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1. 发明申请

WO2013003827A3 MACROGOL 15 HYDROXYSTEARATE FORMULATIONS 审中-公开
标题翻译： MACROGOL 15羟基硬脂酸酯配方
公开(公告)号：WO2013003827A3
公开(公告)日：2013-05-02
申请号：PCT/US2012045145
申请日：2012-06-29
申请人： ALLERGAN INC , GORE ANURADHA V , WARNER KEVIN S , PUJARA CHETAN P , GRAHAM RICHARD S , PARASHAR AJAY P , LEE MU-LAN , JORDAN ROBERT S , LIKITLERSUANG SUKHON
发明人： GORE ANURADHA V , WARNER KEVIN S , PUJARA CHETAN P , GRAHAM RICHARD S , PARASHAR AJAY P , LEE MU-LAN , JORDAN ROBERT S , LIKITLERSUANG SUKHON
IPC分类号： A61K9/00 , A61K47/14
CPC分类号： A61K31/417 , A61K9/0048 , A61K9/06 , A61K9/1075 , A61K31/165 , A61K31/4025 , A61K31/4164 , A61K31/4174 , A61K31/5575 , A61K31/568 , A61K31/5685 , A61K38/13 , A61K47/14
摘要： Provided herein are compositions, which include an active pharmaceutical ingredient and macrogol 15 hydroxystearate, and methods for using the same for treating diseases or disorder.
摘要翻译：本文提供了包含活性药物成分和聚乙二醇15羟基硬脂酸酯的组合物，以及使用其来治疗疾病或病症的方法。

2. 发明申请

WO2011057269A3 COMPOSITIONS FOR ENHANCING HAIR GROWTH 审中-公开
标题翻译：用于增加头发生长的组合物
公开(公告)号：WO2011057269A3
公开(公告)日：2012-07-26
申请号：PCT/US2010056036
申请日：2010-11-09
申请人： ALLERGAN INC , GORE ANURADHA , WARNER KEVIN S
发明人： GORE ANURADHA , WARNER KEVIN S
IPC分类号： A61K8/42 , A61K8/06 , A61Q7/00
CPC分类号： A61Q7/00 , A61K8/062 , A61K8/42
摘要： Methods and compositions for stimulating the growth of hair are disclosed wherein emulsions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I wherein the dashed bonds represent a single or double bond which can be in the cis or trans configuration, A, B, Z, X, R1 and R2 are as defined in the specification. Such compositions are used in treating the skin or scalp of a human or non-human animal.
摘要翻译：公开了用于刺激毛发生长的方法和组合物，其中乳液包括式I表示的环戊烷庚酸，2-环烷基或芳基烷基化合物，其中虚线键代表可以是顺式或反式构型的单键或双键， A，B，Z，X，R 1和R 2如说明书中所定义。这样的组合物用于治疗人或非人动物的皮肤或头皮。

3. 发明申请

WO2007070695A3 FLUX-ENABLING COMPOSITIONS AND METHODS FOR DERMAL DELIVERY OF DRUGS 审中-公开
标题翻译：助燃剂组合物和用于药物递送的方法
公开(公告)号：WO2007070695A3
公开(公告)日：2008-08-21
申请号：PCT/US2006048061
申请日：2006-12-14
申请人： ZARS INC , ZHANG JIE , WARNER KEVIN S , SHARMA SANJAY
发明人： ZHANG JIE , WARNER KEVIN S , SHARMA SANJAY
IPC分类号： A61K8/02 , A61F13/00
CPC分类号： A61K9/7015 , A61K9/0014 , A61K9/0017
摘要： The present invention is drawn to adhesive solidifying formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system comprising at least one volatile solvent, and a non-volatile solvent system comprising at least one non-volatile solvent, wherein at least one non-volatile solvent is a flux-enabling non-volatile solvent(s) capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及粘合剂凝固制剂，药物递送方法和用于药物真皮递送的固化层。制剂可以包括药物，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系，其中至少一种非挥发性溶剂是助熔剂非挥发性溶剂（ s），其能够在持续的时间段内以治疗有效率促进药物的递送。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

4. 发明申请

WO2005117905A3 SYSTEMS AND METHODS FOR TREATING PANIC ATTACKS 审中-公开
标题翻译：处理泛型攻击的系统和方法
公开(公告)号：WO2005117905A3
公开(公告)日：2006-06-01
申请号：PCT/US2005018555
申请日：2005-05-27
申请人： ZARS INC , ZHANG JIE , WARNER KEVIN S , ASHBURN MICHAEL A
发明人： ZHANG JIE , WARNER KEVIN S , ASHBURN MICHAEL A
IPC分类号： A61F13/00 , A61F7/02 , A61F7/03 , A61K9/00 , A61K9/70 , A61K31/4468 , A61K31/4535 , A61K31/66 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/32 , A61M31/00 , A61M37/00 , A61N1/30
CPC分类号： A61K9/0014 , A61F7/032 , A61F7/034 , A61F2007/0261 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0009 , A61K9/0024 , A61K9/7053 , A61K9/7069 , A61K31/4468 , A61K31/4535 , A61K31/66 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/32 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30
摘要： Systems and methods for attenuating a panic attack are provided. Such methods can comprise steps of delivering a drug to a subject such that the drug forms a depot (22) beneath a skin surface, wherein the drug is suitable for attenuating a panic attack if delivered in a pharmaceutically effective amount into systemic circulation of the subject; and applying heat (28) to the skin surface when the subject experiences an onset of the panic attack, thereby causing the pharmaceutically effective amount of the drug to rapidly enter systemic circulation from the depot.
摘要翻译：提供了用于减轻恐慌发作的系统和方法。这样的方法可以包括将药物递送到受试者的步骤，使得药物在皮肤表面下形成贮存库（22），其中该药物适于减少惊厥发作，如果以药学有效量递送到受试者的全身循环中 ; 以及当受试者经历恐慌发作的开始时将热量（28）施加到皮肤表面，从而使药物有效量的药物迅速地从贮库中进入系统循环。

5. 发明申请

WO2005120473A3 DERMAL PEEL-FORMING FORMULATION 审中-公开
标题翻译： DERMAL PEEL-FORMING制剂
公开(公告)号：WO2005120473A3
公开(公告)日：2006-05-11
申请号：PCT/US2005020099
申请日：2005-06-07
申请人： ZARS INC , ZHANG JIE , WARNER KEVIN S , ASHBURN MICHAEL A , RIGBY LARRY D , NIU SUYI
发明人： ZHANG JIE , WARNER KEVIN S , ASHBURN MICHAEL A , RIGBY LARRY D , NIU SUYI
IPC分类号： A61F13/00 , A61K9/70
CPC分类号： A61K9/7015 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/445 , A61K31/573 , A61K47/10 , A61K47/32
摘要： The present invention is drawn to adhesive peel-forming formulations for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a peel-forming agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein the non-volatile solvent system has a solubility for the drug that is within a window of operable solubility for the drug such that the drug can be delivered at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified peelable layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及用于药物真皮递送的粘合剂剥离形成制剂。制剂可以包括药物，溶剂载体和剥离形成剂。溶剂载体可以包括具有一种或多种挥发性溶剂的挥发性溶剂体系和具有一种或多种非挥发性溶剂的非挥发性溶剂体系，其中所述非挥发性溶剂体系对于在窗口内的药物具有溶解性对于药物具有可操作的溶解性，使得药物可以在持续的时间段内以治疗有效的速率递送。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂系统的至少一部分蒸发之后，制剂可以形成固化的可剥离层。

6. 发明申请

WO2007070679A3 COMPOSITIONS AND METHODS FOR DERMALLY TREATING PAIN 审中-公开
标题翻译：用于牙痛治疗的组合物和方法
公开(公告)号：WO2007070679A3
公开(公告)日：2009-01-08
申请号：PCT/US2006047926
申请日：2006-12-14
申请人： ZARS INC , ZHANG JIE , WARNER KEVIN S , SHARMA SANJAY
发明人： ZHANG JIE , WARNER KEVIN S , SHARMA SANJAY
IPC分类号： A01N37/12
CPC分类号： A61K9/0014 , A61K47/10 , A61K47/18
摘要： The present invention is drawn to solidifying formulations for dermal delivery of a drug for treating pain, such as musculoskeletal pain, inflammation, joint pain, or neuropathic pain. The formulation can include a drug selected from certain drug classes, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system comprising at least one volatile solvent, and a non-volatile solvent system comprising at least one non-volatile solvent, wherein the evaporation of at least some of the volatile solvent converts the formulation on the skin into a solidified layer and the non-volatile solvent system is capable of facilitating the topical delivery of the drug(s) at therapeutically effective rates over a sustained period of time.
摘要翻译：本发明涉及用于皮肤递送用于治疗疼痛的药物如肌肉骨骼疼痛，炎症，关节疼痛或神经性疼痛的固化制剂。制剂可以包括选自某些药物类别的药物，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系，其中至少一些挥发性溶剂的蒸发将皮肤上的制剂转化成固化层和非挥发性溶剂体系能够在持续的时间内以治疗有效的速率促进药物的局部递送。

7. 发明申请

WO2007070694A2 SPRAY-ON FORMULATIONS AND METHODS FOR DERMAL DELIVERY OF DRUGS 审中-公开
标题翻译：用于药物递送的喷雾配方和方法
公开(公告)号：WO2007070694A2
公开(公告)日：2007-06-21
申请号：PCT/US2006048060
申请日：2006-12-14
申请人： ZARS INC , ZHANG JIE , WARNER KEVIN S , SHARMA SANJAY
发明人： ZHANG JIE , WARNER KEVIN S , SHARMA SANJAY
IPC分类号： A61K9/12
CPC分类号： A61K9/7015 , A61K47/10 , A61K47/12 , A61K47/32 , A61K47/34
摘要： The present invention is drawn to sprayable formulations, methods of drug delivery, and resultant solidified layers for dermal delivery of a drug. The formulation can include a drug, a non-volatile solvent system, a solidifying agent, and a propellant. The formulation can have an initial viscosity suitable to be expelled out of a pressurized or manual pump container and applied onto a skin surface as a layer. When applied to the skin, the formulation can form a solidified layer after at least a portion of the propellant is evaporated.
摘要翻译：本发明涉及可喷雾制剂，药物递送方法，以及用于药物真皮递送的所得固化层。制剂可以包括药物，非挥发性溶剂体系，固化剂和推进剂。制剂可以具有适于从加压或手动泵容器中排出的初始粘度，并将其施加到作为层的皮肤表面上。当施用于皮肤时，在推进剂的至少一部分蒸发之后，制剂可以形成固化层。

8. 发明申请

WO2006053222A3 INSTANT PATCH FOR DERMAL DRUG DELIVERY 审中-公开
标题翻译：用于皮肤药物递送的即时贴剂
公开(公告)号：WO2006053222A3
公开(公告)日：2006-08-31
申请号：PCT/US2005040938
申请日：2005-11-11
申请人： ZARS INC , ZHANG JIE , WARNER KEVIN S
发明人： ZHANG JIE , WARNER KEVIN S
IPC分类号： A61F13/00 , A61F13/02
CPC分类号： A61K9/703 , A61K9/7084 , A61L15/16 , A61L15/44 , A61L15/60 , A61L2300/40 , A61L2300/602
摘要： The present invention is drawn toward systems, devices, and methods of dermal drug delivery. The system can comprise a gel-triggering agent and a drug-containing composition including a drug and a gelling agent, wherein the drug-containing composition forms a soft, coherent solid when contacted with the gell-triggering agent. A cavity patch (10) is also included having an open cavity (18) configured to be closed at least in part by a skin surface (44). The open cavity can be further configured to facilitate contact between the skin surface and the gel. The gel-triggering agent and the drug-containing composition can be positioned in the system such that they are kept isolated from one another until immediately before or during use.
摘要翻译：本发明涉及皮肤给药的系统，装置和方法。该系统可以包含凝胶触发剂和包含药物和胶凝剂的含药物组合物，其中当与凝胶触发剂接触时，含药物组合物形成柔软的粘附固体。还包括空腔补片（10），其具有构造成至少部分地由皮肤表面（44）封闭的开放空腔（18）。开放腔可以进一步配置成促进皮肤表面和凝胶之间的接触。凝胶触发剂和含有药物的组合物可以位于系统中，使得它们在使用前或使用过程中保持彼此隔离。

9. 发明申请

WO2006053223A3 SYSTEMS AND METHODS FOR TREATING WARTS 审中-公开
标题翻译：用于处理战争的系统和方法
公开(公告)号：WO2006053223A3
公开(公告)日：2006-07-27
申请号：PCT/US2005040939
申请日：2005-11-11
申请人： ZARS INC , ZHANG JIE , WARNER KEVIN S
发明人： ZHANG JIE , WARNER KEVIN S
IPC分类号： A61F13/00 , A61F13/02
CPC分类号： A61K9/703 , A61F13/063 , A61K9/7084 , A61L15/16 , A61L15/44 , A61L15/60 , A61L2300/40 , A61L2300/602
摘要： The present invention is drawn to systems and methods for treating warts. The system can comprise a wart treatment formulation comprising a substance for treating warts and a cavity patch (10) comprising an open cavity (18) being configured to become a closed cavity upon application and adherence to a skin surface (44). The closed cavity can be configured to contain the wart treatment formulation.
摘要翻译：本发明涉及用于治疗疣的系统和方法。该系统可以包括疣治疗制剂，其包括用于治疗疣的物质和包括开放腔（18）的空腔贴片（10），所述开口腔被构造成在施用并粘附到皮肤表面（44）时变成闭合腔。闭合的腔体可以构造成容纳疣治疗制剂。

10. 发明申请

WO2009017767A3 COMPOSITIONS AND METHODS FOR DERMALLY TREATING NEUROPATHY WITH MINOXIDIL 审中-公开
标题翻译：用奥昔地尔皮肤治疗神经病变的组合物和方法
公开(公告)号：WO2009017767A3
公开(公告)日：2009-12-30
申请号：PCT/US2008009222
申请日：2008-07-30
申请人： ZARS PHARMA INC , ZHANG JIE , WARNER KEVIN S , SANJAY SHARMA
发明人： ZHANG JIE , WARNER KEVIN S , SANJAY SHARMA
IPC分类号： A01N43/54 , A61K8/00 , A61K31/505
CPC分类号： A61K31/165 , A61K31/415 , A61K31/445 , A61K31/505 , A61K31/56
摘要： The present invention is drawn to adhesive solidifying formulations containing minoxidil that can be used for treating neuropathies including diabetic neuropathy. The formulation can include an amount of minoxidil, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent capable of facilitating the delivery of the minoxidil at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及含米诺地尔的胶粘剂固化制剂，其可用于治疗包括糖尿病性神经病在内的神经病。该制剂可以包含一定量的米诺地尔，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系，所述挥发性溶剂能够促进米诺地尔在持续的一段时间内以治疗有效的速率递送。在挥发性溶剂体系蒸发之前，该配制剂可以具有适合施用于皮肤表面的粘度。当施用于皮肤时，在至少一部分挥发性溶剂体系蒸发后，制剂可形成固化层。

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