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    • 1. 发明申请
    • IMAGING AND CHARACTERISATION OF THE FOCAL FIELD OF A LENS BY SPATIAL AUTOCORRELATION
    • 通过空间自动化对镜头的焦点场的成像和表征
    • WO1997002477A1
    • 1997-01-23
    • PCT/NL1996000267
    • 1996-06-28
    • STICHTING VOOR DE TECHNISCHE WETENSCHAPPENMÜLLER, Michiel
    • STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN
    • G01M11/02
    • G01M11/0228
    • Method and system for realising a correlation, at least in space, of the focal fields of at least two electromagnetic beams at the focus of an optical focusing element, wherein a specific spatial distribution in amplitude, phase and polarisation of a focal field combined from the focal fields is generated and a physical response to the generated focal field in a sample placed at the focus is measured. A one- or multi-dimensional spatial shift in the focal field of at leat one of the at least two beams is introduced with respect to the focal field of others of the at least two beams. The relative phase of the beams is controlled by a (periodic) variable optical path length for at least one of the beams. The physical response, as a consequence of a physical process in the sample or as a consequence of scattering of the focal field at the sample, is detected, optionally with the aid of a specific collection function which is a combined image of a specific space/time distribution of the physical response at the focus of the focusing element. Microscopic imaging with increased lateral and/or axial resolution is possible when the physical response of a sample subjected to the above-mentioned focal fields is detected by means of a collection function, which may or may not be specific. In addition, the quantitative structure in space and time, related to the point spread function, of the focal field of the focusing element on and alongside the optical axis thereof can be determined in terms of amplitude, phase or polarisation.
    • 至少在空间中实现在光学聚焦元件的焦点处的至少两个电磁波束的焦点的相关性的方法和系统,其中从所述光学聚焦元件组合的焦点的振幅,相位和极化中的特定空间分布 产生焦点场并测量放置在焦点处的样品中对所产生的焦点的物理响应。 相对于至少两个光束中的其他光束的焦点场域,引入至少两个光束中的一个的焦点场中的一维或多维空间偏移。 光束的相对相位由用于至少一个光束的(周期性)可变光程长度控制。 作为样本中的物理过程或作为样本上的焦斑的散射的结果的物理响应可以任选地借助特定的收集功能来检​​测,该特定收集功能是特定空间/ 在聚焦元件的焦点处的物理响应的时间分布。 当通过收集功能检测受到上述焦点场的样品的物理响应时,具有增加的横向和/或轴向分辨率的显微成像是可能的,其可以是或不是特定的。 此外,可以根据振幅,相位或极化来确定聚焦元件在其光轴上及其旁边的焦点的与点扩散函数有关的空间和时间的定量结构。
    • 4. 发明申请
    • INSTRUMENTATION AMPLIFIER
    • 仪表放大器
    • WO1993024993A1
    • 1993-12-09
    • PCT/NL1993000112
    • 1993-06-01
    • STICHTING VOOR DE TECHNISCHE WETENSCHAPPENMETTING VAN RIJN, Alexander, Coenraad
    • STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN
    • H03F03/45
    • H03F3/347H03F3/45475H03F2200/261H03F2203/45511H03F2203/45512H03F2203/45521
    • Instrumentation amplifier comprising a reference stage containing a reference amplifier and a differential stage containing a differential amplifier, a first input of the reference amplifier being connected to a first input of the instrumentation amplifier, a first input of the differential amplifier being connected to a second input of the instrumentation amplifier, and an output of the differential amplifier being connected to an output of the instrumentation amplifier, and a second input of the differential amplifier being connected via a first impedance to an output of the reference amplifier and via a second impedance to the output of the differential amplifier. A filter circuit is incorporated between the second impedance and the output of the differential amplifier, of which filter circuit an output is connected to the second impedance, a first input is connected via a third impedance to the output of the differential amplifier, and a second input is connected to the output of the reference amplifier.
    • 仪表放大器包括:参考级,其包含参考放大器和包含差分放大器的差分级,所述参考放大器的第一输入端连接到所述仪表放大器的第一输入端;所述差分放大器的第一输入端连接到第二输入端 并且所述差分放大器的输出端连接到所述仪表放大器的输出端,并且所述差分放大器的第二输入端通过第一阻抗被连接到所述参考放大器的输出,并且经由第二阻抗连接到所述第二阻抗 输出差分放大器。 滤波器电路被并入在差分放大器的第二阻抗和输出之间,其中滤波电路的输出端连接到第二阻抗,第一输入经由第三阻抗连接到差分放大器的输出, 输入连接到参考放大器的输出。
    • 5. 发明申请
    • METHOD FOR DETERMINING ANAESTHETIC DEPTH
    • 确定神经深度的方法
    • WO1991019453A1
    • 1991-12-26
    • PCT/NL1991000096
    • 1991-06-13
    • STICHTING VOOR DE TECHNISCHE WETENSCHAPPENCLUITMANS, Petrus, Johannes, Maria
    • STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN
    • A61B05/0476
    • A61B5/4821A61B5/04845
    • Method for determining the anaesthetic depth of a patient, comprising the repeated administering of sensory stimuli to the patient; the repeated, non-invasive recording of the electrical activity of the patient's brain during a measurement interval following each stimulus; the computation, from a number of measurement intervals, of a representation of the response of a sensory neural pathway to a single stimulus; and the determination of the latencies and amplitudes of maxima and minima in the representation, which are a measure of the anaesthetic depth, wherein the measurement intervals are chosen such that they partially overlap one another. Preferably the length of time between two successive stimuli is a stochastic variable having a negative exponential distribution, the computed representation being the first order kernel.
    • 用于确定患者的麻醉深度的方法,包括向患者反复施用感觉刺激; 在每个刺激之后的测量间隔期间重复地,非侵入性地记录患者脑的电活动; 从多个测量间隔计算感觉神经通路对单个刺激的反应的表示; 以及在表示中确定最大值和最小值的延迟和幅度,其是麻醉剂深度的量度,其中选择测量间隔使得它们彼此部分重叠。 优选地,两个连续刺激之间的时间长度是具有负指数分布的随机变量,所计算的表示是第一阶内核。
    • 8. 发明申请
    • RF COIL ARRANGEMENT FOR A MAGNETIC RESONANCE APPARATUS
    • 用于磁共振装置的RF线圈布置
    • WO1996033421A1
    • 1996-10-24
    • PCT/IB1996000234
    • 1996-03-18
    • PHILIPS ELECTRONICS N.V.PHILIPS NORDEN ABSTICHTING VOOR DE TECHNISCHE WETENSCHAPPEN
    • PHILIPS ELECTRONICS N.V.PHILIPS NORDEN ABSTICHTING VOOR DE TECHNISCHE WETENSCHAPPENCLAASEN-VUJCIC, Tatjana
    • G01R33/34
    • G01R33/34046
    • The apparatus comprises a mainly cylindrical RF coil (9) which has a central axis (35) extending in its longitudinal direction and comprises a number of axial conductor elements (37) which extend parallel to the central axis across a mainly cylindrical surface, and also comprises end conductor elements which extend around the central axis near the ends of the axial conductor elements. The axial conductor elements (37) are distributed across the circumference of the cylinder in such a manner that they occupy predetermined positions relative to a zero position (39). The RF coil (9) is arranged to generated a substantially sinusoidal current distribution as a function of the position of the axial conductor elements (37) on the circumference of the cylinder, expressed as the angle ( alpha ) of this position relative to the zero position (39), in order to enable a substantially uniforme RF magnetic field, oriented perpendicularly to the cylinder axis (35), to be generated and/or received. Each end conductor element consists of a number of loop conductor segments (43), each of which interconnects the corresponding ends of two axial conductor elements (37). At least some of the axial conductor elements (37) constitute, together with the loop conductor segments (43) connected to their ends, a coil element (44) which is composed of a number of turns of an elongate electric conductor (45), all coil elements thus formed being electrically connected in series.
    • 该装置包括主要为圆柱形的RF线圈(9),其具有在其纵向方向上延伸的中心轴线(35),并且包括多个轴向导体元件(37),所述轴向导体元件(37)跨越主要圆柱形表面平行于中心轴线延伸, 包括在轴向导体元件的端部附近围绕中心轴延伸的端部导体元件。 轴向导体元件(37)以相对于零位置(39)占据预定位置的方式分布在气缸的圆周上。 RF线圈(9)被布置成产生基本上正弦的电流分布,作为在圆柱体的圆周上的轴向导体元件(37)的位置的函数,表示为该位置相对于零的角度(α) 位置(39),以便产生和/或接收垂直于气缸轴线(35)定向的基本均匀的RF磁场。 每个端部导体元件由多个环形导体段(43)组成,每个环形导体段(43)互连两个轴向导体元件(37)的对应端部。 至少一些轴向导体元件(37)与连接到其端部的环形导体段(43)一起构成线圈元件(44),该线圈元件由许多匝的细长电导体(45)组成, 所形成的所有线圈元件串联电连接。