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1. 发明申请

WO2003090939A1 METHOD AND APPARATUS FOR PLASMA DEPOSITION OF CHEMICALLY REACTIVE GROUPS ON SUBSTRATES CHEMICALLY REACTIVE SUBSTRATES OBTAINABLE BY THE METHOD AND USE THEREOF 审中-公开
标题翻译：用于等离子体沉积在基板上的化学反应性基团的方法和装置可通过其方法和使用获得化学反应性基板
公开(公告)号：WO2003090939A1
公开(公告)日：2003-11-06
申请号：PCT/DK2003/000272
申请日：2003-04-25
申请人： NKT RESEARCH & INNOVATION A/S , CHRISTENSEN, Søren, Flygenring , PETERSEN, Steen, Guldager
发明人： CHRISTENSEN, Søren, Flygenring , PETERSEN, Steen, Guldager
IPC分类号： B05D7/24
CPC分类号： H01J37/32082 , B05D1/62 , C03C17/3405 , C23C16/30
摘要： The present invention relates to a method and apparatus for plasma deposition of a chemically reactive group (Y-Z) on a substrate, chemically reactive substrates, and use thereof, e.g. for immobilisation of biomolecules; the method comprising: (a) providing at least one precursor (A-X (Y)) for the chemically reactive group; (b) providing at least one donor (D(Z)), said at least one donor comprising at least one addition group (Z), optionally said at least one addition group (Z) being comprised in said precursor (A-X (Y)) and optionally said at least one donor (D(Z)) is not being provided; (c) providing a substrate (M); (d) providing a gas plasma, said gas plasma having a pressure and an energy to form at least one activated carrier group (B); and (e) reacting said substrate (M), said at least one precursor (A-X (Y)), said at least one donor (D(Z)) in said gas plasma so that said chemically reactive group (Y-Z) is bound to said substrate, either directly (M-Y-Z) or via said at least one activated carrier group (M-B-Y-Z), and so that when exposed to a substance which chemically reacts with said chemically reactive group, said substance binds thereto.
摘要翻译：本发明涉及用于在衬底上等离子体沉积化学反应性基团（Y-Z）的方法和装置，化学反应性底物及其用途，例如，用于固定生物分子; 该方法包括：（a）为化学反应性基团提供至少一种前体（A-X（Y））; （B）提供至少一个供体（D（Z）），所述至少一个供体包含至少一个加成基团（Z），任选地所述至少一种加成基团（Z）包含在所述前体（AX（Y））和任选地所述至少一个供体（D（Z）））; （c）提供衬底（M）; （d）提供气体等离子体，所述气体等离子体具有压力和能量以形成至少一个活化载体组（B）; 和（e）使所述底物（M），所述至少一种前体（AX（Y）），所述至少一种供体（D（Z））在所述气体等离子体中反应，使得所述化学反应性基团（YZ）所述底物直接（MYZ）或通过所述至少一种活化的载体基团（MBYZ），并且当暴露于与所述化学反应性基团发生化学反应的物质时，所述物质与其结合。

2. 发明申请

WO2004088710A2 METHOD AND APPARATUS FOR GAS PLASMA TREATMENT WITH CONTROLLED EXTENT OF GAS PLASMA, AND USE THEREOF 审中-公开
标题翻译：气体等离子体等离子体处理气体等离子体处理方法及装置及其应用
公开(公告)号：WO2004088710A2
公开(公告)日：2004-10-14
申请号：PCT/DK2004/000240
申请日：2004-04-02
申请人： NKT RESEARCH & INNOVATION A/S , CHRISTENSEN, Søren, Flygenring , OVERBY, Bent , CARLSEN, René , PETERSEN, Steen, Guldager , BERENDSEN, Christianus, Wilhelmus, Johannes
发明人： CHRISTENSEN, Søren, Flygenring , OVERBY, Bent , CARLSEN, René , PETERSEN, Steen, Guldager , BERENDSEN, Christianus, Wilhelmus, Johannes
IPC分类号： H01J37/32
CPC分类号： H01J37/3244 , H01J37/32431 , H01J37/32568 , H01J37/32935
摘要： A method of controlling the extent of gas plasma, the method comprising: (A) providing a gas zone (110), said gas zone comprising a gas having a pressure; said gas comprising at least one gas component allowing generation of a plasma; (B) generating a plasma in said gas zone by supplying a potential difference between at least two electrodes (150); said at least two electrodes being configured to wholly or partly encompass said gas zone; and (C) controlling the extent of said generated plasma by controlling at least one of: said gas, said pressure, said potential difference, and said configuration of said at least two electrodes; a plasma treatment apparatus comprising at least one plasma measuring means (160) for measuring the extent of the plasma, and at least one controlling means (180, 191, 131) for controlling the extent of the plasma; and use of the method and apparatus in plasma treatment and/or plasma-assisted surface modification of electrodes and/or substrates.
摘要翻译：一种控制气体等离子体的程度的方法，所述方法包括：（A）提供气体区域（110），所述气体区域包括具有压力的气体; 所述气体包括允许产生等离子体的至少一种气体成分; （B）通过在至少两个电极（150）之间提供电位差来产生所述气体区域中的等离子体; 所述至少两个电极构造成完全或部分地包围所述气体区域; 以及（C）通过控制所述气体，所述压力，所述电位差和所述至少两个电极的所述构造中的至少一个来控制所述产生的等离子体的程度; 一种等离子体处理装置，包括用于测量等离子体的程度的至少一个等离子体测量装置（160）和用于控制等离子体的程度的至少一个控制装置（180,191,131）以及在电极和/或基板的等离子体处理和/或等离子体辅助表面改性中使用该方法和装置。

3. 发明申请

WO2008055718A3 MEDICAL DEVICE CAPABLE OF RELEASING NO 审中-公开
公开(公告)号：WO2008055718A3
公开(公告)日：2008-05-15
申请号：PCT/EP2007/057779
申请日：2007-07-27
申请人： Millimed A/S , NIELSEN, Kent, Høier , POULSEN, Frederik, Enemark , JENSEN, Christian , LARSSON, Lars, Niklas , PETERSEN, Steen, Guldager , ULRICH, Finn, Munk
发明人： NIELSEN, Kent, Høier , POULSEN, Frederik, Enemark , JENSEN, Christian , LARSSON, Lars, Niklas , PETERSEN, Steen, Guldager , ULRICH, Finn, Munk
IPC分类号： A61L31/10 , A61L31/16 , A61L29/08 , A61L29/16
摘要： The present invention relates to the introducer sheath equipment used during the Seldinger technique and related surgical techniques. The introducer sheaths or parts thereof comprise reactive nitrogen adducts which release reactive nitrogen species such as nitric oxide and nitroxyl during use for the prevention of mechanically induced vasospasm. The introducer sheaths are particularly useful for entry via access other than the femoral artery, such as via transradial access. In a preferred embodiement, the sheaths are coated with a linear' poly (ethyleneimine) diazeniumdiolate (L-PEI-NONO) embedded in polyurethane (PU).

4. 发明申请

WO2007085254A1 MEDICAL DEVICE WITH PH DEPENDENT DRUG RELEASE 审中-公开
标题翻译：具有PH依赖性药物释放的医疗装置
公开(公告)号：WO2007085254A1
公开(公告)日：2007-08-02
申请号：PCT/DK2007/000030
申请日：2007-01-24
申请人： MILLIMED A/S , NIELSEN, Kent Hoier , LARSSON, Lars Niklas , POULSEN, Frederik, Enemark , PETERSEN, Steen, Guldager , JENSEN, Christian , ULRICH, Finn Munk
发明人： NIELSEN, Kent Hoier , LARSSON, Lars Niklas , POULSEN, Frederik, Enemark , PETERSEN, Steen, Guldager , JENSEN, Christian , ULRICH, Finn Munk
IPC分类号： A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/602 , C08L79/02
摘要： The invention provides intravascular devices coated with a first domain comprising an alkali formulation of polyethylenimine diazeniumdiolate . The alkali ensures stabilisation of the polyethylenimine diazeniumdiolate during processing of the medical device, whilst allowing controlled release of nitric oxide upon use. The invention also provides medical devices coated with a first domain of polyethylenimine diazeniumdiolate, and an outer-layer which prevents or hinders the release of polyethylenimine diazeniumdiolate upon use in the body, particularly from the alkali first domain. In a preferred embodiment a balloon is coated with linear poly (ethylenimine) diazeniumdiolate (L-PEI-NONO) embedded in polyurethane (PU) and provided with a top coat of poly acrylic acid and PU.
摘要翻译：本发明提供涂覆有第一结构域的血管内装置，所述第一结构域包含聚乙烯亚胺二氮烯鎓二醇的碱配制剂。该碱确保了在处理医疗装置期间聚乙烯亚胺二氮烯鎓二醇的稳定化，同时允许一氧化氮在使用时受控释放。本发明还提供涂覆有聚乙烯亚胺二氮烯鎓二醇盐的第一结构域的医疗装置，以及防止或阻碍聚乙烯亚胺二氮烯鎓二硫酸盐在体内使用，特别是从碱第一区域释放的外层。在一个优选实施方案中，气球用嵌入聚氨酯（PU）中的线性聚（亚乙基亚胺）二氮烯二醇二（L-PEI-NONO）涂覆并提供有聚丙烯酸和PU的顶涂层。

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