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1. 发明申请

WO2009017767A2 COMPOSITIONS AND METHODS FOR DERMALLY TREATING NEUROPATHY WITH MINOXIDIL 审中-公开
标题翻译：用迷迭香治疗神经病变的组合物和方法
公开(公告)号：WO2009017767A2
公开(公告)日：2009-02-05
申请号：PCT/US2008/009222
申请日：2008-07-30
申请人： ZARS PHARMA, INC. , SANJAY, Sharma , ZHANG, Jie , WARNER, Kevin, S.
发明人： SANJAY, Sharma , ZHANG, Jie , WARNER, Kevin, S.
IPC分类号： A61K31/165 , A61K31/415 , A61K31/445 , A61K31/505 , A61K31/56 , A61K9/12 , A61P17/00
CPC分类号： A61K31/165 , A61K31/415 , A61K31/445 , A61K31/505 , A61K31/56
摘要： The present invention is drawn to adhesive solidifying formulations containing minoxidil that can be used for treating neuropathies including diabetic neuropathy. The formulation can include an amount of minoxidil, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent capable of facilitating the delivery of the minoxidil at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及含有可用于治疗包括糖尿病性神经病变神经病变的米诺地尔的粘合剂固化制剂。制剂可以包括一定量的米诺地尔，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种能够在持续的时间内以治疗有效速率递送米诺地尔的至少一种非挥发性溶剂的非挥发性溶剂体系。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

2. 发明申请

WO2008106220A1 TRANSDERMAL DRUG DELIVERY SYSTEMS FOR DELIVERY WITH CONTROLLED HEAT 审中-公开
标题翻译：用控制热量输送的超导药物输送系统
公开(公告)号：WO2008106220A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/002700
申请日：2008-02-28
申请人： ZARS PHARMA, INC. , ZHANG, Jie , WARNER, Kevin, S. , NUI, Suyi , STRONG, Nathan , NELSON, Randal , VAWDRY, Alan , IVERSON, Matt , WESSMAN, Mike
发明人： ZHANG, Jie , WARNER, Kevin, S. , NUI, Suyi , STRONG, Nathan , NELSON, Randal , VAWDRY, Alan , IVERSON, Matt , WESSMAN, Mike
IPC分类号： A61K9/70 , A61F7/00
CPC分类号： A61K9/7061 , A61K9/0004 , A61K31/192
摘要： Systems and methods for transdermal drug delivery with controlled heat are provided Such systems can comprise a heating apparatus that includes an exothermic chemical composition, typically in the form of individual heating elements. The heating apparatus can be exposed to ambient oxygen through a cover.The cover can reduce the amount of ambient oxygen capable of contacting the chemical composition compared to when the cover is not present. The systems can further include a drug-containing layer that includes a drug.The drug-containing layer can have a surface area of about 50 cm2 to about 400 cm2.The systems of the present invention can deliver ketoprofen in an amount sufficient to produce a mean blood plasma concentration of ketoprofen in a human subject of at least 45 ng/ml within four hours after initial application of the system to a skin surface.
摘要翻译：提供具有受控热的透皮药物递送的系统和方法这样的系统可以包括加热装置，其包括通常以个体加热元件形式的放热化学组成。加热装置可以通过盖暴露于环境氧气。与不存在盖时相比，该盖可以减少能够接触化学成分的环境氧的量。该系统可以进一步包括含药物的层，药物含有层可以具有约50cm 2至约400cm 2的表面积。本发明的系统可以以足以产生在将该系统初次应用于皮肤表面后的四小时内，人受试者中酮洛芬的平均血药浓度至少为45ng / ml。

3. 发明申请

WO2008150995A2 TRANSDERMAL DRUG DELIVERY SYSTEMS FOR DELIVERING ANTI-INFLAMMATORY DRUGS 审中-公开
标题翻译：用于递送抗炎药物的转运药物递送系统
公开(公告)号：WO2008150995A2
公开(公告)日：2008-12-11
申请号：PCT/US2008/065285
申请日：2008-05-30
申请人： ZARS PHARMA, INC. , ZHANG, Jie , WARNER, Kevin, S.
发明人： ZHANG, Jie , WARNER, Kevin, S.
IPC分类号： A61K9/70 , A61F7/08
CPC分类号： A61F7/034 , A61F7/007 , A61F2007/0078 , A61K9/7061 , A61K31/192 , A61K31/196 , A61M37/00 , A61M37/0092
摘要： Systems for delivering an anti-inflammatory drug, and methods for treating osteoarthritis are provided. Such systems can comprise, in one embodiment, a transdermal patch with a sufficient amount of anti-inflammatory drug in a formulation for sustained transdermal delivery at a human skin site. The system can further include a permeation composition or device, such as a heating device. The heating device can be configured for application over the transdermal patch and the human skin site. Further, the heating device can be configured for heating the human skin site to a specific temperature range from 36 0 C to 42 0 C, and for maintaining the human skin site within that temperature range for a period of at least 4 or 5 hours.
摘要翻译：提供用于递送抗炎药物的系统和治疗骨关节炎的方法。在一个实施方案中，这样的系统可以包括在人皮肤部位用于持续经皮递送的制剂中具有足够量的抗炎药物的透皮贴剂。该系统还可以包括渗透组合物或装置，例如加热装置。加热装置可以配置用于施用于透皮贴剂和人皮肤部位上。此外，加热装置可以被配置为将人皮肤部位加热到特定温度范围为36℃至42℃，并且用于将人皮肤部位保持在该温度范围内至少4或5小时的时间。

4. 发明申请

WO2009086137A1 PATCHES, FORMULATIONS, AND ASSOCIATED METHODS FOR TRANSDERMAL DELIVERY OF ALPRAZOLAM AND OTHER DRUGS 审中-公开
标题翻译：贴剂，配方及相关方法用于阿尔法唑胺和其他药物的转运
公开(公告)号：WO2009086137A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/087734
申请日：2008-12-19
申请人： ZARS PHARMA, INC. , ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay , YAN, Guang
发明人： ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay , YAN, Guang
IPC分类号： A01N43/62 , A61F13/00 , A61K31/55
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/7023 , A61K9/7084 , A61K31/485 , A61K31/5517 , A61K45/06 , A61K47/10 , A61K47/183
摘要： The present invention is drawn to transdermal drug formulations, transdermal patches incorporating such formulations, as well as associated methods. The formulations can include about 0.3 wt% to about 5 wt% of a drug, such as alprazolam, about 4 wt% to about 30 wt% water, about 10 wt% to about 40 wt% glycerol, about 0.5 wt% to about 6 wt% oleyl alcohol. Other co-solvents and/or additives can be present to achieve a 100 wt% formulation.
摘要翻译：本发明涉及透皮药物制剂，包含这种制剂的透皮贴剂以及相关方法。制剂可以包括约0.3重量％至约5重量％的药物，例如阿普唑仑，约4重量％至约30重量％的水，约10重量％至约40重量％的甘油，约0.5重量％至约6重量％重量％油醇。可以存在其它共溶剂和/或添加剂以实现100重量％的配方。

5. 发明申请

WO2011088333A2 SOLID-FORMING LOCAL ANESTHETIC FORMULATIONS FOR PAIN CONTROL 审中-公开
标题翻译：疼痛控制的固体局部麻醉配方
公开(公告)号：WO2011088333A2
公开(公告)日：2011-07-21
申请号：PCT/US2011/021318
申请日：2011-01-14
申请人： ZARS PHARMA, INC. , NIU, Suyi , HULL, Wade , ZHANG, Jie
发明人： NIU, Suyi , HULL, Wade , ZHANG, Jie
CPC分类号： A61K31/167 , A61K9/0014 , A61K31/136 , A61K47/32 , A61K2300/00
摘要： Solid-forming local anesthetic formulations for pain control can include a lidocaine base and tetracaine base, polyvinyl alcohol, water, and an emulsifier. The formulation can be prepared to be in a semi-solid state prior to application to a skin surface, can form a soft solidified layer after application, and can provide pain relief when applied to a skin surface proximate a pain site.
摘要翻译：用于疼痛控制的固体形成局部麻醉剂制剂可以包括利多卡因碱和丁卡因碱，聚乙烯醇，水和乳化剂。该制剂可以制备成在施用到皮肤表面之前处于半固体状态，可以在施用后形成软凝固层，并且当施用到靠近疼痛部位的皮肤表面时可以提供疼痛缓解。

6. 发明申请

WO2011028542A2 METHODS OF TREATING PAIN ASSOCIATED WITH COMPLEX REGIONAL PAIN SYNDROME 审中-公开
标题翻译：治疗与复合区域疼痛综合征相关的疼痛的方法
公开(公告)号：WO2011028542A2
公开(公告)日：2011-03-10
申请号：PCT/US2010/046523
申请日：2010-08-24
申请人： ZARS PHARMA, INC. , ZHANG, Jie , CROCKETT, Andrew , RIGBY, Larry
发明人： ZHANG, Jie , CROCKETT, Andrew , RIGBY, Larry
IPC分类号： A61K31/245 , A61K31/24 , A61K31/165 , A61K31/167 , A61P17/00 , A61P29/00
CPC分类号： A61K45/06 , A61K31/165 , A61K31/167 , A61K31/24 , A61K31/245 , A61K2300/00
摘要： The present invention is drawn to methods for treating pain associated with complex regional pain syndrome. Specifically, a method for treating pain associated with complex regional pain syndrome includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation which includes at least one local anesthetic. The heating component can be capable of heating the skin surface to a temperature of 36°C to 42°C.
摘要翻译：本发明涉及用于治疗与复杂性区域性疼痛综合征相关的疼痛的方法。具体地说，用于治疗与复杂的局部疼痛综合征有关的疼痛的方法包括将镇痛系统施用于经历疼痛的受试者的皮肤表面，并将止痛系统保持在皮肤表面上至少30分钟的时间。应用于皮肤表面的镇痛系统可以包括加热组分和包括至少一种局部麻醉剂的局部麻醉剂制剂。加热组件能够将皮肤表面加热至36℃至42℃的温度。

7. 发明申请

WO2011140236A3 TRIAMCINOLONE ACETONIDE FORMULATIONS FOR TREATING DERMATITIS AND PSORIASIS 审中-公开
公开(公告)号：WO2011140236A3
公开(公告)日：2011-11-10
申请号：PCT/US2011/035216
申请日：2011-05-04
申请人： ZARS PHARMA, INC. , ALIYAR, Hyder , ZHANG, Jie
发明人： ALIYAR, Hyder , ZHANG, Jie
IPC分类号： A61K9/06 , A61K47/30 , A61K47/34 , A61K31/56 , A61K31/57 , A61P17/00
摘要： The present invention is drawn to formulations and related methods for treating dermatitis or psoriasis. The formulation can include triamcinolone acetonide, a polymer selected from the group of a poly(2-hydroxyalkylacrylate), a poly(2-hydroxyalkylmethacrylate), and combinations thereof. The formulation also includes a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent.

8. 发明申请

WO2009089361A2 SYSTEMS METHODS AND FORMULATION FOR TOPICALLY TREATING NAIL FUNGAL INFECTION AND NAIL PSORIASIS 审中-公开
标题翻译：用于局部治疗指甲真菌感染和指甲脓肿的系统方法和制剂
公开(公告)号：WO2009089361A2
公开(公告)日：2009-07-16
申请号：PCT/US2009/030452
申请日：2009-01-08
申请人： ZARS PHARMA, INC , ZHANG, Jie , WARNER, Kevin , KUMAR, Promod , ALIYAR, Hyder
发明人： ZHANG, Jie , WARNER, Kevin , KUMAR, Promod , ALIYAR, Hyder
IPC分类号： A61K9/10 , A61K31/135 , A61K9/00 , A61P31/10
CPC分类号： A61K31/135 , A61K9/0014 , A61K9/08 , A61K47/32
摘要： The present invention is drawn to systems, methods, and formulations for treating nail disorders. The system comprises an active agent formulation and a first barrier film. The active agent formulation includes an active agent and an aqueous liquid component. The first barrier film is configured to form a sheath over at least a portion of a finger or toe on which the nail is located. An optional second barrier film, with lower moisture vapor transmission rate than the first barrier film, is placed between the first barrier film and the active agent formulation (or between the active agent formulation and the external environment) to reduce the water evaporation from the active agent formulation. The sheath is configured to be capable of securing and retaining the active agent formulation within the sheath on a finger nail or toe nail while reducing evaporation of the liquid component of the aqueous liquid component of the active agent formulation. The active agent formulation can be a 'slow-molding' hydrogel formulation that can slowly flow into the exact shape of the diseased nail to assure intimate contact and continuous delivery of the drug, while cannot be squeezed out of the position during the application.
摘要翻译：本发明涉及治疗指甲疾病的系统，方法和制剂。该系统包含活性剂制剂和第一阻隔膜。活性剂制剂包含活性剂和含水液体组分。第一阻挡膜被构造成在指甲所位于的手指或脚趾的至少一部分上形成护套。在第一隔离膜和活性剂制剂之间（或在活性剂制剂和外部环境之间）放置具有比第一隔离膜更低的湿气渗透率的可选的第二隔离膜以减少活性剂从活性剂剂配方。护套构造成能够将活性剂制剂固定并保持在指甲或脚趾甲上的护套内，同时减少活性剂制剂的水性液体组分的液体组分的蒸发。活性剂制剂可以是'慢模制'水凝胶制剂，其可以缓慢流入患病指甲的确切形状以确保药物的紧密接触和连续递送，而在施用期间不能挤出位置。 / p>

9. 发明申请

WO2007070694A3 SPRAY-ON FORMULATIONS AND METHODS FOR DERMAL DELIVERY OF DRUGS 审中-公开
公开(公告)号：WO2007070694A3
公开(公告)日：2007-06-21
申请号：PCT/US2006/048060
申请日：2006-12-14
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
发明人： ZHANG, Jie , WARNER, Kevin, S. , SHARMA, Sanjay
IPC分类号： A61K9/12
摘要： The present invention is drawn to sprayable formulations, methods of drug delivery, and resultant solidified layers for dermal delivery of a drug. The formulation can include a drug, a non-volatile solvent system, a solidifying agent, and a propellant. The formulation can have an initial viscosity suitable to be expelled out of a pressurized or manual pump container and applied onto a skin surface as a layer. When applied to the skin, the formulation can form a solidified layer after at least a portion of the propellant is evaporated.

10. 发明申请

WO2006053222A2 INSTANT PATCH FOR DERMAL DRUG DELIVERY 审中-公开
标题翻译：用于真菌药物递送的实际配对
公开(公告)号：WO2006053222A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/040938
申请日：2005-11-11
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S.
发明人： ZHANG, Jie , WARNER, Kevin, S.
IPC分类号： A61F13/02 , A61L15/16
CPC分类号： A61K9/703 , A61K9/7084 , A61L15/16 , A61L15/44 , A61L15/60 , A61L2300/40 , A61L2300/602
摘要： The present invention is drawn toward systems, devices, and methods of dermal drug delivery. The system can comprise a gel-triggering agent and a drug-containing composition including a drug and a gelling agent, wherein the drug-containing composition forms a soft, coherent solid when contacted with the gell-triggering agent. A cavity patch (10) is also included having an open cavity (18) configured to be closed at least in part by a skin surface (44). The open cavity can be further configured to facilitate contact between the skin surface and the gel. The gel-triggering agent and the drug-containing composition can be positioned in the system such that they are kept isolated from one another until immediately before or during use.
摘要翻译：本发明涉及皮肤药物递送的系统，装置和方法。该系统可以包含凝胶引发剂和包含药物和胶凝剂的药物组合物，其中当与凝胶引发剂接触时，含药组合物形成柔软的粘连固体。还包括空腔贴片（10），其具有被构造为至少部分地由皮肤表面（44）封闭的开放空腔（18）。开放空腔可进一步构造成促进皮肤表面和凝胶之间的接触。凝胶引发剂和含药物的组合物可以定位在系统中，使得它们彼此隔离直到使用前或使用前。

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