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1. 发明申请

WO2012057865A8 AUTOMATIC ADJUSTMENT OF ARRHYTHMIA DETECTION PARAMETERS 审中-公开
标题翻译：自动调整ARRHYTHMIA检测参数
公开(公告)号：WO2012057865A8
公开(公告)日：2013-04-25
申请号：PCT/US2011034474
申请日：2011-04-29
申请人： MEDTRONIC INC , ZHOU XIAOHONG , STADLER ROBERT , GUNDERSON BRUCE D , OLSON WALTER H
发明人： ZHOU XIAOHONG , STADLER ROBERT , GUNDERSON BRUCE D , OLSON WALTER H
IPC分类号： A61N1/37 , A61B5/0464
CPC分类号： A61N1/3706 , A61B5/046 , A61B5/0464 , A61B5/4836 , A61N1/3621
摘要： Methods and/or devices for initiating an automatic adjustment of arrhythmia detection parameters (e.g., upon delivery of cardiac therapy after detection of VT/VF).
摘要翻译：用于启动心律失常检测参数的自动调整的方法和/或装置（例如，在检测到VT / VF之后递送心脏治疗）。

2. 发明申请

WO2010138534A1 ELONGATE BATTERY FOR IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于可植入医疗装置的电池电池
公开(公告)号：WO2010138534A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/036118
申请日：2010-05-26
申请人： MEDTRONIC, INC. , LUND, Jeffrey, S. , MAY, Steven, J. , MERRITT, Donald, R. , ZHOU, Xiaohong
发明人： LUND, Jeffrey, S. , MAY, Steven, J. , MERRITT, Donald, R. , ZHOU, Xiaohong
IPC分类号： A61N1/378 , H01M4/00 , A61N1/372
CPC分类号： A61N1/378 , A61N1/056 , A61N1/375 , H01M2/0202 , H01M2/022 , H01M6/16
摘要： A battery assembly for a medical device having an axis. The battery assembly includes an elongate cathode, an elongate anode, an electrolyte, and an elongate housing assembly encapsulating the cathode, the anode, and the electrolyte. The housing assembly is substantially coaxial with the cathode and the anode. The battery assembly also includes a first electrode that is exposed from and electrically insulated from the housing assembly and disposed in the open end. One of the anode and the cathode is electrically coupled to the first electrode and the other is electrically coupled to the housing assembly. The cathode and the anode are coaxial and spaced apart in a direction substantially parallel to the axis.
摘要翻译：用于具有轴线的医疗装置的电池组件。电池组件包括细长阴极，细长阳极，电解质以及包封阴极，阳极和电解质的细长外壳组件。壳体组件基本上与阴极和阳极同轴。电池组件还包括第一电极，其从壳体组件暴露并且与壳体组件电绝缘且设置在开口端中。阳极和阴极中的一个电连接到第一电极，而另一个电连接到壳体组件。阴极和阳极在基本上平行于轴线的方向上同轴并间隔开。

3. 发明申请

WO2010120829A2 METHOD FOR REDUCING ARTIFACTS IN MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：减少磁共振成像艺术的方法
公开(公告)号：WO2010120829A2
公开(公告)日：2010-10-21
申请号：PCT/US2010/030951
申请日：2010-04-13
申请人： THE BOARD OF TRUSTEES OF THE UNIVERISITY OF ILLINOIS , ZHOU, Xiaohong, Joe , RANGWALA, Novena, A.
发明人： ZHOU, Xiaohong, Joe , RANGWALA, Novena, A.
IPC分类号： G01R33/54
CPC分类号： G01R33/56518 , G01R33/4833 , G01R33/5617 , G01R33/56563 , G01R33/56572
摘要： Disclosed are methods for magnetic resonance imaging (MRI) that reduce the appearance of artifacts in a final image. Also provided are a computer readable medium comprising instructions that when executed by a CPU results in the reduction of artifacts in a magnetic resonance image, and an MRI apparatus comprising the computer readable medium. Also disclosed is a data processing method that provides further reduction of residual artifacts in a magnetic resonance image. The disclosed methods provide a simple and effective approach to ameliorate various artifacts in virtually any type of MRI scanners.
摘要翻译：公开了用于减少最终图像中伪影出现的磁共振成像（MRI）的方法。还提供了包括指令的计算机可读介质，当由CPU执行时，导致减少磁共振图像中的伪像，以及包括计算机可读介质的MRI装置。还公开了一种数据处理方法，其进一步减少磁共振图像中的残余伪像。所公开的方法提供了简单有效的方法来改善几乎任何类型的MRI扫描仪中的各种伪像。

4. 发明申请

WO2010051426A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 审中-公开
公开(公告)号：WO2010051426A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/062720
申请日：2009-10-30
申请人： MEDTRONIC, INC. , KRAUSE, Paul, G. , BURNES, John, E. , DONOFRIO, William, T. , PEICHEL, David, J. , ARNE, Gerald, P. , ZHOU, Xiaohong , REINKE, James, D.
发明人： KRAUSE, Paul, G. , BURNES, John, E. , DONOFRIO, William, T. , PEICHEL, David, J. , ARNE, Gerald, P. , ZHOU, Xiaohong , REINKE, James, D.
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/08 , A61N1/36114 , A61N1/37 , A61N1/37258 , A61N1/37288
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

5. 发明申请

WO2010051389A1 COMMUNICATION BETWEEN IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：可植入医疗器械之间的通讯
公开(公告)号：WO2010051389A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/062639
申请日：2009-10-29
申请人： MEDTRONIC, INC. , KRAUSE, Paul, G. , DONOFRIO, William, T. , ARNE, Gerald, P. , BURNS, John, E. , PEICHEL, David, J. , ZHOU, Xiaohong
发明人： KRAUSE, Paul, G. , DONOFRIO, William, T. , ARNE, Gerald, P. , BURNS, John, E. , PEICHEL, David, J. , ZHOU, Xiaohong
IPC分类号： A61N1/372 , A61N1/37 , A61N1/362
CPC分类号： A61N1/37288 , A61N1/36082 , A61N1/362 , A61N1/3706 , A61N1/37217 , A61N1/3727
摘要： A first implantable medical device (IMD) implanted within a patient may communicate with a second IMD implanted within the patient by encoding information in an electrical stimulation signal. The delivery of the electrical stimulation signal may provide therapeutic benefits to the patient. The second IMD may sense the electrical stimulation signal, which may be presented as an artifact in a sensed cardiac signal, and process the sensed signal to retrieve the encoded information. The second IMD may modify its operation based on the received therapy information. Crosstalk between the first and second IMDs may be reduced using various techniques described herein. For example, the first IMD may generate the electrical stimulation signal to include a spread spectrum energy distribution or a predetermined signal signature. The second IMD may effectively remove a least some of the signal artifact in a sensed cardiac signal based on the predetermined signal signature.
摘要翻译：植入在患者体内的第一可植入医疗装置（IMD）可以通过对电刺激信号中的信息进行编码来与植入患者内的第二IMD进行通信。电刺激信号的传递可以为患者提供治疗益处。第二IMD可以感测电刺激信号，其可以被呈现为感测到的心脏信号中的伪像，并且处理感测到的信号以检索经编码的信息。第二IMD可以基于接收到的治疗信息修改其操作。可以使用本文所述的各种技术来减少第一和第二IMD之间的串扰。例如，第一IMD可以产生电刺激信号以包括扩频能量分布或预定信号特征。基于预定的信号签名，第二IMD可以有效地去除感测到的心脏信号中的至少一些信号伪像。

6. 发明申请

WO2010051385A1 IMPLANTABLE MEDICAL DEVICE INCLUDING EXTRAVASCULAR CARDIAC STIMULATION AND NEUROSTIMULATION CAPABILITIES 审中-公开
标题翻译：包括超声心动图刺激和神经修复能力的可植入医疗装置
公开(公告)号：WO2010051385A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/062615
申请日：2009-10-29
申请人： MEDTRONIC, INC. , BURNES, John, E. , ZILLMER, Chris , KRAUSE, Paul, G. , ARNE, Gerald, P. , DAVIS, Timothy , PEICHEL, David, J. , REINKE, James, D. , DONOFRIO, William, T. , ZHOU, Xiaohong
发明人： BURNES, John, E. , ZILLMER, Chris , KRAUSE, Paul, G. , ARNE, Gerald, P. , DAVIS, Timothy , PEICHEL, David, J. , REINKE, James, D. , DONOFRIO, William, T. , ZHOU, Xiaohong
IPC分类号： A61N1/36 , A61N1/362 , A61N1/05 , A61N1/39 , A61N1/365 , A61B5/046
CPC分类号： A61N1/0504 , A61B5/046 , A61N1/0587 , A61N1/36114 , A61N1/3622 , A61N1/365 , A61N1/3962
摘要： An implantable medical device may deliver pacing, cardioversion, and/or defibrillation stimulation to a heart of a patient via extravascular electrodes and delivers electrical stimulation to a nonmyocardial tissue site to modulate the autonomic nervous system of the patient. The implantable medical device may include a cardiac therapy module that generates and delivers at least one of pacing, cardioversion, or defibrillation therapy to a patient via an extravascular electrode, and a neurostimulation therapy module that generates and delivers a neurostimulation signal to the patient via a neurostimulation electrode. The cardiac therapy module and neurostimulation therapy module may be disposed in a common housing of the medical device. In some examples, at least one common lead may electrically couple the neurostimulation electrode and the extravascular electrode to the neurostimulation and cardiac therapy modules, respectively.
摘要翻译：可植入医疗装置可通过血管外电极向患者的心脏输送起搏，心脏复律和/或除颤刺激，并将电刺激递送至非心肌组织部位以调节患者的自主神经系统。可植入医疗装置可以包括心脏治疗模块，该心脏治疗模块通过血管内电极产生并向患者输送起搏，心脏复律或除颤疗法中的至少一种，以及神经刺激治疗模块，其通过经由血管内电极产生和递送神经刺激信号给患者神经刺激电极。心脏治疗模块和神经刺激治疗模块可以设置在医疗装置的公共壳体中。在一些示例中，至少一个共同引线可以将神经刺激电极和血管外电极分别电耦合到神经刺激和心脏治疗模块。

7. 发明申请

WO2006060587A1 METHOD AND APPARATUS FOR DETECTION AND MONITORING OF T-WAVE ALTERNANS 审中-公开
标题翻译：用于检测和监测T波形变换器的方法和装置
公开(公告)号：WO2006060587A1
公开(公告)日：2006-06-08
申请号：PCT/US2005/043490
申请日：2005-12-01
申请人： MEDTRONIC, INC. , STADLER, Robert, W. , GILLBERG, Jeffrey, M. , MULLEN, Thomas, J. , ZHOU, Xiaohong
发明人： STADLER, Robert, W. , GILLBERG, Jeffrey, M. , MULLEN, Thomas, J. , ZHOU, Xiaohong
IPC分类号： A61B5/0452
CPC分类号： A61N1/3702 , A61B5/0422 , A61B5/0452
摘要： A system and method are provided for assessing T-wave alternans (TWA) using cardiac EGM signals received from implanted electrodes. A T-wave signal parameter is measured from signals received by an automatic gain control sense amplifier. A TWA measurement is computed from a beat-by-beat comparison of T-wave parameter measurements or using frequency spectrum techniques. The TWA measurement magnitude and measurement conditions are used in detecting a clinically important TWA. TWA assessment further includes discriminating concordant and discordant TWA in a multi-vector TWA assessment, and determining the association of a TWA measurement with QRS alternans, mechanical alternans, and other physiological events. A prediction of a pathological cardiac event is made in response to a TWA assessment. A response to a cardiac event prediction is provided.
摘要翻译：提供了一种使用从植入电极接收的心脏EGM信号评估T波交替（TWA）的系统和方法。从由自动增益控制读出放大器接收的信号测量T波信号参数。通过T波参数测量或使用频谱技术的逐拍比较来计算TWA测量。 TWA测量值和测量条件用于检测临床重要的TWA。 TWA评估还包括在多向量TWA评估中区分一致和不一致的TWA，以及确定TWA测量与QRS交替，机械交替和其他生理事件的关联。病理性心脏事件的预测是针对TWA评估做出的。提供对心脏事件预测的响应。

8. 发明申请

WO2020150726A1 METHODS AND SYSTEMS FOR PRODUCING MAGNETIC RESONANCE IMAGES WITH SUB-MILLISECOND TEMPORAL RESOLUTION 审中-公开
公开(公告)号：WO2020150726A1
公开(公告)日：2020-07-23
申请号：PCT/US2020/014345
申请日：2020-01-21
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , ZHOU, Xiaohong Joe , ZHONG, Zheng , KARAMAN, Meryem Muge
发明人： ZHOU, Xiaohong Joe , ZHONG, Zheng , KARAMAN, Meryem Muge
IPC分类号： G01R33/48 , G01R33/483 , G01R33/50 , G01R33/54 , G01R33/56 , G01R33/561
摘要： A system and method for producing a series of time-resolved magnetic resonance (MR) images is set forth. The system can perform method steps of encoding spatial information into an MRI signal by manipulating a phase of the MRI signal within an MRI system, generating and outputting a phase-encoded MRI signal over time by digitizing a plurality of time points in the MRI signal, repeating the generating and outputting step for a plurality of phase-encoded signals, each phase-encoded signal in synchrony with a trigger, producing a plurality of digitized time points, and reconstructing a series of time resolved MR images, each image of the series of MR images at one specific time point selected from the plurality of digitized time points for each phase-encoded step. Each image in the series of time-resolved MR images corresponding to a specific time point in a cyclic event.

9. 发明申请

WO2011053381A1 MEASURING T-WAVE ALTERNANS 审中-公开
标题翻译：测量T波形ALTERNANS
公开(公告)号：WO2011053381A1
公开(公告)日：2011-05-05
申请号：PCT/US2010/033366
申请日：2010-05-03
申请人： MEDTRONIC, INC. , SHARMA, Vinod , ZHOU, Xiaohong
发明人： SHARMA, Vinod , ZHOU, Xiaohong
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452
摘要： Techniques for monitoring T-wave alternans (TWAs) in a patient are described. An implantable medical device (IMD) (16), such as an implantable pacemaker, cardioverter, or diagnostic device, generates an EGM signal, e.g., a far field EGM signal, samples the EGM signal to obtain a single T-wave amplitude value for each T-wave over a plurality of beats, and stores the T-wave amplitude values in memory. The IMD creates a time series of the T-wave amplitude values stored in memory, calculates the power spectral density of a particular frequency, e.g., 0.5 cycles per beat, as the TWA value. The IMD may periodically determine TWA values for the patient and store the values in memory. The TWA values may be presented to medical personnel, e.g., as a trend. The IMD may deliver or modify therapy, or provide an alert, based on the TWA values.
摘要翻译：描述了用于监测患者中的T波交替（TWAs）的技术。诸如可植入心脏起搏器，心律转复器或诊断装置的可植入医疗装置（IMD）（16）产生例如远场EGM信号的EGM信号，对EGM信号进行采样以获得单个T波振幅值在多个节拍中的每个T波，并将T波振幅值存储在存储器中。 IMD产生存储在存储器中的T波幅度值的时间序列，计算特定频率的功率谱密度，例如每个节拍0.5个循环，作为TWA值。 IMD可以周期性地确定患者的TWA值并将值存储在存储器中。 TWA值可以呈现给医务人员，例如作为趋势。 IMD可以根据TWA值提供或修改治疗或提供警报。

10. 发明申请

WO2010051465A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 审中-公开
公开(公告)号：WO2010051465A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/062805
申请日：2009-10-30
申请人： MEDTRONIC, INC. , DONOFRIO, William, T. , BURNES, John, E. , KRAUSE, Paul, G. , ZHOU, Xiaohong , ARNE, Gerald, P. , PEICHEL, David, J. , REINKE, James, D.
发明人： DONOFRIO, William, T. , BURNES, John, E. , KRAUSE, Paul, G. , ZHOU, Xiaohong , ARNE, Gerald, P. , PEICHEL, David, J. , REINKE, James, D.
IPC分类号： A61N1/05 , A61N1/37 , A61N1/372 , A61B5/0428
CPC分类号： A61N1/36114 , A61B5/04288 , A61B5/7217 , A61N1/3621 , A61N1/36521 , A61N1/3688 , A61N1/3702 , A61N1/37247 , A61N1/37282 , A61N1/3962 , A61N2001/083
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

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