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1. 发明申请

WO2013135737A1 COMPOSITIONS FOR DYSPHAGIA ASSESSMENT 审中-公开
标题翻译：组合物进行血糖评估
公开(公告)号：WO2013135737A1
公开(公告)日：2013-09-19
申请号：PCT/EP2013/055064
申请日：2013-03-13
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： GALLEGOS-MONTES, Chrispulo , BRITO-DE LA FUENTE, Edmundo , MAINOU-SIERRA, José M. , QUINCHIA-BUSTAMANTE, Lida-Andrea , JOZAMI, Mirta Viviana , VALENCIA BARRAGÁN, Conceptión , FRANCO-GÓMEZ, Josè Maria
IPC分类号： A23L1/30 , A61K49/04 , A61K49/18
CPC分类号： A61K49/0404 , A23L29/37 , A23L33/10 , A23V2002/00 , A61K49/0495 , A61K49/1863
摘要： Dysphagia, or abnormal swallowing of foods and/ or liquids, affects people of all ages from the newborn to the elderly. Management of dysphagia is commonly done by the prescription of texture-controlled diets. Ideally, the most appropriate modification of food consistencies should follow from a clear assessment of the swallowing problem. Rheology and swallowing are connected at the diagnosis level. The "gold standard" technique is a videofluoroscopic swallowing study (VFSS). The swallowing process can be visualized using videoradiography by employing either ready-to-use commercial contrast medium or by mixing food with barium sulphate (BaSO 4 ), making it radiopaque. Unfortunately, there is no standardization to perform VFSS. This lack of standardization leads to variability of results as well as their interpretation. In practice, lack of standardization often requires that individual speech pathologist, dieticians and dysphagia food manufacturers determine their own dietary consistencies. Another possibility is the use of encapsulated MRI superparamagnetic contrast agents for oral administration. The main goal of this invention has been to develop new and improved formulations of carriers/vehicles for radio-opaque (barium sulphate) or magnetic contrast agents (superparamagnetic iron oxide) that can be used as ready-to-use/ powder commercial formulations as contrast media for imaging diagnosis (VFSS or MRI) of dysphagia.
摘要翻译：吞咽困难或食物和/或液体异常吞咽会影响新生儿到老年人各个年龄段的人群。吞咽困难的管理通常由配方控制的饮食来完成。理想情况下，对食物一致性进行最合适的修改应遵循对吞咽问题的明确评估。流感和吞咽在诊断水平相连。 “黄金标准”技术是视频荧光吞咽研究（VFSS）。吞咽过程可以通过使用准备使用的商业造影剂或通过将食物与硫酸钡（BaSO 4）混合使用视频放射造影来显现，使其成为不透射线的。不幸的是，没有标准化来执行VFSS。这种缺乏标准化导致了结果的变化以及它们的解释。在实践中，缺乏标准化往往要求个别言语病理学家，营养师和吞咽困难的食品制造商决定自己的膳食一致性。使用封装的MRI超顺磁性造影剂进行口服给药也是可能的。本发明的主要目标是开发用于不透射线（硫酸钡）或磁性造影剂（超顺磁氧化铁）的载体/载体的新型改进制剂，其可用作即用型/粉末商业制剂，如造影剂用于影像诊断（VFSS或MRI）的吞咽困难。

2. 发明申请

WO2013064663A1 DEVICE AND METHOD FOR PREPARING A FLUID COMPOSITION FOR COMPLETE OR SUPPLEMENTAL ENTERAL NUTRITION 审中-公开
标题翻译：制备流体组合物以完成或补充肠内营养的装置和方法
公开(公告)号：WO2013064663A1
公开(公告)日：2013-05-10
申请号：PCT/EP2012/071760
申请日：2012-11-02
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： BRITO-DE LA FUENTE, Edmundo , ASCANIO, Gabriel , MAINOU-SIERRA, José Maria , COLBUS, Heike , MARTÍNEZ GONZÁLEZ, Egon Alejandro
IPC分类号： A47J31/40
CPC分类号： A47J31/40 , A47J31/401 , A47J43/0711 , A47J43/0727 , A47J43/1093 , B01F7/0015 , B01F7/00558 , B01F7/00758 , B01F7/0095 , B01F7/164 , B01F11/0068
摘要： The invention relates to a device (1) for preparing a fluid composition for complete or supplemental enteral nutrition, comprising a liquid feeding device (2), an ingredient feeding device (3) and a mixing device (4) for mixing a liquid fed from the liquid feeding device (2) and at least one ingredient fed from the ingredient feeding device (3), the mixing device (4) comprising a mixer (41) and a mixing container (40) in which the liquid and the at least one ingredient are mixed by the mixer (41). The device is characterized in that the device (1) is operable to move the mixing container (40) relative to the mixer (41) during mixing of the liquid and the at least one ingredient of the fluid composition to be prepared. In this way a device and a method for preparing a fluid composition for complete or supplemental enteral nutrition may be provided which are capable of preparing a fluid composition having a high energy density and at the same time having a pleasantly smooth and homogenous consistency.
摘要翻译：本发明涉及一种用于制备用于完全或补充肠内营养的流体组合物的装置（1），包括液体供给装置（2），成分进料装置（3）和混合装置（4），用于混合从所述液体供给装置（2）和从所述成分供给装置（3）供给的至少一种成分，所述混合装置（4）包括混合器（41）和混合容器（40），在所述混合器中混合所述液体和所述至少一种成分通过混合器（41）混合。该装置的特征在于，在液体和要制备的流体组合物的至少一种成分的混合期间，装置（1）可操作以相对于混合器（41）移动混合容器（40）。以这种方式，可以提供一种用于制备用于完全或补充肠内营养的流体组合物的装置和方法，其能够制备具有高能量密度并且同时具有令人愉快的平滑和均匀稠度的流体组合物。

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