE FORM 审中-公开
标题翻译：品尝药物稳定的药物剂型
公开(公告)号：WO2016038623A2
公开(公告)日：2016-03-17
申请号：PCT/IN2015/000353
申请日：2015-09-09
申请人： ZIM LABORATORIES LIMITED
发明人： DAUD, Anwar Siraj , JAMALUDDIN, Shamsuddin
CPC分类号： A61K9/0095 , A61K9/0056 , A61K9/1611 , A61K9/1617 , A61K9/2009 , A61K9/2013 , A61K31/496 , A61K31/519
摘要： The invention comprises a solid phase pharmaceutical composition of a drug that tastes bitter when it is at its drug-pH, wherein the solid phase pharmaceutical composition comprises the drug the drug-pH of which is modified to a different pH to render it bitter-less or to render its bitterness substantially reduced to make its oral consumption bearable; the pH modified drug being obtained by exposing the drug to a pH modifier under conditions required for modifying the drug-pH to the different pH, and thereafter solidifying the composition containing the pH modified drug; the "drug-pH" being defined as the pH of water when the active form of the water soluble or partly soluble drug is, respectively, dissolved or partly dissolved in water. The solid phase pharmaceutical composition described above may be in the form of tablets, powder, granules or pellets; which are consumed orally as solids or after constituting in a suspension by adding water.
摘要翻译：本发明包括药物的固相药物组合物，当其处于其药物pH时，该药物组合物会苦味，其中固相药物组合物包含药物，其药物的pH值被改变为不同的pH以使其不变或使其苦味大幅度减少，使其口服消费得以承受; 通过在将药物pH调节至不同pH所需的条件下将药物暴露于pH调节剂，然后固化含有pH改性药物的组合物，获得pH改良药物; 当活性形式的水溶性或部分可溶性药物分别溶解或部分溶于水时，将“药物pH”定义为水的pH。上述固相药物组合物可以是片剂，粉剂，颗粒剂或丸剂的形式; 其作为固体口服或通过加入水构成悬浮液后消费。

3. 发明申请

WO2019198109A1 NOVEL PHARMACEUTICAL COMPOSITION OF ESSENTIAL OIL 审中-公开
公开(公告)号：WO2019198109A1
公开(公告)日：2019-10-17
申请号：PCT/IN2019/050305
申请日：2019-04-15
申请人： ZIM LABORATORIES LIMITED
发明人： DAUD, Anwar Siraj , JAMALUDDIN, Shamsuddin , PANDE, Swapnil , ACHLIYA, Girish , ABDUL, Shajahan , JAWED, Abdul
IPC分类号： A61K36/53
摘要： of the Invention The present invention relates to a pharmaceutical composition of an essential oil with pharmaceutically acceptable carriers. More particularly the present invention relates to a capsule 5 dosage form comprising Peppermint Oil and a process for manufacturing the same. 10

4. 发明申请

WO2019008605A1 NOVEL PHARMACEUTICAL CO-CRYSTAL OF DABIGATRAN ETEXILATE 审中-公开
公开(公告)号：WO2019008605A1
公开(公告)日：2019-01-10
申请号：PCT/IN2018/050444
申请日：2018-07-07
申请人： ZIM LABORATORIES LIMITED
发明人： DAUD, Anwar Siraj , POL, Shankar Dadasaheb , NAWALE, Rajesh Bhaskar , PURANIK, Prashant Keshao , MATHUR, Vijay Bhagwanswarup , JAMALUDDIN, Shamsuddin , RAJKONDAWAR, Vishal Vasant
IPC分类号： A61K31/167 , A61K31/198
摘要： The present invention discloses novel co-crystals of dabigatran etexilate or its pharmaceutically acceptable salts. The novel co-crystals of dabigatran etexilate or its pharmaceutically acceptable salts are prepared using an amino acid as a co-former, preferably, with leucine. The present invention also provides formulation comprising novel co-crystals of dabigatran etexilate or its pharmaceutically acceptable salts.

5. 发明申请

WO2018122867A1 THIN FILM FORMULATIONS OF 4-DIPHENYLMETHYL-1-PIPERAZINE DERIVATIVES AND THEIR SALTS 审中-公开
公开(公告)号：WO2018122867A1
公开(公告)日：2018-07-05
申请号：PCT/IN2017/050613
申请日：2017-12-22
申请人： ZIM LABORATORIES LIMITED
发明人： DAUD, Anwar Siraj , SAPKAL, Nidhi Prakash , BONDE, Minal Nandkumar , BARVE, Shikha
IPC分类号： A61K9/24 , A61K9/70 , C07D295/03
摘要： This invention comprises a stable oral dispersible thin film and a process of making the same, the film comprising a 4-Diphenylmethyl-1-piperazinyl derivative or its pharmaceutically acceptable salts; characterized by, during storage of the film, level of the individual impurities arising out of degradation of the 4-Diphenylmethyl-1-piperazinyl derivative or its pharmaceutically acceptable salts not exceeding 1% of the added drug, and total impurities not exceeding 2% and the taste is not less than "acceptable" when scored by a taste panel on a scale of Excellent (5), Pleasant (4), Acceptable (3), Bitter (2) and Extremely bitter (1). The film is also thin, translucent, non-curving, non-tacky and flexible with folding endurance of 25 or more, dissolution not less than 75% in 45 minute. The process comprises a step of adding sodium hydroxide before the film casting is done, selecting temperature range for drying step of the film appropriate for getting a stable film, and adding plasticizer/s.

6. 发明申请

WO2016166767A1 PHARMACEUTICAL FORMULATION COMPRISING LOW MELTING, HIGHLY LIPOPHILIC DRUGS 审中-公开
标题翻译：包含低熔点，高效液体药物的药物制剂
公开(公告)号：WO2016166767A1
公开(公告)日：2016-10-20
申请号：PCT/IN2016/000096
申请日：2016-04-13
申请人： ZIM LABORATORIES LIMITED
发明人： DAUD, Anwar Siraj , SAPKAL, Nidhi , JAMALUDDIN, Shamsuddin
IPC分类号： A61K9/00
CPC分类号： A61K31/00 , A61K9/145 , A61K9/1611 , A61K9/2009
摘要： This invention comprises a pharmaceutical dosage form of, and method of improving dissolution in a substantially aqueous environment/medium of, a low melting highly lipophilic drug/s or its/their pharmaceutically acceptable salts, comprising a solid dispersion further comprising of at least one low melting highly lipophilic drug, at least one surfactant, at least one water soluble dispersant and at least one oxide/s of third row element of periodic table or other pharmaceutically acceptable inert solid powder that is non- cohesive in nature and has an ability to adsorb lipophilic ingredients on its surfaces. The pharmaceutical dosage form of this invention comprises dissolution rate more than 80% in 15 minutes of the low melting highly lipophilic drug Orlistat from its adsorbates in a dissolution test in 900ml of 0.5% of Sodium Chloride containing 3.0% Sodium Lauryl Sulphate, pH 6.0; containing 1-2 drops of n-octanol/10 litres, in a USP 2 Type apparatus (Paddle) with coil wire sinker at a speed of 75 RPM and temperature of 37.0°C± 0.5°C.
摘要翻译：本发明包括一种改善低熔点高亲脂性药物或其药学上可接受的盐的基本上含水环境/介质中溶解的药物剂型和方法，其包含固体分散体，其还包含至少一种低熔化高亲脂性药物，至少一种表面活性剂，至少一种水溶性分散剂和周期表第三排元素的至少一种氧化物或其它药学上可接受的惰性固体粉末，其本质上是非粘性的并且具有吸附能力其表面上具有亲脂性成分。本发明的药物剂型在900ml含3.0％十二烷基硫酸钠（pH6.0）的氯化钠的900ml溶出试验中，在低熔点高亲脂性药物奥利司他的15分钟内溶出率高于80％含有1-2滴正辛醇/ 10升的USP 2型装置（桨）中，线圈接线片以75RPM的速度和37.0℃±0.5℃的温度。

7. 发明申请

WO2015083181A2 WATER SOLUBLE PHARMACEUTICAL FILM WITH ENHANCED STABILITY 审中-公开
标题翻译：具有增强稳定性的水溶性药物膜
公开(公告)号：WO2015083181A2
公开(公告)日：2015-06-11
申请号：PCT/IN2014/000652
申请日：2014-10-13
申请人： ZIM LABORATORIES LIMITED
发明人： DAUD, Anwar Siraj , SAPKAL, Nidhi Prakash , BONDE, Minal Nandkumar
IPC分类号： A61K9/58
CPC分类号： A61K9/006 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38
摘要： This invention comprises an Oral Thin Film that is instantly wettable, rapid dissolving, non-sticky, non-tacky and non-curving, the said Film capable of carrying an active ingredient for oral delivery being a moisture stabilized film that remains non-sticky and non-curving when exposed to 70±5 % RH (Relative Humidity) at 25°C for at least 2 minutes up to 2 hours in open conditions without packaging.; and a process/method of making them. The active ingredient may comprise, without limitation, an active pharmaceutical, nutraceutical or cosmaceutical ingredient. The processes/method comprising (a) drying a casted film in two or more stages, (b) drying of the film after casting is done alternately both the sides, (c) coating the dried film with synthetic water insoluble moisture resistant/moisture repellant hydrophobic polymers that does not melt at high temperature, (d) adding a synthetic water insoluble moisture resistant/moisture repellant hydrophobic polymer that does not melt at high temperature to the solution to be casted as a film.
摘要翻译：本发明包括即时可润湿，快速溶解，不粘，非粘性和非弯曲的口腔薄膜，所述能够携带用于口服的活性成分的膜是保持不粘的湿气稳定膜，在25℃下暴露于70±5％RH（相对湿度）至少2分钟至2小时，在无包装的开放条件下不弯曲。以及制作它们的过程/方法。活性成分可以包括但不限于活性药物，营养品或保健品成分。工艺/方法包括（a）在两个或多个阶段干燥铸膜，（b）浇铸后的膜的干燥交替地进行两侧，（c）用合成的水不溶性的防湿/防水剂涂覆干燥的膜在高温下不会熔融的疏水性聚合物，（d）加入不会在高温下熔融成待浇铸的膜的合成水不溶性防潮/防水疏水性聚合物。

8. 发明申请

WO2014087422A1 CHEWABLE MILK COMPOSITIONS AND FORTIFIED POWDER FORMULATIONS THEREOF 审中-公开
标题翻译：可燃奶酪组合物及其粉末配方
公开(公告)号：WO2014087422A1
公开(公告)日：2014-06-12
申请号：PCT/IN2013/000737
申请日：2013-12-02
申请人： ZIM LABORATORIES LIMITED
发明人： DAUD, Anwar Siraj , SAPKAL, Nidhi Prakash , BONDE, Minal Nandkumar
IPC分类号： A23C9/00 , A23C9/18 , A23C9/152
CPC分类号： A23C9/18 , A23C9/152 , A23C9/154 , A23C9/158
摘要： The invention comprises a solid dosage form of milk that is essentially substantially water insoluble in water and does not contain rice flour or any other staple food source that is used as food in daily diet by a human being or dried egg yolk powder. The invention also includes a process of making the said solid dosage form of milk. The solid dosage form of milk comprises milk powder and at least one binder; and may contain other ingredients. The solid dosage form of milk may be or an essentially water insoluble granulated milk powder when the milk powder composition with or without other ingredients is granulated and dried with a binder that essentially or substantially reduces the solubility of the milk powder in water upon granulation and drying. The granulated and dried milk powder, upon pressing, results into a chewable tablet or other chewable compressed formulation.
摘要翻译：本发明包括基本上水不溶于水的固体剂型，并且不包含米粉或任何其它主要食物来源，其通过人或干蛋黄粉在日常饮食中用作食物。本发明还包括制备所述固体剂型的牛奶的方法。牛奶的固体剂型包括奶粉和至少一种粘合剂; 并可能含有其他成分。当具有或不具有其他成分的奶粉组合物被造粒并用粘合剂干燥时，牛奶的固体剂型可以是基本上或基本上不溶于水的颗粒状奶粉，所述粘合剂基本上或基本上降低了在粉碎和干燥时奶粉在水中的溶解度。颗粒状和干燥的奶粉在压制时，形成咀嚼片或其它可咀嚼的压制制剂。

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