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1. 发明申请

WO0232916A3 SIXTEEN-MEMBERED MACROLIDE COMPOUNDS 审中-公开
标题翻译：第六届会议化妆品化学品
公开(公告)号：WO0232916A3
公开(公告)日：2003-01-16
申请号：PCT/US0130725
申请日：2001-09-24
申请人： KOSAN BIOSCIENCES INC , KATZ LEONARD , ASHLEY GARY , BURLINGAME MARK A , DONG STEVEN D , FU HONG , LI YONG , MYLES DAVID C
发明人： KATZ LEONARD , ASHLEY GARY , BURLINGAME MARK A , DONG STEVEN D , FU HONG , LI YONG , MYLES DAVID C
IPC分类号： A61P31/00 , C07D313/00 , C07H17/08 , A61K31/70 , C07C327/30
CPC分类号： C07H17/08 , C07D313/00
摘要： The present invention provides novel sixteen-membered macrolide compounds that are useful as anti-infective agents or as intermediates thereto. The present invention also provides methods for the preparation of these compounds, and methods and formulations for their use. In one aspect of the present invention, sixteen-membered macrolide possessing a side chain Z are provided where Z is aliphatic, aryl, alkylaryl, halide, =NOR , =NNHR , or -W-R where W is O, S, NC(=O)R , NC(=O)OR , NC(=O)NHR or NR where R and R are each independently hydrogen, aliphatic, aryl or alkylaryl. In another aspect of the present invention, bicyclic compounds are provided where one of the cyclic-components is a sixteen-membered macrolide and the other is a cyclic moiety whose cyclic structure is formed by between 3 and 10 atoms. In another aspect of the present invention, sixteen-membered macrolide compounds that bind to the domain II region of the 23S RNA are provided.
摘要翻译：本发明提供可用作抗感染剂或作为其中间体的新颖的十六元大环内酯化合物。本发明还提供了制备这些化合物的方法及其用途的方法和制剂。在本发明的一个方面，提供了具有侧链Z的十六元大环内酯，其中Z是脂族，芳基，烷基芳基，卤化物，= NOR 3，= NNHR 3或-WR 3，其中W 是O，S，NC（= O）R 4，NC（= O）OR 4，NC（= O）NHR 4或NR 4，其中R 3和R 4是各自独立地为氢，脂族，芳基或烷基芳基。在本发明的另一方面，提供了双环化合物，其中环状组分之一是十六元大环内酯，另一个是其环状结构由3至10个原子形成的环状部分。在本发明的另一方面，提供了结合23S RNA的结构域II的十六元大环内酯化合物。

2. 发明申请

WO2008141234A3 METHODS OF MAKING EPOTHILONES 审中-公开
标题翻译：制作EPOTHILONES的方法
公开(公告)号：WO2008141234A3
公开(公告)日：2009-12-30
申请号：PCT/US2008063313
申请日：2008-05-09
申请人： KOSAN BIOSCIENCES INC , MENZELLA HUGO , REID RALPH C , CARNEY JOHN R , LI YONG
发明人： MENZELLA HUGO , REID RALPH C , CARNEY JOHN R , LI YONG
IPC分类号： C07D277/30 , C07D313/00 , C07D407/00
CPC分类号： C07D309/32 , C07D313/00 , C07D339/08 , Y02P20/582
摘要： The invention provides novel compounds that may be used as intermediates in the preparation of epothilones, epothilone analogs and derivative, as well as new synthetic methods for producing the intermediates and products.
摘要翻译：本发明提供可用作制备埃坡霉素，埃坡霉素类似物和衍生物的中间体的新型化合物，以及用于生产中间体和产物的新合成方法。

3. 发明申请

WO2004043954A3 TRANS-9,10-DEHYDROEPOTHILONE C AND D, ANALOGS THEREOF AND METHOS OF MAKING THE SAME 审中-公开
标题翻译：反式-9,10-脱氢埃可霉素C和D，其类似物和制备该化合物的方法
公开(公告)号：WO2004043954A3
公开(公告)日：2004-11-18
申请号：PCT/US0335411
申请日：2003-11-07
申请人： KOSAN BIOSCIENCES INC , LI YONG , SUNDERMANN KURT , TANG LI , MYLES DAVID
发明人： LI YONG , SUNDERMANN KURT , TANG LI , MYLES DAVID
IPC分类号： C07D405/06 , C07D413/06 , C07D417/06 , A61K31/427
CPC分类号： C07D405/06 , C07D413/06 , C07D417/06
摘要： The present invention provides new trans-9,10-dehydroepothilone C and trans-9,10-dehydroepothilone D based derivative compounds, compositions and methods of inhibiting cellular hyperproliferation and/or stabilizing microtubules in vitro and of treatment of hyperproliferative diseases in vivo. Also disclosed are methods of making the compounds.
摘要翻译：本发明提供新的反式-9,10-脱氢埃坡霉素C和反式-9,10-脱氢埃坡霉素D基衍生化合物，体外抑制细胞过度增殖和/或稳定微管的组合物和方法以及体内过度增殖性疾病的治疗。还公开了制备这些化合物的方法。

4. 发明申请

WO2015120622A9 CHORDLESS TRUSS ELEMENT METHOD AND COMBINED-NODE BRIDGE 审中-公开
标题翻译：无级TRUSS元素方法和组合节点桥
公开(公告)号：WO2015120622A9
公开(公告)日：2016-10-20
申请号：PCT/CN2014072110
申请日：2014-02-14
申请人： LI YONG
发明人： LI YONG
IPC分类号： E01D2/00 , E01D6/00
CPC分类号： E01D2/00 , E01D6/00 , E01D19/00 , E01D2101/268 , E04C3/293
摘要： A chordless truss element method and combined node bridge, wherein the unit elements in the combined node bridge are connected in advance end-to-end into a truss/pier combined overall node structure, forming a combined overall node structure that can be transported and dismantled in one piece; furthermore, the unit elements can directly form a truss segment when connected, thus ensuring the integrity of the nodes and the structure when subjected to forces; furthermore, by means of the truss/pier combined overall node structure, and especially the shear connectors, the discrete unit elements form an integrated truss segment; a top chord and a bottom chord are not necessary, greatly facilitating lifting during construction, and accomplishing construction of steel web members without scaffolding.
摘要翻译：一种无弦桁架元件方法和组合节点桥梁，其中组合节点桥梁中的单元元件预先端对端连接成桁架/码头组合的整体节点结构，形成可以运输和拆卸的组合的整体节点结构在一块; 此外，单元元件在连接时可以直接形成桁架段，从而在承受力时确保节点和结构的完整性; 此外，通过桁架/码头组合的整体节点结构，特别是剪切连接器，分立的单元元件形成一个整体的桁架段; 上弦和下弦并不是必需的，极大地方便了施工过程中的起吊，不用脚手架就可以完成钢筋架的施工。

5. 发明申请

WO2007059296A3 LIGANDS FOR MINERALOCORTICOID RECEPTOR (MR) AND METHODS FOR SCREENING FOR OR DESIGNING MR LIGANDS 审中-公开
标题翻译：矿物受体（MR）的配体和筛选或设计MR配体的方法
公开(公告)号：WO2007059296A3
公开(公告)日：2009-05-07
申请号：PCT/US2006044620
申请日：2006-11-15
申请人： VAN ANDEL RES INST , XU HUAQIANG ERIC , LI YONG
发明人： XU HUAQIANG ERIC , LI YONG
IPC分类号： C12Q1/00
CPC分类号： G01N33/566
摘要： The inventors disclose a 1.95Å crystal structure of the MR ligand binding domain containing a single C808S mutation bound to a corticosterone and the fourth LXXLL motif of steroid receptor coactivator-1 (SRC1-4). The inventors demonstrate that SRC1-4 is the most potent MR-binding motif and mutations that disrupt the MR/ SRC1-4 interactions abolish the ability of the full-length SRC1 to coactivate MR. The structure also reveals a compact steroid binding pocket with a unique topology that is primarily defined by key residues of helices 6 and 7. Also described are novel ligands for MR, methods for screening for and designing novel MR ligands, and methods for treating MR-related diseases.
摘要翻译：本发明人公开了含有与皮质酮结合的单一C808S突变和类固醇受体共激活因子-1（SRC1-4）的第四LXXLL基序的MR配体结合结构域的1.95Å晶体结构。发明人证明SRC1-4是最有效的MR结合基序，并且破坏MR / SRC1-4相互作用的突变消除了全长SRC1共激活MR的能力。该结构还揭示了具有唯一拓扑结构的紧凑型类固醇结合口袋，其主要由螺旋6和7的关键残基定义。还描述了MR的新配体，用于筛选和设计新型MR配体的方法，以及用于治疗MR- 相关疾病

6. 发明申请

WO2010136905A3 PULSE OFFSET ULTRASONIC IMAGING 审中-公开
标题翻译：脉冲超声波超声成像
公开(公告)号：WO2010136905A3
公开(公告)日：2011-03-31
申请号：PCT/IB2010001793
申请日：2010-05-25
申请人： SHENZHEN MINDRAY BIO MED ELECT , FAN RUI , LI SHUANGSHUANG , LI YONG
发明人： FAN RUI , LI SHUANGSHUANG , LI YONG
IPC分类号： A61B8/00
CPC分类号： A61B8/5207 , A61B8/08 , A61B8/14 , G01S7/52038 , G01S7/52046 , G01S15/108 , G01S15/8959
摘要： A diagnostic ultrasound image of a region of interest (ROI) of a body is formed by transmitting into the ROI at least a first and a second ultrasound pulse (P1, P2), in which the second pulse is phase-shifted relative to the first pulse by an amount other than O or a multiple of 180 degrees. Discrete (quantized) received signals (E1, E2) from the pulses are interleaved to form a resultant operating signal (W) that is detected and beamformed as the operating signal.
摘要翻译：通过将至少第一和第二超声脉冲（P1，P2）发射到ROI中，形成身体的感兴趣区域（ROI）的诊断超声图像，其中第二脉冲相对于第一脉冲除O以外的量或180度的倍数。来自脉冲的离散（量化）接收信号（E1，E2）被交织以形成被检测和波束形成作为操作信号的合成操作信号（W）。

7. 发明申请

WO2006116548A3 DIGITAL IMPLEMENTATION OF POWER FACTOR CORRECTION 审中-公开
标题翻译：功率因数校正的数字实现
公开(公告)号：WO2006116548A3
公开(公告)日：2006-12-14
申请号：PCT/US2006015921
申请日：2006-04-27
申请人： INT RECTIFIER CORP , LI YONG
发明人： LI YONG
IPC分类号： G05F1/10 , G05F1/40
CPC分类号： G05F1/565 , H02M1/42 , H02M3/157 , Y02B70/12
摘要： A circuit for providing power factor correction includes a boost converter circuit (L, Q1, BD) and a control circuit receiving as inputs a rectified AC input voltage from a rectifier (BR), a signal proportional to current through the boost inductor and the DC bus voltage across the capacitor of tile boost converter. The control circuit provides a pulse width modulated signal to control the on time of a PFC switch. The control circuit further includes a voltage regulator and a current regulator. The current regulator includes a difference device operable to subtract a signal proportional to the inductor current from the current reference signal, a PI controller adapted to receive the output of the difference device and provide a first control signal, a feed forward device operable to receive the rectified AC input voltage and to provide a second control signal with a smaller dynamic range than the AC input voltage, and an adder operable to add the first control signal to the second control signal to provide a PWM reference signal for generating the pulse width modulated signal. A zero crossing detector and vector rotator may be provided to provide a clean sinusoidal reference to the current regulator. A partial PFC regulator may be provide to provide partial mode PFC if desired.
摘要翻译：用于提供功率因数校正的电路包括升压转换器电路（L，Q1，BD）和控制电路，其接收来自整流器（BR）的整流的AC输入电压作为输入，与通过升压电感器的电流成比例的信号和DC 瓦片升压转换器电容器两端的总线电压。控制电路提供脉宽调制信号来控制PFC开关的导通时间。控制电路还包括电压调节器和电流调节器。电流调节器包括差分器件，其可操作以从电流参考信号中减去与电感器电流成比例的信号; PI控制器，适于接收差分器件的输出并提供第一控制信号;前馈器件，可操作以接收整流的AC输入电压，并且提供具有比AC输入电压更小的动态范围的第二控制信号，以及加法器，用于将第一控制信号加到第二控制信号上，以提供用于产生脉宽调制信号的PWM参考信号。可以提供零交叉检测器和矢量旋转器以向电流调节器提供干净的正弦参考。如果需要，可以提供部分PFC调节器来提供部分模式PFC。

8. 发明申请

WO2010004428A3 SYSTEM AND METHOD FOR PROVIDING INTEROPERABILITY BETWEEN DIAMETER POLICY CONTROL AND CHARGING IN A 3GPP NETWORK 审中-公开
标题翻译：在3GPP网络中提供直径政策控制和充电之间的互操作性的系统和方法
公开(公告)号：WO2010004428A3
公开(公告)日：2010-03-11
申请号：PCT/IB2009006537
申请日：2009-07-10
申请人： BRIDGEWATER SYSTEMS CORP , FOOTTIT TOM A , LI YONG , JONES MARK
发明人： FOOTTIT TOM A , LI YONG , JONES MARK
IPC分类号： H04L12/14 , G06Q10/00 , G06Q30/00 , H04W4/24
CPC分类号： G06Q10/00 , G06Q30/00 , G06Q30/0283 , G06Q30/04 , G06Q40/12 , H04M15/55 , H04M15/57 , H04M15/59 , H04M15/66 , H04M15/8016 , H04M15/81 , H04M15/85 , H04M15/851 , H04M17/00 , H04M17/201 , H04M17/202 , H04M17/204 , H04M17/207 , H04M2017/22 , H04M2017/222 , H04M2017/227 , H04M2017/24 , H04M2017/246 , H04M2215/0112 , H04M2215/2026 , H04M2215/2046 , H04M2215/208 , H04M2215/7414 , H04M2215/815 , H04W4/24
摘要： A system and method are described whereby interoperability is facilitated in a 3GPP network environment in combination with DIAMETER policy controls. Such interoperability enables updated policy rules to be fully communicated in on-line charging situations where quota expirations occur. This invention maintains centralized policy control in a 3GPP network with on-line charging.
摘要翻译：描述了一种系统和方法，其中在3GPP网络环境中结合DIAMETER策略控制便于互操作性。这种互操作性使更新的策略规则能够在发生配额到期的在线计费情况下完全传达。本发明在具有在线计费的3GPP网络中维持集中式策略控制。

9. 发明申请

WO2008125918A3 SYSTEMS AND METHODS FOR POLICY-BASED SERVICE MANAGEMENT 审中-公开
标题翻译：基于政策服务管理的系统与方法
公开(公告)号：WO2008125918A3
公开(公告)日：2009-04-02
申请号：PCT/IB2007004604
申请日：2007-11-20
申请人： BRIDGEWATER SYSTEMS CORP , BIENEK MICHAL , TOPTYGIN DMITRY , HENRY PASCAL , LI YONG
发明人： BIENEK MICHAL , TOPTYGIN DMITRY , HENRY PASCAL , LI YONG
IPC分类号： H04L12/24
CPC分类号： H04L41/5061 , H04L41/0893 , H04L41/16 , H04L41/22
摘要： Systems and method for policy-based service management are provided. An exemplary system includes a rule definition interface module configured to receive a plurality of rule definitions and a separate policy management interface module configured to allow a user to define a rule instance from an existing rule definition instance and to define a policy instance based on the defined rule instance. A policy may be simply expressed via the policy management interface as "perform the following set of action if all of the following rule instances are true unless any of the following rule instances are true." Additionally, policies may be associated with a context at a specific a level in a context hierarchy having multiple levels. The policy may therefore inherit rules from contexts at a higher level in the hierarchy.
摘要翻译：提供了基于策略的服务管理系统和方法。一个示例性系统包括：规则定义接口模块，被配置为接收多个规则定义;以及单独的策略管理接口模块，其被配置为允许用户从现有规则定义实例中定义规则实例，并且基于所定义的规则来定义策略实例规则实例。如果以下所有规则实例都为真，除非下列任何规则实例为真，否则策略可以通过策略管理界面简单地表示为“执行以下一组操作。另外，策略可以与具有多个级别的上下文层级中的特定级别的上下文相关联。因此，该策略可能会从层次结构中的较高级别的上下文继承规则。

10. 发明申请

WO2006052794A3 DIGITAL CONTROL OF BRIDGELESS POWER FACTOR CORRECTION CIRCUIT 审中-公开
标题翻译：无连续功率因数校正电路数字控制
公开(公告)号：WO2006052794A3
公开(公告)日：2007-02-22
申请号：PCT/US2005040113
申请日：2005-11-07
申请人： INT RECTIFIER CORP , LI YONG
发明人： LI YONG
IPC分类号： G05F1/70
CPC分类号： G05F1/70
摘要： A circuit for providing power factor correction includes a bridgeless boost converter circuit and a control circuit receiving an input AC line voltage of the bridgeless boost converter circuit, wherein the control circuit provides a pulse width modulated signal to control the on time of a PFC switch of the bridgeless boost converter circuit. The control circuit also includes a scaling device operable to scale down a bi-polar AC voltage of the input AC line voltage to a uni-polar AC voltage, an analog to digital converter operable to convert the uni-polar AC voltage into digital data and a digital rectifier operable to process the digital data of the uni-polar AC voltage to provide a half-sinusoidal AC signal that is proportional to and in phase with the input AC line voltage for use in providing the pulse width modulated signal.
摘要翻译：用于提供功率因数校正的电路包括无桥升压转换器电路和接收无桥升压转换器电路的输入AC线电压的控制电路，其中控制电路提供脉宽调制信号以控制PFC开关的导通时间无桥升压转换电路。控制电路还包括可操作以将输入AC线电压的双极交流电压降压到单极AC电压的缩放装置，可操作以将单极AC电压转换为数字数据的模数转换器，数字整流器，其可操作以处理单极AC电压的数字数据，以提供与用于提供脉宽调制信号的输入AC线电压成比例并与其成相位的半正弦AC信号。

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