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    • 1. 发明申请
    • BIOINFORMATICS SYSTEMS, APPARATUSES, AND METHODS EXECUTED ON AN INTEGRATED CIRCUIT PROCESSING PLATFORM
    • 一体化电路处理平台执行的生物系统,设备和方法
    • WO2017004589A1
    • 2017-01-05
    • PCT/US2016/040842
    • 2016-07-01
    • EDICO GENOME, CORP.
    • VAN ROOYEN, PieterRUEHLE, MichaelMEHIO, RamiHAHM, Mark
    • C40B60/10G01N33/48G06F19/00
    • G06F19/28G06F19/22
    • A system, method and apparatus for executing a bioinformatics analysis on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit that may be connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits may be arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the bioinformatics analysis on the reads of genomic data. Each subset of the hardwired digital logic circuits may be formed in a wired configuration to perform the one or more steps in the bioinformatics analysis.
    • 用于执行遗传序列数据的生物信息学分析的系统,方法和装置包括由通过物理电互连互连的一组硬连线数字逻辑电路形成的集成电路。 物理电互连之一形成了可与电子数据源连接的集成电路的输入,用于接收基因组数据的读取。 硬连线数字逻辑电路可以被布置为一组处理引擎,每个处理引擎由硬连线数字逻辑电路的子集形成,以在生物信息学分析中对基因组数据的读取执行一个或多个步骤。 硬连线数字逻辑电路的每个子集可以以有线配置形成,以在生物信息学分析中执行一个或多个步骤。
    • 2. 发明申请
    • BIOINFORMATICS SYSTEMS, APPARATUSES, AND METHODS EXECUTED ON AN INTEGRATED CIRCUIT PROCESSING PLATFORM
    • 一体化电路处理平台执行的生物系统,设备和方法
    • WO2014186604A1
    • 2014-11-20
    • PCT/US2014/038246
    • 2014-05-15
    • EDICO GENOME CORP.
    • MCMILLEN, Robert, J.RUEHLE, Michael
    • G01N33/48
    • G06F19/22G06F19/28
    • A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes a structured ASIC formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the structured ASIC connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits are arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis pipeline on the reads of genomic data. Each subset of the hardwired digital logic circuits is formed in a wired configuration to perform the one or more steps in the sequence analysis pipeline.
    • 用于在遗传序列数据上执行序列分析管线的系统,方法和装置包括由通过物理电互连互联的一组硬连线数字逻辑电路形成的结构化ASIC。 物理电互连之一形成了与电子数据源连接的结构化ASIC的输入,用于接收基因组数据的读取。 硬连线数字逻辑电路被布置为一组处理引擎,每个处理引擎由硬连线数字逻辑电路的子集形成,以在序列分析管线中对基因组数据的读取执行一个或多个步骤。 硬连线数字逻辑电路的每个子集以有线配置形成,以执行序列分析流水线中的一个或多个步骤。
    • 3. 发明申请
    • BIOINFORMATICS SYSTEMS, APPARATUSES, AND METHODS FOR PERFORMING SECONDARY AND/OR TERTIARY PROCESSING
    • 用于进行二次和/或三次加工的生物信息系统,设备和方法
    • WO2018081654A1
    • 2018-05-03
    • PCT/US2017/058890
    • 2017-10-27
    • EDICO GENOME, CORP.
    • HAHM, Mark, DavidDE BEER, JacobusJAIN, VarunMEHIO, RamiOJARD, EricRUEHLE, MichaelPTASHEK, AmnonCATREUX, SeverineVISVANATH, Arun
    • G06F19/28G06F19/22G06F21/76
    • A system, method and apparatus for executing a bioinformatics analysis on genetic sequence data is provided. Particularly, a genomics analysis platform for executing a sequence analysis pipeline is provided. The genomics analysis platform includes one or more of a first integrated circuit, where each first integrated circuit forms a central processing unit (CPU) that is responsive to one or more software algorithms that are configured to instruct the CPU to perform a first set of genomic processing steps of the sequence analysis pipeline. Additionally, a second integrated circuit is also provided, where each second integrated circuit forming a field programmable gate array (FPGA), the FPGA being configured by firmware to arrange a set of hardwired digital logic circuits that are interconnected by a plurality of physical interconnects to perform a second set of genomic processing steps of the sequence analysis pipeline, the set of hardwired digital logic circuits of each FPGA being arranged as a set of processing engines to perform the second set of genomic processing steps. A shared memory is also provided.
    • 提供了用于对基因序列数据执行生物信息学分析的系统,方法和装置。 具体而言,提供了用于执行序列分析流水线的基因组分析平台。 基因组学分析平台包括第一集成电路中的一个或多个,其中每个第一集成电路形成响应于一个或多个软件算法的中央处理单元(CPU),该软件算法被配置为指示CPU执行第一组基因组 处理序列分析流水线的步骤。 此外,还提供了第二集成电路,其中每个第二集成电路形成现场可编程门阵列(FPGA),所述FPGA由固件配置为布置一组硬连线数字逻辑电路,所述一组硬连线数字逻辑电路通过多个物理互连互连到 执行序列分析流水线的第二组基因组处理步骤,每个FPGA的该组硬连线数字逻辑电路被布置为一组处理引擎以执行第二组基因组处理步骤。 还提供共享内存。
    • 4. 发明申请
    • BIOINFORMATICS SYSTEMS, APPARATUSES, AND METHODS EXECUTED ON AN INTEGRATED CIRCUIT PROCESSING PLATFORM
    • 在集成电路处理平台上执行的生物信息系统,装置和方法
    • WO2018006022A1
    • 2018-01-04
    • PCT/US2017/040385
    • 2017-06-30
    • EDICO GENOME CORP.
    • VAN ROOYEN, PieterRUEHLE, MichaelMEHIO, RamiHAHM, Mark
    • G06F19/28G06F19/22
    • G16B50/00G16B30/00
    • A system, method and apparatus for executing a bioinformatics analysis on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit that may be connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits may be arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the bioinformatics analysis on the reads of genomic data. Each subset of the hardwired digital logic circuits may be formed in a wired configuration to perform the one or more steps in the bioinformatics analysis.
    • 用于对遗传序列数据执行生物信息学分析的系统,方法和装置包括由通过物理电互连互连的一组硬线数字逻辑电路形成的集成电路。 其中一个物理电互连形成集成电路的输入,其可以与电子数据源连接以接收基因组数据的读取。 硬连线数字逻辑电路可以被布置为一组处理引擎,每个处理引擎由硬连线数字逻辑电路的子集形成,以在关于基因组数据的读取的生物信息学分析中执行一个或多个步骤。 硬连线数字逻辑电路的每个子集可以以有线配置形成以执行生物信息学分析中的一个或多个步骤。
    • 5. 发明申请
    • BIOINFORMATICS SYSTEMS, APPARATUS, AND METHODS FOR PERFORMING SECONDARY AND/OR TERTIARY PROCESSING
    • 用于进行二次和/或三次加工的生物信息系统,装置和方法
    • WO2017214320A1
    • 2017-12-14
    • PCT/US2017/036424
    • 2017-06-07
    • EDICO GENOME, CORP.
    • VAN ROOYEN, PieterRUEHLE, MichaelMEHIO, RamiSTONE, GavinHAHM, MarkOJARD, EricPTASHEK, Amnon
    • G06F19/28
    • A system, method and apparatus for executing a bioinformatics analysis on genetic sequence data is provided. Particularly, a genomics analysis platform for executing a sequence analysis pipeline is provided. The genomics analysis platform includes one or more of a first integrated circuit, where each first integrated circuit forms a central processing unit(CPU) that is responsive to one or more software algorithms that are configured to instruct the CPU to perform a first set of genomic processing steps of the sequence analysis pipeline. Additionally, a second integrated circuit is also provided, where each second integrated circuit forming a field programmable gate array (FPGA), the FPGA being configured by firmware to arrange a set of hardwired digital logic circuits that are interconnected by a plurality of physical interconnects to perform a second set of genomic processing steps of the sequence analysis pipeline, the set of hardwired digital logic circuits of each FPGA being arranged as a set of processing engines to perform the second set of genomic processing steps. A shared memory is also provided.
    • 提供了用于对基因序列数据执行生物信息学分析的系统,方法和装置。 具体而言,提供了用于执行序列分析流水线的基因组分析平台。 基因组学分析平台包括第一集成电路中的一个或多个,其中每个第一集成电路形成响应于一个或多个软件算法的中央处理单元(CPU),该软件算法被配置为指示CPU执行第一组基因组 处理序列分析流水线的步骤。 此外,还提供了第二集成电路,其中每个第二集成电路形成现场可编程门阵列(FPGA),所述FPGA由固件配置为布置一组硬连线数字逻辑电路,所述一组硬连线数字逻辑电路通过多个物理互连互连到 执行序列分析流水线的第二组基因组处理步骤,每个FPGA的该组硬连线数字逻辑电路被布置为一组处理引擎以执行第二组基因组处理步骤。 还提供共享内存。
    • 6. 发明申请
    • GENOMIC INFRASTRUCTURE FOR ON-SITE OR CLOUD-BASED DNA AND RNA PROCESSING AND ANALYSIS
    • 用于现场或基于云的DNA和RNA加工和分析的基因组基因组
    • WO2017123664A1
    • 2017-07-20
    • PCT/US2017/013057
    • 2017-01-11
    • EDICO GENOME, CORP.
    • VAN ROOYEN, PieterMCMILLEN, Robert, J.RUEHLE, MichaelMEHIO, Rami
    • G06F19/28G06F19/22
    • G06F19/28
    • A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes a integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits are arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis pipeline on the reads of genomic data. Each subset of the hardwired digital logic circuits is formed in a wired configuration to perform the one or more steps in the sequence analysis pipeline.
    • 用于在基因序列数据上执行序列分析流水线的系统,方法和装置包括由通过物理电互连互连的一组硬连线数字逻辑电路形成的集成电路。 其中一个物理电互连形成与电子数据源连接的集成电路的输入,用于接收基因组数据的读取。 硬连线数字逻辑电路被布置为一组处理引擎,每个处理引擎由硬连线数字逻辑电路的子集形成,以在序列分析流水线上对基因组数据的读取执行一个或多个步骤。 硬连线数字逻辑电路的每个子集以有线配置形成以执行序列分析流水线中的一个或多个步骤。
    • 7. 发明申请
    • BIOINFORMATICS SYSTEMS, APPARATUSES, AND METHODS EXECUTED ON AN INTEGRATED CIRCUIT PROCESSING PLATFORM
    • 一体化电路处理平台执行的生物系统,设备和方法
    • WO2014113736A1
    • 2014-07-24
    • PCT/US2014/012144
    • 2014-01-17
    • EDICO GENOME CORP.
    • VAN ROOYEN, PieterMCMILLEN, RobertRUEHLE, Michael
    • G01N33/48
    • G06F19/22G06F19/28
    • A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits are arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis pipeline on the reads of genomic data. Each subset of the hardwired digital logic circuits is formed in a wired configuration to perform the one or more steps in the sequence analysis pipeline.
    • 用于在遗传序列数据上执行序列分析管线的系统,方法和装置包括由通过物理电互连互联的一组硬连线数字逻辑电路形成的集成电路。 物理电互连之一形成与用于接收基因组数据读取的电子数据源连接的集成电路的输入。 硬连线数字逻辑电路被布置为一组处理引擎,每个处理引擎由硬连线数字逻辑电路的子集形成,以在序列分析管线中对基因组数据的读取执行一个或多个步骤。 硬连线数字逻辑电路的每个子集以有线配置形成,以执行序列分析流水线中的一个或多个步骤。